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Index of Cleared Science Reviews for Oryzalin (Pc Code 104201)

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July 29, 1977. Memorandum. 1 Page(s).
Special Registrations Officer. Registration Division.
Nitrosamine Generators.
Document (PDF) (51 KB PDF).

January 07, 1981. Memorandum. 8 Page(s).
Mary Quaife. Toxicology Branch.
Oryzalin, TB/HED Evaluation of 2-Year Feeding/Oncogenicity Study in the Rat,
Submitted in Support of Requested Tolerances at 0.05 ppm on Certain Fruits/Nuts.
Manufacturing process info on pages 1-2, and 7 not included.
Tox review 000959. Acc. Nos. 09951.
Document (PDF) (723 KB PDF).

January 23, 1981. Memorandum. 1 Page(s).
Mary Quaife. Toxicology Branch.
Oryzalin... TB/HED Evaluations of Requested Tolerances on Citrus, Pome
and Small Fruits; Stone Fruits; Nuts; Avocado; Kiwi; Olive; Pomegranates;
Pistachios; Figs; Almond Hulls at 0.05 ppm.
Document (PDF) (85 KB PDF).

January 23, 1981. Memorandum. 10 Page(s).
Mary Quaife. Toxicology Branch.
Oryzalin, TB/HED Review of Rat Reproduction, Rat Dominant Lethal, and Bacterial
Mutagenic Studies Submitted in Support of PP No. 6F1859, Accession No. 241742.
Manufacturing process information on pages 1-3, 5-6, and 9-10 is not included.
Document (PDF) (782 KB PDF).

February 03, 1981. Memorandum. 2 Page(s).
P. V. Errico. Residue Chemistry Branch.
PP #8E2075. Oryzalin in/on Sweet Potatoes. Amendment of 9/5/80.
Document (PDF) (168 KB PDF).

March 18, 1981. Memorandum. 1 Page(s).
Mary Quaife. Toxicology Branch.
Oryzalin, 2-Year Rat Studies on, Tables of Skin and Thyroid Tumor Incidence
(Dated 2/25/81) from Eli Lilly Co. Defects in and Request for New Ones.
Document (PDF) (60 KB PDF).

April 14, 1981. Memorandum. 1 Page(s).
Mary Quaife. Toxicology Branch.
Oryzalin, Request for Petitioner to Supply References (Journal Articles or Book Excerpts)
Cited in the 2-Year Rat Feeding Study Report (Accession No. 099517).
Document (PDF) (39 KB PDF).

June 12, 1981. Memorandum. 15 Page(s).
Mary Quaife. Toxicology Branch.
TB/HED Comments on Eli Lilly Responses of 3/6/81 and 2/24/81 to the EPA Letter of 2/4/81
to Lilly, Oryzalin (Surflan). Quality control procedure and manufacturing process info
on pages 3, 11, and 12 are not included. Tox review 000961.
Document (PDF) (1175 KB PDF).

October 22, 1981. Memorandum. 5 Page(s).
Mary Quaife. Toxicology Branch.
Oryzalin, Mouse Oncogenicity/Chronic Study on, TB/HED
Evaluation of Accession Numbers 244746, 244747, 244748.
Product impurity information on page 2 is not included.
Document (PDF) (350 KB PDF).

November 17, 1981. Memorandum. 4 Page(s).
R. Bruce Jaeger. Toxicology Branch.
Oryzalin; Request for Tolerance at 0.05 ppm on Peas. PP #9E2219,
Amendment of 9/9/80, from IR-4, Rutgers University, New Brunswich, New Jersey.
Document (PDF) (178 KB PDF).
Attachment(s) Following:

September 01, 1981. Memorandum.
Mary Quaife. Toxicology Branch.
Oryzalin, PP Nos. 8E2075 and 9E2219, Comment on
Proposed Federal Register (FR) Document by TB/HED.

October 19, 1981. Memorandum.
Robert Jaeger. Toxicology Branch.
Proposed Rule - Tolerance for Oryzalin on Sweet Potatoes and Peas
(PP #8E2075/9E2219).

*End of Attachments*

November 27, 1981. Memorandum. 1 Page(s).
R. B. Jaeger. Toxicology Branch.
Oryzalin - Miscellaneous Data, Additional Information (Teratology Study in Rabbits);
EPA Reg. No. 1471-100.
Document (PDF) (50 KB PDF).

December 17, 1981. Memorandum. 4 Page(s).
Mary Quaife. Toxicology Branch.
Effect of Oryzalin on DNA Repair, TB/HED Comment on.
Pages 2-4 are not included - registrant data.
Document (PDF) (124 KB PDF).

