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Index of Cleared Science Reviews for Thiabendazole (Pc Code 060101)

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Undated. DER. 2 Pages.
Akiva Abramovitch. Environmental Fate & Ground Water Branch.
STUDY 3. 162-2. STUDY ID 416318.
Bioconcentration of 14C-thiabendazole in Bluegill Sunfish.
MRID No. 416318.
Document (PDF) (17 KB PDF).

Undated. DER. 22 Page(s).
J. Breithaupt. Environmental Fate & Ground Water Branch.
Study 1. Determination of aqueous photolysis rate C14-thiabendazole.
Pages 6-22 removed, registrant data. MRID 43328305.
Document (PDF) (222 KB PDF).

Undated. DER. 3 Pages.
Akiva Abramovitch. Environmental Fate & Ground Water Branch.
STUDY 2. 162-2. STUDY ID 41559601. Anaerobic soil metabolism of 14C-thiabendazole.
ABC Final Report No. 37640. MRID No. 41559601.
Document (PDF) (29 KB PDF).

Undated. DER. 59 Page(s).
J. Breithaupt. Environmental Fate & Ground Water Branch.
Study 1. Terrestrial field dissipation for thiabendazole in wheat.
Pages 7-59 removed, registrant data. MRID 43187201.
Document (PDF) (284 KB PDF).

Undated. DER. 60 Page(s).
J. Breithaupt. Environmental Fate & Ground Water Branch.
Study 3. Terrestrial field dissipation for thiabendazole in soybeans.
Pages 8-60 removed, registrant data. MRID 43187203.
Document (PDF) (297 KB PDF).

Undated. Review. 20 Page(s).
James Breithaupt. Environmental Fate & Ground Water Branch.
Reg./File # 148-79-8 Review of an aerobic soil metabolism study.
[Transmittal of review] Pages 9-20 removed, registrant data.
MRID 41791201.
Document (PDF) (295 KB PDF).
Attachment(s) Following:

Undated. DER.
James Breithaupt. Environmental Fate & Groundwater Branch.
DER of MRID 41791201.

*End of Attachments*

Undated. Review. 56 Page(s).
Akiva Abramovitch. Environmental Fate & Ground Water Branch.
Reg./File # : 148-79-8 Review of an accumulation in confined rotational crops...
Pages 19-52 removed, registrant data. MRID 43267801.
Document (PDF) (859 KB PDF).
Attachment(s) Following:

October 12, 1992. Review.
Dynamac Corporation.
Task 1: Review and Evaluation of Individual Studies.

*End of Attachments*

September 02, 1965. Memorandum. 7 Page(s).
Mary Quaife. Division of Toxicological Evaluation.
Thiabendazole, FAP No. 5A-1701. Request for tolerance at maximum residue
concentration of 140 ppm in non-standardized baked goods as a mold inhibitor.
Inert ingredient information on page 1 not included. Tox review 002774.
Document (PDF) (234 KB PDF).

January 30, 1974. Memorandum. 3 Page(s).
OPP. EPA.
Mertect 360 Fungicide and Mertect 340 F Fungicide (new use for old chemical),
request for registration. Inert ingredient information on pages 1 & 2 is not included.
Source information on page 1 is not included. Tox review 001971.
Document (PDF) (159 KB PDF).

June 24, 1974. Review. 1 Page(s).
Ronald Ney. Efficacy & Ecological Effects Branch.
Environmental Chemistry Evaluation of: Thiabendazole PP4E1478.
EPA Reg. No. 618-69 & 618-75.
Document (PDF) (20 KB PDF).

July 31, 1974. Review. 2 Page(s).
Ronald Ney. Efficacy & Ecological Effects Branch.
Environmental Chemistry REview for: Thiabendazole PP# 4F1518 618-IU-84.
Document (PDF) (67 KB PDF).

