Index of Cleared Science Reviews for Fipronil (Pc Code 129121)

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Undated. DER. 36 Pages.
OPP. EPA.
Active Transfer; Animal Hair. Dislodgeable Residues of Fipronil
Following Topical Application of Frontline® Spot-on Treatment to Dogs.
MRID 445312-03.
Document (PDF) (452 KB PDF).

Undated. Memorandum. 7 Page(s).
Anthony Maciorowski. Ecological Effects Branch.
New Chemical Screen-Expedited Review for Fipronil Insecticide [Regent 1.5G]
-(Fipronil Technical: sulfoxide 5-amino-1-[2,6-dichloro-4-trifluoromethly)
phenyl] -4-[ (1 R,S) - (trifluoromethyl) sulyfinyl]-1H-pyrazole-3- carbonitrile.
Document (PDF) (940 KB PDF).

Undated. Review. 13 Page(s).
Dennis Opresko. Oak Ridge National Lab for EPA.
Frontline Plus For Cats And Kittens
STUDY TYPE: Companion Animal Safety - Cat (OPPTS 870.7200)
MRID 44942009.
Document (PDF) (590 KB PDF).

November 01, 1992. Memorandum. 3 Page(s).
G. F. Kramer. Chemistry Branch I.
Fipronil in/on Corn. Request for Petition Method Validation.
PP#5G04583. MRID Nos. 437766-04 & -05.
Document (PDF) (204 KB PDF).

February 28, 1994. DER. 14 Page(s).
Virginia Dobozy. Toxicology Branch II.
M&B 46030: Toxicity study by Oral (Capsule)
Administration to Beagle Dogs for 13 Weeks.
MRID No. 429186-42. Tox Review No. 011086.
Document (PDF) (1134 KB PDF).

March 09, 1994. DER. Review. 10 Page(s).
Ann Stavola. Ecological Effects Branch.
71-2. Avian Dietary LC50 Test.
Species Tested: Mallard Duck (Anas platyrhynchos).
Pages 6-10 removed-registrant data.
MRID No. 429186-21.
Document (PDF) (335 KB PDF).

March 09, 1994. DER. Review. 16 Page(s).
Anthony F. Maciorowski. Ecological Effects Branch.
Request for an experimental use permit (section 5 of FIFRA) for
use of Fipronil 1.5G on corn throughout the mid-western United States.
Document (PDF) (783 KB PDF).

March 10, 1994. DER. 19 Page(s).
Virginia Dobozy. Toxicology Branch II.
M&B 46030: Toxicity Study by Dietary Administration to CD Rats for 13 Weeks.
MRID No. 429186-43. Tox Review No. 011086.
Document (PDF) (1229 KB PDF).

March 11, 1994. DER. Review. 10 Page(s).
James J. Goodyear. Ecological Effects Branch.
71-2. Avian Dietary LC50 Test.
Species Tested: Bobwhite Quail (Colinus virginianus).
Pages 7-10 removed-registrant data. MRID No. 429186-20.
Document (PDF) (359 KB PDF).

March 11, 1994. DER. Review. 7 Page(s).
James J. Goodyear. Ecological Effects Branch.
71-1A. Avian Single Dose Oral LD50 Test.
Species Tested: Bobwhite Quail (Colinus
virginianus). Pages 6-7 removed-registrant data. MRID No. 429186-17.
Document (PDF) (377 KB PDF).

March 11, 1994. DER. Review. 7 Page(s).
James J. Goodyear. Ecological Effects Branch.
71-1A. Avian Single Dose Oral LD50 Test.
Species Tested: Mallard Duck (Anas platyrhynchos).
Pages 5-7 removed-registrant data. MRID No. 429186-16.
Document (PDF) (292 KB PDF).

March 16, 1994. Memorandum. 5 Page(s).
G. F. Kramer. Chemistry Branch I.
New Chemical-Fipronil in/on Corn. Request for Petition Method Validation.
PP#3G04263. MRID Nos. 429186-66.
Document (PDF) (227 KB PDF).

March 21, 1994. DER. 6 Page(s).
Mark Mossler. Ecological Effects Branch.
122-2. Growth and Reproduction of Aquatic Plants - Tier 1.
Species Tested: Anabaena flos-aquae.
Registration Data information removed from pages 5-6.
MRID No. 429186-57.
Document (PDF) (316 KB PDF).

March 21, 1994. DER. 6 Page(s).
Mark Mossler. KBN Engineering for EEB.
Study Type: 122-2. Growth and reproduction of aquatic plants - Tier 1.
Species Tested: Skeletonema costatum. MRID 429186-59.
Pages 5-6 removed, registrant data.
Document (PDF) (326 KB PDF).

March 21, 1994. DER. 7 Page(s).
Mark Mossler. Ecological Effects Branch.
122-2. Growth and Reproduction of Aquatic Plants - Tier 1.
Species Tested: Selenastrum Capricornutum.
Registration Data information removed from pages 6-7.
MRID No. 429186-60.
Document (PDF) (334 KB PDF).

March 21, 1994. DER. Review. 11 Page(s).
James J. Goodyear. Ecological Effects Branch.
72-4. Freshwater Invertebrate Life-Cycle Test. Species Tested: Daphnia magna.
Pages 7-11 removed registrant data. MRID No. 429186-26.
Document (PDF) (569 KB PDF).

March 21, 1994. DER. Review. 12 Page(s).
James J. Goodyear. Ecological Effects Branch.
72-4. Freshwater Invertebrate Life-Cycle Test. Species Tested: Daphnia magna.
Pages 8-12 removed-registrant data. MRID No. 429186-70.
Document (PDF) (533 KB PDF).

March 21, 1994. DER. Review. 26 Page(s).
James J. Goodyear. Ecological Effects Branch.
72-4. Freshwater Fish Early Life-Stage Test. Species Tested: Rainbow Trout
(Oncorhynchus mykiss). Pages 23-26 removed-registrant data. MRID No. 429186-27.
Document (PDF) (986 KB PDF).

March 21, 1994. DER. Review. 6 Page(s).
James J. Goodyear. Ecological Effects Branch.
72-2. Freshwater Invertebrate Acute Flow-Through Toxicity Test.
Species Tested: Daphnia magna. Pages 5-6 removed-registrant data.
MRID No. 429186-69.
Document (PDF) (361 KB PDF).

March 21, 1994. DER. Review. 7 Page(s).
James J. Goodyear. Ecological Effects Branch.
72-1. Freshwater Fish Acute Flow-Through Toxicity Test.
Species Tested: Bluegill Sunfish (Lepomis macrochirus).
Pages 6-7 removed-registrant data. MRID No. 429186-74.
Document (PDF) (362 KB PDF).

March 21, 1994. DER. Review. 7 Page(s).
James J. Goodyear. Ecological Effects Branch.
72-1. Freshwater Fish Acute Flow-Through Toxicity Test.
Species Tested: Bluegill Sunfish (Lepomismacrochirus).
Pages 6-7 removed-registrant data. MRID No. 429186-24.
Document (PDF) (354 KB PDF).

March 21, 1994. DER. Review. 7 Page(s).
James J. Goodyear. Ecological Effects Branch.
72-1. Freshwater Fish Acute Flow-Through Toxicity Test.
Species Tested: Rainbow Trout (Oncorhynchus mykiss).
Pages 6-7 removed-registrant data. MRID No. 429186-73.
Document (PDF) (374 KB PDF).

March 21, 1994. DER. Review. 8 Page(s).
James J. Goodyear. Ecological Effects Branch.
122-2. Growth and Reproduction of Aquatic Plants - Tier 1.
Species Tested: Duckweed (Lemna gibba).
Pages 5-7 removed-registrant data. MRID No. 429186-56.
Document (PDF) (347 KB PDF).

March 21, 1994. DER. Review. 8 Page(s).
James J. Goodyear. Ecological Effects Branch.
72-1. Freshwater Fish Acute Flow-Through Toxicity Test.
Species Tested: Rainbow Trout (Oncorhynchus mykiss).
Pages 5-7 removed-registrant data. MRID No. 429779-02.
Document (PDF) (348 KB PDF).

March 21, 1994. DER. Review. 9 Page(s).
James J. Goodyear. Ecological Effects Branch.
71-1A. Avian Single Dose Oral LD50 Test. Species Tested: House Sparrow
(Passer domesticus). Page 8 removed-registrant data. MRID No. 429186-18.
Document (PDF) (501 KB PDF).

March 22, 1994. DER. 12 Page(s).
James J. Goodyear. Ecological Effects Branch.
71-1A. Avian Single Dose Oral LD50 Test. Species Tested: Bobwhite Quail
(Colinus virginianus). Pages 7-12 removed-registrant data.
MRID No. 429186-19.
Document (PDF) (399 KB PDF).

March 29, 1994. DER. Review. 32 Page(s).
Ann Stavola. Ecological Effects Branch.
72-4. Freshwater Invertebrate Life-Cycle Test. Species Tested: Daphnia magna.
Pages 9-12 removed-registrant data. MRID No. 429186-72.
Document (PDF) (1104 KB PDF).

April 15, 1994. Memorandum. 1 Page(s).
G. F. Kramer. Chemistry Branch I.
New Chemical-Fipronil in/on Corn. Request for Petition Method Validation.
PP#3G04263. MRID Nos. 429186-66.
Document (PDF) (95 KB PDF).

April 19, 1994. Memorandum. 33 Page(s).
Virginia A. Dobozy. Toxicology Branch II.
Fipronil-Review of data to support EUP for Domestic Animal Product (0.25% fipronil)
Pages 14, 23-24, 31-33 removed, registration data. Tox Review 010923.
Document (PDF) (1674 KB PDF).

May 06, 1994. DER. 8 Page(s).
Ann Stavola. Ecological Effects Branch.
71-1A. Avian Single Dose Oral LD50 Test. Species Tested: Pigeon (Columba livia).
Pages 7-8 removed-registrant data. MRID No. 429186-13.
Document (PDF) (429 KB PDF).

May 06, 1994. DER. 8 Page(s).
Ann Stavola. Ecological Effects Branch.
72-2. Freshwater Intertebrate Acute Flow-Through Toxicity Test.
Species Tested: Saphnia magna. Pages 6-7 removed-registrant data.
MRID No. 429186-25.
Document (PDF) (409 KB PDF).

May 06, 1994. DER. Review. 12 Page(s).
Ann Stavola. Ecological Effects Branch.
71-1A. Avian Single Dose Oral LD50 Test.
Species Tested: Red-legged partridge (Alectoris rufa).
Pages 7-11 removed-registrant data. MRID No. 429186-14.
Document (PDF) (462 KB PDF).

May 06, 1994. DER. Review. 14 Page(s).
Ann Stavola. Ecological Effects Branch.
71-1A. Avian Single Dose Oral LD50 Test.
Species Tested: Pheasant (Phasianus colchicus).
Pages 7-13 removed-registrant data. MRID No. 429186-15.
Document (PDF) (428 KB PDF).