January 11, 1982. Memorandum. 1 Page(s).
Mary Quaife. Toxicology Branch.
Oryzalin Metabolism Studies, Accession No. 246113, 10/22/81, TB/HED Comments on.
Document (PDF) (68 KB PDF).

January 11, 1982. Memorandum. 1 Page(s).
Mary Quaife. Toxicology Branch.
Oryzalin, Skin Absorption by Monkeys, Proposed Study Protocol, TB/HED Comment on.
Document (PDF) (64 KB PDF).

January 11, 1982. Memorandum. 1 Page(s).
Mary Quaife. Toxicology Branch.
TB/HED Comment on E. Lilly Letter, Oryzalin, 10/22/81, Hill - Taylor.
Document (PDF) (72 KB PDF).

January 15, 1982. Memorandum. 1 Page(s).
R. Bruce Jaeger. Toxicology Branch.
Oryzalin, EPA Reg. No. 1471-100, 6(a)(2) Data Submission - Mutagenicity Studies.
Caswell No. 623A.
Document (PDF) (615 KB PDF).
Attachment(s) Following:

January 15, 1982. Memorandum. 10 Page(s).
Irving Mauer. Toxicology Branch.
Oryzalin EL-119, Lilly Compound 67019:
Review and Evaluation of Genetic Toxicology Studies for Registration.
Product impurity information on pages 3 and 5 is not included.

*End of Attachments*

March 12, 1982. Memorandum. 8 Page(s).
Bertram Litt. Toxicology Branch.
Carcinogenicity/Oncogenicity Assessment of Oryzalin.
Document (PDF) (575 KB PDF).

March 24, 1982. Memorandum. 9 Page(s).
Bertram Litt. Toxicology Branch.
Carcinogenicity/Oncogenicity Assessment of Oryzalin 'Surflan'
Re: Lilly 2-Year Rat Feeding Study R167 & R177; Permanent Tolerance Action 6F1859;
Registration #1471-96 & 1471-112.
Document (PDF) (370 KB PDF).

June 29, 1982. Review. 2 Page(s).
Samuel Creeger. Environmental Fate Branch.
Review Percutaneous Absorption in Monkeys.
Document (PDF) (51 KB PDF).

July 29, 1982. Review. 6 Page(s).
Maxie Jo Nelson. Residue Chemistry Branch.
Petition Review Quick Form - Potatoes - 0.1 ppm.
Product impurity information on pages 2 and 5 is not included.
Document (PDF) (311 KB PDF).

August 03, 1982. Review. 6 Page(s).
Maxie Nelson. Residue Chemistry Branch.
Petition Review Quick Form - Peppermint and Spearmint Hays (0.05 ppm) and Oils
(0.1 ppm - Fat). Product impurity information on pages 2 and 5 is not included.
Document (PDF) (302 KB PDF).

August 04, 1982. Memorandum. 6 Page(s).
Robert Jaeger. Toxicology Branch.
Oryzalin; Replicated Rabbit Teratology Study; Percutaneous Absorption of
14C-Oryzalin in Monkeys; EPA Reg. Nos. 1471-96 and 1471-112. Caswell No. 623A.
Document (PDF) (249 KB PDF).

August 23, 1982. Memorandum. 2 Page(s).
R. Bruce Jaeger. Toxicology Branch.
Oryzalin; 3rd Species Teratology Considerations; TMRC Analysis. Caswell No. 623A.
Document (PDF) (115 KB PDF).

September 01, 1982. Review. 2 Page(s).
Robert Jaeger. Toxicology Branch.
0.05 ppm Oryzalin in or on Peppermint Hay and Spearmint Hay;
0.1 ppm Oryzalin in or on Peppermint Oil and Spearmint Oil.
Document (PDF) (126 KB PDF).

September 01, 1982. Review. 2 Page(s).
Robert Jaeger. Toxicology Branch.
0.1 ppm Oryzalin in or on Potatoes.
Document (PDF) (124 KB PDF).

December 09, 1982. Memorandum. 1 Page(s).
M. Nelson. Residue Chemistry Branch.
PP #2F2717. Oryzalin in or on Potatoes.
Amendment of 10/19/82 (Revised Section F).
Document (PDF) (46 KB PDF).

December 14, 1982. Review. 2 Page(s).
Robert Jaeger. Toxicology Branch.
Revised Section F - 0.05 ppm in or on Potatoes.
Document (PDF) (98 KB PDF).

January 07, 1983. Memorandum. 2 Page(s).
Robert Jaeger. Toxicology Branch.
Oryzalin - Metabolism Data.
Document (PDF) (77 KB PDF).