February 20, 1975. Memorandum. 2 Page(s).
Mary Quaife. Toxicology Branch.
New toxicity data on "Mertect LSP" EPA File Symbol No. 618-IU.
Tox review 001969.
Document (PDF) (82 KB PDF).

May 14, 1975. Review. 7 Page(s).
William Cox. Chemistry Branch.
PP# 5F1537 & FAP# 5H5061. Thiabendazole on potatoes and in potato waste.
Evaluation of analytical methods and residue data. MRID 0039000.
Document (PDF) (615 KB PDF).

September 02, 1975. Review. 3 Page(s).
Reto Engler. Toxicology Branch.
Thiabendazole... 0.1 tolerance on soybeans. Mertect 340-F registration.
Petition No.: 5F1646. Registration No: 618-75.
Inert ingredient info on page 1 not included.
Document (PDF) (64 KB PDF).

September 30, 1975. Memorandum. 3 Page(s).
Diana Reisa. Toxicology Branch.
1) Experimental Use Permit for Mertect 340-F 2) Temporary tolerances for
thiabendazole on sugar beets at 6ppm. 3) Temporary food additive tolerances for
thiabendazole... Tox review 001972. Inert ingredient info on page 1 deleted.
Document (PDF) (90 KB PDF).

October 06, 1975. Review. 3 Page(s).
Ronald Ney. Efficacy & Ecological Effects Branch.
File or Reg. No. 618-75-AA. Petition 5F1646. Submission Purpose Soybeans.
Document (PDF) (75 KB PDF).

September 22, 1976. Review. 17 Page(s).
Ronald Ney. Efficacy & Ecological Effects Branch.
For use on soybeans.
Document (PDF) (454 KB PDF).

October 22, 1976. Review. 2 Page(s).
Ronald Ney. Efficacy & Ecological Effects Branch.
File or Reg. No. 618-75. Submission Purpose Letter.
Document (PDF) (167 KB PDF).

October 28, 1976. Review. 2 Page(s).
Reto Engler. Toxicology Branch.
Tolerance for Thiabendazole, 2-(4-Thioazyl)- benzimidazole, 0.1 ppm on soybeans.
Petition No.: 5F1646. Registration No.: 618-75. acute dermal toxicity data
acceptable... new tolerances cannot be granted.
Document (PDF) (39 KB PDF).

March 30, 1977. Memorandum. 1 Page(s).
Douglas Campt. Registration Division.
Thiabendazole on Soybeans.
Document (PDF) (45 KB PDF).

April 07, 1977. Memorandum. 2 Page(s).
Reto Engler. Toxicology Branch.
Tolerance for Thiabendazole 4.0 ppm on Sugarbeets (from post harvest application).
Tox review 001973.
Document (PDF) (65 KB PDF).

April 18, 1977. Memorandum. 1 Page(s).
Martin Rogoff.
Thiabendazole on Soybeans.
Document (PDF) (19 KB PDF).

April 18, 1977. Memorandum. 2 Page(s).
Ronald Ney. Efficacy & Ecological Effects Branch.
Response to Campt memo of March 30, 1977 (Thiabendazole on Soybeans).
Document (PDF) (93 KB PDF).

April 19, 1977. Memorandum. 6 Page(s).
Reto Engler. Toxicology Branch.
Tolerances for Thiabendazole; Re-assessment of ADI. Tox review 002773.
Document (PDF) (224 KB PDF).

April 21, 1977. Memorandum. 3 Page(s).
Ronald Ney. Efficacy & Ecological Effects Branch.
Response to Campt memo of March 30, 1977.
Document (PDF) (56 KB PDF).

April 25, 1977. Memorandum. 3 Page(s).
Ronald Ney. Efficacy & Ecological Effects Branch.
Response to Campt memo of March 30, 1977.
Document (PDF) (52 KB PDF).

