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Index of Cleared Science Reviews for Bromacil (Pc Code 012301)
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October 05, 1966. Petition. 7 Page(s).
C. C. Fitzhugh. Petitions Control Branch.
Bromacil on Pineapple and Citrus Fruit. PP 6F0499. Tox review 003308.
Document (PDF) (641 KB PDF).
November 25, 1980. Memorandum. 7 Page(s).
Deloris Graham. Fungicide Herbicide Branch.
EPA Registration No. 1769-EII. National Chemsearch Fenocil Weed Killer.
Pages 5-7 removed, draft label. Tox review 000465.
Document (PDF) (327 KB PDF).
August 17, 1981. Memorandum. 119 Page(s).
J. C. Street. Utah State University, Logan, Utah 84322.
Scientific validation of Bromacil records Inert ingredient information on
pages 8, 9 and 15 is not included. Tox review 003281.
Document (PDF) (5490 KB PDF).
May 05, 1983. Review. 13 Page(s).
Curtis Laird. Ecological Effects Branch.
Registrant Response to Registration Standard.
Document (PDF) (572 KB PDF).
June 17, 1983. Memorandum. 10 Page(s).
Alex Arce. Toxicology Branch.
Registration No. 352-325 Bromacil, Caswell #111 Acc. #249676, Response to
Bromacil Registration Standard Tox review 003882.
Document (PDF) (260 KB PDF).
October 01, 1983. Memorandum. 8 Page(s).
Alex Arce. Toxicology Branch.
Long-Term Feeding Study in Mice with 5-Bromo-3-sec-butyl- 6-methyluracil, INN-976,
Bromacil ID #352-325. Acc. #244069, 244070 and 244071, Caswell Number 111.
Tox review 004272.
Document (PDF) (603 KB PDF).
December 14, 1983. Review. 18 Page(s).
Allen Vaughan. Ecological Effects Branch.
Reg No. 3125-425 Submission of honeybee toxicity study for review. Acc. 251374.
Document (PDF) (776 KB PDF).
February 02, 1984. Memorandum. 2 Page(s).
Alex Arce. Toxicology Branch.
Bromacil ID# 81223-74 Caswell# 111; Granular Herbicide Killer 5% ai EPA
Registration No. 8123-74 Waiver request for acute toxicology data.
Tox review 003580. Source info pages 1 and 2 is not included.
Document (PDF) (157 KB PDF).
May 16, 1984. Memorandum. 6 Page(s).
Deloris Graham. Fungicide Herbicide Branch.
EPA Registration Number: 352-352 DuPont Krovar I Weed Killer Tox review 005265.
Document (PDF) (1166 KB PDF).
January 04, 1985. Memorandum. 13 Page(s).
Bernice Fisher. Toxicology Branch.
Preliminary Risk Assessment for Bromacil Based on Haskel Study #893-80 in CD-1
Mice, CAS #111. Pages 8-13 removed, registration data. Tox review 004183.
Document (PDF) (491 KB PDF).
March 07, 1985. Final Report. 31 Page(s).
Dynamac Corporation.
Bromacil Addendum - Task 1: Review and Evaluation of Individual Studies.
Document (PDF) (1235 KB PDF).
March 19, 1985. Final Report. 7 Page(s).
Dynamac Corporation.
Bromacil Addendum, Final Report, Task 2: Environmental Fate and Exposure
Assessment. Contract Number 68-01-6679.
Document (PDF) (437 KB PDF).
March 25, 1985. Review. 8 Page(s).
Lionel Richardson. Exposure Assessment Branch.
Reg. No. 352-325. Hyvar. Response to Registration Standard.
Document (PDF) (432 KB PDF).
May 23, 1985. Review. 37 Page(s).
John Jordan. Exposure Assessment Branch.
Reg. Nos. 352-324, -352, -351, -325. Diuron and Bromacil. Response to Standard.
Document (PDF) (1693 KB PDF).
