September 16 - 19, 2008: The Agency's Evaluation of the Toxicity Profile of Chlorpyrifos
On this page:
- Federal Register Notice
- Directions and Other Logistics Information
- Agenda
- Panel Members
- Meeting Materials
- Meeting Minutes
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Federal Register Notice
Federal Register Notice extending this meeting by one-half day.
Directions and Other Logistics Information
General directions and other logistical information is no longer available.
Agenda
Agenda (PDF) (5 pp, 24K)
Panel Members
Meeting Materials
Charge to the Panel (PDF) (12 pp, 71K)
Chlorpyrifos Hazard Dose and Response Characterization (Issue Paper) (PDF) (81 pp, 400K)
Revised Table 2 in Section 2.4 of Issue Paper (PDF) (2 pp, 32K)
DDEF Calculations (Excel Spreadsheet)
Appendix A - Metabolism (PDF) (82 pp, 1.5M)
Appendix B - Mode of Action: Inhibition of Acetylcholinesterase (AChE) (PDF) (60 pp, 283K)
Appendix C - Effects on the Developing Brain (PDF) (35 pp, 429K)
Appendix D - Human Epidemiology: Effects in Children (PDF) (97 pp, 590K)
Appendix E - Data Derived Extrapolation Factor Analysis (PDF) (41 pp, 450K)
Appendix F
- Betancourtcarr 2004 acute male pnd 1 brain Power (PDF) (3 pp, 39K)
- Bentancourtcarr 2004 repeat PND 1-6 female brain power model 10% bmr (PDF) (4 pp, 41K)
- Bentancourtcarr 2004 female brain repeated PND 1-3 power model 10% bmr (PDF) (4 pp, 30K)
- BMDs Dam GD6-20 (Excel Spreadsheet)
- Che Dams Lactation Day 1 Forebrain 10% bmr Power Model (PDF) (4 pp, 32K)
- Che DNT Dams Lactation day 1 female rbc 10% bmr power model (PDF) (4 pp, 35K)
- Che PND 12 brain 10% NO power NO power parameter model 10% bmr Brain PND 12 Chlorpyrifos timchalk data (PDF) (4 pp, 49K)
- Che PND 12 brain 10% Timchalk bmd NO Power Output (PDF) (6 pp, 67K)
- Che PND 12 rbc 10% Power Timchalk bmd Output (PDF) (4 pp, 48K)
- Che PND 12 rbc 10% timchalk bmdjl Power Model RBC PND 12 10% bmr chlorpyrifos (PDF) (4 pp, 67K)
- Che PND 17 RBC NO power model 10% bmr RBC PMD 17 Chlorpyrifos timchalk (PDF) (4 pp, 68K)
- Chlorpyrifos Che dams LD1 heart 10% bmd power results (PDF) (4 pp, 31K)
- Chlorpyrifos Che dams LD1 hindbrain 10% bmd power results (PDF) (4 pp, 32K)
- Chyp data for BMD - Mandrella - plasma (Excel spreadsheet)
- Chyp data for BMD - Zheng - adult brain (Excel spreadsheet)
- Chyp data for BMD - Zheng - adult plasma (Excel spreadsheet)
- Chyp data for BMD - Zheng - adult rbc (Excel spreadsheet)
- Chyp data for BMD - Zheng - neonate brain (Excel spreadsheet)
- Chyp data for BMD - Zheng - neonate plasma (Excel spreadsheet)
- Chyp data for BMD - Zheng - neonate rbc (Excel spreadsheet)
- Moser PND17 Male Brain 10% bmr No Power Model (PDF) (4 pp, 33K)
- Zheng BMD summary (Excel spreadsheet)
Appendix G
- Griffin WOE (PDF) (3 pp, 42K)
- Human Studies Table (PDF) (2 pp, 26K)
- Kisicki APPENDIX (PDF) (18 pp, 373K)
- Kisickider (PDF) (29 pp, 247K)
- Kisicki WOE (PDF) (3 pp, 35K)
- Meuling (PDF) (3 pp, 45K)
- Nolan WOE (PDF) (8 pp, 264K)
Supplemental Documents
- DNT Review (PDF) (51 pp, 2.8M)
- DNT Companion Review (PDF) (18 pp, 55K)
- Human Health Risk Assessment (PDF) (138 pp, 359K)
- CHLORPYRIFOS - REEVALUATION BASED ON PHASE 3 (PUBLIC COMMENTS) of the TRAC Process - Report of the Hazard Identification Assessment Review Committee (PDF) (67 pp, 167K)
- Chemical-specific adjustment factors for interspecies differences and human variability: guidance document for use of data in dose/concentration-response assessment (PDF) (100 pp, 731K)
- Discussion of analyses of prenatal chlorpyrifos exposure and neurodevelopmental outcomes (PDF) (31 pp, 214K)
- Discussion of analyses of prenatal chlorpyrifos exposure and birth outcomes (PDF) (29 pp, 498K)
NOTE: All documents for this meeting (including additional background documents and public comments) will be available in the OPP Regulatory Public Docket (Docket # EPA-HQ-OPP-2008-0274). Some of these documents may be available online in the FDMS Docket System located at http://www.regulations.gov. Copyright protected material and material otherwise subject to protection is not placed on the Internet and will be publicly available only at the OPP Regulatory Public Docket in Rm. S-4400, One Potomac Yard (South Bldg), 2777 S. Crystal Dr., Arlington, VA. The hours of operation of this Docket Facility are from 8:30 a.m. to 4:00 p.m., Monday through Friday, excluding legal holidays. The Docket Facility telephone number is (703) 305-5805.