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Index of Cleared Science Reviews for s-Metolachlor (Pc Code 108800)
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Undated. Memorandum. 30 Page(s).
Kevin Costello. Environmental Risk Branch.
Clarification on the Status of Environmental Fate Data for Metolachlor & S-Metolachlor
as Stated in Previous Agency Review(D236884) of Registrant's(Novartis) Rebuttal Comments
to EFGWB Review(April 22, 1997) for Metolachlor & S-Metolachlor (MRID 44303502).
Document (PDF) (1691 KB PDF).
Undated. Supporting Docs. 105 Page(s).
S. Dapson. Health Effects Division.
The RfD/ Peer Review Meeting for alpha-Metolachlor... New chemical. This chemical
requires RfD and developmental toxicity assessments. Mutagenicity studies have
been given to Nancy McCarroll for review.
Document (PDF) (5262 KB PDF).
Attachment(s) Following:
March 26, 1997. DER.
Stephen Dapson. Toxicology Branch.
DER #2 (page 47). Alpha-Metolachlor: Developmental Toxicity Study in Rabbits.
MRID 43928924.
March 27, 1997. DER.
Stephen Dapson. Toxicology Branch.
DER #1 (page 26). Alpha-Metolachlor: Developmental Toxicity Study in Rats.
MRID 43928925.
March 27, 1997. DER.
Stephen Dapson. Toxicology Branch.
DER #3 (page 67). Alpha-Metolachlor: 13-Week Feeding Study in Rats.
MRID 43928923.
April 01, 1997. DER.
Stephen Dapson. Toxicology Branch.
DER #4 (page 88). Alpha-Metolachlor: 13-Week Feeding Study in Dogs.
MRID 43928922.
*End of Attachments*
April 03, 1996. Memorandum. 132 Page(s).
Anthony Maciorowski. Ecological Effects Branch.
D223753 and D223769 - - New chemical screen for CGA- 77102 [a metolachlor
isomer also known as Dual Magnum Herbicide] -- (Chemical Code: 108800).
MRID 439289-06 through -13 and -29 through -33.
Document (PDF) (6815 KB PDF).
September 17, 1996. Memorandum. 151 Page(s).
James Hetrick. Environmental Fate & Ground Water Branch.
New Chemical Screen for Environmental Fate Data for the Metolachlor Stereoisomer
CGA-77102... Pages 20-61, 68-84, 92-114, 122-151 removed, registrant data
MRID 43928935 thru 43928038.
Document (PDF) (3700 KB PDF).
November 15, 1996. Memorandum. 84 Page(s).
Linda Kutney. Chemistry Branch.
PP #: None; Replacement of Metolachlor Technical (Racemic Metolachlor) with
Alpha-Metolachlor (Formerly Called Chiral Metolachlor) Technical; Review of Bridging
Data... MRID 439289-01, -02, 03, 39, 40, 41, 42. ID #: 000100-IRL (000100-815).
Document (PDF) (4073 KB PDF).
March 13, 1997. DER. 9 Page(s).
Allen Vaughan. OPP/EPA.
DATA EVALUATION RECORD ACUTE LC50 TEST WITH AN ESTUARINE/MARINE SHRIMP § 72-3(c).
The Acute Toxicity of CGA-77102 Technical to Mysidopsis bahia (Bay Shrimp).
MRID No.: 439289-13. DP Barcode: D223753 and D223769.
Document (PDF) (588 KB PDF).
April 11, 1997. Review. 5 Page(s).
Daniel Rieder. Ecological Effects Branch.
Reg. File 100-815. Review toxicity data on CGA-77102, chiral metolachlor, an isomer
of metolachlor (108800). Determine if chiral metolachlor is similar toxicologically to
metolachlor. MRID 43928906 thru -13, -29 thru 33.
Document (PDF) (336 KB PDF).
April 22, 1997. Review. 149 Page(s).
Paul Mastradone. Environmental Fate & Ground Water Branch.
To review bridging environmental fate data (soil photolysis, mobility, aerobic soil
metabolism, unaged leaching, adsorption/desorption, and aged soil column leaching)
submitted in support of registration. MRID 43928935 thru -38.
Document (PDF) (3276 KB PDF).
