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Index of Cleared Science Reviews for Brodifacoum (Pc Code 112701)

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Undated. DER. 5 Page(s).
John Jordan. Environmental Fate & Ground Water Branch.
STUDY 2. 162-1. Brodifacoum: Metabolism in soil under aerobic conditions.
Pages 5-13 removed, registrant data. MRID 42579401.
Document (PDF) (475 KB PDF).

Undated. DER. 7 Page(s).
John Jordan. Environmental Fate & Ground Water Branch.
STUDY 1. 161-1. Hydrolysis CONCLUSIONS: This study accepted by EFGWB
on 4/10/95 because additional information received from Zeneca (D210477)
and 43435801 indicated brodifacoum is stable to hydrolysis. MRID 42237701.
Document (PDF) (332 KB PDF).
Attachment(s) Following:

Undated. DER.
John Jordan. Environmental Fate & Groundwater Branch.
Metabolism-Aerobic Soil. MRID 42579401.

*End of Attachments*

Undated. DER. 7 Page(s).
John Jordan. Environmental Fate & Ground Water Branch.
STUDY 3. 163-1 Mobility - Leaching and Adsorption/Desorption.
Pages 7-18 removed, registrant data. MRID 42568301.
Document (PDF) (600 KB PDF).

Undated. Listing. 3 Page(s).
OPP. EPA.
Brodifacoum: ICI.
Document (PDF) (124 KB PDF).

March 21, 1978. Review. 2 Page(s).
R. Balcomb. Ecological Effects Branch.
PP581; Fish Acute 96 hr. LC50, Rainbow Trout. MRID 00066943.
Document (PDF) (122 KB PDF).

August 02, 1978. Memorandum. 2 Page(s).
Roland Gessert. Toxicology Branch.
10182-EUP-10. Talon Rodenticide. Brodifacoum. Original New Anticoagulant
Rodenticide. Vitamin K1 Antagonist. ICI Americas, Inc., Wilmington Delaware.
Document (PDF) (115 KB PDF).

September 12, 1978. Memorandum. 3 Page(s).
John Doherty. Toxicology Branch.
Experimental Use Permit Application for Evaluation of Talon Anticoagulant
Rodenticide for Use Against Microtus in Orchards. Caswell No. 114AAA. 10182-EUP-12.
Document (PDF) (157 KB PDF).

October 19, 1978. Memorandum. 1 Page(s).
John Doherty. Toxicology Branch.
EPA Registration No. 10182-EA, (Rodenticide Pellets) and 10182-ER (Rodenticide Bait Pack).
Document (PDF) (66 KB PDF).

April 21, 1979. Review. 2 Page(s).
Larry Turner. Ecological Effects Branch.
Avian 40-day dietary LC50, mallard duck. MRID 00124476.
Document (PDF) (54 KB PDF).

April 23, 1979. Review. 3 Page(s).
Larry Turner. Ecological Effects Branch.
Avian 40-day dietary LC50, bobwhite quail. MRID 00124477.
Document (PDF) (78 KB PDF).

April 23, 1979. Review. 4 Page(s).
Larry Turner. Ecological Effects Branch.
Secondary Toxicity, rats to beagle dogs. MRID 00080249.
Document (PDF) (134 KB PDF).

April 26, 1979. Study. 10 Page(s).
Patuxent Wildlife Research Center..
Secondary Poisoning of Owls by Anticoagulant Rodenticides.
Document (PDF) (450 KB PDF).

August 31, 1979. Review. 1 Page(s).
M. Nawar. Environmental Fate Branch.
Supplement to Review Dated 8/31/79. Reg. File No. 10182-ET-EO.
Document (PDF) (42 KB PDF).

August 31, 1979. Review. 10 Page(s).
R. W. Cook. Environmental Fate Branch.
Reg./File No.: 10182. Outdoor.
Document (PDF) (490 KB PDF).

August 31, 1979. Review. 13 Page(s).
M. Nawar. Environmental Fate Branch.
File or Reg. No(s) 10182-EA, EE, EG, EI, EL, EN, EO, ER, EU TALON registration
of formulating materials (2) and formulations (7) for commensal rodent control.
Document (PDF) (552 KB PDF).

October 04, 1979. Memorandum. 2 Page(s).
John Doherty. Toxicology Branch.
EPA File Symbols 10182-EN/EA/ER/EL/EU/EG/EE. Products Containing 0.005% Brodifacoum.
Document (PDF) (101 KB PDF).

October 04, 1979. Memorandum. 5 Page(s).
John Doherty. Toxicology Branch.
EPA File No. 10182-EO, Brodifacoum 90.0% Technical.
Pages 3-5 are not included - draft label.
Document (PDF) (69 KB PDF).

October 05, 1979. Memorandum. 5 Page(s).
John Doherty. Toxicology Branch.
EPA File No. 10182-EI, Brodifacoum 0.25% Concentrate.
Pages 3-5 removed, draft label. Tox review 003740.
Document (PDF) (111 KB PDF).