July 09, 1985. Memorandum. 7 Page(s).
Mary Waller. Fungicide Herbicide Branch.
EPA File Symbol 38167-G Setre Simazine-Bromacil 90 WP Acute oral, acute
inhalation, acute dermal, eye irritation, skin irritation, dermal sensitization.
Acc. 254882, 256449 Tox review 006064.
Document (PDF) (642 KB PDF).
October 08, 1985. Record of Call. 1 Page(s).
Tom Armitage. Ecological Effects Branch.
Pesticide-Related Deer Kill in Indiana.
Document (PDF) (60 KB PDF).
January 24, 1986. Memorandum. 8 Page(s).
Deloris Graham. Fungicide Herbicide Branch.
EPA File Symbol 352-UUN. DuPont Krovar II DF Herbicide.
Pages 7-8 removed, draft label.
Document (PDF) (496 KB PDF).
May 14, 1986. Memorandum. 4 Page(s).
Deloris Graham. Fungicide Herbicide Branch.
EPA Registration Number 34913-13. Spra-Kil K-9. Acute oral tox.
Project No. 2214-109. Tox review 006121.
Document (PDF) (284 KB PDF).
May 14, 1986. Memorandum. 4 Page(s).
Deloris Graham. Fungicide Herbicide Branch.
EPA Registration Number 34913-3. Spra-Kil K-4. Acute oral tox;
Project No. 2214-108. Tox review 006055.
Document (PDF) (279 KB PDF).
May 14, 1986. Memorandum. 4 Page(s).
Deloris Graham. Fungicide Herbicide Branch.
EPA Registration Number: 34913-5; Spra-Kil B-4. Acute oral tox study,
Project No. 2214-107. Tox review 006062.
Document (PDF) (278 KB PDF).
May 14, 1986. Memorandum. 4 Page(s).
Deloris Graham. Fungicide Herbicide Branch.
EPA Registration Number: 34913-5; Spra-Kil K-4. Acute oral tox,
Project No. 2214-108. Tox review 006055.
Document (PDF) (232 KB PDF).
September 10, 1986. Memorandum. 8 Page(s).
Deloris Graham. Fungicide Herbicide Branch.
EPA File Symbol 352-EUP-RGT. Krovar I DF Herbicide. Acc. 264275.
Acute tox studies. Pages 6-8 removed, draft label. Tox review 006096.
Document (PDF) (418 KB PDF).
May 01, 1987. Memorandum. 1 Page(s).
Bernice Fisher. Toxicology Branch.
Bromacil, Mouse Study-Males, Re-evaluation of Survival. Tox review 005888.
Document (PDF) (63 KB PDF).
January 31, 1989. Memorandum. 11 Page(s).
Linda Taylor. Section II, HFAS.
California Department of Food and Agriculture - EPA Toxicology Review for
Bromacil (Tox. Chem. No. 111). MRID 00022077 Tox review 008244.
Document (PDF) (859 KB PDF).
August 15, 1989. Memorandum. 2 Page(s).
Richard Schmitt. Dietary Exposure Branch.
Bromacil (SRR) Registration Standard.
Document (PDF) (148 KB PDF).
February 27, 1990. Peer Review. 132 Page(s).
Taylor. Toxicology Branch.
Bromacil. Caswell #111. CAS No. 314-40-9. Pages 102-107 removed, registration
data. Tox review 007712.
Document (PDF) (8027 KB PDF).
September 13, 1990. Data Eval. Rec. 2 Page(s).
Brian Montague. Ecological Effects Branch.
Acute oral LD50 with bobwhite quail MRID 409515-01.
Document (PDF) (145 KB PDF).
September 13, 1990. Data Eval. Rec. 2 Page(s).
Brian Montague. Ecological Effects Branch.
Multiple Chemical/Multiple Species 48 Hour Acute Testing with Aquatic Organisms
MRID 126345.
Document (PDF) (125 KB PDF).