Attachment(s) Following:
April 22, 1997. Review.
Paul Mastradone. Environmental Fate & Groundwater Branch.
(continued) Pages 19-60, 67-84, 91-113, 120-149 removed, registrant data.
*End of Attachments*
July 16, 1997. Memorandum. 9 Page(s).
George Ghali. Health Effects Division.
RfD/Peer Review Report of Alpha-Metolachlor Tox review 012279.
Document (PDF) (739 KB PDF).
September 04, 1997. Memorandum. 431 Page(s).
Stephen Dapson. Chemistry Branch II.
Alpha-Metolachlor: Review of Bridging Data Studies & Acute Toxicity Studies With Formulations.
RD removed pp. 184-188. MRID Nos. 439284-04 thru-08,439285-03 thru-08,439289-15 thru-25,
439283-03 thru-08,441268-02 thru-07,441722-03 thru-10,441280-03 thru-08.
Document (PDF) (24187 KB PDF).
February 05, 1998. Memorandum. 2 Page(s).
Kevin Costello. Environmental Risk Branch.
Eco Data Requirements for alpha-Metolachlor.
Document (PDF) (87 KB PDF).
February 06, 1998. Letter. 3 Page(s).
Joanne Miller. Hebicide Branch.
CGA-77102 Technical; EPA Registration No. 100-815; Dual Magnum Herbicide;
EPA Registration No. 100-816; Your Letter Dated January 20, and January 29, 1998,
Request for Conditional Registration without Expiration Date.
Document (PDF) (127 KB PDF).
January 20, 1999. Memorandum. 2 Page(s).
Brian Montague. Environmental Risk Branch.
Novartis Response Regarding Outstanding Ecological Effects Data requirements for
S-Metolachlor & Proposed Timetable for Completion.
Document (PDF) (153 KB PDF).
June 11, 1999. DER. 12 Page(s).
Ghazi Dannan. Registration Action Branch III.
Review of "Absorption Distribution, and Excretion of [Phenyl-U-14C] CGA-77102 in
the Rat." Metabolism - rat [OPPTS 870.7485 (Sec. 85-1)]. MRID No. 44491401.
Document (PDF) (852 KB PDF).
August 30, 1999. Memorandum. 12 Page(s).
Brian Montague. Environmental Risk Branch.
Review of Honeybee Toxicity Studies with Metolachlor and S-Metolachlor isomer.
MRID 44718401, -02.
Document (PDF) (679 KB PDF).
May 15, 2000. DER. 14 Pages.
Brian Montague. Environmental Fate & Effects Division.
FRESHWATER FISH EARLY LIFE-STAGE TEST GUIDELINE 72-4. S-
Metolachlor (CGA-77102): Early Life-Stage Toxicity Test with Fathead Minnow
(Pimephales promelas). MRID No.: 449959-03. DP Barcode: D262736.
Document (PDF) (653 KB PDF).
May 16, 2000. Memorandum. 70 Page(s).
Brian Montague. Environmental Risk Branch.
Review of Avian Reproduction and Chronic Aquatic Studies for S-Metolachlor
(PC Code 108800) submitted under Barcode 262736 and Submission # S574334.
MRID 44995901, -02, 03.
Document (PDF) (4298 KB PDF).
August 17, 2000. Memorandum. 25 Page(s).
Kevin Costello. Environmental Risk Branch.
Agency Review of Registrant's (Novartis) Rebuttal Comments to the EFGWB
Review (April 22, 1997) for Metolachlor and S-Metolachlor (MRID 44303502) and..
'Equivalency of Pesticides Metolachlor and S-Metolachlor with Respect to Ground
Water Contamination'.
Document (PDF) (1240 KB PDF).
August 29, 2000. Memorandum. 5 Page(s).
Kevin Costello. Environmental Risk Branch.
Consideration of Novartis' Document "Comments on 'Equivalency of Pesticides
Metolachlor and S-Metolachlor with Respect to Ground Water Contamination'".
Document (PDF) (367 KB PDF).
January 08, 2001. DER. 15 Page(s).
William Greear. Registration Action Branch.
Subchronic Oral Toxicity STudy - Rat. [OPPTS 870.3100 (Sec. 82-1a)].