May 10, 1994. DER. 22 Page(s).
Timothy MacMahon. Toxicology Branch II.
[Rat] Metabolism (85-1). MRID 429186-55.
Page 22 is removed, registrant data. Tox Review No. 011086.
Document (PDF) (1412 KB PDF).

May 10, 1994. DER. Review. 73 Page(s).
Ann Stavola. Ecological Effects Branch.
71-4. Avian Reproduction Study. Species Tested: Mallard duck (Anas platyrhynchos).
Pages 9-46 removed-registrant data. MRID No. 429186-23.
Document (PDF) (3463 KB PDF).

May 12, 1994. DER. 35 Page(s).
Virginia Dobozy. Toxicology Branch II.
Combined chronic toxicity/oncogenicity/ Rats.
MRID No. 429186-48. Tox review 011086.
Document (PDF) (2312 KB PDF).

May 16, 1994. DER. Review. 47 Page(s).
Ann Stavola. Ecological Effects Branch.
71-4. Avian Reproduction Study. Species Tested: Bobwhite quail
(Colinus virginianus). Pages 10-20 removed-registrant data.
MRID No. 429186-22.
Document (PDF) (2302 KB PDF).

May 23, 1994. Review. 13 Page(s).
Yiannakis Ioannou. Toxicology Branch.
Chronic toxicity/Dogs (83-1) Toxicity study by oral (capsule) administration
to beagle dogs for 52 weeks. MRID 429186-45 Tox review 011086 (excerpt).
Document (PDF) (876 KB PDF).

June 07, 1994. Memorandum. 24 Page(s).
G. F. Kramer. Chemistry Branch I.
New Chemical-Fipronil in/on Corn RAC's. Evaluation of Residue Data & Analytical
methodology. PP#3G04263. MRID Nos. 428186-01 to -12 & -65 to -68, & 429779-01.
Document (PDF) (1794 KB PDF).

June 07, 1994. Memorandum. 24 Page(s).
Virginia Dobozy. Toxicology Branch.
Fipronil - review of Acute Toxicity Studies to Support EUP for Domestic
Animal Product (0.25% fipronil) MRID 431211-04, 05, 06, 07 , 08, 09.
Document (PDF) (1192 KB PDF).
Attachment(s) Following:

June 07, 1994. Memorandum.
Virginia Dobozy. Toxicology Branch.
(continued) Quality control procedure information and manufacturing process (MP)
info on pages 5, 11, 15 is not included. Pages 17-18 removed, registration data.
Quality control procedure info and MP pages 20, 23 is not included.
Tox review 011024.

*End of Attachments*

June 07, 1994. Memorandum. 77 Page(s).
Virginia Dobozy. Toxicology Branch.
M&B 46030 (Fipronil) - Review of Toxicology Data for an EUP/temporary
tolerance for use on field corn. MRID 429186-29 thru 34, -36 thru 41, -40, -41.
Document (PDF) (6322 KB PDF).
Attachment(s) Following:

June 07, 1994. Memorandum.
Virginia Dobozy. Toxicology Branch.
(continued) Pages 23, 27, 31, 42, 49, 63, 67,
71 removed, registrant data. Tox review 011025.

*End of Attachments*

June 13, 1994. Memorandum. 155 Page(s).
Paul Mastradone. Environmental Fate & Ground Water Branch.
000264-EUP-OL. Review of EUP for corn & environmental fate data
submitted to support the food/feed use EUP. Pages 18-27, 31-53,
58-86, 91-100, 107-118, 123-131, 135-155 removed, registrant data.
MRID Nos. 42194704, 42918662, 42918663, 42918664, 43018801.
Document (PDF) (3064 KB PDF).

June 28, 1994. Memorandum. 310 Page(s).
Virginia Dobozy. Toxicology Branch.
M&B 46030 (Fipronil) - Review of Toxicology Data Submitted by the Registrant
[acute, subchronic, chronic, oncogenicity, developmental, reproduction, mutagenicity,
metabolism, special] MRID 429186-35, -42 thru 55, 79, 80. 429779-03, 04.
Document (PDF) (16688 KB PDF).
Attachment(s) Following:

June 28, 1994. Memorandum.
Virginia Dobozy. Toxicology Branch.
(continued) Pages 27-30, 107, 153-163, 176-192, 280, 289, 297-300, 306-310
removed, registrant data. Manufacturing process information on pages 145, 164,
166 is not included. Tox review 011086.

*End of Attachments*

July 07, 1994. Memorandum. 2 Page(s).
Virginia Dobozy. Toxicology Branch II.
Fipronil (0.25%) - Preliminary Domestic Animal Safety Study in
Kittens to Support Experimental Use of Product in Cats and Kittens.
Document (PDF) (154 KB PDF).

July 07, 1994. Memorandum. 20 Page(s).
Virginia Dobozy. Toxicology Branch.
MB 46513, Fipronil Metabolite - Review of Three Toxicity Studies
[acute oral, acute dermal, 14-day oral tox - rats] MRID 432354-01, 02, 03.
Page 20 removed, registration data. Tox review 011098.
Document (PDF) (1601 KB PDF).

July 15, 1994. Memorandum. 6 Page(s).
Virginia Dobozy. Toxicology Branch II.
MB 46950, Fipronil Metabolite - Review of Acute Oral Toxicity Study.
MRID No. 432797-06. Tox Review No. 011108.
Document (PDF) (412 KB PDF).

August 02, 1994. Memorandum. 3 Page(s).
Timothy MacMahon. Toxicology Branch II.
Fipronil: Review of Additional Toxicology Data Submitted by the Registrant
(rat metabolism study, MRID 429186-55) Tox Review No. 011145.
Document (PDF) (113 KB PDF).

August 03, 1994. Review. 2 Page(s).
Vern McFarland. Insecticide Rodenticide Branch.
Efficacy Review [for fleas and ticks] Petition or Experimental
Permit No. 65331-EUP-R; Fipronil 0.25% Topical Spray. D199700.
MRIDs 43121114 through 43121122.
Document (PDF) (157 KB PDF).

August 10, 1994. Memorandum. 7 Page(s).
Anthony Maciorowski. Ecological Effects Branch.
Reg./File # 264-LLN New Chemical Screen use on turf
MRID 432917-01, 02, 18, 19, 23, 24, 25.
Document (PDF) (434 KB PDF).

September 12, 1994. Memorandum. 1 Page(s).
Virginia Dobozy. Toxicology Branch.
Fipronil Topical Spray (RM 1601C) - Request for Waiver of Dermal
Sensitization and Acute Inhalation Studies with Technical Preparation.
Document (PDF) (59 KB PDF).

September 12, 1994. Memorandum. 6 Page(s).
G. F. Kramer. Chemistry Branch I.
New Chemical-Fipronil in/on Corn. Request for Petition Method Validation.
PP#3G04263. MRID Nos. 429186-66 & 433234-01.
Document (PDF) (248 KB PDF).

September 22, 1994. Memorandum. 6 Page(s).
George Ghali. Health Effects Division.
RfD/Peer Review Report of Fipronil [5-Amino...] Tox review 011232.
Document (PDF) (464 KB PDF).

November 15, 1994. Memorandum. 1 Page(s).
G. F. Kramer. Chemistry Branch I.
Fipronil in/on corn. New Chemical Screening. PP# 5F04426.
MRID No. 434011-04.
Document (PDF) (60 KB PDF).

December 08, 1994. DER. 8 Page(s).
Andrew Bryceland. Ecological Effects Branch.
Study Type: 122-2. Growth and Reproduction of Aquatic Plants - Tier 1.
Species Tested: Navicula pelliculosa. MRID 429186-58.
Pages 7-8 removed, registration data.
Document (PDF) (410 KB PDF).

December 20, 1994. Memorandum. 6 Page(s).
Virginia Dobozy. Toxicology Branch.
Fipronil - Review of Registrant's Response to Upgrade Acute
Inhalation and Dermal Sensitization Studies. Tox review 011366.
Document (PDF) (412 KB PDF).

January 10, 1995. Memorandum. 11 Page(s).
Anthony F. Maciorowski. Ecological Effects Branch.
Rebuttal Letter for Fipronil: Data evaluation Records for the registration of
Fipronil insecticide. (Fipronil Technical: sulfoxide 5-amino-1-[2,6-dichloro-4-
trifluoromethly)phenyl]-4[(1R, S)-(trifluoromethyl) sulyfinyl]-1H-pyrazole-3-carbonitrile.
Document (PDF) (935 KB PDF).
Attachment(s) Following:

January 10, 1995. Memorandum. 11 Page(s).
Anthony F. Maciorowski. Ecological Effects Branch.
MRID Nos. 429186-13 thru 19, 429186-22, 429186-56,
429186-58 429186-72, 429186-26, 429186-70 & 429186-25.

*End of Attachments*

January 10, 1995. Memorandum. 14 Page(s).
Anthony F. Maciorowski. Ecological Effects Branch.
Response to 6 (a)(2) data for Fipronil.
MRID Nos. 432797-02 thru 05, 432979-01.
Document (PDF) (1262 KB PDF).

January 10, 1995. Memorandum. 3 Page(s).
Virginia A. Dobozy. Toxicology Branch II.
Fipronil (0.25% W/V) (Tradename: Frontline) Review of Risk Assessment.
Document (PDF) (154 KB PDF).

January 10, 1995. Memorandum. 41 Page(s).
Anthony F. Maciorowski. Ecological Effects Branch.
Review of data for Fipronil submitted by Rhone-Poulenc, Inc.
Pages 10-13, 21-23, 32-33 & 40-41 removed-registrant data.
MRID Nos. 432917-01 thru 02 & 432917-18 thru 19.
Document (PDF) (3611 KB PDF).

January 18, 1995. Memorandum. 1 Page(s).
G. F. Kramer. Chemistry Branch I.
New Chemical-Fipronil in/on Corn. Answer to Registrants' question
regarding datatranslation between formulation types. PP# 3G04263.
Document (PDF) (72 KB PDF).

January 19, 1995. Review. 4 Page(s).
Anthony Maciorowski. Ecological Effects Branch.
Review rebuttals to DER's.
Document (PDF) (227 KB PDF).

January 25, 1995. Memorandum. 1 Page(s).
G. F. Kramer. Chemistry Branch I.
ID# 00264-EUP-OL. Fipronil- Review of 12/7/94 meeting with Rhone-Poulenc.
Document (PDF) (82 KB PDF).

February 01, 1995. Memorandum. 8 Page(s).
Virginia Dobozy. Toxicology Branch II.
Fipronil (0.25% w/v) (Tradename: Frontline).
Review of Domestic Animal Safety Study in Kittens.
Tox Review 011405. Inert ingredient info on page 6 not included.
Document (PDF) (214 KB PDF).

February 08, 1995. Memorandum. 4 Page(s).
G. F. Kramer. Chemistry Branch I.
New Chemical-Fipronil in/on Corn. Amendment of 1/31/95. PP# 3G04263.
Document (PDF) (243 KB PDF).