September 13, 1990. Data Eval. Rec. 3 Page(s).
Brian Montague. Ecological Effects Branch.
96 hour Acute Test to mysid shrimp (mysidopsis bahia) under static conditions.
MRID 126346.
Document (PDF) (260 KB PDF).
September 13, 1990. Data Eval. Rec. 4 Page(s).
Brian Montague. Ecological Effects Branch.
48-hour Static Acute Test with Daphnia Magna. MRID 409515-04.
Document (PDF) (200 KB PDF).
September 13, 1990. Data Eval. Rec. 4 Page(s).
Brian Montague. Ecological Effects Branch.
Static Acute LC50 Test using bluegill sunfish MRID 409515-02.
Document (PDF) (245 KB PDF).
September 13, 1990. Data Eval. Rec. 5 Page(s).
Brian Montague. Ecological Effects Branch.
Static Acute LC50 Test Using rainbow trout, Onchorhynchus mykiss
MRID 409515-03.
Document (PDF) (322 KB PDF).
September 18, 1990. Data Eval. Rec. 2 Page(s).
Brian Montague. Ecological Effects Branch.
48 Hour Static Acute Toxicity Test with Daphnia magna. MRID 137445.
Document (PDF) (101 KB PDF).
April 23, 1991. Memorandum. 52 Page(s).
David Liem. Toxicology Branch.
Developmental Toxicity Study in Rats with Bromacil. MRID 409848-02. Pages 11-22,
42-51 removed, registrant data. Tox review 008345.
Document (PDF) (2096 KB PDF).
July 26, 1991. Memorandum. 40 Page(s).
David Liem. Toxicology Branch.
Review of a Study: Reproductive and Fertility Effects with Bromacil, Multigeneration
Reproduction Study in Rats. MRID 418046-01. Pages 18-40 removed, registration
data. Tox review 008477.
Document (PDF) (1328 KB PDF).
August 16, 1991. Data Eval. Rec. 3 Page(s).
Brian Montague. Ecological Effects Branch.
48 Hour Embryo-Larvae Acute Toxicity Test with Crassostrea virginica under static
conditions MRID 415887-03.
Document (PDF) (222 KB PDF).
August 16, 1991. Data Eval. Rec. 3 Page(s).
Brian Montague. Ecological Effects Branch.
96-hour Acute Toxicity to Mysidopsis bahia under static conditions MRID 415887-01.
Document (PDF) (198 KB PDF).
August 16, 1991. Data Eval. Rec. 3 Page(s).
Brian Montague. Ecological Effects Branch.
Semi-static Acute 96 Hour Toxicity Test with Cyprinodon variegatus MRID 415887-02.
Document (PDF) (191 KB PDF).
October 28, 1991. Memorandum. 19 Page(s).
Maria Isabel Rodriguez. Environmental Fate & Ground Water Branch.
Review of Re-registration Package for 4-Bromo-3-sec- butyl-6-methyluracil (known as
Bromacil) and its lithium salt. (Case #41).
Document (PDF) (1056 KB PDF).
December 11, 1991. Memorandum. 16 Page(s).
Alan Levy. Toxicology Branch.
Bromacil (DPX-N 976-136) - A One-Year Feeding Study in Dogs (Guideline $83-1).
MRID 418697-01 Tox review 008894.
Document (PDF) (917 KB PDF).
February 28, 1992. Memorandum. 6 Page(s).
Olga Odiott. Registration Support Branch.
EPA Reg. No.: 7001-339 Ureabor Nonselective Weed and Grass Killer Acute
studies and skin irritation. MRID 420986-01, -02, -03. Tox review 010100.
Document (PDF) (265 KB PDF).
April 06, 1992. Review. 13 Page(s).
Dan Rieder. Ecological Effects Branch.
Review and Comment on Proposed Modification to Wording of Precautionary
Statement on Label. Pages 9-13 removed-draft label.
Document (PDF) (616 KB PDF).