MRID No. 44775402.
Document (PDF) (895 KB PDF).
April 25, 2001. DER. 12 Page(s).
Virginia Dobozy. Reregistration Branch.
CGA-51202; (Metolachlor OA)(Degradate of Metolachlor);
Subchronic Oral Toxicity Feeding - Rat [OPPTS 870.3100 82-3)]. MRID No. 44929509.
Document (PDF) (564 KB PDF).
April 25, 2001. DER. 12 Page(s).
Virginia Dobozy. Reregistration Branch.
Developmental Toxicity - Rat; OPPTS 870.3700 (Sec. 83-3a).
Metolachlor OA (CGA-51202 Technical). MRID No. 44929510.
Document (PDF) (615 KB PDF).
April 25, 2001. DER. 13 Page(s).
Virginia Dobozy. Reregistration Branch.
Developmental Toxicity - Rat; [870.3700 (Sec. 83-3a)].
Metolachlor ESA (CGA-354743 Technical). MRID No. 44931711.
Document (PDF) (586 KB PDF).
April 25, 2001. DER. 14 Page(s).
Virginia Dobozy. Reregistration Branch.
CGA-354743 Subchronic Oral Toxicity Feeding - Rat [
OPPTS 870.3100 (Sec. 82-1a)]. MRID No. 44931710.
Document (PDF) (813 KB PDF).
April 25, 2001. DER. 18 Page(s).
Virginia Dobozy. Reregistration Branch.
CGA-354743 (Metolachlor ESA)(Metabolite of Metolachlor); Subchronic Oral
Toxicity Feeding - Dog [OPPTS 870.3150 (Sec. 82-1b)]. MRID No. 44931709.
Document (PDF) (1137 KB PDF).
July 25, 2001. DER. 25 Page(s).
Ghazi Dannan. Registration Action Branch.
Metabolism - rat; [OPPTS 870.7485 (Sec. 85-1)]. MRID No. 44491402.
Registration data removed from pages 16-25.
Document (PDF) (1123 KB PDF).
December 04, 2001. Memorandum. 66 Page(s).
Virginia Dobozy. Reregistration Branch I HED.
Toxicology Chapter for Metolachlor/S-Metolachlor. PC Code: 108801/108800
DP Barcode: D274326.
Document (PDF) (2566 KB PDF).
January 29, 2002. Memorandum. 121 Page(s).
Mark Corbin. Environmental Risk Branch I.
Metolachlor TRED: Estimated Drinking Water Concentrations for Metolachlor & its
Degradation Products for Use in the Human Health Drinking...DP Barcodes D248805,
D228814, D258820, D258817, D258824, D258822,D258812, D259119, D259037 & D2590349.
Document (7420 KB PDF).
February 28, 2002. Memorandum. 126 Page(s).
Mark Corbin. Environmental Risk Branch.
Review of Documents Related to the Equivalency of Racemic Metolachlor
(Metolachlor) and S-Metolachlor for Environmental Fate and Ecotoxicity.
Document (5571 KB PDF).
February 28, 2002. Memorandum. 99 Page(s).
Sherrie Kinard. Reregistration Branch II.
Metolachlor/ S-Metolachlor Residue Chemistry Chapter for the Tolerance
Reassessment Eligibility Decision (TRED); PC Codes 108801 and 108800;
DP Barcode D274328; Case 0001.
Document (PDF) (3769 KB PDF).
February 28, 2002. Memorandum. 100 Page(s).
Sherrie Kinard. Reregistration Branch II.
S-Metolachlor. OPPTS 860.1520: Processed Food/Feed Study on/in Soybeans;
PC code 108800; Rereg. Case 0001; DP Barcode D280215; MRID No. 44516802.
Document (PDF) (3200 KB PDF).
May 22, 2002. Memorandum. 145 Page(s).
Mark Corbin. Environmental Fate & Ground Water Branch.
Revised Metolachlor/ S-Metolachlor TRED: Estimated Drinking Water Concentrations
for Metolachlor/ S-Metolachlor and its Degradation Products for Use in Human Health
Dietary Risk Assessment.
Document (PDF) (7795 KB PDF).
May 23, 2002. Memorandum. 16 Page(s).