February 16, 1995. Memorandum. 2 Page(s).
G. F. Kramer. Chemistry Branch I.
New Chemical-Fipronil in/on Corn RAC's. Amendment of 2/9/95. PP# 3G04263.
Document (PDF) (126 KB PDF).

February 27, 1995. Memorandum. 11 Page(s).
Yiannakis Ioannou. Toxicology Branch II.
Fipronil (REGENT 1.5G): Request for an EUP for use on Field Corn.
MRID Nos. 435444-01 & 435017-03. Tox Review No. 011425.
Document (PDF) (686 KB PDF).

March 29, 1995. Memorandum. 2 Page(s).
G. F. Kramer. Chemistry Branch I.
New Chemical-Fipronil in/on Corn. Results of Petition Method Validation (PMV).
PP# 3G04263 & 5F04426. MRID No. 433234-01.
Document (PDF) (154 KB PDF).

May 10, 1995. Memorandum. 1 Page(s).
G. F. Kramer. Chemistry Branch I.
Multiresidue Method Testing of Fipronil & its metabolites.
Document (PDF) (73 KB PDF).

July 06, 1995. Memorandum. 1 Page(s).
G. F. Kramer. Chemistry Branch I.
June 20, 1995 Meeting with Rhone-Poulenc Concerning Registration of Fipronil on Rice.
Document (PDF) (88 KB PDF).

July 17, 1995. Memorandum. 2 Page(s).
Vern McFarland. Insecticide Rodenticide Branch.
Efficacy Review [for fleas and ticks] File 65331-R; Frontline Spray Treatment
MRID 431211-14 thru -22.
Document (PDF) (218 KB PDF).

July 17, 1995. Review. 19 Page(s).
Lucy Markarian. Registration Support Branch.
EPA File Symbol/EPA Reg. No.: 65331-EUP-E Frontline Spot Treatment.
MRID 431211-14 thru -22.
Document (PDF) (959 KB PDF).

July 18, 1995. Memorandum. 30 Pages.
Virginia Dobozy. Toxicology Branch II.
Carcinogenicity Peer Review of Fipronil. Tox review No. 011616.
Document (PDF) (1046 KB PDF).

July 25, 1995. Memorandum. 41 Page(s).
G. F. Kramer. Chemistry Branch I.
Fipronil in or on Corn & Animal RAC's.
Review of Residue Data & Analytical methodology. PP#5F04426.
MRID Nos. 434011-04 thru -12, 433857-01 & -02, 429186-01 & 435086-01.
Document (PDF) (2823 KB PDF).

August 10, 1995. DER. 8 Page(s).
N. E. Federoff. Ecological Effects Branch.
Fipronil: Chronic toxicity to Mysids (Americamysis bahia)
under flow-through conditions. MRID No. 436812-01.
Document (PDF) (523 KB PDF).

August 17, 1995. Memorandum. 15 Page(s).
Anthony Maciorowski. Ecological Effects Branch.
Fipronil 0.1G EUP on turf (D215537).
Document (PDF) (1027 KB PDF).
Attachment(s) Following:

August 17, 1995. Review.
Anthony Maciorowski. Ecological Effects Branch.
EUP to control mole cricket on turf.

*End of Attachments*

August 29, 1995. DER. 15 Page(s).
N. E. Federoff. Ecological Effects Branch.
Acute Toxicity Text for Estuarine and Marine Organisms
(Shrimp 96-Hour Acute Toxicity Test). Species Tested: Mysidopsis bahia.
MRID No. 432797-01.
Document (PDF) (1097 KB PDF).

August 29, 1995. Memorandum. 4 Page(s).
G. F. Kramer. Chemistry Branch I.
Fipronil in/on Corn & Animal RAC's.
Amendment of 6/27/95. PP# 5F04426. MRID No. 437396-01.
Document (PDF) (423 KB PDF).

September 15, 1995. Memorandum. 33 Page(s).
Virginia Dobozy. Toxicology Branch II.
Fipronil Metabolites - Review of Five Mutagenicity Studies.
DP Barcode: D214544. Tox Review 011678.
MRID Nos. 429186-55, 432917-16, 432917-17, 432917-21, 432917-22, 434011-02.
Document (PDF) (1001 KB PDF).

September 15, 1995. Memorandum. 8 Page(s).
Virginia Dobozy. Toxicology Branch II.
Fipronil (RM 1601C) - Review of Domestic Animal Safety Study in Puppies
MRID 434449-05 Tox Review 011677.
Document (PDF) (683 KB PDF).

September 18, 1995. Memorandum. 16 Page(s).
Paul Mastradone. Environmental Fate & Ground Water Branch.
Review of environmental fate studies (anaerobic aquatic Metabolism, terrestrial field
dissipation, and fish Accumulation) submitted to support the new chemical Registration
of fipronil. In addition, a review of an EUP request for use of fipronil on turf.
Document (PDF) (1624 KB PDF).
Attachment(s) Following:

September 18, 1995. Memorandum. 16 Page(s).
Paul Mastradone. Environmental Fate & Groundwater Branch.
(continued) in Southeastern United States.
MRID Nos. 43291704-thru 43291707.

*End of Attachments*

October 05, 1995. Memorandum. 1 Page(s).
G. F. Kramer. Chemistry Branch I.
ID# 000264-EUP-RNR. Fipronil in/on Corn RAC's.
Amendment to EUP Program.
Document (PDF) (60 KB PDF).

October 10, 1995. Memorandum. 4 Page(s).
G. F. Kramer. Chemistry Branch I.
Fipronil in/on Corn & Animal RAC's. Amendment of 9/8/95. PP# 5F04426.
MRID Nos. 437601-01 & 437614-01.
Document (PDF) (406 KB PDF).

October 17, 1995. Memorandum. 7 Page(s).
Robert P. Zendzian. Toxicology Branch I.
Fipronil, Dermal Absorption in rats.
MRID 437373-08. DP Barcode D218898.
Document (PDF) (180 KB PDF).

October 20, 1995. DER. 6 Page(s).
N. E. Federoff. Ecological Effects Branch.
Citation: 21-day Acute Oral LD50 Study in Bobwhite Quail.
MRID 437766-01.
Document (PDF) (347 KB PDF).

October 20, 1995. DER. 6 Page(s).
N. E. Federoff. Ecological Effects Branch.
Title: 14-Day Acute Oral LD50 Study with MB46513 in Mallard Ducks.
MRID 437766-02.
Document (PDF) (328 KB PDF).

October 26, 1995. Memorandum. 2 Page(s).
G. F. Kramer. Chemistry Branch I.
Fipronil in/on Corn. Results of Petition Method Validation (PMV).
PP# 5F04426. MRID No. 434011-10.
Document (PDF) (139 KB PDF).

October 27, 1995. Memorandum. 20 Page(s).
Virginia Dobozy. Toxicology Branch II.
M&B 46513 (Fipronil Metabolite) - Subchronic Rat Study. Tox Review 011714.
DP Barcode D213239. MRID No. 43559501. Pages 18-22 removed - registrant data.
Document (PDF) (586 KB PDF).

November 27, 1995. Review. 17 Page(s).
Anthony Maciorowski. Ecological Effects Branch.
Request for an experimental use permit (Section 5 of FIFRA) for use of Fipronil
(REGENT 80 WG) on corn throughout the mid-western and eastern United States.
Document (PDF) (937 KB PDF).

January 16, 1996. Review. 29 Page(s).
Anthony Maciorowski. Ecological Effects Branch.
Reg./File # 264-LLN. Section 3-for use on turf.
Document (PDF) (1989 KB PDF).

January 24, 1996. Memorandum. 21 Page(s).
Virginia Dobozy. Occupational & Residential Exposure Branch.
Fipronil Pet Formulations-EUP for Spot-On Product (10% a.i.) and Reponse to
Review of Domestic Animal Safety Study in Puppies. Manufacturing process
information on pages 13 and 20 not included. DP215134/219826, S483920/494457.
MRIDs 43577715 and -16.
Document (PDF) (1180 KB PDF).

January 24, 1996. Memorandum. 22 Page(s).
Virginia Dobozy. Occupational & Residential Exposure Branch.
Fipronil Pet Formulations - EUP for Spot-On Product (10% a.i.)
and Response to Review of Domestic Animal Safety Study in Puppies.
DP Barcode: D215134; D219826. Tox Review 011764.
MRID No. 43444905. Inert ingredient info on pages 14, 21 not included.
Document (PDF) (705 KB PDF).

January 30, 1996. Memorandum. 15 Page(s).
Robert Fricke. Toxicology Branch II.
FlPRONlL. Subchronic Neurotoxicity Screening Battery - Rats.
[OPPTS 870.6200, 82-7]. MRlD No. 432917-03. DP Barcode D214926.
Tox Review 011772.
Document (PDF) (466 KB PDF).

March 05, 1996. Memorandum. 12 Page(s).
Yiannakis Ioannou. Toxicology Branch II.
Fipronil: Waiver for the Chronic Neurotoxicity Study in Rats.
DP Barcode 213806.
Document (PDF) (391 KB PDF).
Attachment(s) Following:

January 30, 1996. Memorandum.
Robert Fricke. Toxicology Branch II.
FlPRONlL Subchronic Neurotoxicity Screening Battery - Rats.
[OPPTS 870.6200, 82-7]. MRID No. 43291703. DP Barcode: D214926.

*End of Attachments*

April 03, 1996. Memorandum. 7 Page(s).
Virginia A. Dobozy. Occupational & Residential Exposure Branch.
Fipronil Pet Products - Review of Domestic Animal Safety Studies with Spot-on
Formulation and Use Information with Spray Formulation. Tox review 011862.
Document (PDF) (424 KB PDF).

April 03, 1996. Review. 12 Page(s).
Anthony Maciorowski. Ecological Effects Branch.
Review mysid chronic study: 6 (a)(2) Adverse data. MRID No. 436812-01.
Document (PDF) (750 KB PDF).

April 16, 1996. Memorandum. 3 Page(s).
Richard Griffin. Risk Characterization & Analysis Branch.
Fipronil: PC Code 129121 Exposure Estimates and Risk Assessment for
Applicators of a Proposed End-Use Product (CHIPCO CHOICE) on Commercial Turf.
Document (PDF) (113 KB PDF).

April 25, 1996. DER. 3 Page(s).
Sanjivani Diwan. Toxicology Branch.
Acute Oral Toxicity/Rats (81-1) MRID 438840-01 Tox review 011948 excerpt.
Document (PDF) (158 KB PDF).

April 26, 1996. Memorandum. 14 Page(s).
David Farrar. Environmental Fate & Effects Branch.
Fipronil: Environmental Assessment, Current for the Turf Registration
(Cas No. 120068-37-3; PC Code 129121).
Document (PDF) (1449 KB PDF).