October 18, 1979. Memorandum. 1 Page(s).
Reto Engler. Toxicology Branch.
Summary Interpretation of Toxicology Reviews on Brodifacoum, Rodent Poison.
Document (PDF) (72 KB PDF).

October 25, 1979. Memorandum. 1 Page(s).
John Doherty. Toxicology Branch.
EPA File No. 10182-EA/ER/EU/EN. Products Containing 0.005% Brodifacoum.
Caswell No. 114AAA.
Document (PDF) (33 KB PDF).

May 15, 1980. Review. 5 Page(s).
Russel Farringer. Ecological Effects Branch.
Registration of Two Formulated Products for Outdoor Use in Urban Situations.
Document (PDF) (271 KB PDF).

June 18, 1980. Memorandum. 1 Page(s).
Russel Farringer. Ecological Effects Branch.
Addendum to Brodifacoum Review for Outdoor Use.
Document (PDF) (39 KB PDF).

June 26, 1980. Memorandum. 3 Page(s).
John Doherty. Toxicology Branch.
EPA File No. 10182-EI and 10182-EO, Teratology Studies with Brodifacoum
and Resubmission of Pesticide Applications for Registration.
Document (PDF) (157 KB PDF).

October 17, 1980. Letter. 2 Page(s).
Paul Hegdal. Fish & Wildlife Service.
Barn Owl - Talon Baiting Study.
Document (PDF) (105 KB PDF).

November 17, 1980. Review. 27 Page(s).
John Tice. Ecological Effects Branch.
Experimental Use Permit to Collect Efficacy and Secondary Hazard Information.
Document (PDF) (1403 KB PDF).

March 10, 1981. Memorandum. 2 Page(s).
John Tice. Ecological Effects Branch.
Brodifacoum (112701) Field Study Notes.
Document (PDF) (163 KB PDF).

May 18, 1981. Review. 17 Page(s).
Russel Farringer. Ecological Effects Branch.
Submission of Final Report of Data Gathered under EUP. Efficacy. Acc. 244802.
Document (PDF) (786 KB PDF).
Attachment(s) Following:

December 16, 1980. Memorandum. 1 Page(s).
John Tice. Ecological Effects Branch.
Trip Report - Front Royal, VA.

*End of Attachments*

June 03, 1981. Review. 6 Page(s).
Ed Fite. Ecological Effects Branch.
EUP for Testing Brodifacoum Oat Groats Against Columbian Ground Squirrel.
Document (PDF) (362 KB PDF).

June 19, 1981. Review. 5 Page(s).
Ed Fite. Ecological Effects Branch.
EUP for Testing Talon Weather Blocks.
Document (PDF) (316 KB PDF).

July 07, 1981. Memorandum. 8 Page(s).
Salvatore Biscardi. Toxicology Branch.
A One-Month Anticoagulant Antidote Study in Beagle Dogs - Final Report.
Document (PDF) (731 KB PDF).

August 11, 1981. Review. 5 Page(s).
Russel Farringer. Ecological Effects Branch.
Proposed Conditional Registration of Uses in Sewers and in and Around Buildings
and Transport Vehicles. Inert ingredient information on page 2 is not included.
Document (PDF) (265 KB PDF).

October 02, 1981. Review. 2 Page(s).
Ed Fite. Ecological Effects Branch.
Proposed Changes in EUP.
Document (PDF) (101 KB PDF).

October 07, 1981. DER. 3 Page(s).
Russel Farringer. Ecological Effects Branch.
TEST TYPE: Dietary LC50 - Secondary hazard Test Species: Laughing Gull
Acc. #245704. MRID 00080232.
Document (PDF) (80 KB PDF).

October 28, 1981. DER. 2 Page(s).
Russel Farringer. Ecological Effects Branch.
LC50 - Dietary; 40 day Laughing Gull Acc. #24504. MRID 00080232.
Document (PDF) (53 KB PDF).

October 28, 1981. Review. 10 Page(s).
Willa Garner. Environmental Fate Branch.
Label Amendment with Data.
Document (PDF) (607 KB PDF).

October 29, 1981. Data Eval. Rec. 5 Page(s).
Russel Farringer. Ecological Effects Branch.
Secondary Poisoning. Test Species: Great-Horned, Saw-Whet and Barn Owls.
Acc# 245704.
Document (PDF) (292 KB PDF).

October 29, 1981. Data Eval. Rec. 9 Page(s).
Russel Farringer. Ecological Effects Branch.
Secondary Toxicity. Test Species: Golden Eagle, Red-Tailed Hawks,
Red-Shouldered Hawks. Acc. 245704.
Document (PDF) (486 KB PDF).

October 30, 1981. Review. 2 Page(s).
Willa Garner. Environmental Fate Branch.
Are Data on File in EFB Sufficient for the Proposed Use as a Rodenticide?.
Document (PDF) (66 KB PDF).

October 30, 1981. Review. 6 Page(s).
Russel Farringer. Ecological Effects Branch.
EUP Application for Evaluation of Secondary Hazards to Screech Owls and Great Horned Owls.
Document (PDF) (378 KB PDF).