Christine Jarvis. Reregistration Branch.
Metolachlor (PC Code 108801) & S-Metolachlor (PC Code 108800); HED's
Response to Comments Submitted During 30-Day Registrant Comment period.
DP Barcode D282607.
Document (PDF) (562 KB PDF).
March 10, 2003. Memorandum. 7 Page(s).
Mark Corbin. Environmental Risk Branch I.
Small-Scale Prospective Ground Water Monitoring Study for Herbicide S-Metolachlor
at a Worst-Case Vulnerable Site in the Midwestern United States.
DP Barcode D278934 MRID 45533101.
Document (PDF) (441 KB PDF).
August 15, 2003. Memorandum. 33 Page(s).
Sherrie Kinard. Reregistration Branch.
S-Metolachlor; Confined Accumulation in Rotational Crops; Lettuce, Radish & Wheat;
OPPTS 860.1850. MRID No. 45672302.
Document (PDF) (1132 KB PDF).
August 15, 2003. Memorandum. 98 Page(s).
Sherrie Kinard. Reregistration Branch II HED.
S-Metolachlor. Information Supporting the Assertion That the Metabolism
of s-Metolachlor is Essentially Similar as for the Racemic Mixture.
DP Barcode: D278742 and D279110 MRID Nos.: 45499603, -04, -05, 45533103.
Document (PDF) (4790 KB PDF).
June 03, 2004. DER. 15 Page(s).
Mark Corbin. Environmental Risk Branch I.
STUDY ID 46224201; 46224202. 2001 S-metolachlor Monitoring Data for Community Water
Systems in 29 States. 2002 S-metolachlor Monitoring Data for Community Water Systems in 43 States.
DP Barcode D301593. MRID Nos. 46224201 and 46224202.
Document (PDF) (978 KB PDF).
August 27, 2004. DER. 15 Page(s).
Douglas Dotson. Registration Action Branch 2.
DACO 7.4.1/OPPTS 861.1500/OECD IIA 6.3.1. 6.3.2, 6.3.3 and IIIA 8.3.1, 8.3.2. 8.3.3.
Crop Field Trial - Fruiting Vegetables Crop Group. S-Metolachlor-Magnitude of the Residues
In or On Representative Commodities of Crop Group 8...MRID No. 46046501.
Document (PDF) (778 KB PDF).
October 21, 2008. DER. 8 Pages.
Dennis McNeilly. RAB2.
S-Metolachlor/PC Code 108800/Sygenta Crop Protection, Inc.
DACO 7.4.5/OPPTS 860.1520/OECD IIA 6.5.4 and IIIA 8.5
Processed Food and Feed – Aspirated Grain Fractions (Sorghum).
DP Barcode 332848. MRID No. 46829503.
Document (PDF) (189 KB PDF).
October 21, 2008. DER. 9 Pages.
Dennis McNeilly. RAB2.
S-Metolachlor/PC Code 108800/Sygenta Crop Protection, Inc.
DACO 7.4.5/OPPTS 860.1520/OECD IIA 6.5.4 and IIIA 8.5
Processed Food and Feed – Aspirated Grain Fractions (Soybean).
DP Barcode 332847. MRID No. 46829502.
Document (PDF) (184 KB PDF).
October 21, 2008. DER. 16 Pages.
Dennis McNeilly. RAB2.
S-Metolachlor/PC Code 108800/Sygenta Crop Protection, Inc.
DACO 7.4.1/7.4.2/OPPTS 860.1500/OECD IIA 6.3.1, 6.3.2, 6.3.3 and IIIA 8.3.1, 8.3.2, 8.3.3
Corp Field Trial/Residue Decline - Corn, field. MRID No. 46829504.
Document (PDF) (1070 KB PDF).
October 21, 2008. DER. 13 Pages.
Dennis McNeilly. RAB2.
DACO 7.4.1/7.4.2/OPPTS 860.1500/OECD IIA 6.3.1,6.3.2,
6.3.3 and IIIA 8.3.1, 8.3.2, 8.3.3 Crop Field Trial/Residue Decline - Soybean.
MRID No. 47304702. DP Barcode No. 350942.
Document (PDF) (900 KB PDF).