May 21, 1996. Memorandum. 6 Page(s).
Carol Lang. Occupation & Residential Exposure Branch.
Revised Exposure Assessment for Application by Veteranarians/Pet Groomers of
Frontline Spray Treatment and Frontline Spot Treatment (active ingredient: fipronil)
on Dogs and Cats for Flea and Tick Control. DP Barcode: D219825, D222391, D226161.
Document (PDF) (484 KB PDF).

June 25, 1996. Memorandum. 4 Page(s).
Sanjivani Diwan. Toxicology Branch.
FIPRONIL: Packaging for Roach and Ant Baits - Risk Estimates
for the Purposes of child Resistant Packaging/Labeling.
Document (PDF) (345 KB PDF).

July 19, 1996. Review. 24 Page(s).
N. E. Federoff. Ecological Effects Branch.
EEB review of Fipronil: 100 NC-Food/Feed Use;
Request for a Section 3 of FIFRA for use of Fipronil (REGENT 1.5G) on corn.
Document (PDF) (1481 KB PDF).

July 22, 1996. Memorandum. 4 Page(s).
Anthony Maciorowski. Ecological Effects Branch.
Response to Rhone-Poulenc Ag Company Regarding the Evaluation of the
Bobwhite Reproduction Study and the Daphnia Magna Life cycle Study.
(Includes Peer Review dated 9/6/1995). MRID Nos. 429186-22 & -26.
Document (PDF) (265 KB PDF).

July 24, 1996. Review. 25 Page(s).
Anthony Maciorowski. Ecological Effects Branch.
Section 3-for use on corn.
Document (PDF) (1597 KB PDF).

February 27, 1997. Review. 10 Page(s).
Rosalind Gross. Registration Support Branch.
Child-Resistant Packaging Review. EPA Reg. No. or File Symbol 64240-GG
& 64240-GE. Examine registration application to ascertain if packaging
is CRP GLM studies 14598A. MRID 44184101.
Document (PDF) (672 KB PDF).

February 27, 1997. Review. 10 Page(s).
Rosalind Gross. Registration Support Branch.
Child-Resistant Packaging Review. EPA Reg. No. or File Symbol 64240-GN.
Examine registration application to ascertain if packaging is CRP GLM
studies 14273A, 14598A, 15040A. MRID 44133701, 44184101.
Document (PDF) (729 KB PDF).

February 27, 1997. Review. 10 Page(s).
Rosalind Gross. Registration Support Branch.
Child-Resistant Packaging Review. EPA Reg. No. or File Symbol 64240-GU
& 64248-RE. Examine registration application to ascertain if packaging
is CRP GLM studies 14507A. MRID 44133602.
Document (PDF) (643 KB PDF).

February 27, 1997. Review. 10 Page(s).
Rosalind Gross. Registration Support Branch.
Child-Resistant Packaging Review. EPA Reg. No. or File Symbol 64248-RR
& 64248-RN. Examine registration application to ascertain if packaging
is CRP GLM studies 14358A. MRID 44135701.
Document (PDF) (661 KB PDF).

March 25, 1997. Memorandum. 3 Page(s).
Francis Griffith. Occupational & Residential Exposure Branch.
Fipronil (Frontline) or Fleas on Cats and Dogs. Review of Protocols to Determine
Worker Exposure. (No MRID #s)[Chem ID# 129121](DP Barcodes D229728, D229718).
Document (PDF) (952 KB PDF).

April 16, 1997. Memorandum. 4 Page(s).
Virginia Dobozy. Occupational & Residential Exposure Branch.
Fipronil - Review of Incident Reports for Three Products.
Frontline Spray (65331-1), Top Spot for Cats (65331-2), and Dogs (65331-3).
Document (PDF) (239 KB PDF).

May 15, 1997. Memorandum. 4 Page(s).
Carol Lang. Occupation & Residential Exposure Branch.
Revised Exposure Assessment for Application of Frontline Spray Treatment
and Frontline Spot Treatment on Dogs and Cats for Flea and Tick Control
DP Barcode: D219825 and D222391 EPA Reg. No. 6533-1; 65331-EUP-E.
Document (PDF) (164 KB PDF).

June 09, 1997. DER. 29 Page(s).
Virginia Dobozy. Toxicology Branch.
Developmental Neurotoxicity Study - rat; OPPTS 870.6300
MRID 44039002.
Document (PDF) (2220 KB PDF).

July 11, 1997. Review. 24 Page(s).
Douglas Urban. Environmental Fate & Effects Division.
Reg. / File #: 264-EUP-RNR Section 5 (EUP)-for use on cotton
MRID 437766-01, 02.
Document (PDF) (1489 KB PDF).

July 11, 1997. Review. 37 Page(s).
N. E. Federoff. Ecological Effects Branch.
Section 5 (EUP)-for use on cotton.
MRID Nos. 437766-01 & 437766-02.
Document (PDF) (1933 KB PDF).

July 29, 1997. Memorandum. 16 Page(s).
G. Maske. Environmental Fate & Ground Water Branch.
To review an amended leaching, adsorption/desorption study Submitted
to support registration of fipronil. Pages 17-23 removed-registrant data.
MRID No. 44039003.
Document (PDF) (1116 KB PDF).

September 11, 1997. Review. 5 Page(s).
Norman Cook. Ecological Effects Branch.
EEB response to Rhone-Polenc rebuttal to Sec 3 for corn.
Document (PDF) (336 KB PDF).

February 25, 1998. Memorandum. 279 Page(s).
Marion Copley. Registration Branch 1.
I.D. Nos.: FIPRONIL. Evaluation of the Data Base for Registration for Use on Rice.
DP Barcode No. D237893. Tox Review 012509.
Document (PDF) (9090 KB PDF).

April 17, 1998. Review. 1 Page(s).
Rosalind Gross. Technical Review Branch.
Child-Resistant Packaging Review. EPA Reg. No. or File Symbol 64240 -32.
Examine to ascertain if packaging is CRP. MRID 444652-02.
Document (PDF) (92 KB PDF).

April 17, 1998. Review. 1 Page(s).
Rosalind Gross. Technical Review Branch.
Child-Resistant Packaging Review. EPA Reg. No. or File Symbol 64240-30.
Examine to ascertain if packaging is CRP. MRID 443875-01.
Document (PDF) (98 KB PDF).

April 17, 1998. Review. 1 Page(s).
Rosalind Gross. Technical Review Branch.
Child-Resistant Packaging Review. EPA Reg. No. or File Symbol 64240-32.
Examine to ascertain if packaging is CRP. MRID 444652-01.
Document (PDF) (387 KB PDF).

April 17, 1998. Review. 1 Page(s).
Rosalind Gross. Technical Review Branch.
Child-Resistant Packaging Review. EPA Reg. No. or File Symbol 64240-34.
Examine to ascertain if packaging is CRP. MRID 44388101.
Document (PDF) (94 KB PDF).

April 17, 1998. Review. 1 Page(s).
Rosalind Gross. Technical Review Branch.
Child-Resistant Packaging Review. EPA Reg. No. or File Symbol 64240-GT.
Examine to ascertain if packaging is CRP. MRID 443251-01.
Document (PDF) (121 KB PDF).

April 17, 1998. Review. 1 Page(s).
Rosalind Gross. Technical Review Branch.
Child-Resistant Packaging Review. EPA Reg. No. or File Symbol 64248-12.
Examine to ascertain if packaging is CRP. MRID 44388101.
Document (PDF) (173 KB PDF).

April 17, 1998. Review. 20 Page(s).
Rosalind Gross. Technical Review Branch.
Child-Resistant Packaging Review. EPA Reg. No. or File Symbol 64240 -33
and 9 related Reg. No Examine to ascertain if packaging is CRP.
MRID 443021-01. (444652-01 etc.).
Document (PDF) (1282 KB PDF).

April 21, 1998. Memorandum. 2 Page(s).
Mark Dow. Insecticides Branch.
Review of Study: "Margin of Exposure Calculations - RBF5 EPA reg. No. 64248-"
[MRID 44353403].
Document (PDF) (140 KB PDF).

April 29, 1998. DER. 8 Page(s).
Marion Copley. Registartion Action Branch (Toxicology).
Developmental Neurotoxicity Study - rat; OPPTS 870.6300
MRID 44501102.
Document (PDF) (699 KB PDF).

April 29, 1998. Memorandum. 6 Page(s).
Virginia Dobozy. Reregistration Branch.
Fipronil - Review of Incident Reports for Three Products.
Document (PDF) (339 KB PDF).

April 30, 1998. Memorandum. 28 Page(s).
Hai-Ming Chou. Versar Inc. for EPA/OREB.
Review of two Dislodgeable Residue Studies - the "Dislodgeable Residues
of Fipronil Following Application of Frontline Spray Treatment to Dogs
(MRID #44433306)" and... Treatment to Cats (MRID #44433307).
Pages 23-27 removed, registrant data.
Document (PDF) (996 KB PDF).

May 01, 1998. Memorandum. 12 Page(s).
Hai-Ming Chou. Versar Inc. for EPA/OREB.
Review of the Exposure Study - Dermal and Inhalation Exposure of Commercial
Pet Groomers During Application of Frontline Spray Treatment (MRID # 44433302).
Document (PDF) (856 KB PDF).

May 22, 1998. Memorandum. 107 Page(s).
George Kramer. Registration Action Branch I.
PP#7F04832. Fipronil for use on Rice (Regent, Icon) and Pets (Frontline).
HED Risk Assessment.
Document (PDF) (7635 KB PDF).

June 12, 1998. Memorandum. 3 Page(s).
Rosalind Gross. Technical Review Branch.
Review of Bitrex Test and Volume of a [Child's] Swallow for Maxforce Gel
Applicators - RBF 5 MRID 44353403.
Document (PDF) (168 KB PDF).

August 24, 1998. Memorandum. 3 Page(s).
Jeff Evans. Health Effects Division.
ID#064248-RU RBF5. Fipronil: Tolerance Determination and Non-Dietary Exposure
Assessment for the Crack and Crevice Application of Gel-Bait Formulation RBF5.
MRID 44353403.
Document (PDF) (186 KB PDF).

October 26, 1998. Review. 2 Page(s).
Kevin Sweeney. Insecticides Branch.
Efficacy Study Review. EPA Reg. or File No.: 264-EUP-RER.
Product Name: Termidor 80 WG Insecticide. DP: D272853 & D274127.
Document (PDF) (41 KB PDF).

November 16, 1998. Meeting. 1 Page.
Rosalind Gross. Registration Division.
COMMENTS ON MEETING MINUTES (11/16/98).
Document (PDF) (87 KB PDF).

November 18, 1998. Memorandum. 6 Page(s).
Jason Lin. Health Canada with EPA HED.
Review of Applicator Exposure to Fipronil S95-1152; S96-1005 MRID 44433302.
Document (PDF) (365 KB PDF).

January 19, 1999. Review. 2 Page(s).
Rosalind Gross. Technical Review Branch.
Child-Resistant Packaging Review. EPA Reg. No. or File Symbol 64240-30.
Examine to ascertain if packaging is CRP GLM 15463A, 97-091A MRID 446477-01.
Document (PDF) (126 KB PDF).