July 01, 1992. Memorandum. 20 Page(s).
Elizabeth Doyle. Toxicology Branch II.
Bromacil - Review of a Combined Chronic/Oncogenicity Study in Rats for FIFRA 88
Phase V. MRID 412617-01. Tox review 009555.
Document (PDF) (1122 KB PDF).
July 17, 1992. Memorandum. 9 Page(s).
Dana Spatz. Environmental Fate & Ground Water Branch.
Bromacil and its Lithium Salt- Label Amendment and Waiver Requests submitted by
E.I. Du Pont de Nemours and Company. Letters dated October 11, 1990 and January
16, 1992 respectively. Pages 4-8 removed-draft label.
Document (PDF) (264 KB PDF).
August 04, 1992. Review. 14 Page(s).
Douglas Urban. Ecological Effects Branch.
Review Request for Waiver of eco-tox testing with Bromacil and Bromacil Lithium
Salt, Registrant Asserts Testing with One Should Suffice for the Other.
Pages 9-13 removed-draft label.
Document (PDF) (658 KB PDF).
August 06, 1992. Memorandum. 4 Page(s).
Steven Knizner. Chemistry Branch II.
Bromacil. Protocol for Nature of the Residue in Plants - Citrus Fruit.
Document (PDF) (273 KB PDF).
September 10, 1992. Memorandum. 2 Page(s).
Linda Tayor. Toxicology Branch II.
Bromacil - Registrant's Response to Review of One-Year Feeding Study in Dogs -
Testicular Effects. Tox review 009717.
Document (PDF) (161 KB PDF).
September 11, 1992. Memorandum. 3 Page(s).
Linda Taylor. Toxicology Branch.
Bromacil - Registrant's Response to Review of 2-Generation Reproduction Study -
Kidney Effects. Tox review 009720.
Document (PDF) (247 KB PDF).
September 23, 1992. Memorandum. 36 Page(s).
David Liem. Toxicology Branch.
Review of Five Dermal Sensitization Studies with Diuron, Krovar I and II, and Diurex
MRID 402288-04 and 409840-16. Tox review 009738.
Document (PDF) (2505 KB PDF).
September 28, 1992. Review. 10 Page(s).
Elizabeth Behl. Environmental Fate & Ground Water Branch.
Review Progress Report of Small-Scale Retrospective Ground-Water Monitoring
Study.
Document (PDF) (1169 KB PDF).
October 05, 1992. Memorandum. 1 Page(s).
Dana Spatz. Environmental Fate & Ground Water Branch.
Bromacil- Request for a confirmation that an Anaerobic Aquatic Metabolism study
(162-3) will satisfy the Anaerobic Soil Metabolism (162-2) data requirement. Submitted
by E.I. duPont on October 20, 1988. Received by EFED on September 21, 1992.
Document (PDF) (69 KB PDF).
January 13, 1993. Memorandum. 10 Page(s).
Linda Taylor. Toxicology Branch.
Subject: Second Carcinogenicity Peer Review of Bromacil.
Document (PDF) (775 KB PDF).
February 09, 1993. Memorandum. 2 Page(s).
Steven Knizner. Chemistry Branch II.
Bromacil. Request for Time Extension for submission of Guideline 171-4(k)
and 171-4(l) Studies. Pineapple Field Residue Trials and Processing Study.
Document (PDF) (115 KB PDF).
February 11, 1993. Review. 37 Page(s).
Douglas Urban. Ecological Effects Branch.
Review Plant Data Submission. MRID 424911-01. Pages 15-32 removed, registrant
data.
Document (PDF) (1325 KB PDF).
February 12, 1993. Memorandum. 56 Page(s).
Linda Taylor. Toxicology Branch.
BROMACIL - Review of Mutagenicty Studies Submitted in Response to 9/91 DCI
MRID 424656-01, 424657-01, 424658-01, 424659-01. Pages 11-14, 24-26, 37-41, 50-56
removed, registrant data. Tox review 010032.
