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Index of Cleared Science Reviews
for Methyl isothiocyanate (Pc Code 068103)
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Undated. DER. 13 Page(s).
Anna Lowit. Reregistration Branch 2 HED.
STUDY TYPE: Prenatal Developmental Toxicity Study - Rabbit;
OPPTS 870.3700b. [83-3b]; OECD 414. MRID 45919418. Tox review 0051394.
Document (PDF) (331 KB PDF).
Undated. DER. 13 Page(s).
Judy Facey. Reregistration Branch HED.
STUDY TYPE: Prenatal Developmental Toxicity Study - Rat;
OPPTS 870.3700a. [83-3a]; OECD 414. MRID 45919417. Tox review 0051394.
Document (PDF) (377 KB PDF).
Undated. DER. 16 Page(s).
Anna Lowit. Reregistration Branch 2 HED.
STUDY TYPE: Oral Developmental Toxicity in Rats. OPPTS Number: 870.3700.
OPP Guideline Number: 83-3a. MRID 44733601, 44733602. Tox review 0051863.
Document (PDF) (491 KB PDF).
Undated. DER. 3 Page(s).
Anna Lowit. Reregistration Branch 2 HED.
STUDY TYPE: 30-Day Dermal Toxicity - rat; OPPTS 870.3250
(rodent) [82-3]; OECD 411. Updated Executive Summary to Previous
TXR # 003991. MRID 00132815. Tox review 0051394.
Document (PDF) (67 KB PDF).
January 31, 1978. Memorandum. 3 Page(s).
William Dykstra. Toxicology Branch.
Vorlex Soil Fumigant EPA Registration # 2139-55 Resubmission with Data.
Document (PDF) (171 KB PDF).
November 03, 1978. Memorandum. 1 Page(s).
William Dykstra. Toxicology Branch.
Vorlex Soil Fumigant EPA Registration # 2139-55 Addition of Precautionary Statements.
Document (PDF) (71 KB PDF).
June 04, 1982. Memorandum. 3 Page(s).
Orville Paynter. Toxicology Branch.
Request for New Use; Vorlex on Utility Poles, Reg. No. 2139-55.
Document (PDF) (159 KB PDF).
December 19, 1982. Memorandum. 8 Page(s).
Gary Burin. Toxicology Branch.
Review of Acute Studies and Subchronic Inhalation Study of Vorlex:
Acc. Nos. 248402, 248403, 248404.
Inert ingredient information on page 5 is not included.
Manufacturing process information on page 6 is not included.
Tox Review No. 002352.
Document (PDF) (489 KB PDF).
April 13, 1983. Memorandum. 3 Page(s).
Gary Burin. Toxicology Branch.
Addemdum to Memo of December 21, 1982:
Review of Acute Studies and Subchronic Inhalation Study of Vorlex;
Acc. No. 249736. Caswell Nos. 175, 573.
Document (PDF) (214 KB PDF).
April 15, 1983. Memorandum. 11 Page(s).
William Burnam. Toxicology Branch.
Addendum to Memo of December 21, 1982; Review of Acute Studies
and Subchronic Inhalation Study of Vorlex; Acc. No. 249736.
Inert ingredient info on page 8 not included.
Document (PDF) (695 KB PDF).
July 30, 1984. Review. 11 Page(s).
Samuel Creeger. Exposure Assessment Branch.
Support registration for utility pole treatment. EPA Reg. No. 2139-REA.
Pages 5-6 removed, registrant data. Pages 9-11 removed, draft labeling.
Document (PDF) (390 KB PDF).
August 06, 1984. Memorandum. 16 Page(s).
Quang Bui. Toxicology Branch.
Evaluation of "13-Week Inhalation Study, Vorlex" Accession #248402
and 249910... MRID 115172, 126771 Manufacturing process info page 2
not included. Pages 9-16 removed, registration data. Tox review 003889.
Document (PDF) (739 KB PDF).
August 16, 1984. Memorandum. 23 Page(s).
Quang Bui. Toxicology Branch.
Application for Registration of SN 584 in Utility Poles.
Inert and commercial/financial info on page 2 not included.
Tox review 003991.
Document (PDF) (1134 KB PDF).
January 29, 1985. Memorandum. 6 Page(s).
Kenneth Dockter. Residue Chemistry Branch.