July 13, 1983. Memorandum. 8 Page(s).
John Chen. Toxicology Branch.
Oryzalin; Request for Permanent Tolerance at 0.05 ppm on Wheat and Barley Grain.
PP #3F2874; Accession No. 071520.
Document (PDF) (383 KB PDF).

September 23, 1983. Memorandum. 1 Page(s).
John Chen. Toxicology Branch.
Oryzalin 1471-96/1471-112: Review of the Study on Exposure of Field Workers to
Oryzalin During Application of Surflan 75W for Weed Control in Trees and Vines.
Accession No. 250136; Caswell No. 623A.
Document (PDF) (53 KB PDF).

November 18, 1983. Memorandum. 13 Page(s).
M. Nelson. Residue Chemistry Branch.
PP #3F2874. Oryzalin in or on Wheat and Barley. Evaluation of Analytical Methodology
and Residue Data. Product impurity information on pages 1 and 6 is not included.
Document (PDF) (750 KB PDF).

December 01, 1983. Memorandum. 3 Page(s).
John Chen. Toxicology Branch.
Oryzalin 1471-96/1471-112: Registrant's Reply to the Previous TB
Review Comments Concerning the Rat Dominant Lethal Study with Oryzalin.
Accession No. 248616.
Document (PDF) (125 KB PDF).

March 07, 1984. Memorandum. 6 Page(s).
M. Nelson. Residue Chemistry Branch.
PP #3F2874. Oryzalin in or on Wheat and Barley.
Amendment of 12/15/83; Accession No. 072238.
Document (PDF) (328 KB PDF).

March 28, 1984. Memorandum. 2 Page(s).
David Ritter. Toxicology Branch.
PP #3F2874 - Proposal to Establish Tolerances of 0.05 ppm Oryzalin on Barley and Wheat.
Document (PDF) (52 KB PDF).

April 06, 1984. Memorandum. 11 Page(s).
Deloris Graham. Fungicide Herbicide Branch.
EPA File Symbol 46574-R. Rout GS. Acute oral... Acc 252260.
Pages 4-11 removed, draft label. Tox review 005477.
Document (PDF) (167 KB PDF).

April 25, 1984. Memorandum. 8 Page(s).
R. Bruce Jaeger. Toxicology Branch.
Oryzalin, Amendment to Tox Branch Reviews of PP #3F2874, Use in or on Wheat and Barley.
Document (PDF) (433 KB PDF).

March 12, 1985. Memorandum. 2 Page(s).
John H.S. Chen. Toxicology Branch.
Oryzalin Registration Standard - Oncogenic Studies on Oryzalin in Rodents.
Tox review 004962.
Document (PDF) (116 KB PDF).

June 21, 1985. Memorandum. 6 Page(s).
R. Bruce Jaeger. Toxicology Branch.
Oryzalin Registration Standard: Need for Worker Safety Risk Assessment.
Caswell No. 623A.
Document (PDF) (305 KB PDF).

November 07, 1985. Memorandum. 3 Page(s).
R. Bruce Jaeger. Toxicology Branch.
Oryzalin; Conference with Elanco Representatives 10/10/85.
Document (PDF) (148 KB PDF).

March 06, 1986. Profile. 3 Page(s).
Reto Engler. Toxicology Branch.
Reference Doses (RFDs) for Oral Exposure - Oryzalin.
Document (PDF) (120 KB PDF).

March 12, 1986. Memorandum. 5 Page(s).
John Quest. Toxicology Branch.
Peer Review of Oryzalin.
Document (PDF) (325 KB PDF).

June 29, 1986. Memorandum. 2 Page(s).
John Chen. Toxicology Branch.
Conserve S.S. 1471-149 (R #154836) - Request for Exemption from the
21-Day Dermal Toxicity Testing of Conserve S.S. (FN-5155) and Guinea
Pig Sensitization Testing of Conserve S.S. (FN-5155). Caswell No. 623A.
Inert ingredient information on page 1 deleted.
Document (PDF) (70 KB PDF).

June 20, 1990. Memorandum. 2 Page(s).
Reto Engler. Science Analysis & Coordination Branch.
Carcinogenic Dose Response Assessment of Oryzalin.
Document (PDF) (95 KB PDF).

September 13, 1990. Memorandum. 3 Page(s).
John Quest. Science Analysis & Coordination Branch.
2nd Peer Review Meeting to Determine Risk Quantification Method for Oryzalin.
Document (PDF) (194 KB PDF).

October 22, 1990. Memorandum. 4 Page(s).
Sheila Moats. Registration Support Branch.
EPA Reg. No./File Symbol: 062719-RTU. Snapshot 80 day flowable.
MRID No. 415765-01C. Tox review No. 008702.
Document (PDF) (143 KB PDF).

