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Index of Cleared Science Reviews for Trimethoxysilyl Quats (Pc Code 107401)
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Undated. Memorandum. 5 Page(s).
Ecological Effects Branch.
Acute Invertebrate Toxicity Data Requirement for Dow Corning 5700 Antimicrobial
Agent (107401). MRID No. 403852-15. Pages 2-5 removed, registrant data.
Document(PDF) (77 KB PDF).
July 01, 1974. Review. 2 Page(s).
John Shaughnessy. Chemistry Branch.
Full registration of XD-5700, a new chemical; non-food use. (34292-R).
Submitted 3-27-74. Manufacturing process information on page 1 not included.
Document(PDF) (184 KB PDF).
November 20, 1974. Review. 5 Page(s).
J. W. Akerman. Ecological Effects Branch.
3-(trimethoxysilyl)-propyl dimethyl octadecyl ammonium chloride.
Mammal LD50 and fish studies reviewed Reg. No. 34292-R.
Document(PDF) (640 KB PDF).
December 03, 1974. Review. 6 Page(s).
Robert Coberly. Toxicology Branch.
Registration No. 34292-R Product Name: X9-5700 Bacteriostat, Fungistat
and Algistat Acute tox, human repeated patch test, 28 day dermal rabbit.
Manufacturing process information on page 1 not included. Tox review 002486.
Document(PDF) (518 KB PDF).
December 31, 1974. Letter. 4 Page(s).
Douglas Campt. Registration Division.
X9-5700 Antimicrobial Agent EPA File Symbol No. 34292-R Application
of March 27, 1974 additional toxicity data required prior to registration.
Document(PDF) (204 KB PDF).
January 21, 1975. Meeting. 2 Page(s).
Robert Coberly. Toxicology Branch.
Meeting between Dow Corning Corporation and Tox Branch OPP Reg. No. 34292-R
Antimicrobial Agent X9-5700 toxicity data requirements.
Document(PDF) (114 KB PDF).
March 03, 1975. Review. 3 Page(s).
Robert F. Carsel. Efficacy & Ecological Effects Branch.
Environmental Chemistry review for 3-trimethoxysilyl-propyl- dimethyl-octadecyl
ammonium chloride (X5700) Reg. No. (File Symbol) 34292-R analytical method, leaching.
Document(PDF) (86 KB PDF).
May 05, 1975. Review. 5 Page(s).
D. Cook. Ecological Effects Branch.
3-(trimethoxysilyl)-propyl dimethyl octadecyl ammonium chloride (42%).
Mammal LD50 study reviewed. Reg. No. 34292-R. Page 5 removed, draft label.
Document(PDF) (988 KB PDF).
June 11, 1975. Review. 8 Page(s).
Robert Coberly. Toxicology Branch.
File Symbol 34292-R X9-5700 Bacteriostat, Fungistat and Algistat Dow Corning Corp.;
acute rat inhalation Manufacturing process info on pages 1, 4 not included.
Pages 5-8 removed, registrant data. ** Tox review 002487.
Document(PDF) (210 KB PDF).
April 23, 1976. Review. 2 Page(s).
Reto Engler. Toxicology Branch.
Registration Human Safety Review EPA #34292-1 TB objects to the registration of the..
use on socks primary eye irritation, human patch test, rabbit patch test, human wear test.
(MRID 59237).
Document(PDF) (241 KB PDF).
May 14, 1976. Review. 7 Page(s).
Doris Jean Jenkins. Efficacy & Ecological Effects Branch.
File or Reg. No. 34292-1 Review of additional use pattern and claim prior to formal
application for amended registration.
Document(PDF) (579 KB PDF).
May 27, 1976. Review. 2 Page(s).
A. Rathman. Chemistry Branch.
Dow Corning Q9 5700. EPA Reg. No. 34292-1 fabric treatment
Manufacturing process information on page 1 not included.
Document(PDF) (188 KB PDF).
June 02, 1976. Review. 1 Page(s).
Reto Engler. Toxicology Branch.
Registration of Dow Corning Q9 5700 for treatment of socks.
Registration No.: 34292-1 (amendment).
Document(PDF) (68 KB PDF).
June 04, 1976. Note. 3 Page(s).
EPA Office of Pesticide Programs.
Robert Underhill, Robert Becker on behalf of Burlington Industries and Dow Corning.
teratology and mutagenicity data needed.
Document(PDF) (2686 KB PDF).
July 29, 1976. Review. 1 Page(s).
Reto Engler. Toxicology Branch.
Protocol Review for Teratology and Mutagenicity Studies Registration Number 34292-1
teratogenicity protocol adequate, mutagenicity study is not acceptable.
Document(PDF) (31 KB PDF).
June 02, 1977. Review. 6 Page(s).
Doris Jean Jenkins. Efficacy & Ecological Effects Branch.
File or Reg. No. 34292-1 Submission of test protocol for comments
(efficacy and relation of bacterial numbers to sock odor).
Document(PDF) (362 KB PDF).
November 09, 1977. Review. 7 Page(s).
Doris Jean Jenkins. Efficacy & Ecological Effects Branch.
Comments regarding Dow Corning letter of 10/25/77 and Meeting of 10/13/77; Dow Corning
Antimicrobial Agent EPA No. 34292-1 bacteriostatic claim, inhibition of odor-causing bacteria.
Document(PDF) (682 KB PDF).
November 11, 1977. Review. 5 Page(s).
Dennis Guse. Efficacy & Ecological Effects Branch.
File or Reg. No. 34292-1 Amendment with data efficacy data relative to textile products.
Document(PDF) (241 KB PDF).
April 13, 1978. Review. 2 Page(s).
William Dykstra. Toxicology Branch.
Validation of IBT Studies (IBT No. F1905, IBT No. 601-04030, IBT No. 663-06493,
8533-10127, 8531-08440, 8533-10126) (MRID 29140, 104765, 58118, 84132, 67672).
Document(PDF) (71 KB PDF).
April 26, 1978. Review. 2 Page(s).
Carlos A. Rodriguez. Toxicology Branch.
Q9-5700 Antimicrobial Agent Registration No. 34292-1 Mutagenic, teratogenic studies.
IBT 8533-10127, 8533-10126. Manufacturing process information on page 1 not included.
Tox review 002488.
Document(PDF) (111 KB PDF).
July 06, 1978. Review. 8 Page(s).
Doris Jean Jenkins. Efficacy & Ecological Effects Branch.