January 19, 1999. Review. 2 Page(s).
Rosalind Gross. Technical Review Branch.
Child-Resistant Packaging Review. EPA Reg. No. or File Symbol 64240-33,
64248-11,64248-10. Examine to ascertain if packaging is CRP GLM 15218A, 97-046.
MRID 446476-01.
Document (PDF) (106 KB PDF).

January 25, 1999. Review. 2 Page(s).
Rosalind Gross. Technical Review Branch.
Child-Resistant Packaging Review. EPA Reg. No. or File Symbol 64240-30.
Examine to ascertain if packaging is CRP GLM 16367A, 98-068. MRID 446536-01
(amended report to 447333-01).
Document (PDF) (209 KB PDF).

January 25, 1999. Review. 2 Page(s).
Rosalind Gross. Technical Review Branch.
Child-Resistant Packaging Review. EPA Reg. No. or File Symbol 64240-30.
Examine to ascertain if packaging is CRP GLM 16369A, 98-070. MRID 446536-02
(amended report to 447333-02).
Document (PDF) (194 KB PDF).

January 27, 1999. Review. 2 Page(s).
Rosalind Gross. Technical Review Branch.
Child-Resistant Packaging Review. EPA Reg. No. or File Symbol 64240-33.
Examine to ascertain if packaging is CRP. (GLM 16368A, 98-071) amended report
MRID 447332-01. MRID 446590-01.
Document (PDF) (237 KB PDF).

February 22, 1999. Review. 2 Pages.
Rosalind Gross. Technical Review Branch.
CHILD-RESISTANT PACKAGING REVIEW. EPA Reg. No. or File Symbol 65331-2.
DP Barcode D253197 D253209. Data Accession No(s). 447491-01 (1365-025).
Product Name(s) Frontline Top Spot for Cats. Submission Purpose Examine
to ascertain if packaging is CRP.
Document (PDF) (184 KB PDF).

April 16, 1999. Memorandum. 19 Page(s).
James Hetrick. Environmental Risk Branch.
EFED's Section 3 Registration Eligibility Decision Chapter for Fipronil
Use Rice as a Pre-Plant Broadcast Treatment.
Document (PDF) (2181 KB PDF).

May 14, 1999. Review. 1 Page(s).
Rosalind Gross. Technical Review Branch.
Child-Resistant Packaging Review. EPA Reg. No. or File Symbol 64248-11.
Examine to ascertain if packaging is CRP (98-082). MRID 446681-01.
Document (PDF) (329 KB PDF).

May 19, 1999. Review. 1 Page(s).
Rosalind Gross. Technical Review Branch.
Child-Resistant Packaging Review. EPA Reg. No. or File Symbol 64248-10.
Examine to ascertain if packaging is CRP (98-081). MRID 446473-01.
Document (PDF) (96 KB PDF).

May 25, 1999. Review. 1 Page(s).
Rosalind Gross. Technical Review Branch.
Child-Resistant Packaging Review. EPA Reg. No. or File Symbol 64240-33.
Examine to ascertain if packaging is CRP. MRID 446680-01.
Document (PDF) (61 KB PDF).

May 27, 1999. Review. 2 Page(s).
Rosalind Gross. Technical Review Branch.
Child-Resistant Packaging Review. EPA Reg. No. or File Symbol 64240-30.
Examine to ascertain if packaging is CRP. MRID 446679-02 (98-078) 446679-01 (98-077).
Document (PDF) (219 KB PDF).

June 29, 1999. Memorandum. 14 Page(s).
Dana Vogel. Registration Analysis Branch.
Occupational and Residential Exposure and Risk Assessment/ Characterization
for Fipronil. Pc Code: 129121. DP Barcode: D254430, D254365. Tox review 013548.
Document (PDF) (588 KB PDF).

July 09, 1999. Review. 3 Page(s).
Eugenia McAndrew. Technical Review Branch.
CHILD-RESISTANT PACKAGING REVIEW. EPA Reg. No. or File Symbol 65331-1.
Product Name(s): Frontline Spray Treatment. Examine to ascertain if packaging is CRP.
DP Barcode: D256535. MRID Nos.: 448277-01, 448277-02, 448342-01.
Document (PDF) (51 KB PDF).

August 10, 1999. Review. 1 Page(s).
Rosalind Gross. Technical Review Branch.
Child-Resistant Packaging Review. EPA Reg. No. or File Symbol 64240 - 30.
Examine to ascertain if packaging is CRP (99-04). MRID 448723-01.
Document (PDF) (60 KB PDF).

August 10, 1999. Review. 1 Page(s).
Rosalind Gross. Technical Review Branch.
Child-Resistant Packaging Review. EPA Reg. No. or File Symbol 64248-11.
Examine to ascertain if packaging is CRP (90-03). MRID 448724-01.
Document (PDF) (124 KB PDF).

August 10, 1999. Review. 2 Page(s).
Rosalind Gross. Technical Review Branch.
Child-Resistant Packaging Review. EPA Reg. No. or File Symbol 64240-34.
Examine to ascertain if packaging is CRP. MRID 448683-01 (99-06) 448684-01 (99-05).
Document (PDF) (235 KB PDF).

August 10, 1999. Review. 2 Page(s).
Rosalind Gross. Technical Review Branch.
Child-Resistant Packaging Review. EPA Reg. No. or File Symbol 64248-12.
Examine to ascertain if packaging is CRP (99-06, 99-05). MRID 448683-01, 448684-01.
Document (PDF) (237 KB PDF).

August 18, 1999. Memorandum. 1 Page(s).
Rosalind Gross. Technical Review Branch.
Incidents and Adverse Effects Regarding EPA Registration Number 65331-1,
65331-2 , and 65331-3.
Document (PDF) (717 KB PDF).

August 26, 1999. Memorandum. 1 Page(s).
Rosalind Gross. Technical Review Branch.
Certification to Compliance with Child-Resistant Packaging Regulations.
EPA File No: 64240-GT.
Document (PDF) (75 KB PDF).

August 26, 1999. Memorandum. 1 Page(s).
Rosalind Gross. Technical Review Branch.
Certification to Compliance with Child-Resistant Packaging Regulations.
EPA FILE No: 64248-RL.
Document (PDF) (43 KB PDF).

November 08, 1999. Memorandum. 1 Page(s).
Rosalind Gross. Technical Review Branch.
EPA Registration No 64240-33 Bracketing of CRP Test Data.
Document (PDF) (122 KB PDF).

November 15, 1999. Note. 1 Page(s).
Rosalind Gross. Technical Review Branch.
EPA Reg. No. 65331-3, 65331-2, 65331-1 Response re 6(a)(2).
Document (PDF) (124 KB PDF).

December 20, 1999. Review. 4 Page(s).
Rosalind Gross. Technical Review Branch.
Child-Resistant Packaging Review. EPA Reg. No. or File Symbol 64240-33
& 64248-5-64240. Examine to ascertain if packaging is CRP (98-069) GLM 16386A
MRID 446942-01.
Document (PDF) (266 KB PDF).

December 29, 1999. Efficacy Review. 2 Page(s).
Vern McFarland. Insecticides Branch.
File or Reg. No. 65331-L Provide performance data in support of claims for killing
of adult fleas, flea eggs & larvae for new combination of active ingredients.
MRID 44942105 & -06; D261554.
Document (PDF) (187 KB PDF).

January 24, 2000. Memorandum. 1 Page(s).
Rosalind Gross. Technical Review Branch.
Certification to Compliance with Child-Resistant Packaging Regulations.
EPA FILE NO: 64248-12.
Document (PDF) (100 KB PDF).

January 24, 2000. Memorandum. 4 Page(s).
Virginia Dobozy. Reregistration Branch.
Fipronil - Review of Incident Reports for Three Products.
Registration No. 65331-1, -2, -3.
Document (PDF) (122 KB PDF).

February 04, 2000. Review. 2 Page(s).
Rosalind Gross. Technical Review Branch.
Child-Resistant Packaging Review. EPA Reg. No. or File Symbol 64248-14.
Examine to ascertain if CRP required and acceptable for refillable bait station.
Document (PDF) (167 KB PDF).

February 04, 2000. Review. 2 Page(s).
Rosalind Gross. Technical Review Branch.
Child-Resistant Packaging Review. EPA Reg. No. or File Symbol 64248-17. Examine to
ascertain if CRP required and acceptable for refillable bait station and retail package.
Document (PDF) (139 KB PDF).

February 07, 2000. Review. 1 Page(s).
Rosalind Gross. Technical Review Branch.
Child-Resistant Packaging Review. EPA Reg. No. or File Symbol 64240-33.
Examine to ascertain if CRP acceptable. [... is acceptable based on MRID 448724-01].
Document (PDF) (63 KB PDF).

February 07, 2000. Review. 1 Page(s).
Rosalind Gross. Technical Review Branch.
Child-Resistant Packaging Review. EPA Reg. No. or File Symbol 64240-34.
Examine to ascertain if CRP certification acceptable.
Document (PDF) (113 KB PDF).

February 07, 2000. Review. 1 Page(s).
Rosalind Gross. Technical Review Branch.
Child-Resistant Packaging Review. EPA Reg. No. or File Symbol 64248-11.
Examine to ascertain if CRP certification acceptable. [based on MRID 448724-01].
Document (PDF) (73 KB PDF).

February 18, 2000. Review. 1 Page(s).
Rosalind Gross. Technical Review Branch.
Child-Resistant Packaging Review. EPA Reg. No. or File Symbol 64240-30.
Examine to ascertain if CRP certification needs amendment. [not required].
Document (PDF) (69 KB PDF).

February 23, 2000. Memorandum. 3 Page(s).
Virginia Dobozy. Reregistration Branch 1 HED.
Fipronil - Review of Registrant's Incident Analysis for Three Products.
[Frontline, Reg. Nos. 65331-1, -2, -3] "The data submitted... are inadequate."
Tox review 014010.
Document (PDF) (83 KB PDF).

March 13, 2000. Memorandum. 1 Page(s).
Rosalind Gross. Technical Review Branch.
Certification to Compliance with Child-Resistant Packaging Regulations.
EPA FILE NO: 64240-34.
Document (PDF) (78 KB PDF).

March 13, 2000. Memorandum. 1 Page(s).
Rosalind Gross. Technical Review Branch.
Certification to Compliance with Child-Resistant Packaging Regulations.
EPA FILE NO: 64248-12.
Document (PDF) (72 KB PDF).

April 12, 2000. Memorandum. 14 Page(s).
Masih Hashim. Technical Review Branch.
EPA Reg. No: 65331-U Frontline Plus for Cats. DP Barcodes: D261563.
Case No: 066318. MRID 44942009.
Document (PDF) (716 KB PDF).

April 14, 2000. Memorandum. 1 Page(s).
Rosalind Gross. Technical Review Branch.
Certification to Compliance with Child-Resistant Packaging Regulations.
EPA FILE NO: 64240-30.
Document (PDF) (82 KB PDF).

