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Index of Cleared Science Reviews for Azinphos-methyl (PC Code 058001)
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Undated. Report. 2 Page(s).
Jerome Blondell.
Guthion Poisoning Statistics Summary.
Document (PDF) (111 KB PDF).
Undated. Review. 26 Page(s).
Environmental Fate and Ground Water Branch.
Check off sheets for status of EFGWB data requirements.
Document (PDF) (1102 KB PDF).
October 04, 1962. Memorandum. 11 Page(s).
G. J. Beusch. Pesticide Branch & Div. of Pharmacology.
PP #355, Guthion on Brussels Sprouts and Citrus Fruits. FAP #793, Guthion on
Citrus Peel and in Dried Citrus Pulp. Chemagro Corporation, Kansas City, Missouri.
Document (PDF) (840 KB PDF).
November 26, 1962. Memorandum. 2 Page(s).
G. J. Beusch. Pesticide Branch & Div. of Pharmacology.
PP #355, Guthion on Brussels Sprouts and Citrus Fruits. FAP #793, Guthion in Dried
Citrus Pulp. Chemagro Corporation, Kansas City 20, Missouri.
Document (PDF) (80 KB PDF).
June 02, 1965. Memorandum. 4 Page(s).
A. E. H. Houk. Petitions Control Branch.
PP #5F0442: Guthion on Sugarcane; Evaluation of Analytical Method and Residue Data.
Document (PDF) (461 KB PDF).
May 10, 1966. Review. 1 Page(s).
Ronald Ney. Environmental fate & Ground Water Branch.
Evaluation of Data for Registration of Guthion Application of January 13, 1966 by
Chemagro Corporation Registration No. 3125-102, 123 and 125.
Document (PDF) (62 KB PDF).
May 10, 1966. Review. 2 Page(s).
Ronald Ney. Environmental fate & Ground Water Branch.
Evaluation of Data for Registration of Guthion Application of March 22, 1966 by
Chemagro Corporation Registration No. 3125.
Document (PDF) (154 KB PDF).
May 27, 1966. Review. 3 Page(s).
Ronald Ney. Environmental fate & Ground Water Branch.
Evaluation of Data for Registration of Guthion Application of May 17, 1966 by
Chemagro Corporation Registration No. 3125-132 & 167.
Document (PDF) (172 KB PDF).
October 27, 1966. Review. 8 Page(s).
J. A. Shaughnessy. Environmental Fate & Ground Water Branch.
Evaluation of Residue Data in Petition Number 7F0539 For Guthion in 16 Crops Filed
on October 5, 1966, by Chemagro Corporation Due November 4, 1966.
Document (PDF) (582 KB PDF).
April 10, 1967. Review. 2 Page(s).
J. A. Shaughnessy. Environmental Fate & Ground Water Branch.
Evaluation of Residue Data to Add to Use For Guthion Liquid Concentrate on Sugar
Cane Submitted by Chemagro On February 7, 1967.
Document (PDF) (106 KB PDF).
April 13, 1967. Review. 4 Page(s).
Ronald Ney. Environmental fate & Ground Water Branch.
Evaluation of Pesticide Petition Number 7F0582 For O,O-Dimethyl S-[4-oxo-1,2,3-
benzotriazin-3 (4H)-ylmethyl] phosphorodithioate (Guthion). Submitted by Chemagro
Corporation, Filed on March 31, 1967.
Inert ingredient info. on pages 1 and 2 not included.
Document (PDF) (216 KB PDF).
April 18, 1967. Review. 1 Page(s).
R. L. Caswell. Environmental Fate & Ground Water Branch.
Evaluation of Data For Registration of Guthion on Cotton.
Submitted April 12, 1967 by Chemagro.
Document (PDF) (53 KB PDF).
July 28, 1967. Review. 2 Page(s).
J. A. Shaughnessy. Environmental Fate & Ground Water Branch.
Evaluation of Data for Registration of Guthion ULV on Sugarcane in Louisiana
Submitted by Chemagro on July 14, 1967.
Document (PDF) (85 KB PDF).
October 27, 1967. Memorandum. 3 Page(s).
Ronald Ney. Environmental fate & Ground Water Branch.
Evaluation of Pesticide Petition No. 8F0653 for O,O-Diethyl S-[4-oxo-1,2,3-
benzotriazine-3(4H)-ylmethyl] (4H)-ylmethyl] phosphorodithioate (Ethyl Guthion)
Submitted by Chemagro Corporation, Filed October 13, 1967.
Inert ingredient info. on page 1 removed.
Document (PDF) (152 KB PDF).
October 31, 1967. Memorandum. 1 Page(s).
Harry Hays. Environmental fate & Ground Water Branch.
Pesticide Petition No. 8F0653 requesting tolerances for O,O-Diethyl S-[4-oxo-1,2,3-
benzotriazine-3(4H)-ylmethyl] phosphorodithioate (Ethyl Guthion) submitted by
Chemagro Corporation, and filed October 13, 1967.
Document (PDF) (332 KB PDF).
November 22, 1967. Review. 3 Page(s).
Ronald Ney. Environmental fate & Ground Water Branch.
Evaluation to Amendment of Pesticide Petition No. 7F0582 For Guthion, submitted by
Chemagro Corp. Filed March 31, 1967 Amended by letter on November 10, 1967.
Document (PDF) (275 KB PDF).
February 01, 1968. Review. 4 Page(s).
Ronald Ney. Environmental fate & Ground Water Branch.
Reevaluation Pesticide Petition No. 7F0539 For... (Guthion) Submitted by Chemagro
Corp. Filed October 5, 1966 Letter of December 5, 1967.
Document (PDF) (405 KB PDF).
October 17, 1968. Review. 2 Page(s).
Ronald Ney. Environmental fate & Ground Water Branch.
Evaluation Pesticide Petition No. 9F0762 For... (Guthion) Submitted by Chemagro
Corp. Filed October 9, 1968.
Document (PDF) (198 KB PDF).
September 23, 1969. Review. 7 Page(s).
Ronald Ney. Environmental fate & Ground Water Branch.
Evaluation Pesticide Petition No. 0F0869 for... (Guthion) Submitted by Chemagro
Corporation Filed August 29, 1969 Inert ingredient information on page 2 is not included.
Document (PDF) (693 KB PDF).
February 03, 1970. Review. 2 Page(s).
J. A. Shaughnessy. Environmental Fate & Ground Water Branch.
Evaluation of Pesticide Petition No. 0F0934 for Ethyl Guthion on Cotton and
Potatoes Filed January 15, 1970, by Chemagro.
Document (PDF) (166 KB PDF).
February 04, 1970. Memorandum. 1 Page(s).
J. A. Shaughnessy. New Chemicals Evaluation Staff.
Pesticide Petition Number 0F0934 Requesting a Tolerance for Ethyl Guthion,
Submitted by Chemagro Corporation, and Filed January 15, 1970.
Document (PDF) (48 KB PDF).
July 06, 1970. Review. 3 Page(s).
Ronald Ney. Environmental fate & Ground Water Branch.
Evaluation of PP. No. 0F0976 for O,O-dimethyl s- [4-oxo-1,2,3-benzotriuzin3(4H)-
ylmethyl] phosphorodithioate (Guthion) Submitted by Chemagro Corporation filed May
11, 1970 Inert ingredient information on page 1 is not included.
Document (PDF) (365 KB PDF).
July 15, 1970. Review. 3 Page(s).
Ronald Ney. Environmental fate & Ground Water Branch.
Evaluation of PP. No. 0F0984 for O,O-dimethyl s-[4- oxo-1,2,3-benzotriuzin3(4H)-
ylmethyl] phosphorodithioate (Guthion) submitted by Chemagro Corporation, filed May 21, 1970.
Document (PDF) (352 KB PDF).
October 21, 1970. Review. 2 Page(s).
Ronald Ney. Environmental fate & Ground Water Branch.
Reevaluation of PP No. 0F0869 for O,O-dimethyl S-[4-oxo-1,2,3-benzotriazin-3(4H)-
ylmethyl] phosphorodithioate (Guthion) Submitted by Chemagro Corporation Filed August 29, 1969.
Document (PDF) (200 KB PDF).
February 25, 1971. Review. 3 Page(s).
Environmental Fate and Ground Water Branch.
Evaluation of data for Guthion in response to PR Notice 70-15 Submitted by
Chemagro Corporation Letter of February 25, 1971.
Document (PDF) (103 KB PDF).
March 23, 1971. Summary. 8 Page(s).
Toxicology Branch.
Supplement No. 1 (Synopsis of Guthion Toxicology Data).
Document (PDF) (553 KB PDF).
May 05, 1971. Review. 2 Page(s).
Ronald Ney. Environmental fate & Ground Water Branch.
Reevaluation No. 1 of pp No. 0F0984 for. .. (Guthion) Submitted by Chemagro
Corporation Filed May 21, 1970 Revised December 4, 1970.
Document (PDF) (243 KB PDF).
June 15, 1971. Review. 3 Page(s).
Ronald Ney. Environmental fate & Ground Water Branch.
Evaluation of Data for O,O-Dimethyl S-[3-mercaptomethyl-1,2,3-benzotriazin-4(3H)-
one]phosphorodithioate (Guthion) Submitted by Chemagro Corp. June 15, 1971.
Document (PDF) (122 KB PDF).
October 13, 1971. Review. 6 Page(s).
Ronald Ney. Environmental fate & Ground Water Branch.
Evaluation of Data for O,O-Dimethyl S-[3-mercaptomethyl-1,2,3-benzotriazin -4(3H)-
one]phosphorodithioate (Guthion) Submitted by Chemagro Corp. June 15, 1971.
Document (PDF) (467 KB PDF).
October 25, 1972. Review. 3 Page(s).
Ronald Ney. Environmental fate & Ground Water Branch.
Preliminary Evaluation for Registration of... (Guthion) PP No. 2F1292, Reg. No. 3125-123
Submitted by Chemagro Corporation, Filed July 12, 1972 Inert ingredient
information on page 1 is not included.
Document (PDF) (107 KB PDF).
January 16, 1974. Review. 2 Page(s).
Ronald Ney. Ecological Effects Branch.
Environmental Chemistry evaluation No. 2 for Guthion Reg. No. 3125-123, 2F1292 Chemagro Corp.
Document (PDF) (89 KB PDF).
February 21, 1974. Review. 2 Page(s).
Ronald Ney. Ecological Effects Branch.
Environmental Chemistry evaluation No. 2 for Guthion Registration No. 3125-123,
2F1292 Chemagro Corporation.
Document (PDF) (60 KB PDF).
December 04, 1974. Memorandum. 3 Page(s).
Robert Jaeger. Toxicology Branch.
Request for Tolerances of Residues of Guthion in or on Pasture Grass Hay at 5 ppm
and Pasture Grass at 2 ppm (PP #5F1546; Old PP #1F1166); Corn Forage Fodder at
5 ppm and Field Corn Grain at 0.1 ppm (PP #5F1547; Old PP #2F1292) and Sorghum Grain…
Document (PDF) (230 KB PDF).
March 03, 1975. Review. 2 Page(s).
Ronald Ney. Efficacy & Ecological Effects Branch.
Environmental Chemistry Review for O,O-Dimethyl s-[(4-oxo- 1,2,3-benzotriazin-
3(4H)-yl) methyl] phosphorodithioate [Guthion-2 s] PP# 5F-1547, EPA Reg No. 3125-123
Chemagro Corp., Submitted August 28, 1974.
Document (PDF) (64 KB PDF).
March 31, 1975. Review. 2 Page(s).
Ronald Ney. Efficacy & Ecological Effects Branch.
Environmental Chemistry Review of. ..(Guthion) Petition No. 5F1546
Reg. No. 3125-25,102,123,193 Company Name: Chemagro Corp.
Document (PDF) (76 KB PDF).
April 23, 1975. Review. 2 Page(s).
Ronald Ney. Efficacy & Ecological Effects Branch.
Environmental Chemistry Review for...(Guthion) Reg. No. 3125-25, 102
Company: Chemagro Letter of March 20, 1975.
Document (PDF) (46 KB PDF).
May 22, 1975. Review. 2 Page(s).
Ronald Ney. Efficacy & Ecological Effects Branch.
Environmental Chemistry Review for O,O-Dimethyl S-@(4-oxo... File or Reg. No.: 3125-123
etition or Exp. Permit No.: 5F1548 Product Name: Guthion Spray Concentate
Company Name: Chemagro Corp, Submission Purpose: New Use.
Document (PDF) (70 KB PDF).
June 09, 1975. Review. 2 Page(s).
Ronald Ney. Efficacy & Ecological Effects Branch.
Reg. No. 3125-25 Guthion 25% Wettable Powder Chemagro Additional Use to Label.
Document (PDF) (73 KB PDF).
October 06, 1976. Review. 30 Page(s).
Efficacy and Ecological Effects Branch.
Reg. No. 3125-25, 193, 123, 102 Petition 5F1546 Chemagro Amendment to add
pasture grass in states east of Mississippi and for alfalfa and clover-mixed
stands in states east of MS.
Document (PDF) (2549 KB PDF).
September 01, 1978. Summary. 5 Page(s).
Roger Gardner. Toxicology Branch.
Guthion (Toxicity).
Document (PDF) (428 KB PDF).
February 23, 1979. Memorandum. 4 Page(s).
Byron Backus. Insecticide Rodenticide Branch.
EPA Reg. No. 2749-263. Azinphos-methyl 50WP Crop Insecticide Water Soluble
Pouch. Caswell #374.
Document (PDF) (455 KB PDF).
November 30, 1979. Memorandum. 3 Page(s).
Larry Anderson. Toxicology Branch.
Request for Tolerances of 2.0 ppm for Azinphos-methyl... in or on Turnip-Rooted
Parsley Roots and Parsley (Fresh Market). PP #9E2233.
Document (PDF) (285 KB PDF).
July 07, 1980. Review. 119 Page(s).
Enviro Control, Inc.
Task 1R: Review of Guthion Final Report.
Document (PDF) (3710 KB PDF).
November 20, 1980. Review. 14 Page(s).
Willa Garner. Environmental Fate Branch.
Reg. No. 3125-102, 123, 25, 193 Guthion 2S, 2L, 25% WP, 50% WP Environmental
Chemistry Data.
Document (PDF) (781 KB PDF).
March 06, 1981. Review. 2 Page(s).
Enviro Control, Inc.
Task 5. Development of the Chemical/Physical Profile: O,O-Dimethyl S-... Final Report.
Document (PDF) (57 KB PDF).
January 05, 1982. Review. 6 Page(s).
Willa Garner. Environmental Fate Branch.
Reg. No. 3125-102, -123, -193, and -301 GUTHION 2L, GUTHION 2S, GUTHION
50% Wettable Powder, and GUTHION 50% Wettable Powder Crop Insecticide in
Water- Soluble Packets To add the crop Birdsfoot trefoil to each label.
Document (PDF) (1004 KB PDF).
March 19, 1982. Review. 7 Page(s).
Willa Garner. Environmental Fate Branch.
Reg. No. 3125-102, 3125-102, 3125-123, 3125-123 Guthion Response to reviewer's
comments regarding deficiencies.
Document (PDF) (350 KB PDF).
October 31, 1983. Review. 23 Page(s).
Carolyn Offutt. Exposure Assessment Branch.
Reg. No. 3125-102, 3125-123 Guthion 2S and Guthion 2L EEB wants EEC for
Amended Registration Application.
Document (PDF) (1200 KB PDF).
April 08, 1985. Review. 3 Page(s).
Carolyn Offutt. Exposure Assessment Branch.
Reg. No. 3125 - 123 and 3125 - 102 GUTHION Submission of Fieldworker (Reentry) Data.
Document (PDF) (128 KB PDF).
August 16, 1985. Memorandum. 30 Page(s).
George Robinson. Toxicology Branch.
Guthion: Miscellaneous Toxicity Data. Accession Numbers 255242 and 255245.
TXR No. 004622.
Document (PDF) (2570 KB PDF).
October 24, 1985. DER. 8 Page(s).
Curtis E. Laird. Ecological Effects Branch.
21 day Toxicity study. Species Tested: Daphnia magna.
MRID No. 00143785.
Document (PDF) (575 KB PDF).
October 24, 1985. DER. 5 Page(s).
Curtis E. Laird. Ecological Effects Branch.
Early Life-cycle. Species Tested : Rainbow Trout.
MRID No. 00145592.
Document (PDF) (399 KB PDF).
November 01, 1985. Review. 2 Page(s).
Samuel Creeger. Exposure Assessment Branch.
Reg. No. 3125-102, -301, -193 and -123 GUTHION Add tight-heading variety of
cabbage to label.
Document (PDF) (85 KB PDF).
December 06, 1985. Review. 4 Page(s).
Samuel Creeger. Exposure Assessment Branch.
Reg. No. 3125-108 Guthion Submission in Response to GWDCI.
Document (PDF) (139 KB PDF).
March 17, 1986. Review. 7 Page(s).
Samuel Creeger. Exposure Assessment Branch.
Response to GWDCI.
Document (PDF) (321 KB PDF).
March 31, 1986. Review. 16 Page(s).
Dynamac Corporation.
Azinphosmethyl Final Report Task 2: Environmental Fate and Exposure Assessment.
Document (PDF) (761 KB PDF).
April 11, 1986. Memorandum. 1 Page(s).
Samuel Creeger. Exposure Assessment Branch.
Azinphosmethyl Registration Standard- EAB Science Chapter.
Document (PDF) (59 KB PDF).
May 14, 1986. Memorandum. 3 Page(s).
Charles Trichilo. Residue Chemistry Branch.
Azinphos-methyl (Guthion) Registration Standard- Addendum #1.
Document (PDF) (101 KB PDF).
June 12, 1986. Review. 14 Page(s).
George Ghali. Health Effects Division.
Reference Doses (RFDs) for Oral Exposure Chemical: Guthion (Azinphos-methyl)
Chronic oral toxicity in dogs. MRID 00083620 Tox review 007590.
Document (PDF) (728 KB PDF).
Attachment(s) Following:
November 20, 1969. Memorandum.
M. Quaifeigr. Food and Drug Administration.
Guthion... tolerances requested Pesticide Petition No. 0F0-869 Food Additive
Petition No. QM-2450 Rat, 2-year feeding; Dog, 19-week cholinesterase; Dog,
2-year feeding; Rabbit, reproduction.
*End of Attachments*
June 12, 1986. Review. 4 Page(s).
Carolyn Offutt. Exposure Assessment Branch.
Response to the 2/28/85 Reentry Data Call In Notice:Mobay is submitting a protocol
& proposing to combine the required studies with studies on METASYSTOX-R, DI-
SYSTON and DYRENE and is asking for an extension of the due date.
Document (PDF) (254 KB PDF).
June 23, 1986. Memorandum. 2 Page(s).
Samuel Creeger. Exposure Assessment Branch.
Azinphos-methyl (Guthion) Registration Standard - Addendum #1
(Interim Rotational Crop Resriction).
Document (PDF) (116 KB PDF).
June 26, 1986. Memorandum. 5 Page(s).
Amy Rispin. Hazard Evaluation Division.
Cover Memo for Azinphos-methyl (Guthion).
Document (PDF) (294 KB PDF).
July 09, 1986. Memorandum. 3 Page(s).
William Anthony. Residue Chemistry Branch.
EPA Reg. #10163-78. Azinphos-methyl (Guthion): Amended Registration for
Almonds (in California) (RCB #893) (Acc. #262397).
Document (PDF) (183 KB PDF).
September 03, 1986. Memorandum. 4 Page(s).
D. Ritter. Toxicology Branch II.
Guthion Registration Standard. Pages 2-4 are not included - registration standard
changes based on OGC input and deliberations.
Document (PDF) (99 KB PDF).
September 30, 1986. Review. 4 Page(s).
Carolyn Offutt. Exposure Assessment Branch.
Proposed (3/24/86 Mobay letter) reduction of the number of applications specified on
the label without further change in the tolerance.
Document (PDF) (173 KB PDF).
September 30, 1986. Review. 5 Page(s).
Carolyn Offutt. Exposure Assessment Branch.
Proposed (7/22/86 Mobay letter) Protocol for Azinphos Methyl (Guthion) Worker
Reentry Study (Cucumber Harvesting Study).
Document (PDF) (245 KB PDF).
September 30, 1986. Review. 7 Page(s).
Carolyn Offutt. Exposure Assessment Branch.
Special Data Call-In for Reentry on Guthion,(Dyrene,Disyston and Metasystox-R)
(See Mobay's letter of 7/30/86).
Document (PDF) (410 KB PDF).
February 03, 1987. Memorandum. 3 Page(s).
Francis Suhre. Residue Chemistry Branch.
EPA Reg. No. 10163-78; Amended Registration; Azinphos-methyl on Pistachios.
No Accession Number. RCB No. 1723.
Document (PDF) (183 KB PDF).
February 04, 1987. Memorandum. 2 Page(s).
Martha Bradley. Residue Chemistry Branch.
3125-108. Azinphos-methyl Guidance Document. Request for Time Extension by
Mobay, December 8, 1986. Accession Number: None. RCB No. 1748.
Document (PDF) (54 KB PDF).
February 24, 1987. Review. 3 Page(s).
James Adams. Exposure Assessment Branch.
Reg. No. 3125-108 Request for six-month extension (to Dec 1987) to complete
photolysis studies required by Registration Standard.
Document (PDF) (300 KB PDF).
August 06, 1987. Review. 5 Page(s).
Therese Dougherty. Exposure Assessment Branch.
Reg. No. 3125-193 Action relates to all products with azinphos methyl Review
mesocosm test protocol as required by registration standard.
Document (PDF) (476 KB PDF).
August 19, 1987. Memorandum. 6 Page(s).
William Anthony. Residue Chemistry Branch.
EPA Reg. No. 10163-78. Azinphos-methyl (Guthion): Amended Registration on
Almonds in California Only; New Residue Data Included (RCB #2215) (MRID #40167201).
Document (PDF) (336 KB PDF).
September 28, 1987. Memorandum. 25 Page(s).
John Chen. Toxicology Branch.
Azinphos-methyl (Guthion) Registration Standard, EPA ID No. 3125-108:
Submission of Mutagenicity Study. Caswell No. 374.
Pages 5-25 not included-registration data.
Document (PDF) (353 KB PDF).
September 29, 1987. Memorandum. 5 Page(s).
William Anthony. Residue Chemistry Branch.
ID #3125-338. Azinphos-methyl (Guthion 3F): Amendment on Apples & Pears
(RCB #2552) (MRID #402244-01).
Document (PDF) (272 KB PDF).
October 22, 1987. Memorandum. 3 Page(s).
Kenneth Dockter. Residue Chemistry Branch.
Azinphos-methyl (Guthion; EPA Reg. No. 10163-78) on Pistachios. Residue Data
of 5/15/87 to Support Amendment of 7/15/86. MRID No. 40248501. RCB No. 2799.
Document (PDF) (168 KB PDF).
October 30, 1987. Memorandum. 17 Page(s).
D. Ritter. Toxicology Branch.
EPA Reg. #11678-4: Cotnion-M; Azinphos-Methyl Technical 85D.
Submission of Toxicity Data.
Document (PDF) (1324 KB PDF).
November 27, 1987. Review. 3 Page(s).
Emil Regelman. Exposure Assessment Branch.
Reg. No. 3125-301 Review of data submitted in support of a 28-day Pre-Harvest
Interval (PHI) for almonds.
Document (PDF) (119 KB PDF).
December 11, 1987. Review. 23 Page(s).
Therese Dougherty. Exposure Assessment Branch.
Reg. No. 3125-108 Action relates to all products with azinphosmethyl Review
photodegradation in water/soil submitted in response to registration standard.
Pages 8-23 are not included-registrant data.
Document (PDF) (292 KB PDF).
December 17, 1987. Memorandum. 10 Page(s).
D. Ritter. Toxicology Branch.
EPA Reg. #11678-4: Cotnion-M; Azinphos Methyl, Technical. Review of Data.
Pages 5-10 are not included - registration data.
Document (PDF) (420 KB PDF).
December 18, 1987. Memorandum. 16 Page(s).
Gobind Makhijani. Residue Chemistry Branch.
Mobay Corporation - Response to the Product Chemistry Chapter - Azinphos-methyl
(Guthion) Registration Standard (MRID Nos. 403678-01 & 403678-05; October 6,
1987) - EPA Registration No. 3125-108. RCB No. 2906. Pages 7-16 deleted - MP,
QCP, & inert info.
Document (PDF) (284 KB PDF).
December 22, 1987. Memorandum. 6 Page(s).
D. Ritter. Toxicology Branch.
EPA # 10163-80; Response to Data Call In, Azinphos-M 2EC. Registrant: Gowan
Co., Yuma, Arizona.
Document (PDF) (287 KB PDF).
December 22, 1987. Memorandum. 9 Page(s).
D. Ritter. Toxicology Branch.
EPA ID #3125-108 - Azinphos Methyl; Guthion Technical; R-1582. Review of Two
Generation Rat Study Submitted Under 6 (a) (2). Review of a 28 Day Cholinesterase
Study and a Chronic Toxicity Study in Virgin SPR Wistar Female Rats.
Document (PDF) (426 KB PDF).
January 29, 1988. Memorandum. 2 Page(s).
William Anthony. Residue Chemistry Branch.
EPA Reg. #3125-301. Azinphos-methyl (Guthion): Registration for Almonds in
California Only (RCB #3080) (MRID Nos. 4109011-10, 4568010-11).
Document (PDF) (107 KB PDF).
March 01, 1988. Review. 5 Page(s).
Emil Regelman. Exposure Assessment Branch.
Reg. No. 3125-108 To comment on the waiver request submitted in response to
registration standard.
Document (PDF) (219 KB PDF).
March 14, 1988. Memorandum. 11 Page(s).
John Chen. Toxicology Branch.
Azinphos-Methy (Guthion): EPA ID # 8125-108; Record No. 205829; Tox Chem No. 374.
Pages 7-11 are not included - registration data.
Document (PDF) (342 KB PDF).
June 24, 1988. Memorandum. 11 Page(s).
D. Ritter. Toxicology Branch.
3125-108 - Azinphos-Methyl Registration Standard: Submission of Rat Teratology
Study. Pages 8-11 are not included - registration data.
Document (PDF) (354 KB PDF).
June 30, 1988. Memorandum. 6 Page(s).
D. Ritter. Toxicology Branch.
3125-108 - Azinphos-Methyl Registration Standard: Submission of 28 Day Range-
Finding Study in Rats.
Document (PDF) (365 KB PDF).
September 15, 1988. Memorandum. 2 Page(s).
Kenneth Dockter. Dietary Exposure Branch.
Azinphos-methyl (Guthion; EPA Reg. No. 3125-108). Amendment to Reduce the
PHI for Almonds. No MRID Number. Branch No. 4328.
Document (PDF) (91 KB PDF).
January 27, 1989. Memorandum. 4 Page(s).
H. Fonouni. Dietary Exposure Branch.
PP #9F3713. Guthion (Azinphos-methyl) in or on Almond Meats and Hulls.
Evaluation of Analytical Methodology and Residue Data. DEB No. 4748.
Document (PDF) (279 KB PDF).
February 27, 1989. Memorandum. 2 Page(s).
Linda Propst. Dietary Exposure Branch.
EPA Reg. No. 3125-123. Guthion 2S (Azinphos-methyl) on Parsley. No MRID
Number. DEB No. 4879.
Document (PDF) (72 KB PDF).
March 06, 1989. Memorandum. 2 Page(s).
H. Fonouni. Dietary Exposure Branch.
PP #9F3713. Guthion (Azinphos-methyl) in or on Almond Nutmeats and Hulls.
Notice of Method Validation Request. DEB No. 4946.
Document (PDF) (63 KB PDF).
March 06, 1989. Memorandum. 4 Page(s).
H. Fonouni. Dietary Exposure Branch.
PP #9F3713. Guthion (Azinphos-methyl) in or on Almond Nutmeats and Hulls.
Method Validation Request.
Document (PDF) (224 KB PDF).
Attachment(s) Following:
February 21, 1989. Memorandum. 2 Page(s).
Anne Lindsay. Registration Division.
Request for Expedited Review of Data Entitled "Gas Chromatographic Method
for Determination of Guthion Residue in Plant Material".
*End of Attachments*
March 15, 1989. Memorandum. 1 Page(s).
D. Ritter. Toxicology Branch.
Response to Registration Standard, Azinphos-Methyl, Teratology Study.
Document (PDF) (36 KB PDF).
April 07, 1989. Memorandum. 7 Page(s).
Michael Firestone. Non-Dietary Exposure Branch.
Request for Comprehensive Software Package Use Assessment for Guthion on
Pomegranates. HED #9-1166.
Document (PDF) (238 KB PDF).
April 14, 1989. Memorandum. 8 Page(s).
Ray Landolt. Toxicology Branch II.
Azinphos-Methyl. Action Requested: Review an Acute Delayed Neurotoxicity
Study (81-7) Submitted in Response to the Registration Guidance Document
Dated Sept. 11, 1986.
Document (PDF) (427 KB PDF).
April 19, 1989. Memorandum. 2 Page(s).
Maxie Jo Nelson. Dietary Exposure Branch.
PP #8E3618. Azinphos-methyl in or on Pomegranates. Amendment of
September 20, 1988. DEB #4505. HED #9-0166. MRID Nos. 405817-01, 407558-01.
Document (PDF) (128 KB PDF).
May 02, 1989. Memorandum. 6 Page(s).
Linda L. Kutney. Non-Dietary Exposure Branch.
Handler Exposure Assessment for Azinphos-Methyl (Guthion) Use on Pomegranates.
Document (PDF) (362 KB PDF).
May 03, 1989. Memorandum. 22 Page(s).
Ray Landolt. Toxicology Branch II.
Azinphos-Methyl. Action Requested: Review a General Metabolism Study (85-1) in
Rats Submitted in Response to the Registration Guidance Document Dated
September 11, 1986. Pages 8-16, 18-21 are not included - registration data.
Document (PDF) (683 KB PDF).
May 08, 1989. Memorandum. 19 Page(s).
D. Ritter. Toxicology Branch II.
Azinphos-Methyl - Review a Developmental Toxicity Study in Rabbits.
Document (PDF) (1063 KB PDF).
May 10, 1989. Memorandum. 2 Page(s).
H. Fonouni. Dietary Exposure Branch.
PP #9F3713. Guthion (Azinphos-methyl) in or on Almond Nutmeats and Hulls.
Notice of Method Validation Request; Mobay Corporation's Response to the
Questions Raised by the Analytical Chemistry Branch (ACB/BEAD). DEB No. 5282.
Document (PDF) (62 KB PDF).
May 10, 1989. Memorandum. 2 Page(s).
H. Fonouni. Dietary Exposure Branch.
PP #9F3713. Guthion (Azinphos-methyl) in or on Almond Nutmeats and Hulls;
Mobay Corporation's Response to Questions Raised by the Analytical Chemistry
Branch (ACB/BEAD) on the Submitted Method (Letter of April 17, 1989).
Document (PDF) (209 KB PDF).
Attachment(s) Following:
April 17, 1989. Letter. 3 Page(s).
John Thornton. Mobay Corporation.
Azinphos-methyl (Guthion). Pesticide Petition No. 9F3713.
Analytical Methodology Validation.
*End of Attachments*
June 02, 1989. Memorandum. 2 Page(s).
John Chen. Toxicology Branch II.
Azinphos-Methyl (Guthion). Review of the Registrant's Response to the Previous
Toxicology Branch Review Comments Concerning the Ames Test with Cotnion-M
(Guthion) (LSRIL Study No. MAK/141AZN; May 6, 1987).
Document (PDF) (94 KB PDF).
June 08, 1989. Memorandum. 6 Page(s).
H. Fonouni. Dietary Exposure Branch.
PP #9F3713, Amendment 1. Guthion (Azinphos-methyl) in or on Almond Nutmeats
and Hulls; Revised Label and the Analytical Laboratory Report on Method Validation.
Document (PDF) (375 KB PDF).
June 19, 1989. Memorandum. 11 Page(s).
William Woodrow. Registration Support Branch.
EPA Reg. No./File Symbol 51036-RAU, Azinphos-methyl 50W Acute Tox Studies.
MRID No. 410513-02. Tox Reviw No. 009087.
Document (PDF) (821 KB PDF).
June 30, 1989. Memorandum. 6 Page(s).
Ray Landolt. Toxicology Branch II.
Azinphos-Methyl. Action Requested: Review a Dermal Sensitization Study in
Guinea Pigs Submitted in Response to the Registration Guidance Document Dated
September 11, 1986.
Document (PDF) (243 KB PDF).
August 30, 1989. EFGWB One-Liner. 4 Page(s).
Environmental Fate and Ground Water Branch.
EFGWB One-Liner.
Document (PDF) (135 KB PDF).
January 04, 1990. Memorandum. 5 Page(s).
Ray Landolt. Toxicology Branch II.
Azinphos-Methyl. Action Requested: In Response to the Deficiencies Cited in the
Review by D. Ritter, May 8, 1989, of a Teratology Study in the Rabbit with Azinphos-
Methyl (MRID 407139-01), Mobay Corp. has Submitted the Requested Historical Control Data.
Document (PDF) (316 KB PDF).
January 08, 1990. DER. 10 Page(s).
Brian Montague. Ecological Effects Branch.
Data Evaluation Report Ecological Effects Branch. Early life stage toxicity- rainbow trout.
Accession No. 40579-01.
Document (PDF) (706 KB PDF).
March 08, 1990. Review. 89 Page(s).
Ray Landolt. Toxicology Branch.
Peer Review Files. Guthion (Azinphos-Methyl). Pages 49-88 are not included - not
responsive (Dinoseb Peer review).
Document (PDF) (5051 KB PDF).
May 03, 1990. Review. 22 Page(s).
Emil Regelman. Environmental Fate & Ground Water Branch.
Reg. No 3125-123 Review of label amendment to add the use in pomegranates
(California only) [GUTHION 2S] Pages 4-5 are not included-draft labeling.
Document (PDF) (1201 KB PDF).
June 12, 1990. Memorandum. 2 Page(s).
John Chen. Toxicology Branch.
Azinphos-Methyl (Guthion). ID No. 3125-108. Action Requested: Review of the
Registrant's Response to the Previous Review Comments Concerning the In-Vitro
Cytogenetic Assay with Azinphos-Methyl in the Human Lymphocyte Culture
Tox Review No. 007974.
Document (PDF) (112 KB PDF).
September 10, 1990. Memorandum. 12 Page(s).
Elizabeth Doyle. Toxicology Branch II.
Azinphos-Methyl - Review of a Mouse Oncogenicity Study Provided in Response to a DCI.
MRID No. 460091-01 Tox Review No. 008094.
Document (PDF) (723 KB PDF).
March 20, 1991. Memorandum. 8 Page(s).
Ray Landolt. Toxicology Branch II.
Azinphos-Methyl. Action Requested: Review a Chronic Feeding/Carcinogenicity
Study in Rats Submitted in Response to the Reregistration Guidance Document of
September 11, 1986. MRID No. 411199-01. Tox Review No. 008300.
Document (PDF) (472 KB PDF).
October 24, 1991. Memorandum. 16 Page(s).
Ray Landolt. Toxicology Branch II.
Azinphos-Methyl. One-Generation Rat Reproduction Study (83-4), Section 6 (a) (2)
MRID No. 419168-01. Tox Review No. 008748.
Document (PDF) (862 KB PDF).
December 19, 1991. Data Eval. Rec. 27 Page(s).
Sylvia Termes. Environmental Fate & Ground Water Branch.
STUDY ID 41393601 Chopade, H.M., and L.L. Bosnak. 1990. [Phenyl-UL-C14]
azinphos methyl rotational crop study. Pages 8-20 are not included-registrant data.
Document (PDF) (528 KB PDF).
December 30, 1991. Memorandum. 6 Page(s).
Henry Jacoby. Environmental Fate & Ground Water Branch.
Azinphos-Methyl (ALISS) PC #58001 confined rotational crop study (#41393601).
Document (PDF) (307 KB PDF).
January 02, 1992. Review. 25 Page(s).
Henry Jacoby. Environmental Fate & Ground Water Branch.
Review of accumulation in Confined Rotational Crops(165-1; MRID #413936601);
Update of Status of Data Requirements. Pages 21-25 are not included-registrant data.
Document (PDF) (701 KB PDF).
January 08, 1992. Memorandum. 55 Page(s).
Douglas J. Urban. Ecological Effects Branch.
Review of a Fish Full Life-Cycle Test (72-5, sheepshead minnow) from exposure
to azinphos-methyl (Guthion). MRID No. 420216-01.
Document (PDF) (1457 KB PDF).
March 23, 1992. Review. 4 Page(s).
Henry Jacoby. Environmental Fate & Ground Water Branch.
Review of proposed DCI for this chemical.
Document (PDF) (318 KB PDF).
April 06, 1992. Memorandum. 10 Page(s).
Ray Landolt. Toxicology Branch II.
Azinphos-Methyl. One-Year Dog Feeding Study (83-1b). MRID No. 418948-01.
Tox Review No. 009414.
Document (PDF) (610 KB PDF).
April 11, 1992. Memorandum. 2 Page(s).
Jean Holmes. Environmental Fate & Effects Division.
EFED's Comments on Proposed DCI for Guthion.
Document (PDF) (81 KB PDF).
May 28, 1992. Memorandum. 3 Page(s).
Henry Jacoby. Environmental Fate & Ground Water Branch.
Environmental Fate and Transport of Azinphos-methyl(GUTHION) for Inclusion
in Briefing Document.
Document (PDF) (168 KB PDF).
January 12, 1993. Memorandum. 2 Page(s).
Henry Jacoby. Environmental Fate & Ground Water Branch.
Azinphos-methyl Response to Miles Agricultural Division's Waiver Request for
Accumulation in Irrigated Crops (163-3).
Document (PDF) (83 KB PDF).
December 10, 1993. Memorandum. 15 Page(s).
John Bazuin. Science Analysis & Coordination Branch.
Azinphos-methyl Dietary Exposure Analysis: The Effects of the Addition of
Anticipated Residures and the Incorporation of a New Reference Dose (RfD).
Document (PDF) (1041 KB PDF).
April 25, 1997. Memorandum. 41 Page(s).
Brian Steinwand. Science Analysis Branch.
Dietary Exposure Analysis for Azinphos-Methyl in Support of the Reregistration
Eligibility Decision.
Document (PDF) (2792 KB PDF).
April 20, 1998. Memorandum. 18 Page(s).
Nancy McCarroll. Toxicology Branch.
Azinphos-methyl - Report of the Hazard Identification Assessment Review Committee
Tox review 012591.
Document (PDF) (1183 KB PDF).
May 07, 1998. Memorandum. 121 Page(s).
Catherine Eiden. Risk Characterization & Analysis Branch.
The HED Chapter of the Reregistration Eligibility Decision Document (RED) for
Azinphos methyl; (This includes the Toxicology, Product and Residue Chemistry,
Occupational/ Residential Exposure Assessment, Dietary Risk Analysis.).
Document (PDF) (6255 KB PDF).
November 17, 1998. Memorandum. 4 Page(s).
Jean Holmes. Environmental Fate & Effects Division.
EFED RED Chapter for azinphos methyl. PC Code No. 058001 ; Case No. 0234.
DP Bar codes D234006, D234029, D234030.
Document (PDF) (9645 KB PDF).
Attachment(s) Following:
Undated. Memorandum. 146 Page(s).
Environmental Fate & Effects Division.
Azinphos Methyl.
*End of Attachments*
January 07, 1999. Memorandum. 3 Page(s).
Jean Holmes. Environmental Fate & Effects Division.
Azinphos-methyl: Revision of Draft EFED Reregistration Eligibility Decision (RED)
Science Chapter to Include Registrant's Comments.
Document (PDF) (783 KB PDF).
May 12, 1999. Memorandum. 25 Page(s).
Felicia Fort. Health Effects Division.
Azinphos-methyl. Revised Monte Carlo Assessment (Case 0235; Chemical No. 058001).
DP Barcode D255395. No MRID No.
Document (PDF) (1356 KB PDF).
May 18, 1999. Memorandum. 5 Page(s).
Jerome Blondell. Chemistry & Exposure Branch.
Update to Review of Azinphosmethyl Incident Reports, DP Barcode 256164,
Chemical #058001, Rereg. Case #0235.
Document (PDF) (331 KB PDF).
May 19, 1999. Memorandum. 147 Page(s).
Catherine Eiden. Health Effects Division.
Human Health Risk Assessment Azinphos-Methyl.
Document (PDF) (8186 KB PDF).
October 26, 2001. Memorandum. 7 Page(s).
Jess Rowland. Health Effects Division.
Azinphos-Methyl - Repeated Dose Oral Study - Report of the Hazard Identification
Assessment Review Committee. Tox Review No. 0050230.
Document (PDF) (368 KB PDF).
October 26, 2001. Memorandum. 7 Page(s).
Jess Rowland. Health Effects Division.
Azinphos-Methyl - Single Dose Oral Study - Report of the Hazard Identification
Assessment Review Committee. Tox Review No. 0050229.
Document (PDF) (333 KB PDF).
July 18, 2002. Memorandum. 5 Pages.
Susan Makris. Toxicology Branch.
D283831: Azinphos-methyl (PC Code 058001) Comparative Cholinesterase Study
Protocols. TXR # 0050885.
Document (PDF) (196 KB PDF).
October 21, 2005. Memorandum. 25 Pages.
John Doherty. Reregistration Branch III.
EPA Id No.: 058001. Azinphos methyl: Review of the acute (2003. MRID No. 46162101),
repeat dosing (2004, MRID No. 46239001) & maternal gestational exposure
(2004, MRID No. 46291101) comparative cholinesterase inhibition studies.
TXR # 0052325. DP #D298150.
Document (PDF) (971 KB PDF).