EPA No. 34292-1 Amendment: Added use pattern and claims efficacy on finished,
end [textile] articles Accession 012092.
Document(PDF) (311 KB PDF).
July 06, 1978. Review. 9 Page(s).
Doris Jean Jenkins. Efficacy & Ecological Effects Branch.
File or Reg. No. 34292-1 Amendment: Added use pattern and claims bacteriostatic
preservative for unfinished textile (MRID 164910, 164913).
Document(PDF) (364 KB PDF).
August 11, 1978. Review. 20 Page(s).
Dennis Guse. Disinfectants Branch.
File or Reg. No. 34292-1 Amendment with data (use on carpets).
Pages 15-18 removed, registrant data. Acc # 232333, 232334, 232335.
Document(PDF) (938 KB PDF).
September 15, 1978. Review. 1 Page(s).
Efficacy and Ecological Effects Branch.
File or Reg. No. 34292-1 add a number of textile end-use items for rot and mildew
claims Accession 012092, 232335, 232336; letter of 8-1-78; application of 6-12-78.
Document(PDF) (31 KB PDF).
September 15, 1978. Review. 23 Page(s).
Dennis Guse. Efficacy & Ecological Effects Branch.
File or Reg. No. 34292-1 Amendment with data (new use on disposable hospital
surgical gowns and drapes) Acc. 233856 [sic].
Document(PDF) (886 KB PDF).
September 18, 1978. Review. 18 Page(s).
Doris Jean Jenkins. Efficacy & Ecological Effects Branch.
File or Reg. No. 34292-1 Application for amended registration, with data, to add claim
"the treatment is bacteriostatic and inhibits the growth of odor-causing bacteria on socks"
Accession 233246 [sic].
Document(PDF) (856 KB PDF).
March 21, 1979. Review. 10 Page(s).
Dennis Guse. Disinfectants Branch.
Technical Support Section Efficacy Review EPA Reg. No. or File Symbol 34292-1
Test protocol (control of odor-causing bacteria on outerwear).
Document(PDF) (456 KB PDF).
March 21, 1979. Review. 19 Page(s).
Dennis G. Guse. Disinfectants Branch.
Reg. No. 34292-1; Efficacy Review Testing Protocol (control of odor-causing bacteria on outerwear).
Document(PDF) (847 KB PDF).
March 26, 1979. Review. 4 Page(s).
Dennis Guse. Disinfectants Branch.
Technical Support Section Efficacy Review EPA Reg. No. or File Symbol 34292-1
Additional data "in support of all pending amended registrations" Accession 233247 [sic].
Document(PDF) (148 KB PDF).
April 03, 1979. Review. 7 Page(s).
Dennis Guse. Disinfectants Branch.
Technical Support Efficacy Review EPA Reg. No. or File Symbol 34292-1 Test
protocol (control of odor-causing bacteria on underwear).
Document(PDF) (289 KB PDF).
April 19, 1979. Memorandum. 3 Page(s).
M. Adrian Gross. Toxicology Branch.
Memorandum of Conference Dow Corning 5700 Antimicrobial Agent Data
requirements for a hazard assessment were discussed..
Document(PDF) (79 KB PDF).
May 07, 1979. Review. 6 Page(s).
Dennis Guse. Disinfectants Branch.
Technical Support Section Efficacy Review EPA Reg. No. or File Symbol 34292-1
Revised collateral labeling (Bulletin 19-022).
Document(PDF) (274 KB PDF).
May 10, 1979. Review. 5 Page(s).
Dennis Guse. Disinfectants Branch.
Technical Support Section Efficacy Review EPA Reg. No. or File Symbol 34292-1
Added durability data Accession 232332 [sic].
Document(PDF) (137 KB PDF).
May 11, 1979. Memorandum. 3 Page(s).
EPA Office of Pesticide Programs.
Data Requirement to Support Amended Registration EPA Reg. No. 34291-1 DC-5700
fabric treatment; dermal adsorption.
Document(PDF) (157 KB PDF).
May 11, 1979. Review. 7 Page(s).
Dennis Guse. Disinfectants Branch.
Technical Support Section Efficacy Review Amendment with data
(added use for treatment on bed sheets) Acc. 232336.
Document(PDF) (239 KB PDF).
May 14, 1979. Review. 8 Page(s).
Dennis G. Guse. Disinfectants Branch.
Reg. No. 34292-1. Efficacy Review Amendment with data
(added use to treat disposable polyurethane foam cushions for Lapidus Airfloat System).
Document(PDF) (273 KB PDF).
May 31, 1979. Letter. 2 Page(s).
Reto Engler. Disinfectants Branch.
RE: D.C. 5700 Antimicrobial Agent Reg. No. 34292-1 "adsorption study".
Document(PDF) (62 KB PDF).
January 18, 1980. Memorandum. 4 Page(s).
R. E. Landolt. Toxicology Branch.
(1) Durability of Dow Corning 5700 Antimicrobial Agent on Fabrics when Exposed to
Simulated Human Sweat (2) Mutagenicity Data Review.
Document(PDF) (237 KB PDF).
June 13, 1980. Memorandum. 3 Page(s).
Henry Spencer. Toxicology Branch.
Dow Corning 5700 Antimicrobial on Fabrics.
Inert ingredient information on page 1 is not included.
Document(PDF) (121 KB PDF).
October 14, 1980. Memorandum. 2 Page(s).
Henry Spencer. Toxicology Branch.
Comments to file on Dow Corning 5700 Antimicrobial Agent - Phone Conversation
10/8/80 Dow Corning submitted a proposed protocol on a subcutaneous absorption
study in rabbits for D.C. 5700.
Document(PDF) (56 KB PDF).
April 28, 1981. Review. 8 Page(s).
William Rabert. Ecological Effects Branch.
IBT Data Gap Evaluation Form.
Document(PDF) (545 KB PDF).
September 23, 1981. Memorandum. 1 Page(s).
Henry Spencer. Toxicology Branch.
DC 5700 Anitmicrobial Reg. No. 34292-1.
Document(PDF) (54 KB PDF).
February 01, 1982. Memorandum. 1 Page(s).
Richard Loranger. Residue Chemistry Branch.
EPA File No. 46620-R. Chemical identity of Requat Antimicrobial Liquid. determine
whether... identical or substantially similar to the a.i. in Dow Corning 5700
Antimicrobial Agent. Manufacturing process information on page 25 not included.