May 03, 2000. Memorandum. 4 Page(s).
Virginia Dobozy. Reregistration Branch 1 HED.
Secondary Review of DER for Companion Animal Safety Study
DP Barcode: D265179 MRID: 44942009.
Document (PDF) (168 KB PDF).

May 05, 2000. Memorandum. 16 Page(s).
Byron Backus. Technical Review Branch.
EPA File Symbol: 65331-L FRONTLINE PLUS FOR DOGS DP Barcode: D261551
Animal safety study on beagle puppies. MRID 44942104.
Document (PDF) (1727 KB PDF).

June 05, 2000. Review. 1 Page(s).
Rosalind Gross. Technical Review Branch.
Child-Resistant Packaging Review. EPA Reg. No. or File Symbol 64240 - 33.
Examine change in CSF to ascertain if CRP Certifications are still valid.
Document (PDF) (109 KB PDF).

June 05, 2000. Review. 1 Page(s).
Rosalind Gross. Technical Review Branch.
Child-Resistant Packaging Review. EPA Reg. No. or File Symbol 64240 -34.
Examine change in CSF to ascertain if CRP Certifications are still valid.
Document (PDF) (115 KB PDF).

June 05, 2000. Review. 1 Page(s).
Rosalind Gross. Technical Review Branch.
Child-Resistant Packaging Review. EPA Reg. No. or File Symbol 64248 -12.
Examine change in CSF to ascertain if CRP Certifications are still valid.
Document (PDF) (90 KB PDF).

August 17, 2000. Review. 6 Page(s).
Rosalind Gross. Technical Review Branch.
EPA Reg. No. or File Symbol 64240 -32. Examine 6 CRP studies, 2 of which involve
weathered stations to see if the crp certification is acceptable for this 18 station
retail package...MRID 44647701, 44733201, 44668001 (44387501, 44659001).
Document (PDF) (362 KB PDF).

August 24, 2000. Review. 2 Page(s).
Rosalind Gross. Technical Review Branch.
EPA Reg. No. or File Symbol 64240 - 32. Examine weld strength test method and results
for sample stations retained at factory to see if CRP certification is acceptable for
this 18 station retail package with a 12 month use claim.
Document (PDF) (187 KB PDF).

August 28, 2000. DER. 6 Page(s).
Whang Phang. Reregistration Branch 1.
STUDY TYPE: Subchronic Oral Toxicity (dietary -rat); OPPTS 870.3100; [§82-1a].
DP BARCODE: D261080. TEST MATERIAL (PURITY): MB 46513 (Fipronil photometabolite).
MRID No. 43559501; 44963501; 44963502.
Document (PDF) (187 KB PDF).

August 30, 2000. Memorandum. 11 Page(s).
Virginia Dobozy. Reregistration Branch.
Fipronil-Review of Registrant's Incident Analysis for Three Frontline Products.
Document (PDF) (576 KB PDF).

September 21, 2000. Review. 2 Page(s).
Rosalind Gross. Technical Review Branch.
Child-Resistant Packaging Review. EPA Reg. No. or File Symbol 64240 - 32.
Examine results of CRP test to see if the CRP certification is acceptable
for this 18 station retail package with a 12 month use claim.
Document (PDF) (150 KB PDF).

September 25, 2000. Memorandum. 1 Page(s).
Rosalind Gross. Technical Review Branch.
Self Certification to Compliance with Child-Resistant Packaging
Regulations Per PR Notice 96-2 for Clorox. EPA FILE NO: 64240-32.
Document (PDF) (59 KB PDF).

September 25, 2000. Review. 2 Page(s).
Rosalind Gross. Technical Review Branch.
Child-Resistant Packaging Review. EPA Reg. No. or File Symbol 64240 - 32.
Examine results of CRP test to see if the CRP certification is acceptable for this 24
station retail package with a 12 month use claim and if certification is possible.
Document (PDF) (128 KB PDF).

September 25, 2000. Review. 2 Page(s).
Rosalind Gross. Technical Review Branch.
EPA Reg. No. or File Symbol 64240 -32. Examine results of CRP test to see if the
CRP certification is acceptable for this 18 station (as 3 6-ups)retail package with
a 12 month in use claim and if self certification is possible.
Document (PDF) (135 KB PDF).

May 01, 2001. Review. 5 Page(s).
Kevin Sweeney. Insecticides Branch.
Efficacy Review. EUPs: 432-EUP-U [sic] and 264-EUP-121.
Product Names: Termidor SC Termidor WG. DP: D272853 & D274127.
Document (PDF) (154 KB PDF).

June 22, 2001. Memorandum. 22 Page(s).
Byron T. Backus. Technical Review Branch.
Product Name: FRONTLINE TOP SPOT (DOGS). EPA Reg. No.: 65331-3.
DP Barcode: D275794. Case No.: 060305. Submission: S599233.
MRID 43577708, 43577709.
Document (PDF) (1625 KB PDF).

July 11, 2001. Memorandum. 1 Page(s).
Rosalind Gross. Technical Review Branch.
Notification of Resin Change and Compliance with Child-Resistant Packaging
Regulations EPA FILE NO: 64248-1, 64248-2, 64248-3, 64248-10, 64248-11,
64248-12, 64248-15. [change in resin].
Document (PDF) (101 KB PDF).

August 21, 2001. Review. 5 Page(s).
Kevin Sweeney. Insecticides Branch.
Efficacy Review EPA Reg. Number: 432-901 Product Name: Termidor SC "...
a label amendment to add pre-construction use..." MRID 45452802 thru 45452805
(efficacy progress reports).
Document (PDF) (310 KB PDF).

February 25, 2002. Memorandum. 3 Page(s).
Byron T. Backus. Technical Review Branch.
Product Name: FRONTLINE TOP SPOT FOR DOGS. EPA Reg. No.: 65331-3.
DP Barcode: D278799. Case No: 060305. Submission: S605213.
Document (PDF) (434 KB PDF).

February 25, 2002. Memorandum. 3 Page(s).
Byron T. Backus. Technical Review Branch.
Product Name: FRONTLINE TOP SPOT FOR CATS. EPA Reg. No.: 65331-2.
DP Barcode: D278798. Case No: 046906. Submission: S605212.
Document (PDF) (338 KB PDF).

May 08, 2002. Review. 9 Page(s).
Kevin Sweeney. Insecticides Branch.
Efficacy Review EPA Reg. Number: 432-900 & 432-901 Product Name: Termidor
Amendment: ant control, sub. termites above ground, drywood
MRID 45558001 thru 45558005, 45558101 thru 45558105.
Document (PDF) (921 KB PDF).

May 09, 2002. Efficacy Review. 4 Page(s).
Vern McFarland. Insecticides Branch.
File or Reg. No. 65331-5 Provide performance data in support of claims for chewing
lice and sarcoptic mange mites on dogs with standard label rate of subject product.
MRID 44628201, 45612701, 45620501, -04, -05, -06.
Document (PDF) (493 KB PDF).

May 14, 2002. Efficacy Review. 4 Page(s).
Vern McFarland. Insecticides Branch.
File or Reg. No. 65331-1. Provide performance data in support of claims for chewing
lice and flea allergy dermatitis on cats with standard label rate of subject product.
MRID 45615801, 45628101, -02, -03; D282314.
Document (PDF) (657 KB PDF).

July 15, 2002. Review. 3 Page(s).
Rosalind Gross. Technical Review Branch.
Child-Resistant Packaging Review. EPA Reg. No. or File Symbol 432-REUI.
Examine Child-Resistant test to ascertain if acceptable.
Document (PDF) (250 KB PDF).

July 15, 2002. Review. 7 Page(s).
Rosalind Gross. Technical Review Branch.
Child-Resistant Packaging Review. EPA Reg. No. or File Symbol 432-REUI.
Develop bracketing child test scheme and senior adult use effectiveness test
along with other requirements to fulfill CRP requirements for this product.
Document (PDF) (428 KB PDF).

September 23, 2002. Memorandum. 21 Page(s).
Byron T. Backus. Technical Review Branch.
Product Name: FRONTLINE PLUS FOR CATS. EPA Reg. No.: 65331-4.
DP Barcode: D282326. Case No: 066318. Submission: S613512.
MRID 45618502.
Document (PDF) (820 KB PDF).

September 24, 2002. Memorandum. 2 Page(s).
Byron T. Backus. Technical Review Branch.
Product Name: FRONTLINE® TOP SPOT® FOR CATS. EPA Reg. No.: 65331-2.
DP Barcode: D282329. Case No: 046906. Submission: S613891.
MRID 44942009, 45618502.
Document (PDF) (273 KB PDF).

October 21, 2002. Memorandum. 33 Page(s).
Byron T. Backus. Technical Review Branch.
Product Name: FRONTLINE® TOP SPOT FOR DOGS. EPA Reg. No.: 65331-3.
DP Barcode: D282266. Case No: 060305. Submission: S613844.
MRID: 45612702, 45620507.
Document (PDF) (1662 KB PDF).

October 21, 2002. Memorandum. 33 Page(s).
Masih Hashim. Technical Review Branch.
Product name: FRONTLINE PLUS FOR DOGS EPA Reg. No.: 65331-5
DP Barcode: D282205 Dog safety and safety/tolerance/reproduction.
MRID 45612702, 45620507.
Document (PDF) (3575 KB PDF).

November 04, 2002. Review. 6 Page(s).
Rosalind Gross. Technical Review Branch.
EPA Reg. No. or File Symbol 432-REUI. Review protocol testing scheme for child-resistant
effectiveness test (including bracketing scheme) and senior adult use effectiveness test
along with other requirements to fulfill CRP requirements for this product.
Document (PDF) (499 KB PDF).

December 03, 2002. Review. 6 Page(s).
Kevin Sweeney. Insecticides Branch.
Product Performance EPA Reg. No.: 264-EUP-121, 432-EUP-4 and 432-900 and 432-901
Product Name: Termidor DP: D282432, D282436. "... new application pattern"
MRID 45635101 thru 45635107.
Document (PDF) (649 KB PDF).

May 27, 2003. Memorandum. 2 Page(s).
Byron T. Backus. Technical Review Branch.
Product Name: FRONTLINE TOP SPOT FOR CATS. EPA Reg. No.: 65331-2.
DP Barcode: D288436. Case No: 046906. Submission: S620232.
Document (PDF) (294 KB PDF).

June 23, 2003. Review. 7 Page(s).
Rosalind Gross. Technical Review Branch.
Child-Resistant Packaging Review. EPA Reg. No. or File Symbol 432-REUI.
Review Protocol Testing Data from 3 Child-Resistant Effectiveness Tests
(Including Bracketing Scheme) and...
Document (PDF) (532 KB PDF).
Attachment(s) Following:

June 23, 2003. Review.
Rosalind Gross. Technical Review Branch.
(continued) Senior Adult Use Effectiveness Test along with other requirements to
fulfill CRP requirements for this product (Saliva Solubility Test and Soaking Test).
MRID 459259-01 thru -05.