November 13, 1981. DER. 7 Page(s).
Russel Farringer. Ecological Effects Branch.
TEST TYPE: Secondary Toxicity Test Species: American Kestrel ACC. #245704.
MRID 80244.
Document (PDF) (218 KB PDF).

November 19, 1981. Review. 5 Page(s).
Russel Farringer. Ecological Effects Branch.
Requested Rereview in Light of Additional Data.
Inert ingredient information on page 2 is not included.
Document (PDF) (324 KB PDF).

November 19, 1981. Review. 9 Page(s).
Russel Farringer. Ecological Effects Branch.
Proposed Conditional Registration of Outdoor Use for Commensal Rodents.
Acc. 254704.
Document (PDF) (1545 KB PDF).

December 01, 1981. DER. 2 Page(s).
Russel Farringer. Ecological Effects Branch.
Field Monitoring Barn Owls (Tyto alba). MRID 00080239.
Document (PDF) (91 KB PDF).

December 04, 1981. DER. 2 Page(s).
Russel Farringer. Ecological Effects Branch.
Acute Oral beagle dogs and cats. MRID 00087134.
Document (PDF) (71 KB PDF).

December 10, 1981. Memorandum. 1 Page(s).
Samuel Creeger. Environmental Fate Branch.
Meeting - ICI, EEB, EFB, PM 16.
Document (PDF) (78 KB PDF).

December 21, 1981. Review. 8 Page(s).
Russel Farringer. Ecological Effects Branch.
Proposed Conditional Registration of Microtus Control in Fruit and Nut Orchards.
Pages 5-8 are not included - draft label.
Document (PDF) (222 KB PDF).

February 02, 1982. Review. 4 Page(s).
Willa Garner. Environmental Fate Branch.
Use in Sewers (in Block Bait).
Document (PDF) (279 KB PDF).

February 26, 1982. Review. 2 Page(s).
Willa Garner. Environmental Fate Branch.
Rodenticide - Pack and Bait - Use in Orchards.
Document (PDF) (118 KB PDF).

August 25, 1982. Review. 6 Page(s).
Russel Farringer. Ecological Effects Branch.
EUP for Use Against Pocket Gophers.
Document (PDF) (365 KB PDF).

September 07, 1982. Memorandum. 2 Page(s).
Russel Farringer. Ecological Effects Branch.
FlIE or REG. No.: 10182-38. Talon-G Pellets.
Proposed conditional registration of control of ground squirrels in and around buildings.
Document (PDF) (95 KB PDF).

February 24, 1983. Memorandum. 2 Page(s).
Russel Farringer. Ecological Effects Branch.
Talon Rodenticide Pellets EPA Experimental Use Permit No. 10182-EUP-20, Request for Renewal.
Document (PDF) (121 KB PDF).

July 08, 1983. Review. 8 Page(s).
Richard Moraski. Exposure Assessment Branch.
Review Data to Support Use on Fruit and Nut Orchards in Virginia, West Virginia,
Maryland and Pennsylvania. Pages 6-8 are not included - draft label.
Document (PDF) (257 KB PDF).

July 28, 1983. DER. 2 Page(s).
Russel Farringer. Ecological Effects Branch.
Test Type: Primary hazard field study Test species: Ring-necked pheasant
Acc# 250077. MRID 00139518.
Document (PDF) (56 KB PDF).

August 15, 1983. Review. 62 Page(s).
Russel Farringer. Ecological Effects Branch.
Submission of Field Data for Secondary Hazards of Volid to Screech Owls when
Volid is Used in Orchards. Inert ingredient information on pages 5, 30-32, 34,
and 36 is not included. Acc. 250077.
Document (PDF) (3729 KB PDF).

September 23, 1983. Memorandum. 2 Page(s).
B. T. Backus. Insecticide Rodenticide Branch.
Brodifacoum Rodenticide; Human Exposure in Indonesia. Tox review No. 003266.
Document (PDF) (132 KB PDF).

February 01, 1984. Memorandum. 8 Page(s).
Robert Jaeger. Toxicology Branch.
Talon (Brodifacoum) Anticoagulant Rodentacide. Tox Chem. No. 114AA
Treatment of the anticoagulant effects of brodifacoum with Vitamin K1.
Acc. 251781 Tox review 003568.
Document (PDF) (427 KB PDF).

April 06, 1984. Memorandum. 10 Page(s).
Daniel Peacock. Insecticide-Rodenticide Branch.
Attendance at Meeting on April 27, 1984, and Review of Data.
Document (PDF) (564 KB PDF).

April 10, 1984. Memorandum. 2 Page(s).
Raymond Matheny. Ecological Effects Branch.
Talon (Brodifacoum) Use at the National Zoo.
Document (PDF) (145 KB PDF).

May 04, 1984. Review. 6 Page(s).
Russel Farringer. Ecological Effects Branch.
Submission of Data and Rebuttal for Meeting.
Commercial/financial information on page 3 is not included.
Document (PDF) (444 KB PDF).