Document(PDF) (49 KB PDF).
March 08, 1982. Memorandum. 10 Page(s).
Henry Spencer. Toxicology Branch.
1. Registration of Dow Corning 5700 on fabrics. Reg #34292-1 2.
Review of Dermal Absorption study in rabbits. Tox review 001597.
Document(PDF) (190 KB PDF).
March 30, 1982. Memorandum. 9 Page(s).
Henry Spencer. Toxicology Branch.
Registration of Dow Corning 5700 on fabrics. Reg No. 34292-1
Review of Dermal Absorption study on rabbits.
Document(PDF) (341 KB PDF).
May 07, 1982. Review. 2 Page(s).
Laurence Chitlik. Toxicology Branch.
IBT Validation Report Registration No. 34292-1 IBT No. 8533-10127. Host-Mediated
Assay for Detection of Mutations Induced by TX-1347 (Test Species: Albino Rats).
Tox review 003209.
Document(PDF) (34 KB PDF).
May 26, 1982. Review. 2 Page(s).
Laurence Chitlik. Toxicology Branch.
IBT Validation Report Registration No. 34292-1 Three-week vaginal irritation study
with treated panty hose fabric (cotton and nylon) in beagle dogs. Tox review 002934.
Document(PDF) (36 KB PDF).
August 10, 1982. Review. 2 Page(s).
Laurence Chitlik. Toxicology Branch.
IBT Validation Report Registration No. 34292-1 IBT 8533-10126.
Teratogenic Study with TX 1348 in Albino Rats. May 6, 1977. Tox review 002935.
Document(PDF) (38 KB PDF).
August 16, 1982. Review. 2 Page(s).
Laurence Chitlik. Toxicology Branch.
IBT Validation Report Registration No. 34292-1 IBT F 1905.
Human Repeated-Insult Patch Test with TX-793. Tox review 002937.
Document(PDF) (35 KB PDF).
September 17, 1982. Review. 2 Page(s).
Laurence Chitlik. Toxicology Branch.
IBT Validation Report Registration No. 34292-1 IBT No. 601-04030. 28-Day Subacute
Dermal Toxicity Study with Treated Fabrics in Albino Rabbits. Tox review 002936.
Document(PDF) (35 KB PDF).
September 29, 1982. Memorandum. 3 Page(s).
Robert Jaeger. Toxicology Branch.
Dow Corning 5700 Antimicrobial Agent EPA Reg. No. 34292-1 Leaching study on 100% cotton
Caswell No. 892-B.
Document(PDF) (100 KB PDF).
June 30, 1983. Review. 1 Page(s).
Anna Skapars. Disinfectants Branch.
Chemistry Review EPA Reg. No. 34292-E 'Please submit the following chemistry data...'.
Document(PDF) (46 KB PDF).
July 01, 1983. Review. 4 Page(s).
James Wilson. Disinfectants Branch.
Technical Support Section Toxicology Review Reg. No. 34292-E Acc 250353.
Acute oral... New Application.
Document(PDF) (168 KB PDF).
November 07, 1983. Review. 2 Page(s).
Anna Skapars. Disinfectants Branch.
Chemistry Review - II Reg. No. 34292-E
Inert ingredient info on pages 1 and 2 not included.
Document(PDF) (209 KB PDF).
November 10, 1983. Review. 3 Page(s).
Henry Spencer. Toxicology Branch.
Need to replace IBT Studies. Reg. No. 34292-1 (Dow Corning 5700) additional IBT studies..
not required (ref 10/21/83 review).
Document(PDF) (116 KB PDF).
Attachment(s) Following:
Undated. Note.
EPA Office of Pesticide Programs.
Note to HED Reviewer IBT Studies Submitted for Dow Corning 5700 Antimicrobial
EPA Reg. No. 34292-1 certain data not pertinent to the product's use pattern.
*End of Attachments*
February 02, 1984. Review. 1 Page(s).
Anna Skapars. Registration Support Branch.
EPA Reg. No. or File Symbol 34292-E Deficiencies... in our letter Dec. 7, 1984
Items a through h have been submitted and are acceptable.
Document(PDF) (90 KB PDF).
July 03, 1984. Review. 1 Page(s).
Anna Skapars. Disinfectants Branch.
Chemistry Review - II Reg. No. 34292-3; Sylgard Antimicrobial Treatment.
Document(PDF) (52 KB PDF).
July 27, 1984. Review. 8 Page(s).
Dennis G. Guse. Disinfectants Branch.
Efficacy Review - I Reg. No. 34292-1 Proposed test protocol for self-sanitizing
activity against athlete's foot fungi. Page 3-6 removed, registrant data.
Document(PDF) (159 KB PDF).
August 14, 1984. Review. 1 Page(s).
Anna Skapars. Disinfectants Branch.
Chemistry Review - II Reg. No. 34292-3.
Document(PDF) (41 KB PDF).
February 20, 1985. Memorandum. 1 Page(s).
Anna Skapars. Disinfectants Branch.
Chemistry Review - II Reg. No. 34292-3
14-month storage and stability data... is acceptable.
Document(PDF) (41 KB PDF).
May 16, 1985. Memorandum. 4 Page(s).
Henry Spencer. Toxicology Branch.
Dow Corning 5700. Request for Additional New Uses for Dow Corning 5700
on Air Filters and Polyurethane Foam.
Document(PDF) (190 KB PDF).
May 17, 1985. Memorandum. 1 Page(s).
Henry Spencer. Toxicology Branch.
Dow Corning 5700. Request for Added New Use to Treat Premoistened
Disposable Towelettes or Tissue Wipes.
Document(PDF) (44 KB PDF).
September 18, 1985. Memorandum. 1 Page(s).
Henry Spencer. Toxicology Branch.
New-use Requested for DC 5772. EPA Registration No. 34292-2 premoistened
towellettes and tissue wipes.
Document(PDF) (57 KB PDF).
September 18, 1985. Memorandum. 2 Page(s).
Henry Spencer. Toxicology Branch.
New Use Requested for DC 5700 (Anti-Microbial Agent) EPA Reg. No. 34292-1
"additional uses... on disposable wiping cloths".
Document(PDF) (65 KB PDF).
December 10, 1985. Review. 3 Page(s).
Carl Grable. Fungicide-Herbicide Branch.
Efficacy Review File or Reg. No. 34292-1 and 34292-2 Add use as laundry additive.