*End of Attachments*

July 02, 2003. Efficacy Review. 3 Page(s).
Kevin Sweeney. Insecticides Branch.
EPA Registration No. 65331-5 Efficacy of Frontline Plus to control mosquitoes
MRID 45866901, -02.
Document (PDF) (343 KB PDF).

October 21, 2003. Efficacy Review. 2 Page(s).
Kevin Sweeney. Insecticides Branch.
EPA Registration No. 65331-2, 3, 4 and 5 Decision Nos. 329453,
200325, 333158, 213526. Determine if products kill adult mosquitoes.
MRID 45866901, -02, 46019201 and -02.
Document (PDF) (264 KB PDF).

October 14, 2004. Review. 82 Page(s).
Kevin Sweeney. Insecticides Branch.
Product Performance Evaluation. EPA Reg. No.: 7969-209 & 210. amend Termidor
SC and Termidor 80WG labels to include "Exterior Perimeter/Localized Interior
Treatment Use..." MRID 46215101 thru -04, 4585604. Pages 10-82 removed, RD.
Document (PDF) (266 KB PDF).

January 26, 2005. Memorandum. 2 Pages.
James A. Hetrick et. al. Environmental Risk Bransh 1.
Special Local Needs Registration [Section 24(c)] for Fipronil (Topchoice®)
Use to Control Fire Ants in Arizona (PC Code 129121; DP Barcode D311943).
Document (PDF) (94 KB PDF).

January 26, 2005. Memorandum. 5 Pages.
James Hetrick et. al. Environmental Risk Branch I.
Special Local Needs Registration [Section 24(c)] for Fipronil (Topchoice®)
Use to Control Fire Ants in Arizona (PC Code 129121 ; DP Barcode D311943).
Document (PDF) (436 KB PDF).

January 31, 2005. Memorandum. 3 Pages.
James A. Hetrick et. al. Environmental Risk Bransh 1.
Ecological Risk Assessment Issues Associated with the Addition of
Lasius neoniger (nuisance ant) to the Ceasefire® Fire Ant Bait Label
(PC Code 129121; DP Barcode D308382).
Document (PDF) (179 KB PDF).

January 31, 2005. Memorandum. 3 pages.
James Hetrick et. al. Environmental Risk Branch I.
Ecological Risk Assessment Issues Associated with the Addition of
Lasius neoniger (nuisance ant) to the Ceasefire® Fire Ant Bait Label
(PC Code 129121; DP Barcode D308382).
Document (PDF) (175 KB PDF).

February 08, 2005. DER. 10 Pages.
William Evans. Environmental Risk Branch I.
Data Evaluation Report on the Acute Toxicity of Fipronil Metabolite
RPA 200766 to Freshwater Invertebrates -Chironomus riparius.
MRID No. 463767-01. DP Barcode 301708.
Document (PDF) (322 KB PDF).

February 08, 2005. Memorandum. 11 Pages.
William Evans. Environmental Risk Branch I.
Secondary Reviews of DERs for: Fipronil RPA 200766 Degradate,
Chemical Code: 129121, DP Barcode: 301708. MRID No. 463767-01.
Document (PDF) (418 KB PDF).

July 21, 2005. Memorandum. 74 Pages.
James Hetrick & Kevin Costello. Environmental Risk Branch 1.
Comparative Drinking Water Assessment for Proposed and Registered Fipronil Uses
(PC Code 129121; DP Barcodes D318481, D318373, D313295).
Document (PDF) (3120 KB PDF).

August 11, 2005. Review. 8 Page(s).
Mark Suarez. Insecticides Branch.
Efficacy Review. EPA Reg. Number: 7969-209, 7969-210 Product Name: Termidor
Pests: Subterranean termites MRID: 46496401.
Document (PDF) (760 KB PDF).

August 25, 2005. Memorandum. 95 Pages.
James Hetrick & Kevin Costello. Environmental Risk Branch 1.
Revised Comparative Drinkiug Water Assessment for Proposed and
Registered Fipronil Uses (PC Code 129121; DP Barcode D319940).
Document (PDF) (2624 KB PDF).

August 31, 2005. Memorandum. 56 Pages.
Kevin Costello et. al. Environmental Risk Branch 1.
Section 18 Ecological Risk Assessment for Fipronil Use to Control
Cabbage Maggot in Turnip and Rutabaga. DP Barcode: D356402.
Document (PDF) (3398 KB PDF).

March 22, 2006. Memorandum. 45 Pages.
Nader Elkassabany & Edward Odenkirchen. Environmental Risk Branch 1.
Review of Aquatic Invertebrate Toxicity Studies for Fipronil.
DP Barcode: D306156. MRID Nos.: 46329902, 46329903, 46329904, 46329905.
Document (PDF) (1329 KB PDF).

June 26, 2006. Memorandum. 83 Pages.
James Hetrick & Nancy Andrews. Environmental Risk Branch 1.
Revision of Drinking Water Assessment in Response to Registrant Comments on
Comparative Drinking Water Assessment for Proposed and Registered Fipronil Uses
(PC Code 129121 ; DP Barcode 322415). DP Barcodes: 322415, 319940, 328892.
(MRID 46658201).
Document (PDF) (2733 KB PDF).

February 06, 2007. Risk Assessment. 535 Pages.
James Hetrick et. al. Environmental Risk Branch I.
Ecological Risk Assessment for Fipronil Uses. DP Barcodes: 331595, 331519,
331593, 329522, 314530, 332424, 325983, 326009, 326000, 325999, 325997,325990,
326003, 331867, 314530, 322414, 314197, 331714, 331713, 313295, 331872, 335805.
Document (PDF) (12000 KB PDF).

March 30, 2007. Risk Assessment. 3 Pages.
Edward Odenkirchen et. al. Environmental Risk Branch I.
Ecological Risk Assessment for Fipronil Uses (Addendum). DP Barcodes: 331595, 331519,
331593, 329522, 314530, 332424, 325983, 326009, 326000, 325999, 325997, 325990,
326003, 331867, 314530, 322414, 314197, 331714, 331713, 313295, 331872, 335805.
Document (PDF) (123 KB PDF).

April 18, 2007. Memorandum. 71 Pages.
Nancy Andrews & Edward Odenkirchen. Environmental Risk Branch 1.
Updated Section 18 Ecological Risk Assessment for Fipronil Use to
Control Cabbage Maggot in Turnip and Rutabaga. DP Barcode: D338854.
Document (PDF) (2851 KB PDF).

April 26, 2007. Memorandum. 12 Pages.
Nancy Andrews & Edward Odenkirchen. Environmental Risk Branch 1.
Preliminary Ecological Risk Assessment for Fipronil Use on Tennessee
Nursery Stock, Fire Ant Quarantine Considerations. DP Barcode: DP 338388.
Document (PDF) (418 KB PDF).

April 30, 2007. Risk Assessment. 10 Pages.
Edward Odenkirchen et. al. Environmental Risk Branch I.
Ecological Risk Assessment for Fipronil Uses (Addendum 2: providing additional time
series output for onion seed). DP Barcodes: 331595, 331519, 331593, 329522, 314530,
332424, 325983, 326009, 326000, 325999, 325997, 325990, 326003, 331867, 314530,….
Document (PDF) (160 KB PDF).

May 15, 2007. Memorandum. 6 Pages.
Nancy Andrews & Edward Odenkirchen. Environmental Risk Branch 1.
Section 18 Ecological Risk Assessment for Fipronil Use to Control Cabbage
Maggot in Turnip and Rutabaga. Addendum regarding assessment of potential
for effects to listed fishes. DP Barcode: D338854.
Document (PDF) (279 KB PDF).

June 19, 2007. Memorandum. 1 Page.
James Hetrick et. al. Environmental Risk Branch I.
Clarification on the Revised Drinking Water Assessment in Response to
Registrant Comments on Comparative Drinking Water Assessment for Proposed
and Registered Fipronil Uses (PC Code 129121 ; DP Barcode 322415).
DP Barcode: 322415, 319940, 328892.
Document (PDF) (40 KB PDF).

September 20, 2007. Note. 1 Page.
Rosalind Gross. Registration Division.
CRP Protocol and Certification to Compliance with Child-Resistant Packaging
Regulations EPA FILE NO: 65331-2, 3, 4, and 5 DP 341663, 341669, 341670, and
341671 Decision # 381219, 381220, 381221 , and 381222.
Document (PDF) (41 KB PDF).

May 02, 2008. DER. 18 Pages.
James Hetrick. EPA.
Data Evaluation Report of Modeling Fate and Transport from Turf.
MRlD No. 46936103.
Document (PDF) (654 KB PDF).

May 06, 2008. DER. 10 Pages.
James Hetrick. EPA.
Data Evaluation Report of Degradation Kinetics.
MRID No. 46936101.
Document (PDF) (322 KB PDF).

May 06, 2008. DER. 15 Pages.
James Hetrick. EPA.
Data Evaluation Report of Water Monitoring Study. MRID No. 46490304.
Document (PDF) (582 KB PDF).

May 06, 2008. DER. 20 Pages.
James Hetrick. EPA.
Data Evaluation Report of Modeling Calibration from Runoff Plots.
MRID No.46936102.
Document (PDF) (624 KB PDF).

May 06, 2008. DER. 31 Pages.
James Hetrick. EPA.
Data Evaluation Report of Surface Water Monitoring Study.
MRlD No. 46733902.
Document (PDF) (1369 KB PDF).

May 06, 2008. DER. 36 Pages.
James Hetrick. EPA.
Data Evaluation Report of Drinking Water Monitoring Study.
MRID No. 45526101.
Document (PDF) (1021 KB PDF).

May 06, 2008. DER. 38 Pages.
James Hetrick. EPA.
Data Evaluation Report of Surface Water Monitoring Study.
MRID No. 46733903.
Document (PDF) (1940 KB PDF).

May 06, 2008. DER. 40 Pages.
James Hetrick. EPA.
Data Evaluation Report of Vegetative Buffer Study.
MRID No. 46490303.
Document (PDF) (2185 KB PDF).

May 06, 2008. DER. 46 Pages.
James Hetrick. EPA.
Data Evaluation Report of Surface Water Monitoring Study.
MRID No. 46477003.
Document (PDF) (1314 KB PDF).

May 06, 2008. DER. 51 Pages.
James Hetrick. EPA.
Data Evaluation Report of Vegetative Buffer Study.
MRID No. 46490302.
Document (PDF) (2165 KB PDF).

May 06, 2008. DER. 53 Pages.
James Hetrick. EPA.
Data Evaluation Report of Vegetative Buffer study.
MRID No. 46490301.
Document (PDF) (2397 KB PDF).

May 06, 2008. DER. 58 Pages.
James Hetrick. EPA.
Data Evaluation Report of Water Monitoring Study.
MRID No. 46733905.
Document (PDF) (2457 KB PDF).