EPA Reg. No. 7969-60. Dazomet as "temporary soil sterilant" for raising food crops.
Accession Number 253681.
Document (PDF) (442 KB PDF).
June 19, 1985. Review. 7 Page(s).
Samuel Creeger. Exposure Assessment Branch.
Hydrolysis study to support use as a wood preservative. EPA Reg. No. 45639-OE.
Document (PDF) (292 KB PDF).
July 31, 1985. Memorandum. 48 Page(s).
Quang Bui. Toxicology Branch.
Review of Teratology Studies with Methyl Isothiocyanate.
EPA Accession Nos. 257764 and 257765. Caswell No. 573.
Pages 9-24, 33-48 removed, registrant data. Tox review 005414.
Document (PDF) (1071 KB PDF).
March 14, 1986. Review. 3 Page(s).
Samuel Creeger. Exposure Assessment Branch.
Response to GWDCI.
Document (PDF) (127 KB PDF).
May 06, 1986. Review. 3 Page(s).
Samuel Creeger. Exposure Assessment Branch.
Response to submission for GWDCI/.
Document (PDF) (155 KB PDF).
August 05, 1986. Data Eval. Rec.. 36 Page(s).
Laurence Chitlik. Toxicology Branch.
Methylisothiocynate: A chronic oral (drinking water) toxicity
and carcinogenicity study in the rat. Acc. No. 257766.
Pages 13-36 removed, registrant data.
Document (PDF) (785 KB PDF).
August 06, 1986. Memorandum. 60 Page(s).
Winnie Teeters. Toxicology Branch.
Application for Registration of SN 584
(Methyl Isothiocyanate, MITC) for Utility Pole Fumigation.
Inert & commercial/financial info on pages 1-2 not included.
Pages 19-42, 54-60 removed, registrant data.
Ingredient source info. on p. 43 deleted. Tox review 005415.
Document (PDF) (2054 KB PDF).
August 19, 1986. Memorandum. 36 Page(s).
James Rowe. Toxicology Branch.
Review of 3 Mutagenicity Studies/MITC.
Pages 12-36 removed, registrant data. Tox review 005368.
Document (PDF) (1189 KB PDF).
April 08, 1987. Memorandum. 1 Page(s).
Quang Bui. Toxicology Branch.
Chronic Dog Study - Methyl Isothiocyanate. Caswell No. 573.
Tox Project No. 7-0526.
Document (PDF) (41 KB PDF).
May 05, 1987. Memorandum. 7 Page(s).
Mary L. Waller. Fungicide Herbicide Branch.
EPA File Symbol 54289-E. Acute dermals...
Acc 264387, 264390, 264386, 264389, 264385. Tox review 006165.
Document (PDF) (358 KB PDF).
December 11, 1987. Review. 3 Page(s).
Patrick Holden. Exposure Assessment Branch.
Response to Ground-Water Data Call-In.
Document (PDF) (173 KB PDF).
April 25, 1989. Review. 11 Page(s).
Emil Regelman. Environmental Fate & Ground Water Branch.
Review of an anaerobic aquatic metabolism study MRID 40622401
Pages 5-10 removed, registrant data.
Document (PDF) (173 KB PDF).
April 26, 1989. Memorandum. 13 Page(s).
Ray Landolt. Toxicology Branch.
Methyl Isothiocyanate (MITC). Project No. 9-0789. Tox Chem. No. 573.
MRID 409746-01, 02. Two generation rat reproduction. Tox review 007145.
Document (PDF) (655 KB PDF).
September 08, 1989. Review. 12 Page(s).
Emil Regelman. Environmental Fate & Ground Water Branch.
Reg. /File # 45639-90 Acknowledge FIFRA data audit conducted by EPA
@ NOR-AM Chemical Co. , Exton, PA, of a soil dissipation study of Vorlex
(164-1, MRID# 402938-01).
Document (PDF) (655 KB PDF).
November 17, 1989. Memorandum. 2 Page(s).
Ray Landolt. Toxicology Branch.
Methylisothiocyanate (MITC).
Document (PDF) (55 KB PDF).
December 19, 1990. Data Eval. Rec. 6 Page(s).
Dennis McLane. Ecological Effects Branch.
Acute Oral Toxicity (LD 50) Mallard Duck. MRID #00119180.
Document (PDF) (238 KB PDF).