Document(PDF) (243 KB PDF).
January 10, 1986. Review. 1 Page(s).
William Campbell. Disinfectants Branch.
File or Reg. No. 34292-1 and 34292-2 to amend the registrations to add laundry
additive as a new use.
Document(PDF) (32 KB PDF).
July 09, 1986. Memorandum. 2 Page(s).
Henry Spencer. Toxicology Branch.
Amended Registration - New Use and Amended Label Review of Dow Corning (DC) 5772
(72% ai, 12% methanol) EPA Registration No. 34291-2 - New Use Proposed: To Be Used
in Liquid Laundry Detergent Formaulations at Levels of 0.1 to 1.0% Active Ingredient.
Document(PDF) (80 KB PDF).
July 09, 1986. Memorandum. 2 Page(s).
Henry Spencer. Toxicology Branch.
Amended Registration - New Use of Dow Corning 5700 and Label Review, New use
Proposed: to be Used in Liquid Laundry Detergent Formulations at Levels of 0.1 to
1.0% Active Ingredient - EPA Registration No. 34292-1 (42% ai, 50% methanol).
Document(PDF) (79 KB PDF).
July 11, 1986. Memorandum. 2 Page(s).
Henry Spencer. Toxicology Branch.
Amended Registration - Technical Bulletin EPA Registration No. 34292-3 (Dow Corning
Sylgard Antimicrobial Treatment 42% ai in 50% methanol) - Amended Statement of Use.
Document(PDF) (70 KB PDF).
January 16, 1987. Memorandum. 2 Page(s).
Henry Spencer. Toxicology Branch.
Sylgard - Requested New Uses EPA Registration No. 34292-3 (Dow Corning Sylgard
Antimicrobial Treatment 42% ai in 50% Methanol) - Amended Statement of Use.
Document(PDF) (120 KB PDF).
March 04, 1987. Data Call In. 21 Page(s).
James Akerman. Registration Division.
Data Call-In Notice for Subchronic and Chronic Toxicological Data for Antimicrobial
Pesticide Active Ingredients.
Document(PDF) (758 KB PDF).
June 10, 1988. Review. 2 Page(s).
Srinivas Gowda. Disinfectants Branch.
Amendment to add residual self-sanitizing acitivity claims against athlete's foot fungi
for impregnated socks with efficacy data and proposed label. MRID No. 405173-01.
Document(PDF) (78 KB PDF).
July 28, 1988. Memorandum. 52 Page(s).
Henry Spencer. Toxicology Branch.
Evaluation of Option 1, Tier 1 Data Submitted to Satisfy Antimicrobial Registration of
Q9-DC5700 MRID 403852-01, -12, -13. Product impurity info on pages 17, 20 not included.
Pages 26-30, 40-49 removed, reg. data. Tox review 006796.
Document(PDF) (1459 KB PDF).
August 22, 1989. Memorandum. 7 Page(s).
Henry Spencer. Toxicology Branch.
Evaluation of Proposed New Use for the Antimicrobial DC 5700 (Sylgard)
new use for treatment of food storage areas.
Document(PDF) (425 KB PDF).
October 31, 1989. Letter. 4 Page(s).
Arthur A. Birdsall. Dow Corning.
Dow Corning Corp. Phase 2 Reregistration Response Trimethoxysilyl Quats Case No. 3148.
Document(PDF) (201 KB PDF).
January 05, 1990. Memorandum. 5 Page(s).
Henry Spencer. Toxicology Branch.
Review of 3 studies submitted: (a) Eye, (b) Skin Irritation and (c) Inhalation on Dow
Corning X-9-5700 to Fulfill Reregistration Requirements MRID Nos. 411578-01, -02, -03
Tox review 007667.
Document(PDF) (196 KB PDF).
May 16, 1990. Review. 9 Page(s).
Srinivas Gowda. Antimicrobial Branch.
Amendment to add residual self-sanitizing activity claims against athlete's foot fungi
for impregnated socks with efficacy data and proposed label. MRID No. 413911-01.
Pages 3-7 removed, registration data.
Document(PDF) (160 KB PDF).
May 24, 1990. Review. 1 Page(s).
Anna Skapars. Registration Support Branch.
EPA Reg. No. or File Symbol 34292-3 submit chemical identity of "Fonyl".
Document(PDF) (59 KB PDF).
July 17, 1990. Worksheet. 16 Page(s).
A. A. Birdsall. Dow Corning Corp.
Reregistration Phase 3 Chemical Response Worksheet for Trimethoxysilyl quats.
MRID No. 93218-00.
Document(PDF) (913 KB PDF).
July 10, 1991. Memorandum. 25 Page(s).
John Redden. Toxicology Branch.
3-(trimethoxysilyl)propyl dimethyl octadecyl ammonium chloride; 1. Range-Finding
Developmental Toxicity Study in Rats, and 2. Developmental Toxicity Study in Rats.
MRID Nos. 414380-02, and -03 Tox review 008446.
Document(PDF) (1109 KB PDF).
March 10, 1992. Review. 2 Page(s).
Alex Arce. Disinfectants Branch.
EPA Reg. No. 34292-1 Review of a skin sensitization study... MRID 421974-01.
Document(PDF) (120 KB PDF).
October 27, 1992. Memorandum. 3 Page(s).
John Redden. Toxicology Branch.
3-(Trimethoxysilyl)propyl diemthyl octadecyl ammonium chloride, the active ingredient
in Dow Corning antimicrobial products: 6(a) 2 data submission. MRID No. 423341-01.
Inert ingredient on page 2 not included.
Document(PDF) (233 KB PDF).
January 06, 1993. Review. 12 Page(s).
Sami Malak. Registration Support Branch.
Product Chemistry Review of a Reregistration Action for a Technical Grade Active
Ingredient Phase IV, Trimethoxysilyl Quats. MRID Nos. 932180-01C, 424565-01, & etc.
QCP info. deleted from page 5. Pages 8-12 deleted-Product manufacturing process, QCP.
Document(PDF) (1037 KB PDF).
February 23, 1993. Review. 5 Page(s).
P. A. Fenner-Crisp. Occupational & Residential Exposure Branch.
OREB Transmittal Sheet for Phase 4 Reviews Foliar residue dissipation,
soil residue dissipation, dermal exposure, inhalation exposure.
Document(PDF) (192 KB PDF).
February 26, 1993. Review. 4 Page(s).