May 06, 2008. DER. 61 Pages.
James Hetrick. EPA.
Data Evaluation Report of Surface Water Monitoring Study.
MRID No. 46433904.
Document (PDF) (2603 KB PDF).

May 06, 2008. DER. 63 Pages.
James Hetrick. EPA.
Data Evaluation Report of Water Monitoring Study.
MRID No. 46490305.
Document (PDF) (2978 KB PDF).

May 16, 2008. Review. 3 Pages.
James Hetrick & Nancy Andrews. Environmental Risk Branch 1.
Review of Fipronil Runoff Studies. DP Barcodes: 314197, 332742, 314530.
MRID Nos. 46433904, 46490302, 46490303, 46490304, 46490305, 46733902,
46733903, 46733905, 4690301, 46936101, 46936102, 46936103.
Document (PDF) (130 KB PDF).

August 05, 2008. Memorandum. 5 Pages.
Stephen Wente et. al. Environmental Risk Branch I.
Review - Protocol for Experiments to Understand the Movement
of Fipronil from Treated Onion Seeds. DP Barcodes: D353645.
Document (PDF) (232 KB PDF).

November 14, 2008. Note. 2 Pages.
Rosalind Gross. Registration Division.
Protocol Review for Compliance with Child-Resistant Packaging Regulations
EPA FILE NO: 65331-2, 65331-3, 65331-4, and 65331-5 DP 357383, 357384,
357420, and 357421, Decision # 401081, 401084, 401083, and 401082.
Document (PDF) (72 KB PDF).

November 19, 2008. Memorandum. 8 Pages.
Edward Odenkirchen et. al. Environmental Risk Branch I.
Response to registrant Comments on Combined Fipronil (129121)
Ecological Risk Assessment (Aquatic Issues) DP353647.
MRID No. 47438301.
Document (PDF) (411 KB PDF).

November 21, 2008. Memorandum. 6 Pages.
Stephen Wente et. al. Environmental Risk Branch I.
Response to Comments on Review of Fipronil-treated Onion Seed Protocol.
DP Barcodes: D357719 and D353645.
Document (PDF) (321 KB PDF).

March 12, 2009. DER. 24 Pages.
Anita Ullagaddi. ERB1.
AQUATIC INVERTEBRATE LIFE CYCLE TEST GUIDELINE 72-4(B).
Fipronil - Life-Cycle.Toxicity Test with Mysids (Americamysis bahia)
Under Static Conditions in a Water-Sediment System.
MRID No.: 466191-03. DP Barcode: D321165.
Document (PDF) (1030 KB PDF).

March 12, 2009. DER. 37 Pages.
Anita Ullagaddi. ERB1.
Data Evaluation Record. Non-guideline Mesocosm Study. Chipco®
TopChoiceTM - Effects on Aquatic Fauna in Outdoor Simulate Ponds.
MRID No. 467339-01; DP 325893.
Document (PDF) (1878 KB PDF).

March 13, 2009. Memorandum. 4 Pages.
Anita Ullagaddi & Edward Odenkirchen. Environmental Risk Branch I.
Transmittal of Data Evaluation Records (DERs) for Fipronil (129121) Ecological
Risk Assessment (Aquatic Issues). DP Barcodes 321165, 325983, 306156, 306157,
306173, 306174, 306176, 332742. MRID Nos. 46619103, 46733901, 47245001,
46329901, 46936105.
Document (PDF) (184 KB PDF).

April 16, 2009. Memorandum. 4 Pages.
Kelly Sherman. Office of Pesticide Programs.
Ethics Review of Fipronil Pet Groomer Exposure Study.
MRID No. 44433303.
Document (PDF) (25 KB PDF).

May 14, 2009. Memorandum. 2 Pages.
Edward Odenkirchen. ERB I.
Response to registrant Comments on Combined Fipronil (129121)
Ecological Risk Assessment (Terrestrial Wildlife Issues) DP353647.
MRID No. 47438301.
Document (PDF) (116 KB PDF).

June 04, 2009. Memorandum. 2 Pages.
Stephen Wente et. al. Environmental Risk Branch I.
Review of Registrant Submitted Documents on NAWQA Surface Water Data
Summary for Fipronil and a Five Year Soil Accumulation Study for Fipronil.
DP Barcodes: D362974, D362975, and D362976.
MRID Nos. 47683000, 47683001, 47683002.
Document (PDF) (95 KB PDF).

July 02, 2009. Memorandum. 2 Pages.
Stephen Wente et. al. Environmental Risk Branch I.
Review - The Movement of Fipronil from Treated Onion & Corn Seeds
(MRID 47760001). DP Barcode: D365999.
Document (PDF) (106 KB PDF).

July 27, 2009. Memorandum. 9 Pages.
Stephen Wente et. al. Environmental Risk Branch I.
EFED Comments on "Response to Data Evaluation Reports for Environmental
Monitoring and Modeling Studies Related to Fipronil Uses for Fire Ant Control".
MRIDs 46490301 thru 46490303. DPs: D362385, D362384, D362382, D362381,
D362380, D362378, D362377….
Document (PDF) (494 KB PDF).

August 10, 2009. Memorandum. 4 Pages.
Kelly Sherman. Office of Pesticide Programs.
Ethics Review of Fipronil Pet Treatment Post-Application Exposure Study.
MRID No. 44531203.
Document (PDF) (65 KB PDF).

September 22, 2009. Memorandum. 38 Page(s).
Danette Drew, John Doherty et. al. Risk Assessment Branch V.
Fipronil. Human Health Risk Assessment Petition to Support and Maintain
the Established Rice Grain Tolerance for Imported Rice. DP Barcode: D360652.
Decision No.: 403380. TXR No.: NA. MRID No.: NA. CAS No.: 120068-37-3. 40
CFR: §180.517.
Document (PDF) (493 KB PDF).

October 02, 2009. Memorandum. 13 Pages.
Anita Ullagaddi & Nancy Andrews. Environmental Risk Branch I.
DER Transmittal Memo for One Study on a Fipronil Degradate (MB 45950).
DP Barcode: 289903. MRID No. 458510-01.
Document (PDF) (591 KB PDF).

September 22, 2010. Memorandum. 28 Page(s).
Byron Backus. Technical Review Branch.
Name of Pesticide Product: CERTIFECT FOR DOGS.
EPA Reg. No. /File Symbol: 65331-T. DP Barcode: DP 372058.
Decision No.: 423378. Action Code: R320.
MRID No.: 47914235.
Document (PDF) (666 KB PDF).

October 05, 2010. Memorandum. 12 Page(s).
Byron Backus. Technical Review Branch.
Name of Pesticide Product: CERTIFECT FOR DOGS.
EPA Reg. No. /File Symbol: 65331-T. DP Barcode: DP 375363.
Decision No.: 423378. Action Code: R320.
MRID No.: 47914238.
Document (PDF) (486 KB PDF).

October 05, 2010. Memorandum. 16 Page(s).
Byron Backus. Technical Review Branch.
Name of Pesticide Product: CERTIFECT FOR DOGS.
EPA Reg. No. /File Symbol: 65331-T. DP Barcode: DP 377589.
Decision No.: 423378. Action Code: R320.
MRID No.: 47914237.
Document (PDF) (252 KB PDF).

October 05, 2010. Memorandum. 23 Page(s).
Byron Backus. Technical Review Branch.
Name of Pesticide Product: CERTIFECT FOR DOGS.
EPA Reg. No. /File Symbol: 65331-T. DP Barcode: DP 377588.
Decision No.: 423378. Action Code: R320.
MRID No.: 47914236.
Document (PDF) (355 KB PDF).

November 03, 2010. Efficacy Review. 24 Page(s).
Autumn Metzger..
Product: CERTIFECT. File Symbol: 65331-T. DP Barcode: 372045. Purpose: To
determine efficacy for registration of new spot-on combination product for dogs.
MRIDs: 47914207 thru 47914228
Document (PDF) (476 KB PDF).

November 23, 2010. Memorandum. 19 Pages.
Byron T. Backus. Technical Review Branch.
Name of Pesticide Product: SERGEANT'S FIPRONIL + CYPHENOTHRIN.
SQUEEZE-ON FOR DOGS. EPA Reg. No. /File Symbol: 2517-RUN.
DP Barcode: DP 380756. Decision No.: 435798. Action Code: R310.
MRID Nos. 481296-03 thru 08.
Document (PDF) (259 KB PDF).

December 03, 2010. Memorandum. 4 Pages.
Byron T. Backus. Technical Review Branch.
Name of Pesticide Product: SERGEANT'S FIPRONIL + CYPHENOTHRIN.
SQUEEZE-ON FOR DOGS. EPA Reg. No. /File Symbol: 2517-RUN.
DP Barcode: DP 380758. Decision No.: 435798. Action Code: R310.
MRID No. 48129614.
Document (PDF) (56 KB PDF).

December 06, 2010. Efficacy Review. 8 Pages.
Clayton Myers. RD-IB.
Products: Sergeant's Fipronil + Cyphenothrin Squeeze-on for Dogs.
EPA Reg. #: 2517-RUN. Decision #s: 435798. DP#s: 380757.
Submission: R310, New Products, RD Science Review.
MRIDs: 48129609, 48129610, 48129611, 48129612, 48129613.
Document (PDF) (123 KB PDF).

January 04, 2011. DER. 5 Pages.
Indira Gairola. Technical Review Branch.
FIPRONIL. CYPHENOTHRIN. (Sergeant's Fipronil + Cyphenothrin Squeeze-On for Dogs).
Product Identity and Composition (OPPTS 830.1550). Description of Materials Used
to Produce the Product (OPPTS 830.1600)...MRID Nos. 481296-01, 481296-02. DP D380755.
Document (PDF) (85 KB PDF).

January 04, 2011. Memorandum. 8 Page(s).
Byron Backus. Technical Review Branch.
Acute Toxicity, Response to Second Rebuttal for Dermal Sensitization.
Name of Pesticide Product: CERTIFECT FOR DOGS. EPA Reg. No. /File Symbol: 65331-T.
DP Barcode: DP 384819. MRID No.: 48321001.
Document (PDF) (105 KB PDF).

February 01, 2011. Efficacy Review. 6 Page(s).
Autumn Metzger..
PRODUCT: CERTIFECT. FILE SYMBOL: 65331-T. DP BARCODE: DP 386346.
To determine efficacy for the label claim "Effective after exposure to sunlight"
on a new registration for a spot-on combination product for dogs.
MRIDs: 48342901, 48342902.
Document (PDF) (210 KB PDF).

February 10, 2011. Memorandum. 13 Page(s).
Byron Backus. Technical Review Branch.
Companion Animal Safety, Response to Rebuttal from Merial.
Name of Pesticide Product: CERTIFECT FOR DOGS.EPA Reg. No. /File Symbol: 65331-T.
DP Barcode: DP 384668. Decision No.: 423378. Action Code: R320.
MRIDs 47914235, 47914236, and 47914237.
Document (PDF) (400 KB PDF).

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