June 01, 1984. Review. 4 Page(s).
Russel Farringer. Ecological Effects Branch.
Submission of Label in Response to Meeting.
Document (PDF) (286 KB PDF).

June 07, 1984. Letter. 7 Page(s).
Clayton Bushong. Ecological Effects Branch.
Formal Section 7 Consultation on the Proposed Registration of Volid on Apple Orchards.
Document (PDF) (848 KB PDF).

July 23, 1984. Data Eval. Rep. 1 Page(s).
Robert Zendzian. Toxicology Branch.
Brodifacoum PP 581.
Document (PDF) (32 KB PDF).

July 23, 1984. Data Eval. Rep. 2 Page(s).
Robert Zendzian. Toxicology Branch.
Brodifacoum WBA 8119.
Document (PDF) (60 KB PDF).

July 27, 1984. Data Eval. Rep. 3 Page(s).
Robert Zendzian. Toxicology Branch.
Brodifacoum WBA 8119.
Document (PDF) (187 KB PDF).

August 31, 1984. Memorandum. 15 Page(s).
William Burnam. Toxicology Branch.
Brodifacoum, Rodentacide EPA Reg. No. 10182-LI.
Acc. 250077, 245704, 252894. Tox review 003989.
Document (PDF) (1391 KB PDF).

September 24, 1984. Memorandum. 8 Page(s).
Robert Zendzian. Toxicology Branch.
Brodifacoum, Rodenticide. Tox Review 003989.
Document (PDF) (415 KB PDF).

September 26, 1984. Review. 38 Page(s).
Russel Farringer. Ecological Effects Branch.
Submission of Meeting Notes for Comment. Review of minutes of the meeting
with ICI concerning brodifacoum use in apple orchards to control Microtus spp.
Commercial/financial information on pages 9, 15, & 31 not included.
Pages 35-38 deleted, draft label.
Document (PDF) (2483 KB PDF).

August 26, 1985. Memorandum. 2 Page(s).
Alex Arce. Toxicology Branch.
Volid. Accession # 258368.
Document (PDF) (68 KB PDF).

November 08, 1985. Memorandum. 1 Page(s).
Daniel Rieder. Ecological Effects Branch.
Special Review Status Based on Adverse Effects Data.
Document (PDF) (68 KB PDF).

November 15, 1985. Review. 3 Page(s).
Samuel Creeger. Exposure Assessment Branch.
Application for an EUP for Continued Evaluation of Secondary Hazards to Screech Owls.
Document (PDF) (123 KB PDF).

December 17, 1985. Memorandum. 7 Page(s).
Daniel Rieder. Ecological Effects Branch.
Registrability of Brodifacoum the Anticoagulant ICI America's proposed field study protocol.
Document (PDF) (471 KB PDF).

December 19, 1985. Review. 53 Page(s).
Daniel Rieder. Ecological Effects Branch.
Submission of Adverse Effects Data for Review.
Pages 11-18A, 26-35A, and 43-53 are not included - registrant data.
Document (PDF) (1163 KB PDF).

February 06, 1986. Review. 13 Page(s).
Daniel Rieder. Ecological Effects Branch.
Proposed EUP for Continued Evaluation of Secondary Hazards to Screech Owls.
Document (PDF) (820 KB PDF).

June 03, 1986. Memorandum. 4 Page(s).
Byron Backus. Toxicology Branch.
6(a)(2) Data on Brodifacoum-containing Rodentiacides EPA Reg. Nos. 10182-38, -39,
-40, -41, -60, -61, -75, -76. Page 4 removed, draft label. Acc. No. 262910.
Tox review 005183.
Document (PDF) (196 KB PDF).

June 06, 1986. Memorandum. 4 Page(s).
Byron Backus. Toxicology Branch.
6(a)(2) Data on Brodifacoum-containing Rodenticides; EPA Reg. No. 10182-38, -39,
-40, -41, -60, -61, -75, -76. Tox Review No. 005183. Acc. No. 262910.
Document (PDF) (87 KB PDF).

June 25, 1986. Review. 3 Page(s).
Larry Turner. Ecological Effects Branch.
Submission of Adverse Effects Data Concerning Talon Products. Comments Requested by PM.
Document (PDF) (141 KB PDF).

February 20, 1987. Review. 3 Page(s).
Daniel Rieder. Ecological Effects Branch.
Response to Previous EEB Review (Comments by Mr. Jackson, Mr. Hegdal and Dr. Colvin).
Document (PDF) (178 KB PDF).

February 27, 1987. Memorandum. 1 Page(s).
Byron Backus. Toxicology Branch.
Packaging (and Registration) of Home-Use Products Containing Brodifacoum.
Document (PDF) (54 KB PDF).

November 02, 1987. Review. 4 Page(s).
Daniel Rieder. Ecological Effects Branch.
Submission of 6(a)(2) (Adverse Effects) Data Concerning Secondary Poisoning
Incident with Talon Weather Bloks Used in Denver Zoo.
Document (PDF) (182 KB PDF).

October 04, 1989. Memorandum. 15 Page(s).
Robert Zendzian. Toxicology Branch.
Brodifacoum; Report of Apparent Human Self Poisoning, Further Information.
telephone call from Dr. Mike Murphy of the University of Minnesota... analytical
method for brodifacoum in blood.
Document (PDF) (796 KB PDF).

October 13, 1989. Memorandum. 2 Page(s).
Robert Zendzian. Toxicology Branch.
Brodifacoum, Report of Apparent Human Self Poisoning.
Information protected by the Privacy Act on page 1 is not included.
Document (PDF) (116 KB PDF).

October 26, 1989. Memorandum. 11 Page(s).
Robert Zendzian. Toxicology Branch.
Brodifacoum, Teratology Studies and Other Data Requirements.
MRID 403072-01, -02, 52442, 52443. Tox review 007588.
Document (PDF) (560 KB PDF).

January 04, 1991. DER. 4 Page(s).
James Goodyear. Ecological Effects Branch.
STUDY TYPE - Avian Dietary Single-dose Oral LD50 Species tested - Mallard duck.
MRID 41563303.
Document (PDF) (149 KB PDF).

January 04, 1991. Response. 1 Page(s).
James Goodyear. Ecological Effects Branch.
EEB review of Brodifacoum Phase IV studies. Accepted: 9219503.
Rejected: 066942, 124472, 124473, 124474, 128442, 088011, 080248.
Fully Acceptable: 41563303, 124477, 124476.
Document (PDF) (49 KB PDF).

January 04, 1991. Response. 2 Page(s).
James Goodyear. Ecological Effects Branch.
71-2 (a). Avian dietary LC50 (Bobwhite quail). MRIDs 124477, 92195004.
Document (PDF) (96 KB PDF).

January 04, 1991. Response. 2 Page(s).
James Goodyear. Ecological Effects Branch.
71-2(b). Avian dietary LC50 (Mallard duck) MRID 124476, 92195005.
Document (PDF) (95 KB PDF).

January 04, 1991. Response. 2 Page(s).
James Goodyear. Ecological Effects Branch.
71-3. Wild Mammal Toxicity. Oral LD50, Mink. MRID 00080248, 92195006.
Document (PDF) (102 KB PDF).

January 04, 1991. Response. 2 Page(s).
James Goodyear. Ecological Effects Branch.
71-5. Field study. Ring-necked pheasant study, not Barn owl. Requirement not met.
Correct study should be submitted. MRIDs 139518, 92195007.
Document (PDF) (83 KB PDF).

January 04, 1991. Response. 2 Page(s).
James Goodyear. Ecological Effects Branch.
72-1 (d). Acute toxicity for freshwater fish (TEP). LC50 Rainbow trout.
MRIDs 124473, 92195011.
Document (PDF) (112 KB PDF).

January 04, 1991. Response. 2 Page(s).
James Goodyear. Ecological Effects Branch.
72-2 (a) & (b). Acute toxicity test, freshwater invertebrate.
MRIDs 128442, 92195012.
Document (PDF) (114 KB PDF).

January 09, 1991. DER. 3 Page(s).
James Goodyear. Ecological Effects Branch.
Wild Mammal Toxicity Test [mink] Guideline Number: 71-3.
Pages 2-3 removed, registrant data. MRID 00080248.
Document (PDF) (86 KB PDF).

January 09, 1991. DER. 5 Page(s).
James Goodyear. Ecological Effects Branch.
72-2 (a) & (b); Toxicity to Daphnia magna. MRIDs 128442, 92195012.
Document (PDF) (179 KB PDF).
Attachment(s) Following:

April 18, 1979. Review.
Larry Turner. Ecological Effects Branch.
Aquatic invertebrate acute 48 hour LC50, Daphnia magna
MRID 128442 Acc. #234655.

*End of Attachments*

January 09, 1991. DER. 5 Page(s).
James Goodyear. Ecological Effects Branch.
Acute toxicity for freshwater fish (TG) - Bluegill sunfish. MRIDs 88011, 9219508.
Document (PDF) (306 KB PDF).

January 09, 1991. DER. 5 Page(s).
Leslie Touart. Ecological Effects Branch.
72-1 (d); Acute toxicity to Rainbow trout. MRID 124473.
Document (PDF) (180 KB PDF).
Attachment(s) Following:

April 16, 1979. Review.
Larry Turner. Ecological Effects Branch.
Fish acute 96 hour LC50, Rainbow trout MRID 124473 Acc. #234655.

*End of Attachments*

January 09, 1991. DER. 5 Page(s).
Leslie Touart. Ecological Effects Branch.
Avian Single Dose Oral LD50 - Mallard duck. MRID 66942.
Document (PDF) (176 KB PDF).
Attachment(s) Following:

April 14, 1979. DER.
Larry Turner. Ecological Effects Branch.
Avian acute oral LD50, mallard duck MRID 66942 Acc. #234655.

*End of Attachments*

January 09, 1991. DER. 7 Page(s).
Leslie Touart. Ecological Effects Branch.
72-1 (b); Acute toxicity to Bluegill sunfish. MRIDs 124474, 92195009.
Document (PDF) (300 KB PDF).
Attachment(s) Following:

April 17, 1979. Review.
Larry Turner. Ecological Effects Branch.
Fish acute 96 hour LC50, Bluegill sunfish MRID 124474 Acc. # 234655.

*End of Attachments*

January 09, 1991. DER. 7 Page(s).
Leslie Touart. Ecological Effects Branch.
Acute toxicity for freshwater fish - Rainbow trout. MRIDs 124472, 92195010.
Document (PDF) (278 KB PDF).
Attachment(s) Following:

April 14, 1979. Review.
Larry Turner. Ecological Effects Branch.
Fish acute 96 hour LC50, Rainbow trout MRID 124472 Acc. #234655.

*End of Attachments*

January 09, 1991. DER. 4 Page(s).
James Goodyear. Ecological Effects Branch.
Avian Oral Acute Toxicity Test. Avian Dietary Single-dose Oral LD50.
Species tested- Mallard duck Anas platyrhynchos. MRID 415633-03.
Document (PDF) (40 KB PDF).

November 09, 1992. Review. 61 Page(s).
Akiva Abramovitch. Environmental Fate & Ground Water Branch.
Review of 161-1 and 163-1 studies [hydrolysis; mobility - adsorption/desorption].
Pages 17-38, 48-61 removed, registrant data. MRID 42237701, 42024501.
Document (PDF) (693 KB PDF).

February 12, 1993. Memorandum. 8 Page(s).
Byron Backus. Toxicology Branch.
Brodifacoum Acute Dermal LD50 in Study Rats.
MRID 422321-01. Tox review 010031.
Document (PDF) (543 KB PDF).
Attachment(s) Following:

February 18, 1992. Memorandum.
Byron Backus. Toxicology Branch.
Acute Data for Brodifacoum.

*End of Attachments*

April 03, 1993. Review. 4 Page(s).
James Goodyear. Ecological Effects Branch.
Secondary toxicity of anticoagulant-killed rodents fed to owls.
MRID 40077202.
Document (PDF) (205 KB PDF).

May 25, 1993. Review. 10 Page(s).
Byron Backus. Toxicology Branch.
STUDY TYPE: Antidotal - Dog MRID No.: 42007501.
Pages 7-10 removed, registrant data. Tox review 010297.
Document (PDF) (371 KB PDF).

May 26, 1993. Review. 17 Page(s).
Byron Backus. Toxicology Branch.
STUDY TYPE: Metabolism - rat MRID No.: 42007502.
Pages 11-16 removed, registrant data.
Document (PDF) (613 KB PDF).

July 12, 1993. Review. 54 Page(s).
Akiva Abramovitch. Environmental Fate & Ground Water Branch.
Review of 162-1 and 163-1 studies for reregistration.[aerobic soil metabolism;
mobility/aged column leaching]. Pages 14-25, 32-45 removed, registrant data.
DP Barcode D186631 MRID 42579401, 42568301.
Document (PDF) (995 KB PDF).

August 09, 1993. DER. 11 Page(s).
Mark Mossler. KBN Engineering for EEB.
STUDT TYPE: 72-1. Freshwater Fish Acute Toxicity Test. Species Tested: Bluegill sunfish.
Pages 6-9 removed, registrant data. MRID 42641901.
Document (PDF) (324 KB PDF).

April 10, 1995. Memorandum. 14 Page(s).
John Jordan. Environmental Fate & Ground Water Branch.
Response to Zeneca's Letter (10/28/94) Concerning the Status of the Brodifacoum
Studies: Hydrolysis, Aerobic Soil Metabolism, Adsorption/Desorption and Soil
Column Leaching. DP Barcode: D210477.
Document (PDF) (805 KB PDF).

June 28, 1996. Memorandum. 7 Page(s).
Byron Backus. Toxicology Branch.
Brodifacom Acute Inhalation Toxicity Study (rat) DP Barcode: D201024
MRID 43110501. Tox review 011967.
Document (PDF) (349 KB PDF).

August 22, 1996. Memorandum. 45 Page(s).
Byron Backus. Toxicology Branch.
Acute Oral LD50, Acute Dermal LD50, Primary Dermal Irritation, and Dermal
Sensitization Studies on 0.25% Brodifacom Formulation Concentrate; Metabolism
Study on Brodifacom. DP Barcode D227302. Tox review 012026.
Document (PDF) (2392 KB PDF).

October 25, 1996. Memorandum. 52 Page(s).
Byron Backus. Toxicology Branch.
Developmental Toxicity (Rat and Rabbit) and Acute Oral LD50 Studies on Brodifacom.
DP Barcode: D189478. Tox review 012085.
Document (PDF) (2589 KB PDF).