December 19, 1990. Data Eval. Rec. 6 Page(s).
Dennis McLane. Ecological Effects Branch.
Mallard Duck Dietary LC 50 Test. MRID #00119182.
Document (PDF) (252 KB PDF).
December 19, 1990. Data Eval. Rec. 6 Page(s).
Dennis McLane. Ecological Effects Branch.
Pheasant Dietary LC 50 Test. MRID #00119184.
Document (PDF) (254 KB PDF).
March 22, 1991. Memorandum. 10 Page(s).
Dana Spatz. Environmental Fate & Ground Water Branch.
Review of Phase IV Package for Methyl Isothiocyanate MRID 41710901,
92114020, 00158163, 41221415, 92114022, 41221416, 92114023, 40622401,
92114024, 41221417, 92114025, 92114026, 41221418, 92114027.
Document (PDF) (571 KB PDF).
September 24, 1991. DER. 3 Page(s).
Allen Vaughan. Ecological Effects Branch.
MITC, 48-Hour EC50, Daphnia magna. MRID 41819302.
Document (PDF) (61 KB PDF).
September 26, 1991. Memorandum. 5 Page(s).
Douglas Urban. Ecological Effects Branch.
Aquatic Phase IV Data.
Document (PDF) (218 KB PDF).
September 26, 1991. Review. 5 Page(s).
Curtis Laird. Ecological Effects Branch.
Review data in support of registration MRID 418193-02
48-Hour EC50; Daphnia magna.
Document (PDF) (179 KB PDF).
January 23, 1992. Review. 27 Page(s).
Douglas Urban. Ecological Effects Branch.
602 Review Phase 3 Response, 001 Phase 4 Review MRID 420580-01,
420580-02 Freshwater Fish Acute Flow-Through Toxicity Test; Bluegill
Sunfish and Rainbow Trout. Pages 11-14, 22-25 removed, registrant data.
Document (PDF) (1076 KB PDF).
September 15, 1992. Memorandum. 3 Page(s).
Ray Landolt. Toxicology Branch.
Methylisothiocyanate (MITC) Phase IV Data Response
MRID Nos. 162324-162327. Tox review 009742.
Document (PDF) (164 KB PDF).
November 23, 1993. DER. 11 Page(s).
Nancy McCarrol. Clement International Corp. for HED.
Study Type: Mutagenicity: Microbial/Mammalian Microsome Mutagenicity
and DNA Damage/Repair (Rec) Assays. MRID 41221410. Tox review 011275 excerpt.
Document (PDF) (354 KB PDF).
May 26, 1994. Review. 4 Page(s).
Anthony Maciorowski. Ecological Effects Branch.
Reg. /File # : 068103-054289 Review aquatic studies.
MRID 420580-01, 420580-02, 418193-02.
Document (PDF) (192 KB PDF).
September 26, 1994. Data Eval. Rec.. 9 Page(s).
Ray Landolt. Toxicology Branch II.
Study Type: Inhalation Study - Rat (82-4) MRID 412214-07.
Manufacturing process information on page 2 not included.
Pages 8-9 removed, registrant data.
Document (PDF) (490 KB PDF).
October 06, 1994. Memorandum. 24 Page(s).
Ray Landolt. Toxicology Branch.
Generic Data in Support of Reregistration of Methyl Isothiocyanate (MITC).
Manufacturing process info on page 7 not included.
Pages 13-14 removed, registration data.
Document (PDF) (1324 KB PDF).
December 06, 1994. Review. 6 Page(s).
Ray Landolt. Toxicology Branch.
Study type: One Year Dog Toxicity Study (83-1) MRID 41240701.
Document (PDF) (404 KB PDF).
February 24, 1995. Review. 5 Page(s).
Mike Ioannou. Toxicology Branch.
Toxicology Endpoint Selection Document Chemical Name: Methyl isothiocyanate
(MITC) Revised Report (Replaces Document Dated 1/26/95)
Tox review 013477.
Document (PDF) (267 KB PDF).
April 24, 1995. Memorandum. 8 Page(s).
George Ghali. RfD/PA Peer Review Committee.
RfD/Peer Review Report of Methyl Isothiocyanate (MITC).
Document (PDF) (711 KB PDF).
June 02, 1995. Memorandum. 2 Page(s).