Document (PDF) (2214 KB PDF).
March 10, 1993. Memorandum. 15 Page(s).
Anthony Maciorowski. Ecological Effects Branch.
Aquatic Plant toxicity testing with Bromacil MRID 425164-01. Pages 6-9 removed,
registrant data.
Document (PDF) (742 KB PDF).
April 01, 1993. Memorandum. 2 Page(s).
R. B. Perfetti. Chemistry Branch II.
Response to the Lithium Bromacil Reregistration Standard: Residue Chemistry Data
Waiver Requests.
Document (PDF) (104 KB PDF).
June 28, 1993. Memorandum. 5 Page(s).
K. Dockter. Chemistry Branch II.
Bromacil Reregistration. Du Pont's 2/2/93 response to the Bromacil Data Call-In of
9/91. MRID No. 42648401. Pages 4-5 deleted - manufacturing process.
Document (PDF) (207 KB PDF).
July 21, 1993. Review. 5 Page(s).
David Wells. Environmental Fate & Ground Water Branch.
Review Supplemental Submission to Small-Scale Retrospective Ground-Water
Monitoring Study.
Document (PDF) (372 KB PDF).
October 26, 1993. Review. 3 Page(s).
Elizabeth Behl. Environmental Fate & Ground Water Branch.
Review Supplemental Submission, Bromacil 6(a)(2).
Document (PDF) (241 KB PDF).
October 27, 1993. Review. 3 Page(s).
Elizabeth Behl. Environmental Fate & Ground Water Branch.
Review Supplemental Submission, Bromacil 6(a)(2).
Document (PDF) (162 KB PDF).
November 23, 1993. Memorandum. 50 Page(s).
Linda Taylor. Toxicology Branch.
BROMACIL - Review of Metabolism Study Pages 16-23, 28-33, 38-50 removed,
registrant data. MRID 428252-01. Tox review 010674.
Document (PDF) (1841 KB PDF).
March 15, 1994. Memorandum. 1 Page(s).
La Tangila Edwards. Chemistry Branch II.
Reregistration of Bromacil. Multi-Residue Testing Data. MRID No. 43078801.
Document (PDF) (72 KB PDF).
March 15, 1994. Memorandum. 1 Page(s).
La Tangila Edwards. Chemistry Branch II.
Testing of Bromacil through FDA Multi-Residue Protocol A through E.
MRID No. 43078801.
Document (PDF) (65 KB PDF).
March 24, 1994. Memorandum. 4 Page(s).
Freshteh Toghrol. Chemistry Branch II.
Bromacil Lithium Salt Reregistration. MRID Nos. 43076201, 43076301.
Manufacturing process on page 3 removed.
Document (PDF) (279 KB PDF).
March 29, 1994. Review. 3 Page(s).
Anthony Maciorowski. Ecological Effects Branch.
Respond to registrants acetone data on plants.
Document (PDF) (161 KB PDF).
April 08, 1994. Memorandum. 4 Page(s).
Leung Cheng. Chemistry Branch II.
Bromacil. Case No. 0041. Goat Metabolism. MRID No. 42998901.
Document (PDF) (317 KB PDF).
April 19, 1994. Memorandum. 13 Page(s).
Anthony Maciorowski. Ecological Effects Branch.
Modification to Precautionary Label Statements for Hyvar L (EPA Reg. No. 352-425)
and Hyvar X-L (EPA Reg. No. 352-346) Pages 3-6, 9-13 removed, draft label.
Manufacturing process info on page 7 not included.
Document (PDF) (395 KB PDF).
May 17, 1994. Memorandum. 2 Page(s).
Dana Spatz. Environmental Fate & Ground Water Branch.
Lithium Salt of Bromacil- Label Amendment and Data Waiver Request submitted E.I.
Du Pont de Nemours and Company. Received by EPA on March 15, 1994.
Document (PDF) (117 KB PDF).