November 26, 1996. Memorandum. 18 Page(s).
Byron Backus. Toxicology Branch.
Toxicology Chapter for the Brodificoum RED. DP Barcode D231157.
Document (PDF) (964 KB PDF).

December 02, 1996. Memorandum. 16 Page(s).
Byron Backus. Toxicology Branch.
Salmonella typhimurium (Ames) Assay and Mouse Micro- nucleus Assay
Mutagenicity Studies on Brodifacoum. DP Barcode: D230214. Tox review 012110.
Document (PDF) (687 KB PDF).

December 23, 1996. Memorandum. 15 Page(s).
Tom Campbell. Occupational & Residential Exposure Branch.
Occupational and Residential Exposure Assessment and Recommendations for the
Reregistration Eligibility Decision Document for Brodifacoum. DP Barcode D231156.
Document (PDF) (740 KB PDF).

January 01, 1997. Memorandum. 6 Page(s).
Virginia Dobozy. Toxicology Branch II.
Review of Incident Reports in Domestic Animals with the Anticoagulant
Rodenticides Brodifacoum, Chlorophacinone and Diphacinone.
Document (PDF) (616 KB PDF).

January 23, 1997. Memorandum. 4 Page(s).
William Jacobs. Insecticide Rodenticide Branch.
WeatherBlok Bait wit Bitrex EPA Reg. No. 10182-339 Your amended application of
7/16/96; Your letter of 10/31/96 product chemistry, efficacy data - rats and mice.
MRIDs 44063401 thru -05.
Document (PDF) (348 KB PDF).

April 25, 1997. Memorandum. 29 Page(s).
John Redden. Risk Characterization & Analysis Branch.
HED Chapter of the Reregistration Eligibility Decision Document (RED) for Brodifacoum.
Tox review # 012209.
Document (PDF) (1504 KB PDF).

January 21, 2000. Memorandum. 2 Page(s).
Marianne Lewis. Product Reregistration Branch.
EPA Reg. No.: 10182-29/Brodifacoum Technical. The acute inhalation study (81-3)
requirement for the subject products has been waived.
Document (PDF) (60 KB PDF).

January 21, 2000. Memorandum. 4 Page(s).
Marianne Lewis. Product Reregistration Branch.
EPA Reg. No.: 10182-334/Talon-G Rodenticide Bait Pack... [and EPA Reg. Nos. 10182-335,
-336, -337, -338, -341] The acute inhalation study (81-3) requirement for the subject
products has been waived. All... will be classified as Toxicity category I.
Document (PDF) (152 KB PDF).

March 04, 2002. Review. 4 Page(s).
Paul Horng. Product Reregistration Branch.
Product Chemistry Review of End-Use Product Barcode No.: D281210; D262384;
EPA Reg No.: 100-1054. Pages 3-4 removed, inert, manufacturing process and
quality control information. MRIDs 44992201, 45502601, 45583502.
Document (PDF) (122 KB PDF).

March 04, 2002. Review. 4 Page(s).
Paul Horng. Product Reregistration Branch.
Product Chemistry Review of End-Use Product. Barcode No. D281209; D262382;
EPA Reg. No. 100-1053; Product Name: Havoc Rodenticide Bait Pack Pellets w/Bitrex.
Pages 3-4 removed, inert and manufacturing process info.
MRID 44992201, 45502602, 45583502.
Document (PDF) (118 KB PDF).

March 04, 2002. Review. 4 Page(s).
Paul Horng. Product Reregistration Branch.
Product Chemistry Review of End-Use Product. Barcode No. D281213; D262380;
EPA Reg. No. 100-1052; Product Name: Talon-G Rodenticide Pellets with Bitrex.
Pages 3-4 removed, inert and manufacturing process info.
MRID 44992201, 45417701, 45502601.
Document (PDF) (123 KB PDF).

March 04, 2002. Review. 4 Page(s).
Paul Horng. Product Reregistration Branch.
Product Chemistry Review of End-Use Product. Barcode No. D281214; D262401;
EPA Reg. No. 100-1057; Product Name: Talon-G Rodenticide Mini-Pellets with Bitrex.
Pages 3-4 removed, inert and manufacturing process info.
MRID 44992201, 45502601, 45417702.
Document (PDF) (130 KB PDF).

March 04, 2002. Review. 4 Page(s).
Paul Horng. Product Reregistration Branch.
Product Chemistry Review of End-Use Product. Barcode No. D281281;D262370;
EPA Reg. No. 100-1050; Product Name: Talon-G Rodenticide Bait Pack (mini) w/Bitrex.
Pages 3-4 removed, inert and manufacturing process info.
MRID 44992201, 45502601, 45583502.
Document (PDF) (118 KB PDF).

March 05, 2002. Review. 5 Page(s).
Paul Horng. Product Reregistration Branch.
Product Chemistry Review of End-Use Product. Barcode No. D281281.
EPA Reg. No. 100-1055. Inert information on page 3 not included.
Pages 4-5 removed, inert ingredient and manufacturing process information.
MRID 44063401, -02, -03 and 45575801.
Document (PDF) (168 KB PDF).