John Redden. Toxicology Branch.
Phase Four Review "Note: this only contains additions and changes from the Phase 2 response."
MRID 93218011, 93218010, (Dupe of -11), 40385201 93218049, 42456511;
93218024, 42456512, 41339402..
Document(PDF) (370 KB PDF).
April 01, 1993. Memorandum. 2 Page(s).
John Redden. Toxicology Branch.
Dow Corning 5700 Hydrolysate: submission of compound purity for MRID Nos. 414380-02 and -03.
Page 2 removed, identity of product impurities and description of product manufacturing process.
Document(PDF) (100 KB PDF).
May 04, 1993. Memorandum. 18 Page(s).
Tom Bailey. Ecological Effects Branch.
Acute Fish Toxicity Data Requirement for Dow Corning 5700 Antimicrobial Agent (107401).
Pages 2-6, 17 removed, registration data. MRID 403852-17.
Document(PDF) (717 KB PDF).
May 06, 1993. Review. 7 Page(s).
Anthony Maciorowski. Ecological Effects Branch.
Phase IV: Identification of data requirements.
Document(PDF) (273 KB PDF).
July 29, 1993. Memorandum. 2 Page(s).
John Redden. Toxicology Branch.
Dow Corning 5700: Review of data package. Range-finding developmental toxicity study.
14 Day range- finding dermal study. Subchronic dermal toxicity in rats. Mutagenicity.
MRID 413394-01, 02, 03, 413533-01, 02.
Document(PDF) (134 KB PDF).
August 04, 1993. Rereg. Status. 32 Page(s).
Alan Dixon. EPA OPP.
Expedite; 72-Hour Review This DCI is being sent to you for 72-hour review
Pages 20-32 removed, registrant data.
Document(PDF) (515 KB PDF).
September 13, 1993. Memorandum. 71 Page(s).
John Redden. Toxicology Branch.
DC 5700 Hydrolysate: review of three mutagenicity studies and one range finding study.
Pages 15-24, 33-40, 56-71 removed, registrant data. MRID 41296801, -02, 03, 04.
Tox review 010556.
Document(PDF) (979 KB PDF).
February 09, 1994. Memorandum. 3 Page(s).
Winston Dang. Occupational & Residential Exposure Branch.
OCCUPATIONAL AND RESIDENTIAL EXPOSURE ASSESSMENT FOR 3-Trimethoxysilyl-propyl
-dimethyl-octadecyl ammonium chloride AND THE IMPURITIES DP Barcode: D198719.
Manufacturing process information on pages 2,3 not included.
Document(PDF) (153 KB PDF).
September 15, 1994. Memorandum. 40 Page(s).
Edwin Budd. Toxicology Branch.
EPA Reg. No. 34291-01; Dow Corning 5700 Antimicrobial Agent; 6(a)(2) Adverse Data Submission;
Review of Subchronic Inhalation Toxicity Study on Impurity Found in 5 Dow Corning Antimicrobial
Agents, All Containing 3-(Trimethoxysilyl)propyldimethyloctadecyl...
Document(PDF) (1218 KB PDF).
Attachment(s) Following:
September 15, 1994. Memorandum.
Edwin Budd. Toxicology Branch.
(continued) Ammonium Chloride as the Active Ingredient; Risk Assessment for Impurity.
DP Barcode D183975 Tox review 011212.
September 15, 1994. Memorandum.
Edwin Budd. Toxicology Branch.
(continued) Manufacturing process information on pages 1 through 8, 11, 12,19 not included.
Pages 21-28 removed, detailed review of data claimed confidential.
Pages 29-40 removed, registrant data.
*End of Attachments*
October 13, 1994. Memorandum. 28 Page(s).
Edwin Budd. Toxicology Branch.
EPA ID No. 34291-1; Dow Corning 5700 Antimicrobial Agent, Containing 3-(Trimethoxsilyl)..
as the Active Ingredient;... DP Barcode: D208081. MRID 41339401, -02, -03, 41353301, -02.
Tox review 011290. Pages 13-16, 23-28 removed, registration data.
Document(PDF) (535 KB PDF).
October 13, 1994. Memorandum. 5 Page(s).
Edwin Budd. Toxicology Branch.
EPA ID No. 107401-034292, reregistration Case # 3148; Dow Corning 5772 Antimicrobial Agent;..
Review of Acute Dermal Toxicity Study on Rabbits and Comment on Developmental Toxicity Study on Rats.
MRID No. 43219901 Tox review 011292.
Document(PDF) (177 KB PDF).
April 24, 1995. Review. 1 Page(s).
Linnea Hansen. Toxicology Branch.
TRIMETHOXXSILYL-PROPYL-DIMETHYL-OCTADECYL AMMONIUM CHLORIDE
and DIDECYL-N-METHYL-3-(TRIMETHOXYSILYL) PROPAMINIUM CHLORIDE.
Case no. 3148. Request to share data for these two chemicals.
(PC 107401 / 169160). Manufacturing process information not included.
Document(PDF) (40 KB PDF).
May 16, 1995. Review. 1 Page(s).
Linnea Hansen. Toxicology Branch.
Didecyl-N-methyl-3-(trimethoxysilyl) propaminium chloride. Case no. 3148. Request to
bridge data for this chemical (169160) using data for 107401... Minor use low volume
waiver request for developmental and mutagenicity studies. MP info. Deleted.
Document(PDF) (60 KB PDF).
June 16, 1995. Memorandum. 14 Page(s).
Aubry Dupuy. Biological & Economic Analysis Division.
DC-5772 (Anti-Microbial Agent) Method Review Summary - Report No. ECM 0059W1
hydrolysis analytical method Manufacturing process information on page 10 not included.
Document(PDF) (531 KB PDF).
Attachment(s) Following:
March 05, 1996. Letter.
Jay Ellenberger. Accelerated Reregistration Branch.
Review of submission for Case 3148, A. I. 107401, Dow Corning 5772 Antimicrobial Agent.
Analytical Method, "Hydrolysis of DC-5772 as a Function ofpH".
*End of Attachments*
October 29, 1996. Review. 2 Page(s).
Anna Skapars. Risk Assessment & Science Support Branch.
Product Chemistry Review DP Barcode D230843. Reg. No. or File Symbol 70087-R.
Document(PDF) (171 KB PDF).
December 03, 1996. Memorandum. 3 Page(s).
Kathleen Depukat. Accelerated Reregistration Branch SRRD.