May 08, 1977. Memorandum. 2 Page(s).
Reto Engler. Toxicology Branch.
Arbotect 20 S and S. Reg. No. 618-II and IO Thiabendazole.
Inert ingredient information on page 1 not included. Tox review 001970.
Document (PDF) (67 KB PDF).

July 28, 1977. Review. 4 Page(s).
Ecological Effects Branch..
Study Date: July 28, 1977. Data Review No: ES-C-2.
Avian Acute Oral LD50. Bobwhite quail. Acc. 232421.
Document (PDF) (60 KB PDF).

August 23, 1977. Review. 3 Page(s).
Ronald Ney. Efficacy & Ecological Effects Branch.
PROTOCOL.
Document (PDF) (80 KB PDF).

October 03, 1977. Review. 2 Page(s).
Ecological Effects Branch..
Study date: October 3, 1977. Data Review Number: ES-D-2 (and page 2, ES-C-2).
Avian subacute dietary LC50. Bobwhite quail. Acc. 232421.
Document (PDF) (24 KB PDF).

October 04, 1977. Review. 3 Page(s).
Ecological Effects Branch..
Study Date: October 4, 1977. Data Review Number: ES-C-3.
Avian acute oral LD50 - Mallard Duck. Acc. 232421.
Document (PDF) (52 KB PDF).
Attachment(s) Following:

May 10, 1979. Memorandum.
Arthur Riel. Ecological Effects Branch.
Registration of Mertect LSP (Thiabendazole) 618-IU. "Area of contention
involves an avian acute oral LD50 test... A memo by Akerman (3-13-78) accepts
studies using 14-day old birds during an interim period of 2-10-76 to 3-13-78.".

*End of Attachments*

November 29, 1977. Review. 3 Page(s).
Ronald Ney. Efficacy & Ecological Effects Branch.
Postharvest use sugabeets.
Document (PDF) (73 KB PDF).

November 29, 1977. Review. 4 Page(s).
Ronald Ney. Efficacy & Ecological Effects Branch.
New use wheat seed treatment.
Document (PDF) (124 KB PDF).

November 29, 1977. Review. 8 Page(s).
Ronald Ney. Efficacy & Ecological Effects Branch.
Reg. No. 618-75. 6F1860. New Use (soybeans).
Document (PDF) (251 KB PDF).

May 12, 1978. Review. 18 Page(s).
John Tice. Efficacy and Ecological Effects Branch.
File or Reg. No. 618-88. Data Submission; Arbotect 20-S; Merck & Company, Inc.
Accession 232421. [avian studies, trout, bluegill, daphnia].
Document (PDF) (436 KB PDF).

June 15, 1978. Review. 2 Page(s).
Karen Sampson. Efficacy & Ecological Effects Branch.
EUP on rice grain, hulls, and straw.
Document (PDF) (42 KB PDF).

August 18, 1978. Memorandum. 1 Page(s).
William Dykstra. Toxicology Branch.
Mertect LSP Fungicide EPA Reg. No. 618-IU Caswell #849 A.
Tox review 001976.
Document (PDF) (37 KB PDF).

August 28, 1978. Memorandum. 3 Page(s).
John Doherty. Toxicology Branch.
Reregistration No: 6452-EUP-6, Freers Oak Wilt Arrester.
Inert ingredient information on page 1 not included. Tox review 001977.
Document (PDF) (110 KB PDF).

November 21, 1978. Review. 14 Page(s).
Clayton Bushong. Ecological Effects Branch.
File or Reg. No. 618-84. Fish and Wildlife Studies.
Mertect LSP Fungicide -30% TBZ. [avian studies, daphnia, trout, bluegill].
Document (PDF) (256 KB PDF).

January 19, 1979. Memorandum. 5 Page(s).
John Preston. Toxicology Branch.
Application for amended registration, Mertect-340 F for Post-harvest application
to Sugar Beets. Inert ingredient info on page 1 not included. Tox review 001975.
Document (PDF) (211 KB PDF).

March 02, 1979. