Jump to main content.


Index of Cleared Science Reviews for TPTH (Pc Code 083601)

You will need Adobe Reader to view some of the files on this page. See EPA's PDF page

Undated. Memorandum. 1 Page(s).
Daniel Rieder. Ecological Effects Branch.
Acute EC50 Test with Eastern Oyster for TPTH (73-2(b)) (MRID 44023901) (D227257).
Document (PDF) (35 KB PDF).

July 25, 1980. Memorandum. 25 Page(s).
John Doherty. Toxicology Branch.
EPA Registration Nos. 148-689 and 148-1195 and PP #0F2282 and FAP #0H5242.
Conditional Registrations for the Use of DU-TER to Control Fungal Disease...
Tox Review 001492. Manufacturing process info. on page 4 and inert ingredient
info. on page 5 deleted.
Document (PDF) (1633 KB PDF).

September 24, 1981. Data Eval. Rec. 3 Page(s).
Stephen Hopkins. Ecological Effects Branch.
Cuprous Oxide, Plus Triphenyltin Hydroxide. Acute Toxicity of Kansai Rabamarine
to Bluegill Sunfish; Received 7/21/81 Under 46197-1; Unpublished Report Prepared
by EG & G Bionomics for M & T Chemicals, Inc.
Document (PDF) (92 KB PDF).

September 25, 1981. Data Eval. Rec. 2 Page(s).
Stephen Hopkins. Ecological Effects Branch.
Cuprous Oxide, Plus Triphenyltin Hydroxide. Acute Toxicity of Kansai Rabamarine
to the Water Flea; Received 7/21/81 Under 46197-1; Unpublished Report Prepared by
EG & G Bionomics for M & T Chemicals.
Document (PDF) (82 KB PDF).

September 25, 1981. Data Eval. Rec. 3 Page(s).
Stephen Hopkins. Ecological Effects Branch.
Cuprous Oxide, Plus Triphenyltin Hydroxide. Acute Toxicity of Kansai Rabamarine
to the Rainbow Trout: Received 7/21/81 Under 46197-1; Unpublished Report Prepared
by EG & G Bionomics for M & T Chemicals.
Document (PDF) (87 KB PDF).

April 20, 1982. Memorandum. 7 Page(s).
John Doherty. Toxicology Branch.
PP #0F2282. Teratogenic Evaluation of Triphenyltin Hydroxide. Tox Review 001782.
Document (PDF) (551 KB PDF).

February 15, 1984. DER. 4 Page(s).
Leslie Touart. Ecological Effects Branch.
The chronic toxicity of triphenyltin hydroxide (TPTH) to the water flea (Daphnia magna).
TEST TYPE: Aquatic Invertebrate Life-cycle Toxicity Study. TEST SPECIES: Daphnia magna.
MRID No. 00125270.
Document (PDF) (302 KB PDF).

March 06, 1984. DER. 4 Page(s).
Leslie Touart. Ecological Effects Branch.
The toxicity of triphenyltin hydroxide (TPTH) to fathead minnow (Pimephales promelas)
embryos and larvae. TEST TYPE: Fish early life-stage toxicity study. TEST SPECIES : Fathead minnow.
MRID No. 00125273.
Document (PDF) (294 KB PDF).

March 06, 1984. Data Eval. Rec. 4 Page(s).
Leslie Touart. Ecological Effects Branch.
Static 96 Hour Toxicity Study of Thompson Hayward Chenical Sample TH-TPTH in
Bluegill Sunfish, Rainbow Trout and Fathead Minnows. EPA Reg. No. 148-689.
MRID 00086574. Acc. No. 099053.
Document (PDF) (219 KB PDF).

March 27, 1984. Memorandum. 68 Page(s).
Edwin Budd. Toxicology Branch.
Submission of the Toxicology Branch Chapter of the Registration Standard for
Triphenyltin Hydroxide. Tox review 007915.
Document (PDF) (5141 KB PDF).

August 10, 1984. Memorandum. 3 Page(s).
Edwin Budd. Toxicology Branch.
Triphenyltin Hydroxide Registration Standard. Applicator "Risk Assessment" for Use
on Pecan Trees. Tox review 001012.
Document (PDF) (174 KB PDF).

November 06, 1984. Memorandum. 6 Page(s).
Marion Copley. Toxicology Branch.
EPA Petition No. 3F2823: Registrant's Responses to Previous Reviews by TB.
Review of Responses Concerning the Embryotoxicity, Immunotoxicity, and
Reproduction Studies with Triphenyltin Hydroxide. Tox Chem. 896E.
Accession No. 072734. Tox Review 004085.
Document (PDF) (411 KB PDF).

November 16, 1984. Review. 3 Page(s).
Samuel Creeger. Exposure Assessment Branch.
Reg. No. 8340-15 Protocol review - anaerobic soil metabolism MRID 143246.
Document (PDF) (108 KB PDF).

January 23, 1985. Memorandum. 1 Page(s).
Marion Copley. Toxicology Branch.
Responses from American Hoechst Corporation Regarding the Special Review of
Triphenyltin Hydroxide (TPTH).
Document (PDF) (49 KB PDF).

February 01, 1985. Memorandum. 4 Page(s).
Marion Copley. Toxicology Branch.
EPA Reg. No. 1812-244; Super-Tin 4L; Griffin Corporation's Requested Change in
Precautionary Language Regarding Triphenyltin Hydroxide. Pages 3-4 are not
included - draft label.
Document (PDF) (125 KB PDF).

April 25, 1985. Memorandum. 5 Page(s).
John Doherty. Toxicology Branch.
EPA Reg. No. 8340-15. Review of Rat Teratology Study with Triphenyltin Hydroxide
Submitted by the American Hoechst Corporation. Tox Review 004413.
Document (PDF) (440 KB PDF).

May 02, 1985. Memorandum. 7 Page(s).
Edwin Budd. Toxicology Branch.
Triphenyltin Hydroxide (TPTH). Review of Developmental Toxicology Study,
Performed and Reported by Robert Kavlock, Ph.D. (EPA Health Effects Research
Laboratory, Research Triangle Park), Dated March 28, 1985.
Document (PDF) (467 KB PDF).

June 18, 1985. Memorandum. 5 Page(s).
John Doherty. Toxicology Branch.
EPA Reg. No. 8340-17. Review of Protocols for a 90-Day Dog Study, 13-Week Rat
Study, 2-Generation Rat Reproduction Study, and Chromosome Aberration Study
with Triphenyltin Hydroxide.
Document (PDF) (322 KB PDF).

July 02, 1985. Memorandum. 1 Page(s).
John Doherty. Toxicology Branch.
Dermal Penetration and Skin Diffusion Studies with Triphenyltin Hydroxide.
Document (PDF) (42 KB PDF).

July 22, 1985. Memorandum. 1 Page(s).
John Doherty. Toxicology Branch.
EPA Reg. No. 1812-279. Triphenyltin Hydroxide (TPTH). Skin Diffusion Test -
Humans (in vitro).
Document (PDF) (160 KB PDF).
Attachment(s) Following:

July 17, 1985. Memorandum. 2 Page(s).
Robert Zendzian. Toxicology Branch.
Triphenyltin, Review of Dermal Absorption Studies.

*End of Attachments*

August 08, 1985. Memorandum. 3 Page(s).
John Doherty. Toxicology Branch.
EPA Reg. No. 8340-15. Triphenyltin Hydroxide (TPTH). Additional Data Submitted
Related to the Rat and Hamster Teratology Studies Conducted at the Batelle
Research Laboratories Acc. No. 257882. MRID 148907.
Document (PDF) (158 KB PDF).

August 22, 1985. Memorandum. 13 Page(s).
John Doherty. Toxicology Branch.
EPA Registration No. 8340-14. Triphenyltin Hydroxide. Review of 21-Day Dermal
Toxicity Study (Rats); Teratology Study with Development Phase (Rats); Dermal
Sensitization Study (Guinea Pigs). Tox Review 004624.
Product impurity info. on page 10 deleted.
Document (PDF) (775 KB PDF).

August 30, 1985. Memorandum. 2 Page(s).
Irwin Baumel. Health & Environmental Review Division.
Immunotoxicity Potential of Triphenyltin Hydroxide.
Document (PDF) (109 KB PDF).

September 24, 1985. Memorandum. 7 Page(s).
Allan Reiter. Residue Chemistry Branch.
#8340-15. Evaluation of TPTH Analytical Methods. [Acc.#258228 & 258332; RCB
#1135] MRID 142876, 128877.
Document (PDF) (552 KB PDF).

October 07, 1985. Memorandum. 6 Page(s).
John Doherty. Toxicology Branch.
EPA Reg. No. 8340-15. Dermal Penetration Study with Triphenyltin Hydroxide -
Request for Additional Data. Tox review 004709..
Document (PDF) (295 KB PDF).

October 07, 1985. Memorandum. 7 Page(s).
Robert Zendzian. Toxicology Branch.
Triphenyltin, Review of Dermal Absorption Studies. MRID 00142881.
Document (PDF) (294 KB PDF).

December 12, 1985. Memorandum. 5 Page(s).
John Doherty. Toxicology Branch.
Triphenyltin Hydroxide: Rebuttal Comments to PD 1 and Request for Additional
Immunotoxicity Studies.
Document (PDF) (392 KB PDF).

December 12, 1985. Memorandum. 8 Page(s).
John Doherty. Toxicology Branch.
EPA Reg. No. 8340-15. Teratology Studies with Triphenyltin Hydroxide. Receipt of
Reprint Discussing Significance of Hydronephrosis as a Teratogenic Lesion in Rats.
Document (PDF) (887 KB PDF).

December 20, 1985. Memorandum. 1 Page(s).
John Doherty. Toxicology Branch.
EPA Reg. No. 8340-17. Triphenyltin Hydroxide (TPTH). Return of Submission of
Mutagenicity Studies to Registration Division Because of Incomplete Copies.
Document (PDF) (49 KB PDF).

December 20, 1985. Memorandum. 2 Page(s).
John Doherty. Toxicology Branch.
Triphenyltin Hydroxide (TPTH). Company Response to Toxicology Branch's Request
to Analyze the Tissue Samples from the Dog Long Term Toxicity Studies.
Document (PDF) (110 KB PDF).

February 04, 1986. Memorandum. 1 Page(s).
John Doherty. Toxicology Branch.
Triphenyltin Hydroxide. Request for Additional Studies to Clarify
Potential Immunotoxicity.
Document (PDF) (174 KB PDF).
Attachment(s) Following:

December 20, 1985. Memorandum. 2 Page(s).
Roy Sjoblad. Toxicology Branch.
Recommended Studies for Establishing a NOEL for Triphenyltin Hydroxide on
Cells of the Immune System.

*End of Attachments*

February 12, 1986. Memorandum. 2 Page(s).
John Doherty. Toxicology Branch.
Triphenyltin Hydroxide - Special Review. Requirement for a Rabbit Teratology Study.
Document (PDF) (98 KB PDF).

March 05, 1986. Memorandum. 9 Page(s).
Robert Zendzian. Toxicology Branch.
Triphenyltin Hydroxide. Review of Additional Data from Dermal Absorption Study
MRID 156325. Tox review 004961.
Document (PDF) (742 KB PDF).
Attachment(s) Following:

October 09, 1985. Protocol. 5 Page(s).
Robert Zendzian. Toxicology Branch.
Procedure for Studying Dermal Absorption.

*End of Attachments*

March 13, 1986. Memorandum. 4 Page(s).
Robert Zendzian. Toxicology Branch.
Triphenyltin Hydroxide. Margin of Safety for Maternal Toxicity Utilizing Data on
Exposure While Spraying Pecans and Dermal Absorption Data.
Document (PDF) (248 KB PDF).

March 21, 1986. Memorandum. 1 Page(s).
John Doherty. Toxicology Branch.
EPA Reg. No. 8340-17. Triphenyltin Hydroxide. Preliminary Report on the General
Metabolism Study.
Document (PDF) (74 KB PDF).

March 31, 1986. Memorandum. 6 Page(s).
John Doherty. Toxicology Branch.
EPA Reg. No. 8340-17. Triphenyltin Hydroxide. Review of Revised Protocols for
Analyses of Dog and Rat Tissue Samples for Triphenyltin Hydroxide and its Metabolites.
Document (PDF) (302 KB PDF).

April 10, 1986. Memorandum. 3 Page(s).
John Doherty. Toxicology Branch.
EPA Registration No. 8340-17. Triphenyltin Hydroxide. Core Classification of the
Cannon Laboratories Mouse Oncogenicity Study.
Document (PDF) (182 KB PDF).

April 18, 1986. Memorandum. 2 Page(s).
John Doherty. Toxicology Branch.
Triphenyltin Hydroxide. Comments on the Cannon 1976 Study and Battelle 1981
Study and Justification of Toxicology Branch's Position that Triphenyltin Hydroxide is
Not Teratogenic in the Rat at the Dose Levels Tested.
Document (PDF) (153 KB PDF).

May 08, 1986. Memorandum. 20 Page(s).
John Doherty. Toxicology Branch.
Triphenyltin Hydroxide. Meeting with Registrants to Discuss the Dermal Penetration
Study, Immunotoxicity Testing, Comments on the Cannon Mouse Oncogenicity Study
and Future Mouse Oncogenicity Testing and Correction of Toxicology Branch Comments….
Document (PDF) (1086 KB PDF).

May 08, 1986. Memorandum. 5 Page(s).
John Doherty. Toxicology Branch.
EPA Registration No. 8340-17. Triphenyltin Hydroxide. Reevaluation of the Dermal
Sensitization Studies and Comments on Missing Data in a 21-Day Dermal Toxicity
Study and a One-Generation Reproduction and Teratology Study.
Document (PDF) (296 KB PDF).

June 09, 1986. Memorandum. 4 Page(s).
Richard Levy. Toxicology Branch.
Testing for Decreasing Dose-Related Trends for Immunoglobulins G, A, M, in the 13-
Week Clinical Biochemistry of Mouse Subchronic Feeding Studies with Triphenyltin
Hydroxide (TPTH). EPA Reg. No. 8340-17. Tox Review 005299.
Document (PDF) (211 KB PDF).

July 09, 1986. Memorandum. 5 Page(s).
Susan Hummel. Residue Chemistry Branch.
Triphenyl Tin Hydroxide, Response to Registration Standard: M&T Residue
Analytical Method. EPA Reg. No. 8340-17, File Symbol 5204-AO. Accession No. 260289,
RCB No 813] MRID 153228. Manufacturing process info on 2 not included.
Document (PDF) (347 KB PDF).

July 15, 1986. Memorandum. 22 Page(s).
John Doherty. Toxicology Branch.
EPA Registration No. 8340-17. Review of Rat and Mouse Subchronic Feeding
Studies with Triphenyltin Hydroxide. Tox Review 005299.
Document (PDF) (1311 KB PDF).

July 30, 1986. Memorandum. 3 Page(s).
John Doherty. Toxicology Branch.
EPA ID No. 8340-17: Triphenyltin Hydroxide - Review of Mutagenicity Studies:
Gene Conversion in S. cerevisiae D4 and unscheduled DNA Synthesis in Rat
Primary Hepatocytes. MRID 155521, 155522. Guideline 84-2 (a), 84-4.
Document (PDF) (181 KB PDF).

August 18, 1986. Memorandum. 10 Page(s).
John Doherty. Toxicology Branch.
EPA Registration No. 8340-17 - Review of Mutagenicity Studies with Triphenyltin
Hydroxide (TPTH): DNA Damage in Human Lymphocytes, Gene Mutation in
Schizosaccharomyces Pombe, Mouse Micronucleus Test, and Mouse Lymphoma
Mutation Assay. MRID 152223-152227.
Document (PDF) (653 KB PDF).

August 26, 1986. Memorandum. 17 Page(s).
Thomas Armitage. Ecological Effects Branch.
Response to Registrant's Amendment for Mallard Dietary Study on Triphenyltin
Hydroxide (TPTH) Pages 11-12, 16-17 removed, registrant data.
Document (PDF) (723 KB PDF).
Attachment(s) Following:

August 15, 1985. Review.
Les Touart. Ecological Effects Branch.
Reg. No 8340-15, 47916-37 Submission of data in support of registration.
Acc. 258233, 258314. MRID 00142885, 00142758.

*End of Attachments*

September 04, 1986. Memorandum. 18 Page(s).
Susan Hummel. Residue Chemistry Branch.
056227 - Triphenyl Tin Hydroxide, Response to Registration Standard: M&T Residue
Analytical Method + Residue Data. EPA File Symbol 5204-Q. Accession Nos.
263218, 263219, 263220, 263221, 263222; RCB No. 1096. MRID 160465 - 160469.
MP info on page 3 deleted.
Document (PDF) (1075 KB PDF).

January 20, 1987. Memorandum. 27 Page(s).
John Doherty. Toxicology Branch.
EPA Registration No. 8340-17. Triphenyltin Hydroxide. Review of Protocols for
Dermal Absorption (Extended Duration) and Placental Transfer with 14C Triphenyltin
Hydroxide. Pages 6-27 removed, registrant data.
Document (PDF) (377 KB PDF).
Attachment(s) Following:

August 28, 1986. Memorandum.
John Doherty. Toxicology Branch.
Triphenyltin Hydroxide. Request to Review Protocol for a Special Dermal
Absorption Study with Labelled (14C) Test Material.

*End of Attachments*

February 24, 1987. Memorandum. 2 Page(s).
John Doherty. Toxicology Branch.
EPA ID No. 083601. Triphenyltin Hydroxide. Review of a Dermal Absorption Study
with the Test Material Dissolved in an EC Formulation. Request for Extended Due Date.
Document (PDF) (104 KB PDF).

April 22, 1987. Memorandum. 9 Page(s).
John Doherty. Toxicology Branch.
EPA Registration No. 8340-17. Triphenyltin Hydroxide. Review of a Two-Generation
Reproduction Study in Rats. MRID 162655. Tox review 005848.
Document (PDF) (687 KB PDF).

May 01, 1987. Memorandum. 6 Page(s).
Francis Suhre. Residue Chemistry Branch.
Triphenyl Tin Hydroxide; Response to Registration Standard; M&T Residue
Analytical Method (TA-49); Residue data for Pecans and Peanuts;
Accession Nos. 266045 and 266046; RCB Nos. 1702. MRID 165010, 165025.
Document (PDF) (435 KB PDF).

May 05, 1987. Review. 16 Page(s).
Emil Regelman. Exposure Assessment Branch.
Reg. No. 8340-17 Review of Confined Rotation Accumulation Study MRID 161670.
Document (PDF) (592 KB PDF).

May 27, 1987. Memorandum. 5 Page(s).
Robert Zendzian. Toxicology Branch.
Triphenyltin Hydroxide, Dermal Absorption in Rats MRID 401983-01.
Tox review 005913.
Document (PDF) (244 KB PDF).

May 27, 1987. Memorandum. 6 Page(s).
Robert Zendzian. Toxicology Branch.
Triphenyltin Hydroxide (TPTH), Dermal Absorption Study in Rats. Inert ingredient
information on page 3 is not included MRID 400730-01. Tox review 005912.
Document (PDF) (378 KB PDF).

May 28, 1987. Memorandum. 10 Page(s).
John Doherty. Toxicology Branch.
EPA Reg. No. 8340-17. Triphenyltin Hydroxide. Review of Pilot and Definitive
Rabbit Teratology Studies. MRID 40104801. Tox review 005917.
Document (PDF) (725 KB PDF).

August 27, 1987. Memorandum. 42 Page(s).
John Doherty. Toxicology Branch.
EPA Reg. No. 8340-17. Triphenyltin Hydroxide. Review of Subchronic Inhalation
and Metabolism Studies in Rats Submitted in Response to Data Requirements Listed
in the Registration Standard. Pages 22-23 and 29-39 are not included - registrant data.
Document (PDF) (2323 KB PDF).

September 01, 1987. Memorandum. 15 Page(s).
Francis Suhre. Residue Chemistry Branch.
Triphenyl Tin Hydroxide (TPTH): Amendment to 056227; Submitted in response to
RCB memo of 9-4-86 (S. Hummel); MRID Nos. 401494-01 and 401494-02, RCB No. 2213.
Document (PDF) (1199 KB PDF).

September 02, 1987. Memorandum. 21 Page(s).
Francis Suhre. Residue Chemistry Branch.
Triphenyl Tin Hydroxide (TPTH): Response to Registration Standard; Review of
Field Studies for Peanuts, Sugar Beets, Pecans, Potatoes, and Carrots.
MRID Numbers 401493-01, -02, -03, -04, and -05; RCB No. 2264.
Document (PDF) (1350 KB PDF).

September 02, 1987. Memorandum. 8 Page(s).
John Doherty. Toxicology Branch.
EPA Reg. No. 8340-17. Triphenyltin Hydroxide. Review of Registrant's Summary
Paper on Immunotoxicity and an Immunotoxicity Study Testing Host Resistance in
Rats to Trichinella spiralis. Tox review 006466.
Document (PDF) (887 KB PDF).
Attachment(s) Following:

August 05, 1987. Memorandum. 4 Page(s).
Roy Sjoblad. Toxicology Branch.
Review of Summary Report of Drs. W. Seinen and A.H. Penninks (University of
Utrecht, Netherlands) on Literature Concerning the "Immunotoxicity of
Triphenyltin Compounds" (Report Date: April 1, 1987). Acc. No. 402003-02.

*End of Attachments*

September 03, 1987. Memorandum. 5 Page(s).
Francis Suhre. Residue Chemistry Branch.
Triphenyl Tin Hydroxide (TPTH): Response to Registration Standard; Amendments
to EPA Accession Nos. 266045 and 266046, in Response to RCB Memo of 5-1-87
(F. Suhre). MRID No. 402776-01; RCB No. 2697.
Document (PDF) (343 KB PDF).

September 28, 1987. Memorandum. 2 Page(s).
John Doherty. Toxicology Branch.
EPA Reg. No. 8340-17. Triphenyltin Hydroxide. Review of Protocols for Rat and
Mouse Immunotoxicity Studies.
Document (PDF) (344 KB PDF).
Attachment(s) Following:

September 10, 1987. Memorandum. 3 Page(s).
Roy Sjoblad. Toxicology Branch.
Review of Proposed Immunotoxicity Testing Protocols for Triphenyltin Hydroxide
(TPTH) as Submitted by American Hoechst Corporation.

*End of Attachments*

October 07, 1987. Memorandum. 12 Page(s).
John Doherty. Toxicology Branch.
EPA Reg. No. 8340-17. Triphenyltin Hydroxide. Review of a Dog Chronic Feeding
Study Submitted in August 1987 in Response to the Data Requirement Indicated in
the Registration Standard. Tox Review 006351.
Document (PDF) (800 KB PDF).

October 29, 1987. Memorandum. 7 Page(s).
John Doherty. Toxicology Branch.
EPA Reg. No. 8340-17. Triphenyltin Hydroxide. Review of a Second
Immunotoxicity Study Testing Host Resistance in Rats to Trichinella spiralis.
Tox Review 006402.
Document (PDF) (433 KB PDF).

October 30, 1987. Memorandum. 7 Page(s).
John Doherty. Toxicology Branch.
EPA Reg. No. 8340-15. Triphenyltin Hydroxide. Review of Guinea Pig
Sensitization Study.
Document (PDF) (527 KB PDF).

November 06, 1987. Memorandum. 10 Page(s).
John Doherty. Toxicology Branch.
Request for Inhalation Exposure Estimates to Applicators, Mixers/Loaders and
Bystanders (Including Those in the Path of any Spray Drift) Resulting from All
Uses of Triphenyltin Hydroxide.
Document (PDF) (754 KB PDF).

November 06, 1987. Memorandum. 8 Page(s).
John Doherty. Toxicology Branch.
Triphenyltin Hydroxide. Update (November 1987) on Major Toxicity Issues Related to
Special Review. Request for Additional Teratology (Rabbit Dermal) Data.
Document (PDF) (642 KB PDF).

December 09, 1987. Review. 60 Page(s).
Emil Regelman. Exposure Assessment Branch.
Reg. No. 8340-17 and 53265-Q Addendum to Standard Acc. 260854 (MRID 156002 thru 156007).
Acc. 261019 (MRID 155453). MRIDs 401065-01, 02.
Document (PDF) (2561 KB PDF).

December 15, 1987. Memorandum. 2 Page(s).
Leung Cheng. Residue Chemistry Branch.
EPA Reg. No. 5204-86. TPTH (Triphenyl Tin Hydroxide). Storage Stability Data.
No MRID #. RCB No. 2816.
Document (PDF) (98 KB PDF).

December 28, 1987. Review. 9 Page(s).
Allen Vaughan. Ecological Effects Branch.
Reg. No 47916-35 Submission of mallard dietary study with formulated product,
in response to registration standard. MRID 401733-00.
Document (PDF) (532 KB PDF).
Attachment(s) Following:

March 15, 1989. Memorandum.
James Akerman. Ecological Effects Branch.
Triphenyltin hydroxide EEC Modeling Analysis Report.

*End of Attachments*

January 15, 1988. Memorandum. 3 Page(s).
Francis Suhre. Residue Chemistry Branch.
Triphenyl Tin Hydroxide (TPTH): Clarification of previously cited deficiencies;
RD Record No. 208184; RCB No. 3036.
Document (PDF) (219 KB PDF).

February 11, 1988. Memorandum. 14 Page(s).
John Doherty. Toxicology Branch.
EPA Reg. No.: 8340-17 Triphenyltin Hydroxide. Review of a mutagenicity study
(Cytogenic test in bone marrow of Chinese Hamster) and overview of mutagenicity
studies prepared by Dr. Kerry Dearfield. MRID 40371102. Tox review 0006589.
Document (PDF) (443 KB PDF).

April 19, 1988. Memorandum. 3 Page(s).
John Doherty. Toxicology Branch.
EPA Reg. No.: 8340-17 Triphenyltin Hydroxide: Review of protocol for a subchronic
(90 day) inhalation toxicity study to be conducted at the Research and Consulting
Company Ag (Switzerland) in the spring of 1988.
Document (PDF) (210 KB PDF).

June 16, 1988. Memorandum. 57 Page(s).
David Warburton. Ecological Effects Branch.
Review of avian reproduction studies submitted in response to TPTH Registration
Standard. Acc. 263193 and 263954 (Amendment).
Document (PDF) (2460 KB PDF).

June 16, 1988. Review. 3 Page(s).
David Warburton. Ecological Effects Branch.
Reg. No 53265-O Submission of avian reproduction studies in response to
Registration Standard MRID 161655, 161680.
Document (PDF) (140 KB PDF).

August 26, 1988. Review. 10 Page(s).
James Akerman. Ecological Effects Branch.
Reg. No 8340-17 EAB deferral to EEB concerning adequacy of fish accumulation
study MRID 40185901, 40185902.
Document (PDF) (459 KB PDF).

November 03, 1988. Memorandum. 4 Page(s).
John Doherty. Toxicology Branch.
EPA Reg. No. 8340-17. Triphenyltin Hydroxide: Registrant's Response to Toxicology
Branch's Review of the Chronic Dosing Study with Dogs Concerning: 1) the Certificate
of Analysis of the Test Material; 2) the Qualifications of the Pathologist...TXR 006915.
Document (PDF) (153 KB PDF).

June 30, 1989. Memorandum. 18 Page(s).
John Doherty. Toxicology Branch.
EPA Reg. No.: 8340-17. Triphenyltin Hydroxide: Review of a subchronic (90 day)
inhalation study in rats (RCC Study No.: 202353, dated February, 1989).
Page 18 removed, registration data. MRID 410177-01.
Document (PDF) (982 KB PDF).

September 14, 1989. Oneliner. 3 Page(s).
Environmental Fate and Ground Water Branch..
Pesticide Environmental Fate One Line Summary Triphenyltin hydroxide.
Document (PDF) (79 KB PDF).

September 27, 1989. Memorandum. 39 Page(s).
John Doherty. Toxicology Branch.
EPA Reg. No. 8340-17. Triphenyltin Hydroxide: Review of Rat Chronic
Feeding/Oncogenicity and Mouse Oncogenicity Studies Conducted by the RCC
Laboratory and Submitted May 1989. Indications of Oncogenic Effects...
Tox review 007501. MRIDs 41085701, -02.
Document (PDF) (3014 KB PDF).

November 28, 1989. Memorandum. 14 Page(s).
John Doherty. Toxicology Branch I.
Subject: TPTH - Qualitative Risk Assessment, Dietary Studies in Mice and Rats
Tox review 008006.
Document (PDF) (665 KB PDF).

January 09, 1991. Peer Review. 44 Page(s).
Victor Miller. Science Analysis & Coordination Branch.
Peer Review of Triphenyltin Hydroxide (TPTH), Tox Chemical No. 896E.
Document (PDF) (2073 KB PDF).

June 17, 1991. Memorandum. 8 Page(s).
James Akerman. Ecological Effects Branch.
TPTH Avian Reproduction Studies (MRIDs No.'s 263193 - 263954) and the
Requirement for Estuarine/Marine Acute Toxicity Testing.
Document (PDF) (353 KB PDF).

July 30, 1991. Memorandum. 12 Page(s).
John Doherty. Toxicology Branch I.
Triphenyltin Hydroxide: Request for an updated DER for the rat two-year chronic
feeding study conducted at the Centraal Institut voor Voedingsonderzoek in 1970 and
reclassification of 1989 rat chronic feeding study conducted at RRC (continued).
Document (PDF) (730 KB PDF).
Attachment(s) Following:

July 30, 1991. Memorandum.
John Doherty. Toxicology Branch I.
(continued) Accession 099050 Tox review 008480.

*End of Attachments*

August 06, 1991. SAP Package. 1 Page(s).
John Doherty. Toxicology Branch.
Triphenytin Hydroxide: Submission of Documents for Consideration by the Scientific
Advisory Panel.
Document (PDF) (6080 KB PDF).
Attachment(s) Following:

July 30, 1986. Memorandum. 3 Page(s).
John Doherty. Toxicology Branch.
EPA ID No. 8340-17: Triphenyltin Hydroxide - Review of Mutagenicity Studies:
Gene Conversion in S. cerevisiae D4 and Unscheduled DNA Synthesis in Rat
Primary Hepatocytes. Tox Review 005617.

August 18, 1986. Memorandum. 10 Page(s).
John Doherty. Toxicology Branch.
EPA Registration No. 8340-17 - Review of Mutagenicity Studies with
Triphenyltin Hydroxide (TPTH): DNA Damage in Human Lymphocytes, Gene
Mutation in Schizosaccharomyces Pombe, Mouse Micronucleus Test, and
Mouse Lymphoma Mutation Assay. Tox review 005361.

February 11, 1988. Memorandum. 12 Page(s).
John Doherty. Toxicology Branch.
EPA Reg. No. 8340-17 - Triphenyltin Hydroxide. Review of a Mutagenicity
Study (Cytogenic Test in Bone Marrow of Chinese Hamster) and Overview of
Mutagenicity Studies Prepared by Dr. Kerry Dearfield. Tox Review 006589.

September 21, 1989. Data Eval. Rep. 15 Page(s).
John Doherty. Toxicology Branch.
83-2 - Oncogenicity - Mice. MRID No. 410857-01 (Five Volumes).

September 21, 1989. Data Eval. Rep. 20 Page(s).
John Doherty. Toxicology Branch.
83-1 and -2 - Oncogenicity and Chronic Feeding - Rats.
MRID No. 410857-02 (8 Volumes).

November 16, 1989. Peer Review. 17 Page(s).
Esther Rinde. Health Effects Division.
Peer Review on Triphenyltin Hydroxide (TPTH).

May 24, 1990. Peer Review. 18 Page(s).
Roy Sjoblad. Science Analysis & Coordination Branch.
Peer Review of Triphenyltin Hydroxide (TPTH).

*End of Attachments*

September 06, 1991. Memorandum. 18 Page(s).
John Doherty. Toxicology Branch.
EPA Id. #8340-17. Triphenyltin hydroxide: Registrants response to the review of the
rat chronic feeding/oncogenicity study dated September 27, 1989... Pages 13-14 removed,
registrant data. MRID 412975-01.
Document (PDF) (1146 KB PDF).

October 02, 1991. Memorandum. 4 Page(s).
Robert Jaeger. FIFRA Scientific Advisory Panel.
Transmittal of the Final FIFRA Scientific Advisory Panel Report on the September 18,
1991, Meeting.
Document (PDF) (270 KB PDF).

October 21, 1991. Memorandum. 24 Page(s).
John Doherty. Toxicology Branch.
EPA ID #8340-17. Triphenyltin Hydroxide: Review of rat metabolism studies
following oral administrat- ion and utilizing Sn113 and C14 labelled material and rats
with bile duct fistulas. Summary of metabolism studies following oral administration.
Document (PDF) (1748 KB PDF).
Attachment(s) Following:

October 21, 1991. Memorandum.
John Doherty. Toxicology Branch I.
(continued) MRID 413091-01, -02, 413872-01. Tox review 008721.

*End of Attachments*

October 22, 1991. Memorandum. 31 Page(s).
Robert Zendzian. Science Analysis & Coordination Branch.
Triphenyltin Hydroxide (TPTH). Evaluation of the Relative Absorption by Oral and
Dermal Routes. Route Conversion Factors. Tox review 008724.
Document (PDF) (3636 KB PDF).

November 05, 1991. Memorandum. 4 Page(s).
John Doherty. Toxicology Branch.
EPA ID # 8340-17. Triphenyltin Hydroxide: Verification of the content of the test
material used in the chronic toxicity study in dogs (RCC study # 047013/047024, June
1987). Reclassification of the study to Guideline. (continued).
Document (PDF) (206 KB PDF).
Attachment(s) Following:

November 05, 1991. Memorandum.
John Doherty. Toxicology Branch.
Page 4 removed, quality control procedurte information. Tox review 008756.

*End of Attachments*

March 16, 1992. Review. 5 Page(s).
Emil Regelman. Environmental Fate & Ground Water Branch.
Super Tin, Griffin Corporation/Hoechst Celanese Registrant response to a 12/9/87
review of a field dissipation study. Request to reclassify. MRID 42063501.
Document (PDF) (446 KB PDF).

March 18, 1992. Memorandum. 90 Page(s).
E. Zager. Chemistry Branch.
Triphenyltin Hydroxide (TPTH) Product and Residue Chemistry Reregistration
Standard Updates. CBRS No. 8985; DP Barcode No. D171632. Pages 33-35
removed, manufacturing process and quality control procedure information.
Document (PDF) (6653 KB PDF).

July 27, 1992. Memorandum. 3 Page(s).
George Ghali. Science Analysis & Coordination Branch.
Report of RfD/Peer Review of Triphenyltin Hydroxide.
Document (PDF) (140 KB PDF).

July 29, 1992. Memorandum. 6 Page(s).
John Doherty. Toxicology Branch.
EPA ID# 083601. Triphenyltin hydroxide: Review of a proposed rabbit dermal
developmental toxicity study.
Document (PDF) (500 KB PDF).
Attachment(s) Following:

June 24, 1992. Letter.
Berthold Volker. Hoechst Celanese Corporation.
To: Mike Berringer, SRRD...to provide draft protocol outlines for the rabbit dermal
developmental toxicity study.

*End of Attachments*

August 25, 1992. Memorandum. 2 Page(s).
Douglas Urban. Ecological Effects Branch.
Fish Life Cycle Protocol for TPTH.
Document (PDF) (97 KB PDF).

January 29, 1993. Review. 53 Page(s).
Emil Regelman. Environmental Fate & Ground Water Branch.
Review photodegradation in water and photodegradation in soil studies.
Pages 9-27, 32-53 removed, registrant data MRIDs 420495-02, 421198-01.
Document (PDF) (1019 KB PDF).

February 04, 1993. Memorandum. 2 Page(s).
R. B. Perfetti. Chemistry Branch.
Animal Feeding Studies: Requirement Status Modification
(No MRID #, No CBRS #, No Barcode).
Document (PDF) (97 KB PDF).

March 01, 1993. Review. 7 Page(s).
Jeff Evans. Occupational & Residential Exposure Br.
Review of reentry data submission to support the reregistration of triphenyltin
hydroxide (TPTH) MRID 425078-01.
Document (PDF) (206 KB PDF).

April 27, 1993. Memorandum. 3 Page(s).
Anthony Maciorowski. Ecological Effects Branch.
TPTH Estuarine/Marine Study Requirements This memorandum is to document that
EEB has received both SRRD's letter to Hoechst Celanese Corp. of February 2,
1993 and Griffin Corp. letter of March 4, 1993 concerning estuarine and marine
studies...
Document (PDF) (205 KB PDF).

October 29, 1993. Memorandum. 4 Page(s).
John Doherty. Toxicology Branch.
EPA File no.: 083601. Triphenyltin Hydroxide: Review of a series 83-3 special
dermal developmental toxicity study in rabbits. MRID 429091-01.
Document (PDF) (267 KB PDF).

November 23, 1993. Memorandum. 21 Page(s).
Leung Cheng. Chemistry Branch.
Triphenyltin Hydroxide (TPTH). Case No. 0099. Registrants' Response to
Registration Standard Update of 3/92. CBRS No. 12109. DP Barcodes: D192579.
Document (PDF) (1437 KB PDF).
Attachment(s) Following:

September 10, 1993. Review.
Acurex Environmental Corporation.
Triphenyltin Hydroxide Task 3 Registrant's Response to Residue Chemistry
Data Requirements.

*End of Attachments*

December 21, 1993. Review. 9 Page(s).
Margaret Rice. Special Review & Reregistration Div.
TPTH Rabbit dermal Developmental study submitted 8/31/93 under FIFRA section
6(a)(2) MRID 429091-01.
Document (PDF) (566 KB PDF).

September 12, 1994. Data Eval. Rec. 22 Page(s).
Dennis McLane. Ecological Effects Branch.
72-3 (b) Acute Estuarine/Marine Toxicity Mollusk Eastern Oyster.
Pages 19-22 removed, registrant data. MRID 43212703.
Document (PDF) (828 KB PDF).

September 12, 1994. Data Eval. Rec. 39 Page(s).
Dennis McLane. Ecological Effects Branch.
71-4 Avian Reproduction Study, Mallard MRID 43178502.
Document (PDF) (2371 KB PDF).

September 12, 1994. Data Eval. Rec. 7 Page(s).
Dennis McLane. Ecological Effects Branch.
72-3 (c) Acute toxicity test for estuarine and marine organisms: Mysid shrimp
(Mysidopsis bahia) MRID 43212701.
Document (PDF) (384 KB PDF).

September 12, 1994. Data Eval. Rec.. 8 Page(s).
Dennis McLane. Ecological Effects Branch.
72-3 Estuarine Fish 96-hour Acute Toxicity Test. Sheephead minnow
MRID 43212702.
Document (PDF) (420 KB PDF).

September 14, 1994. Memorandum. 106 Page(s).
Anthony Maciorowski. Ecological Effects Branch.
EEB Review of TPTH Bobwhite Quail and Mallard Duck Reproduction Studies
(D201655) and Review of an Acute LC50 for Mysid and Sheepshead Minnow, and a
Shell Deposition Study with easter Oyster (D203510).
Pages 91-92 removed, registrant data.
Document (PDF) (4597 KB PDF).
Attachment(s) Following:

September 12, 1994. Data Eval. Rec.
Dennis McLane. Ecological Effects Branch.
72-3 (b) Acute Estuarine/Marine Toxicity Mollusk Eastern Oyster.
MRID 43212703.

September 12, 1994. Data Eval. Rec.
Dennis McLane. Ecological Effects Branch.
72-3 (c) Acute toxicity test for estuarine and marine organisms: Mysid Shrimp
(Mysidopsis bahia) MRID 43212701.

September 12, 1994. Data Eval. Rec.
Dennis McLane. Ecological Effects Branch.
72-3 Estuarine Fish 96-hour Acute Toxicity Test. Sheepshead Minnow
MRID 43212702.

September 12, 1994. Data Eval. Rec.
Dennis McLane. Ecological Effects Branch.
Avian Reproduction Study, Mallard MRID 43178502.

September 14, 1994. Data Eval. Rec..
Dennis McLane. Ecological Effects Branch.
Acute and Chronic Toxicity of Triphenyltin Hydroxide to Fathead Minnows.
MRID 43349601.

*End of Attachments*

April 20, 1995. Data Eval. Rec.. 20 Page(s).
Dennis McLane. Ecological Effects Branch.
Fish Life-Cycle Toxicity Test, Guideline 72-5 MRID 43490101.
Document (PDF) (1178 KB PDF).

April 26, 1995. Memorandum. 20 Page(s).
Anthony Maciorowski. Ecological Effects Branch.
Submission of 72-5 Full Fish Life-Cycle Study with Triphenyltin Hydroxide and
Fathead Minnow MRID No. 43490101.
Document (PDF) (1148 KB PDF).

August 09, 1995. Memorandum. 14 Page(s).
Anthony Maciorowski. Ecological Effects Branch.
Reconsideration for Guideline acceptance of the Shell Deposition Study with Eastern
Oyster (43212701) (D215275) and the Bobwhite Quail (43278501) and Mallard
(43178502) Duck Reproduction Studies (D217213). Pages 5-7, 10-14 removed,
registrant data.
Document (PDF) (410 KB PDF).

August 09, 1995. Review. 14 Page(s).
Anthony Maciorowski. Ecological Effects Branch.
Review additional data required for avian studies [71-4 Avian reproduction studies]
MRID 43178501, 43178502. Pages 5-7, 10-14 removed, registrant data.
Document (PDF) (422 KB PDF).

February 23, 1996. Memorandum. 4 Pages.
Leung Cheng. Chemistry Branch II.
TPTH/Fentin Hydroxide. Case 0099. Additional Data for Analytical Method (171-4c).
MRID 43874701 & 02. CBRS 16787. DP Barcode: D222078. MRID No. 43874700.
Document (PDF) (115 KB PDF).

February 28, 1996. Review. 7 Page(s).
Jeff Evans. Occupational & Residential Exposure Br.
Potential Daily Exposure of Reentry Workers Entering Pecan Groves Treated with
Triphenyltin Hydroxide (TPTH) MRID 435574-01.
Document (PDF) (588 KB PDF).

June 25, 1996. Review. 6 Page(s).
Anthony Maciorowski. Ecological Effects Branch.
Review Agrevo response to fish life cycle review.
Document (PDF) (385 KB PDF).
Attachment(s) Following:

June 25, 1996. Memorandum.
Anthony Maciorowski. Ecological Effects Branch.
Agrevo's March 19, 1996 Letter; Full Life-Cycle Toxicity of... TPTH... to Fathead
Minnow... MRID 43490101.

*End of Attachments*

September 06, 1996. Memorandum. 9 Page(s).
Dennis McLane. Ecological Effects Branch.
Review of an 73-2(b) Acute EC50 Test with Eastern Oyster for TPTH (Triphenyltin
Hydroxide... MRID 44023901.
Document (PDF) (583 KB PDF).

December 16, 1996. Review. 25 Page(s).
Mah Shamim. Environmental Fate & Ground Water Branch.
Review Accumulation in Fish Study. Pages 8-25 removed, registrant data.
MRID 42995601.
Document (PDF) (656 KB PDF).

January 14, 1998. Memorandum. 10 Page(s).
Sarah Law. Risk Characterization & Analysis Branch.
Triphenyltin Hydroxide: Registrants' Response to Residue Chemistry Data
Requirements. MRID # 44667001.
Document (PDF) (650 KB PDF).

August 18, 1998. Memorandum. 2 Page(s).
Bernice Fisher. Science Analysis Branch.
TPTH -Revised Q1* (3/4's Interspecies Scaling Factor), Female Wistar Rat Study.
Tox review 012819.
Document (PDF) (145 KB PDF).

September 09, 1998. Memorandum. 3 Page(s).
Tara Chand-Goyal. Antimicrobials & Plant Pathogens Branch.
Use Data for Exposure Analysis of TPTH: Additional Information II.
Document (PDF) (225 KB PDF).

November 13, 1998. Memorandum. 16 Page(s).
John Doherty. Health Effects Division.
Triphenyltin Hydroxide (TPTH) - Report of the Hazard Identification Assessment
Review Committee. Tox review 012972.
Document (PDF) (1151 KB PDF).

December 17, 1998. Memorandum. 6 Page(s).
Brenda Tarplee. Health Effects Division.
Triphenyltin Hydroxide (TPTH)-Report of the FQPA Safety Factor Committee.
Tox review 013030.
Document (PDF) (405 KB PDF).

December 23, 1998. Memorandum. 4 Page(s).
Jerome Blondell. Chemistry & Exposure Branch II.
Review of Triphenyltin Incident Reports. DP Barcode D251180, Chemical #083601...
Document (PDF) (246 KB PDF).

February 26, 1999. Memorandum. 5 Page(s).
Dirk Young. Environmental Fate & Effects Division.
Tier I Estimated Environmental Concentrations for Triphenyltin Hydroxide.
Document (PDF) (354 KB PDF).

March 20, 1999. Memorandum. 40 Page(s).
John Doherty. Health Effects Division.
EPA Id. No.: 083601. Triphenyltin Hydroxide: Toxicology Branch Chapter for the
RED. Tox review 013284.
Document (PDF) (2790 KB PDF).

April 02, 1999. Usage Analysis. 2 Page(s).
John Faulkner. EPA.
TPTH; EPA's Quantitative Usage Analysis; Data years: 1988-98.
Document (PDF) (85 KB PDF).

April 12, 1999. Memorandum. 59 Page(s).
Catherine Eiden. Risk Characterization & Analysis Branch.
Triphenyltin Hydroxide: Product and Residue Chemistry Chapters of the RED.
Document (PDF) (3662 KB PDF).

April 13, 1999. Memorandum. 10 Page(s).
Sarah Law. Health Effects Division.
SUBJECT: TPTH: Acute Dietary Exposure Analysis..
Document (PDF) (592 KB PDF).

May 06, 1999. Memorandum. 47 Page(s).
Kelly O'Rourke. Health Effects Division.
Occupational and Residential Exposure Assessment and Recomendations for the
Reregistration Eligibility Decision Document for Triphenyltin Hydroxide.
Document (PDF) (3194 KB PDF).

May 14, 1999. Memorandum. 55 Page(s).
Sarah Law. Health Effects Division.
TPTH (Triphenyltin Hydroxide): HED Risk Assessment for the Reregistration
Eligibility Decision (RED) Document. Tox review 013372 excerpt.
DP Barcode D250103.
Document (PDF) (1918 KB PDF).

June 08, 1999. Memorandum. 55 Page(s).
D. Young. Environmental Fate & Effects Division.
TPTH RED Chapter..
Document (PDF) (3804 KB PDF).

July 28, 1999. Memorandum. 5 Pages.
Sarah Levy. Risk Characterization and Analysis Branch.
TPTH: DETERMINATION OF RESIDUES IN AGED FIELD SAMPLES OF
SUGAR BEET LEAVES AND INTERIM REPORT OF STORAGE STABILITY
STUDY OF RESIDUES IN FORTIFIED SUGAR BEET LEAVES.
MRlDs: 44840501 and 44840502; Reregistration Case: 0099;
DP Barcode: D256821.
Document (PDF) (125 KB PDF).

August 05, 1999. Memorandum. 18 Page(s).
Tara Chand-Goyal. Antimicrobials & Plant Pathogens Branch.
Triphenyltin Hydroxide (TPTH) Benefits Analysis.
Document (PDF) (1299 KB PDF).

August 20, 1999. Memorandum. 20 Pages.
Sarah Levy. Risk Characterization and Analysis Branch.
Review of Registrant Submitted Monte Carlo (Probabilistic) Acute and Chronic (Non-
Cancer and Cancer) Dietary Exposure Analyses for TPTH Residues in Pecans,
Potatoes, Sugar Beets, Meat and Milk. MRID 44852101. DP Barcode D257154.
Document (PDF) (655 KB PDF).

August 25, 1999. Memorandum. 60 Page(s).
Catherine Eiden. Risk Characterization & Analysis Branch.
This document supercedes the previous chapter dated April 12, 1999... Revised
Triphenyltin Hydroxide: Product and Residue Chemistry Chapters of the RED.
Document (PDF) (3964 KB PDF).

August 31, 1999. Memorandum. 7 Page(s).
Sarah Levy. Health Effects Division.
TPTH: Response to EPA Transmittal of the Preliminary HED Risk Assessment for
TPTH, PC Code # 083601, DP Barcode: D258270. Tox review 013718.
Document (PDF) (473 KB PDF).

September 02, 1999. Memorandum. 2 Page(s).
Tara Chand-Goyal. Antimicrobials & Plant Pathogens Branch.
Response to Registrant's Comments to TPTH Updated Benefit Assessment.
Document (PDF) (119 KB PDF).

September 08, 1999. Memorandum. 24 Page(s).
Sarah Levy. Health Effects Division.
TPTH: Revised Acute and Chronic (Non-Cancer and Cancer) Dietary Exposure
Analyses for HED Revised Risk Assessment.
Document (PDF) (1402 KB PDF).

September 13, 1999. Memorandum. 5 Page(s).
Dirk Young. Environmental Risk Branch IV.
EFED's response to the TPTH Task Force rebuttal of the EFED TPTH RED Chapter.
Document (PDF) (318 KB PDF).

September 14, 1999. Memorandum. 60 Page(s).
Kelly O'Rourke. Health Effects Division.
Revised Occupational and Residential Exposure Assessment and
Recommendations for the Reregistration Eligibility Decision Document for
Triphenyltin Hydroxide (TPTH). Revision Reflects Modified Unit Value for
Mixing/Loading Wettable Powder...
Document (PDF) (3457 KB PDF).

September 15, 1999. Memorandum. 3 Page(s).
Kelly O'Rourke. Health Effects Division.
TPTH: Response to EPA Transmittal of the Preliminary HED and EFED Risk
Assessments [for TPTH, PC Code # 083601] dated June 30, 1999.
Document (PDF) (220 KB PDF).

September 17, 1999. Letter. 3 Page(s).
Robert McNally. Special Review Branch.
To: Ronald Landis, Landis International Re: Remaining Risk Concerns for TPTH
Registration.
Document (PDF) (228 KB PDF).

September 21, 1999. Memorandum. 65 Page(s).
Sarah Levy. Health Effects Division.
TPTH (Triphenyltin Hydroxide): HED Revised Risk Assessment for the
Reregistration Eligibility Decision (RED) Document...
Document (PDF) (5215 KB PDF).

October 07, 1999. Letter. 3 Page(s).
Robert McNally. Special Review Branch.
To: Jim Yowell, AGTROL International Re: TPTH - RED Settlement.
Document (PDF) (176 KB PDF).

October 07, 1999. Letter. 3 Page(s).
Robert McNally. Special Review Branch.
To: Ronald Landis, Landis International Re: TPTH - RED Settlement.
Document (PDF) (176 KB PDF).

November 05, 1999. Letter. 2 Page(s).
Robert McNally. Special Review Branch.
To: Jim Yowell, AGTROL International. .. in response to your letter of October 6, 1999
regarding EPA's failure to include Agtrol in the RED Chapter review...
Document (PDF) (95 KB PDF).

March 23, 2001. Memorandum. 3 Page(s).
John Doherty. Health Effects Division.
Triphenyltin Hydroxide: Report of the Hazard Identification Assessment Review
Committee: Reconsideration on the need for a developmental immunotoxicity study
and sustaining the requirement for the developmental neurotoxicity study.
Tox review 014509.
Document (PDF) (198 KB PDF).

April 17, 2001. DER. 11 Pages.
Thomas Steeger. Environmental Risk Branch IV.
DATA EVALUATION RECORD EC50 TEST WITH LEMNA GlBBA § 122-2
(TIER II). TPTH Technical - Toxicity to Duckweed, Lemna gibba.
MRlD No.: 45276004. DP Barcode: D271849.
Document (PDF) (601 KB PDF).

April 17, 2001. DER. 19 Pages.
OPP. EPA.
DATA EVALUATION RECORD AQUATIC INVERTEBRATE LIFE CYCLE
TEST § 72-4(B). TPTH Technical - Life-Cycle Toxicity Test with Mysids (Mysidopsis
bahia). MRID No.: 45276002. DP Barcode: D271841.
Document (PDF) (1049 KB PDF).

April 17, 2001. DER. 9 Pages.
OPP. EPA.
DATA EVALUATION RECORD ALGAE OR DIATOM EC50 TEST §123-2 (TIER
II). TPTH Technical - Acute Toxicity to the Freshwater Green Alga,
Pseudokirchneriella subcapitata. MRID No.: 45276003. DP Barcode: D271849.
Document (PDF) (504 KB PDF).

June 04, 2001. Memorandum. 8 Pages.
Robert Zendzian. Science Analysis Branch HED.
Fentinhydroxide (TPTH) In vitro dermal absorption studies. DP Barcode # D26137.
MRID Nos. 449409-01 and 449280-01. Tox review No. 014581.
Document (PDF) (214 KB PDF).

March 21, 2002. DER. 14 Pages.
Thomas Steeger. Environmental Risk Branch IV.
DATA EVALUATION RECORD FISH EARLY LIFE-STAGE TOXICITY TEST
72-4(A). TPTH Technical - Early Life-Stage Toxicity Test with Sheepshead Minnow
(Cyprinodon variegatus). MRID No.: 45276001. DP Barcode: D271841.
Document (PDF) (1024 KB PDF).

March 21, 2002. Memorandum. 1 Page.
Thomas Steeger. Environmental Risk Branch IV.
Review of Early Life Stage Toxicity Test of Fentin Hydroxide (TPTH) using
Sheepshead Minnows. DP Barcode: D271841. MRID No. 452760-01.
Document (PDF) (216 KB PDF).

October 10, 2002. Memorandum. 2 Pages.
Thomas Steeger. Environmental Risk Branch IV.
Review of Rebuttle to Data Evaluation Record on Early Life Stage Toxicity Test of
Fentin Hydroxide (TPTH) using Sheepshead Minnows. MRID 452760-01.
DP Barcode : D285244.
Document (PDF) (258 KB PDF).

June 18, 2004. Memorandum. 22 Pages.
John Doherty. Reregistration Branch III.
EPA Id No.: 083601. Triphenyltin hydroxide. Review of a subchronic neurotoxicity
study (2001, MRID No.: 45546001). TXR # 0050309. DP Barcode No.: D279514.
Document (PDF) (823 KB PDF).

June 25, 2004. Memorandum. 20 Pages.
John Doherty. Reregistration Branch III.
Triphenyltin hydroxide: Review ofthe acute neurotoxicity screen study
(2000, MRID No.: 45299901). TXR # 0052373
DP Barcode No.: D272193.
Document (PDF) (830 KB PDF).

September 28, 2005. Memorandum. 11 Pages.
John Doherty. Reregistration Branch III.
EPA Id No.: 083601. Triphenyltin hydroxide: Review of the non-guideline special
study (2003, MRID No.: 45890101) on milk secretion. TXR No.: 0051781.
DP Barcode D289372.
Document (PDF) (413 KB PDF).

October 03, 2005. Memorandum. 40 Pages.
John Doherty. Reregistration Branch III.
EPA Id No.: 083601. Triphenyltin Hydroxide: Review of the developmental
neurotoxicity study (2003, MRID No.: 46055701) in rats. TXR # 0052163.
DP Barcode No.: D294568.
Document (PDF) (1304 KB PDF).

October 26, 2007. Review. 4 Pages.
Jose J. Morales. Reregistration Branch 3.
Analysis of Triphenyltin Hydroxide (TPTH)by Pesticide Analytical Manual
Multiresidue Methods. MRID No. 452582-01.
Document (PDF) (47 KB PDF).

February 18, 2009. Memorandum. 12 Pages.
Anwar Y Dunbar. Risk Assessment Branch 1.
Fentin Hydroxide: Review and generation of a Data Evaluation Record.
DP Barcode: D273507. TXR No.: 0054718. MRID No.: 45350301.
Document (PDF) (633 KB PDF).

Publications | Glossary | A-Z Index | Jobs


Local Navigation


Jump to main content.