Dennis McLane. Ecological Effects Branch.
MITC Ecological Effects Information.
Document (PDF) (99 KB PDF).
December 13, 1995. Memorandum. 16 Page(s).
Timothy McMahon. Toxicology Branch.
Methyl isothiocyanate: Review of Mutagenicity Data.
MRIDs 412214-11, 412214-12. Tox review 011736.
Document (PDF) (862 KB PDF).
October 13, 1998. DER. 8 Page(s).
Mark Mossler. Golder Associates Inc. for EEB.
72-1 Acute LC50 test with a coldwater fish. Rainbow trout.
MRID 44523413.
Document (PDF) (383 KB PDF).
October 13, 1998. DER. 8 Page(s).
Mark Mossler. Golder Associates Inc. for EEB.
72-1(A) Acute LC50 test with a warmwater fish. Bluegill sunfish.
MRID 44523412.
Document (PDF) (389 KB PDF).
November 08, 2001. DER. 13 Page(s).
Joycelyn Stewart. Toxicology Branch.
STUDY TYPE: Subchronic Inhalation Toxicity - Rat; OPPTS 870.3465 (82-4).
MRID 45314802. Tox review 0052720.
Document (PDF) (377 KB PDF).
December 03, 2003. DER. 4 Page(s).
Anna Lowit. Reregistration Branch 2 HED.
STUDY TYPE: Carcinogenicity (drinking water) - rat; OPPTS 870.4200a
[83-2a]; OECD 451. Updated Executive Summary to Previous TXR # 005415.
MRID 00150078. Tox review 0051394.
Document (PDF) (192 KB PDF).
January 12, 2004. DER. 5 Page(s).
Anna Lowit. Reregistration Branch 2 HED.
STUDY TYPE: Reproduction and fertility Effects Study - rat
DP Barcode: D284267 MRIDs 40974601, -02, -03, 41057601, 92114015.
Document (PDF) (272 KB PDF).
April 07, 2004. DER. 5 Page(s).
Anna Lowit. Reregistration Branch 2 HED.
STUDY TYPE: Carcinogenicity - mice, [drinking water] OPPTS 870.4200b
[83-2]; OECD 451. Updated executive Summary to Previous TXR # 005415.
MRID 00150075, 151942. Tox review 0051394.
Document (PDF) (253 KB PDF).
April 07, 2004. Memorandum. 7 Page(s).
Anna Lowit. Reregistration Branch 2 HED.
Data evaluation records, updated executive summaries, and toxiclogy
information for Metam Sodium (PC Code 039003); Methyl isothiocyanate
(MITC, PC Code 068103); and Carbon Disulfide (PC Code 600017).
[see undated, cleared MITC DERs] Tox review 0051394.
Document (PDF) (299 KB PDF).
May 13, 2004. Memorandum. 6 Page(s).
Anna Lowit. Reregistration Branch 2 HED.
Quantification of carcinogenic potential for MITC with metam sodium
cancer slope factor. Tox review 0052547.
Document (PDF) (178 KB PDF).
August 15, 2004. DER. 15 Page(s).
Anna Lowit. Reregistration Branch 2.
Special Study: Human Eye Irritation & Odor Threshold.
Tox Review No. 0051475. MRID No. 44400401.
Document (PDF) (428 KB PDF).
August 15, 2004. DER. 3 Page(s).
Judy Facey. Reregistration Branch 2.
28-Day Inhalation Toxicity -[rat]; OPPTS 870.3465 [82-4]; OECD 413.
Tox Review Nos. 0051475 & 0052720. MRID No. 45314802.
Document (PDF) (102 KB PDF).
August 19, 2004. Memorandum. 8 Page(s).
Anna Lowit. Reregistration Branch 2 HED.
Addendum to Memo from May 13, 2004 (TXR No. 0052547): Quantification
of carcinogenic potential for MITC with metam sodium cancer slope factor
and cancer classification of metam sodium. Tox review 0052776.
Document (PDF) (269 KB PDF).
September 30, 2004. Memorandum. 64 Page(s).
Sherrie Kinard. Reregistration Branch 2 HED.
Metam sodium: HED Human Health Risk Assessment For Phase 1:
DP Barcode 308417, Metam Sodium PC Code: 039003, MITC PC Code: 068103.
Document (PDF) (3021 KB PDF).