Case 3148, Trimethoxsilyl Quats Status of Reregistration Requirements hydrolysis
MRID 43578601.
Document(PDF) (127 KB PDF).
February 26, 1997. Review. 5 Page(s).
Anna Skapars. Risk Assessment & Science Support Branch.
Product Chemistry Review DP Barcode D233225. Reg. No. or File Symbol 70087-R
product chemistry data, no MRID, dated 12-6-96 Guideline Series 61, 62 and 63.
Document(PDF) (332 KB PDF).
March 24, 1997. Review. 1 Page(s).
Anna Skapars. Risk Assessment & Science Support Branch.
Product Chemistry Review DP Barcode D234689. Reg. No. or File Symbol 4822-UIU
chemical identity of fragrance.
Document(PDF) (64 KB PDF).
April 24, 1997. Review. 1 Page(s).
Anna Skapars. Risk Assessment & Science Support Branch.
EPA Reg. No. or File Symbol 70087-R storage stability. DP Barcode: D235097
Document(PDF) (73 KB PDF).
May 08, 1997. Review. 1 Page(s).
Anna Skapars. Risk Assessment & Science Support Branch.
Product Chemistry Review of DP Barcode D235100; Reg. No. or File Symbol No. 4822-UIU
chemical identity of perfume Inert ingredient info on page 1 not included.
Document(PDF) (83 KB PDF).
May 08, 1997. Review. 1 Page(s).
Anna Skapars. Risk Assessment & Science Support Branch.
Product Chemistry Review of DP Barcode D235202; Reg. No. or File Symbol No. 4822-UIU
product chemistry and composition for fragrance Inert ingredient info on page 1 not included.
Document(PDF) (89 KB PDF).
June 11, 1997. Review. 1 Page(s).
Anna Skapars. Risk Assessment & Science Support Branch.
EPA Reg. No. or File Symbol 70871-R. DP Barcode D236248.
repackaging manufacturing use product 70871-E.
Document(PDF) (89 KB PDF).
June 11, 1997. Review. 6 Page(s).
Anna Skapars. Risk Assessment & Science Support Branch.
Product Chemistry Review DP Barcode D236247; Reg. No. or File Symbol 70871-E
Inert ingredient info on page 1 not included. MRID 44279401 thru -04.
Document(PDF) (247 KB PDF).
June 12, 1997. Review. 1 Page(s).
Anna Skapars. Risk Assessment & Science Support Branch.
Product Chemistry Review EPA Reg. No. or File Symbol 70087-R.
Inert ingredient info on page 1 not included.
Document(PDF) (47 KB PDF).
June 16, 1997. Review. 4 Page(s).
Srinivas Gowda. Risk Assessment & Science Support Branch.
EPA Reg. No. or File Symbol 4822-UIU New application with efficacy data and proposed label.
MRID 44186009 to 44186016.
Document(PDF) (140 KB PDF).
June 19, 1997. Letter. 2 Page(s).
Walter Waldrop. Reregistration Branch III.
Mr. Plinio Goes, Dow Corning Corp. Case 3148, Trimethoxsilyl Quats, A.I. 107401
Status of Environmental Fate and Ecological Effects Data Requirements.
Document(PDF) (53 KB PDF).
July 08, 1997. Review. 2 Page(s).
Srinivas Gowda. Risk Assessment & Science Support Branch.
EPA Reg. No. or File Symbol 4822-UIU Resubmission of residual self-sanitizing
data in response to Agency letter dated June 20 1997 MRID 44186014.
Document(PDF) (205 KB PDF).
September 02, 1997. Memorandum. 3 Page(s).
Wallace Powell. Risk Assessment & Science Support Branch.
Bioshield AM 500 I, EPA File Symbol 70871-E Data Package D236250 a request for waiver
of all product acute toxicity testing Inert ingredient info on pages 1 and 2 not included.
Product ingredient source info on pages 1,2,3 not included.
Document(PDF) (191 KB PDF).
October 06, 1997. Review. 1 Page(s).
Wanda Jakob. Risk Assessment & Science Support Branch.
Product Chemistry Review of: DP Barcode: D238628 Reg. No. or File Symbol: 70871-E
product chemistry Guidelines 62-1, 62-2, 62-3.
Document(PDF) (68 KB PDF).
October 22, 1997. Review. 1 Page(s).
Anna Skapars. Risk Assessment & Science Support Branch.
DP Barcode D239767. Reg. No. or File Symbol 70871-G product chemistry.
MRID 44376001, -02, -03.
Document(PDF) (113 KB PDF).
October 23, 1997. Review. 1 Page(s).
Anna Skapars. Risk Assessment & Science Support Branch.
Product Chemistry Review DP Barcode D239759. Reg. No. or File Symbol 70871-L.
MRID 44379401, 02, 03.
Document(PDF) (150 KB PDF).
November 28, 1997. Review. 5 Page(s).
A. Najm Shamim. Risk Assessment & Science Support Branch.
Product Chemistry Review of End-Use Product BST Protectant 50 DP Barcode No: D239763
MRID 44376201, -02, -03.
Document(PDF) (280 KB PDF).
December 04, 1997. Memorandum. 3 Page(s).
Timothy McMahon. Risk Assessment & Science Support Branch.
3-Trimethoxxsilyl-propyl-dimethyl-octadecyl ammonium chloride: review of a data waiver
request BST Mold and Mildew Remover and All Purpose Cleaner 25 DP Barcode: D239858.
Document(PDF) (251 KB PDF).
January 13, 1998. Memorandum. 4 Page(s).
Wallace Powell. Risk Assessment & Science Support Branch.
BST Protectant Concentrate C15 EPA File Symbol 70871-G Data Package D239768
a request for waivers Product ingredient source info on page 3 not included.
Document(PDF) (207 KB PDF).
February 05, 1998. Review. 5 Page(s).
Anna Skapars. Risk Assessment & Science Support Branch.
Product Chemistry Review DP Barcode D240665; Reg. No. or File Symbol 70871-R
registration of a new product MRID 44279402, -03, -04.
Document(PDF) (395 KB PDF).
March 26, 1998. Review. 1 Page(s).
Srinivas Gowda. Risk Assessment & Science Support Branch.
Product Chemistry Review DP Barcode D242535. Reg. No. 70087-R application for
registration of a new product.
Document(PDF) (68 KB PDF).
August 07, 1998. Memorandum. 3 Page(s).