September 27, 1993. Memorandum. 107 Page(s).
Virginia Dobozy. Toxicology Branch.
Oryzalin - Update on Decisions of RfD/Peer Review Committee - Revised DER's.
MRIDs 26779, 44332, 70569, 26780, 68079, 98461, 26785, 52557, 73552.
Tox review 010612.
Document (PDF) (5862 KB PDF).
Attachment(s) Following:

September 27, 1993. Memorandum.
Virginia Dobozy. Toxicology Branch.
(continued) Manufacturing process info on pages 32, 44, 45 not included.
Pages 70-74, 91-101 removed, registrant data.

*End of Attachments*

May 22, 1996. DER. 11 Page(s).
Rosemary Graham Mora. Ecological Effects Branch.
Oryzalin: Acute Flow-Through Mollusc Shell Deposition Test.
MRID No. 438877-02.
Document (PDF) (709 KB PDF).

May 22, 1996. DER. 7 Page(s).
Rosemary Graham Mora. Ecological Effects Branch.
Oryzalin: Acute Toxicity to the Sheepshead Minnow, Cyprinodon variegatus.
MRID No. 438877-01.
Document (PDF) (505 KB PDF).

May 22, 1996. DER. 8 Page(s).
Rosemary Graham Mora. Ecological Effects Branch.
Oryzalin: Acute Toxicity to the Grass Shrimp, Palaemonetes pugio.
MRID No. 438877-03.
Document (PDF) (548 KB PDF).

May 23, 1996. DER. 9 Page(s).
Rosemary Graham Mora. Ecological Effects Branch.
Evaluation of the Chronic Toxicity of Oryzalin Herbicide
(3,5-Dinitro-N4,N4-di (N-propyl) sulfanilamide) to the Daphnid,
Daphnia magna Straus. MRID No. 439869-01.
Document (PDF) (635 KB PDF).

June 25, 2003. Memorandum. 41 Page(s).
Jessica Kidwell. Cancer Assessment Review Committee.
Oryzalin: Report of the Cancer Assessment Review Committee.
Tox review 050173.
Document (PDF) (2114 KB PDF).

May 19, 2011. DER. 11 Page(s).
Chuck Peck. OPP/EPA.
Data Evaluation Record on the hydrolysis of oryzalin.
EPA Guideline: 835.2120. DP Barcode: 378627. MRID No.: 41378401.
Document (PDF) (416 KB PDF).

May 19, 2011. DER. 15 Page(s).
Chuck Peck. OPP/EPA.
Data Evaluation Record on the leaching of oryzalin in an aged soil column.
EPA Guideline: 835.1240. DP Barcode: 378627. MRID No.: 41479801.
Document (PDF) (427 KB PDF).

May 19, 2011. DER. 20 Page(s).
Chuck Peck. OPP/EPA.
Data Evaluation Record on the adsorption-desorption of oryzalin in soil.
EPA Guideline: 835.1230. DP Barcode: 378627. MRID No.: 41479802.
Document (PDF) (459 KB PDF).

May 19, 2011. DER. 25 Page(s).
Chuck Peck. OPP/EPA.
Data Evaluation Record on the aerobic biotransformation of oryzalin in soil.
EPA Guideline: 835.4100. DP Barcode: 378627. MRID No.: 41322801.
Document (PDF) (477 KB PDF).

May 19, 2011. DER. 26 Page(s).
Chuck Peck. OPP/EPA.
Data Evaluation Record on the anaerobic biotransformation of oryzalin in soil.
EPA Guideline: 835.4200. DP Barcode: 378627. MRID No.: 41322802.
Document (PDF) (481 KB PDF).

May 19, 2011. DER. 26 Page(s).
Chuck Peck. OPP/EPA.
Data Evaluation Record on the phototransformation of oryzalin on soil.
EPA Guideline: 835.2410. DP Barcode: 378627. MRID No.: 41050001.
Document (PDF) (497 KB PDF).

May 19, 2011. DER. 26 Page(s).
Chuck Peck. OPP/EPA.
Data Evaluation Record on the terrestrial field dissipation of oryzalin.
EPA Guideline: 835.6100. DP Barcode: 378627. MRID No.: 42138001.
Document (PDF) (301 KB PDF).

May 24, 2011. Memorandum. 6 Page(s).
Chuck Peck. ERB IV / EFED.
Oryzalin: Transmittal of Data Evaluation Records for Environmental Fate Studies.
DP Barcode: 390055. MRID Nos.: 41378401, 41050001, 41322801, 41322802, 41479802,
41479801, 42138001.
Document (PDF) (139 KB PDF).

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