March 06, 2002. Review. 6 Page(s).
Paul Horng. Product Reregistration Branch.
Product Chemistry Review of Technical Product. Barcode No. D281104;
EPA Reg. No. 100-987; Product Name: Brodifacoum Technical.
Pages 3-6 removed, description of manufacturing process.
MRID 129706, 41892201, -02.
Document (PDF) (198 KB PDF).

June 05, 2002. Review. 5 Page(s).
Paul Horng. Product Reregistration Branch.
Product Chemistry Review of End-Use Product
Barcode No.: D283407; D281281; Reg. No. 100-1055. Inert info. on page 3 deleted.
Pages 4-5 removed, manufacturing process, inert, quality control procedure info.
MRID 44063401, -02, -03; 45575801; 456724-01.
Document (PDF) (174 KB PDF).

August 07, 2002. Memorandum. 4 Page(s).
Marianne Lewis. Product Reregistration Branch.
EPA Reg. No.: 100-987/Brodifacoum Technical. DP Barcode: D283985. Four acute
toxicity studies cited are acceptable... skin irritation, skin sensitization
waiver requests granted. MRID 42687501, 42232101, 43110501, 66938.
Document (PDF) (131 KB PDF).

October 16, 2002. Memorandum. 5 Page(s).
Marianne Lewis. Product Reregistration Branch.
EPA Reg. No.: 100-1055/WeatherBlok Bait with Bitrex. DP Barcode: D285919.
8 month response to Rodenticide Cluster RED... registrant is citing acute
toxicity studies and an attrition study.
MRID 44983701, 45718901, 45760701, 44597901, 44021703, 44021704.
Document (PDF) (174 KB PDF).

October 16, 2002. Memorandum. 5 Page(s).
Marianne Lewis. Product Reregistration Branch.
Reg. No.: 100-1052/Talon-G Rodenticide Pellets w/Bitrex. DP Barcode: D285919.
8 month response to Rodenticide Cluster RED... registrant is citing acute
toxicity studies and an attrition study.
MRID 44983701, 45718901, 45760701, 44597901, 44021703, 44021704.
Document (PDF) (189 KB PDF).

October 16, 2002. Memorandum. 5 Page(s).
Marianne Lewis. Product Reregistration Branch.
Reg. No.: 100-1054/HAVOC Rodenticide Bait Pack... Bitrex DP Barcode: D285919.
8 month response to Rodenticide Cluster RED... registrant is citing acute
toxicity studies and an attrition study.
MRID 44983701, 45718901, 45760701, 44597901, 44021703, 44021704.
Document (PDF) (196 KB PDF).

October 16, 2002. Memorandum. 5 Page(s).
Marianne Lewis. Product Reregistration Branch.
Reg. No.: 100-1056/HAVOC Rodenticide Bait Pack...Bitrex. DP Barcode: D285919.
8 month response to Rodenticide Cluster RED... registrant is citing acute
toxicity studies and an attrition study.
MRID 44983701, 45718901, 45760701, 44597901, 44021703, 44021704.
Document (PDF) (194 KB PDF).

January 14, 2003. Review. 7 Page(s).
Paul Horng. Product Reregistration Branch.
Product Chemistry Review of Technical Product Barcode No.: D287736; D281104;
EPA Reg. No. 100-987 Manufacturing process information on page 1 not included.
Pages 5-7 removed MP and quality control procedure info.
MRID 41892201, -02; 45832101.
Document (PDF) (181 KB PDF).

March 27, 2003. Review. 5 Page(s).
Bentley Gregg. Product Reregistration Branch.
Product Chemistry Review of End Use Product Barcode No.: D289002;
EPA Reg. No. 100-987. Manufacturing process information on page 2 not included.
Pages 3-5 removed MP and quality control procedure info. MRID 45859401.
Document (PDF) (175 KB PDF).

May 01, 2003. Review. 3 Page(s).
Bentley Gregg. Product Reregistration Branch.
Product Chemistry Review of End Use Product Barcode No.: D289698
EPA Reg. No. 100-987. Manufacturing process information on page 2 not included.
MRID 45859401.
Document (PDF) (169 KB PDF).

October 16, 2003. Review. 6 Page(s).
Paul Horng. Product Reregistration Branch.
Product Chemistry Review of Technical Product EPA Reg No.: 100-987.
Pages 4-6 removed, identity of product impurities and manufacturing process information.
MRIDs 41892201, -02, 46013501, 46058101.
Document (PDF) (135 KB PDF).

August 24, 2005. Memorandum. 95 Page(s).
Mary Frankenberry. Environmental Fate & Effects Division.
EFED Evaluation of "A" Probabilistic Assessment of the Risk of Brodifacoum to
Nontarget Predators & Scavengers, "by The Cadmus Group, September 10, 2004,
Submitted by Syngenta Crop Protection, Inc. DP Barcode 306327.
Document (PDF) (3481 KB PDF).

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