Ian Blackwell. Efficacy & Science Support Branch.
Acute Toxicity Review for EPA Reg. No.: 70871-R, 70871-E DP Barcode: D246360,
D246364 primary eye irritation. MRID 44553501.
Document(PDF) (135 KB PDF).
August 31, 1998. Memorandum. 3 Page(s).
Ian Blackwell. Efficacy & Science Support Branch.
Acute Toxicity Review for EPA Reg. No.: 70871-R, 70871-E. DP Barcode: D246360, D246364
Manufacturing process information on page 2 not included. MRID 42197401, dermal sensitization.
Data waiver request.
Document(PDF) (216 KB PDF).
July 13, 1999. Memorandum. 4 Page(s).
Wallace Powell. Efficacy & Science Support Branch.
D256959 BST Protectant 50, Product No. 70871-U primary eye irritation;
other acute toxicity data cited. MRID 44789801.
Document(PDF) (356 KB PDF).
July 13, 1999. Memorandum. 5 Page(s).
Wallace Powell. Efficacy & Science Support Branch.
D255210 BST Protectant Concentrate C15, Product No. 70871-G primary eye irritation;
other acute toxicity cited. MRID 44789901.
Document(PDF) (541 KB PDF).
July 15, 1999. Memorandum. 2 Page(s).
Timothy McMahon. Risk Assessment & Science Support Branch.
3-Trimethoxxsilyl-propyl-dimethyl-octadecyl ammonium chloride (Bioshield AM 500):
Review of data requirements for residential use. DP Barcode: D256888.
Document(PDF) (163 KB PDF).
October 06, 1999. Review. 4 Page(s).
Alex Traska. Product Science Branch AD.
Product Chemistry Review of Bioshield AMS 1860. DP Barcode D258500;
Reg. No.or File Symbol 70871-RE new product registration, "me too".
Manufacturing process information on pages 2, 3 not included.
Document(PDF) (190 KB PDF).
November 23, 1999. Memorandum. 4 Page(s).
Wallace Powell. Product Science Branch AD.
BST Protectant 75 EPA File Symbol 70871-L Data Package D254692 Bioshield Technologies
has cited studies for acute toxicity. Inert ingredient info on pages 2 and 3 not included.
Document(PDF) (586 KB PDF).
November 29, 1999. Memorandum. 5 Page(s).
John W. Newland. Product Science Branch.
Efficacy Label Review for BST Protectant 75, EPA Reg. No. 70871-L.
DP Barcode: D254818.
Document(PDF) (47 KB PDF).
December 06, 1999. Memorandum. 5 Page(s).
Doreen Aviado. Risk Assessment & Science Support Branch.
Human Exposure Considerations Human Exposure Assessment for BIOSHIELD AM 500
Microbistatic Agent Containing the Active Ingredient Trimethoxxsilyl-propyl-
dimethyl-octadecyl ammonium chloride. DP Barcode D256889.
Ingredient source info on 2 not included.
Document(PDF) (548 KB PDF).
December 06, 1999. Memorandum. 7 Page(s).
Timothy McMahon. Risk Assessment & Science Support Branch.
3-Trimethoxxsilyl-propyl-dimethyl-octadecyl ammonium chloride (Bioshield AM 500):
Non-dietary risk assessment. DP Barcode: D260609.
Document(PDF) (568 KB PDF).
December 30, 1999. Review. 2 Page(s).
Alex Traska. Product Science Branch AD.
Product Chemistry Review of BioShield BSTI 1860. DP Barcode: D261410.
Reg. No. or File Symbol: 70871-RE registrant responded to Agency letter dated 9/30/99.
MRID 44972401.
Document(PDF) (99 KB PDF).
January 18, 2000. Memorandum. 20 Page(s).
Michele Wingfield. Product Science Branch AD.
Efficacy Label Review for BD1, EPA Reg. No. 4822-484. DP Barcode: D261295
residual efficacy claim. Inert ingredient info on pages 13 and 19 not included.
Document(PDF) (964 KB PDF).
Attachment(s) Following:
March 24, 1997. Review.
Anna Skapars. Registration Support Branch.
Product Chemistry Review of: DP Barcode D234689; Reg. No. or File Symbol No. 4822-UIU
application for registration of new product.
May 08, 1997. Review.
Anna Skapars. Registration Support Branch.
Product Chemistry Review of DP Barcode D235100; Reg. No. or File Symbol No. 4822-UIU
chemical identity of perfume.
May 08, 1997. Review.
Anna Skapars. Registration Support Branch.
Product Chemistry Review of DP Barcode D235202; Reg. No. or File Symbol No. 4822-UIU
product chemistry and composition for fragrance.
June 13, 1997. Memorandum.
Timothy McMahon. Antimicrobials Division.
Raid BD493: Review of Acute Toxicity Data Submitted by the Registrant.
DP Barcode: D235923 MRID 44186004 through -08, 44218901.
June 16, 1997. Review.
Srinivas Gowda. Risk Assessment & Science Support Branch.
EPA Reg. No. or File Symbol 4822-UIU New application with efficacy data
and proposed label MRID 44186009 to -16.
July 08, 1997. Review.
Srinivas Gowda. Risk Assessment & Science Support Branch.
EPA Reg. No. or File Symbol 4822-UIU Resubmission of residual self-sanitizing
data in response to Agency letter dated Jun 20 1997 MRID 44186014.
January 27, 1998. Review.
Ibrahim Barsoum. Antimicrobials Division.
Efficacy Review EPA Reg. No.: 4822-484 DP Barcode D249784
MRID 44649601, -02, -03.
*End of Attachments*
February 02, 2000. Memorandum. 7 Page(s).
Timothy McMahon. Risk Assessment & Science Support Branch.
3-(Trimethoxysilyl) propyl dimethyl octadecyl ammonium chloride
(AEM 5700 Antimicrobial): Risk Characterization for non-food use.
Document(PDF) (468 KB PDF).
August 09, 2000. Memorandum. 33 Page(s).
Ian Blackwell. Product Science Branch.
Acute Toxicity Review for EPA Reg. No. 70871-RG/AM3651PI. DP Barcode: D266606.
MRID Nos. 451213-03 thru 08.
Document(PDF) (1318 KB PDF).
August 16, 2000. Review. 5 Page(s).
Anna Skapars. Efficacy & Science Support Branch.
Product Chemistry Review. DP Barcode D266605. Reg. No. or File Symbol 70871-RG.
MRID 45121301, 45121302.
Document(PDF) (311 KB PDF).
August 18, 2000. Review. 2 Page(s).
Anna Skapars. Product Science Branch.
Product Chemistry Review DP Barcode D266605 Reg. No. or File Symbol 70871-RG
All product chemistry data for this product is adequate. MRID 45121301, 45121302.
Document(PDF) (94 KB PDF).
January 18, 2001. Memorandum. 3 Page(s).
Siroos Mostaghimi. Risk Assessment & Science Support Branch.
Review of the proposed uses of Bioshield AM 500 as material preservative on dried
latex paints and in can paints. DP Barcode: D270623 and D270618.
Document(PDF) (142 KB PDF).
June 04, 2001. Memorandum. 5 Page(s).
Nancy Whyte. Product Science Branch.
Efficacy Review EPA Reg. No. 70871-RL AM 3651 P; DP Barcode: D273615.
MRID Nos. 45347601 & -02.
Document(PDF) (204 KB PDF).
June 08, 2001. Review. 8 Page(s).
Nancy Whyte. Product Science Branch AD.
Product chemistry review of: AM 3651P. DP Barcode: 273613; Reg. No.: 70871-RL.
MRID 44885901, 44972401, 45121301, -02, 44876601, (45245701, -02 [sic]).
Document(PDF) (698 KB PDF).
February 28, 2003. Review. 2 Page(s).
Chris Jiang. Product Science Branch AD.
Product chemistry and acute toxicity review of: AM-7 Antimicrobial
DP Barcode: D287377 and D287378; Reg. No.: 48737-R.
Manufacturing process information on page 2 not included. MRID 45810101, -02, -03.
Document(PDF) (94 KB PDF).
May 21, 2003. Review. 2 Page(s).
Chris Jiang. Product Science Branch AD.
Product chemistry review for: AM-7 Antimicrobial DP Barcode: D290189
The registrant submitted a rebuttal to chemistry review D287377, D287378.
Manu. process info on page 2 not included.
Document(PDF) (73 KB PDF).
August 14, 2003. Review. 3 Page(s).
Bipin Gandhi. Product Science Branch AD.
Product Chemistry Review of: SIS AM500. DP Barcode: 292204; Reg. No. 75174-E.
Inert and manufacturing process info on page 2 not included. MRID 46023001, -02, -03.
Document(PDF) (89 KB PDF).
October 20, 2003. Review. 6 Page(s).
Robert Turpin. Product Science Branch AD.
Product Chemistry Review of: Miltrol. DP Barcode: D294150; Reg. No. or File Symbol: 79652-R.
Inert and manufacturing process info on page 2 not included.
MRID 46054801, -02, -03.
Document(PDF) (376 KB PDF).
January 29, 2004. Review. 3 Page(s).
Alex Traska. Product Science Branch AD.
Product Chemistry Review of Bioshield AM 3651PI. DP Barcode: D297616.
Reg. No. or File Symbol: 75497-7 re-submission... in support of declaring
"trimethoxxsilyl" as component of the active ingredient of the product as packaged and sold.
Document(PDF) (159 KB PDF).
February 24, 2004. Review. 2 Page(s).
Robert Turpin. Product Science Branch AD.
Product Chemistry review of: Miltrol. DP Barcode: D298577; Reg. No. or File Symbol: 79652-R
revised confidential statement of formula. Inert ingredient and source info on page 2 not included.
Document(PDF) (174 KB PDF).
September 07, 2004. Review. 2 Page(s).
Robert Turpin. Product Science Branch AD.
Product Chemistry Review of: Miltrol DP Barcode: D305848 Reg. No. or File Symbol: 79652-R.
MRID 46279601.
Document(PDF) (129 KB PDF).
November 15, 2005. Review. 2 Page(s).
Mark Suarez. Insecticides Branch.
EPA Reg. No. 79652-1. Product Name: Miltrol efficacy on dust mites. MRID 46579201.
Document(PDF) (187 KB PDF).
January 27, 2006. Review. 8 Page(s).
Juan Negron. Product Science Branch AD.
Product Chemistry Review of: SiShield Technologies, Inc. DP Barcode: D324179
Reg. No. or File Symbol 75174-U Manufacturing process information on pages 2, 3 not included.
Inert info on page 3 not included. MRID 46682901, -02, -03.
Document(PDF) (300 KB PDF).
February 08, 2006. Note to Jacket. 1 Page(s).
Tracy Lantz. EPA OPP.
75174-U. "I received a chemistry review.. . dated 2/1/06. Dennis and I discussed
deficiencies identified in the recommendations section of this review...".
Inert and manufacturing process info on page 1 not included.
Document(PDF) (54 KB PDF).
February 27, 2006. Memorandum. 16 Page(s).
Ian Blackwell. Product Science Branch AD.
Acute Toxicity Review EPA Reg. No. 64881-A/ Aegis 444-02 RTU DP Barcode: D324457
MRID 46693803 thru -08. *document has no page 17.
Document(PDF) (320 KB PDF).
March 10, 2006. Review. 7 Pages.
Chris Jiang. Product Science Branch.
PRODUCT CHEMISTRY REVIEW OF: Aegis 444-02 RTU Antimicrobial. DP Barcode: D324449.
Reg. No. Or File Symbol: 64881-A. TGAl\MUP [] Or End-use Product [X].
MRID Nos. 46693801 & 46693802. Inert ingredient information on page 2 is deleted.
Document(PDF) (166 KB PDF).
March 28, 2006. Review. 3 Page(s).
Chris Jiang. Product Science Branch AD.
Product Chemistry Review of: Nanoguard. DP Barcode: D326031.
Reg. No. or File Symbol: 82077-R. MRID 46731001, -02, -03.
Document(PDF) (118 KB PDF).
April 13, 2006. Review. 4 Page(s).
Juan Negron. Product Science Branch AD.
DP Barcode: D327271. Subject: SIS 7200. Reg. No. or File Symbol: 75174-U.
Inert ingredient info on page 3 not included.
Document(PDF) (237 KB PDF).
May 30, 2006. Review. 3 Page(s).
Chris Jiang. Product Science Branch AD.
DP Barcode: D324449 MRID: Follow-up response to March 10 review.
Reg. No. or File Symbol: 64881-A (MRID 46693801, -02).
Document(PDF) (360 KB PDF).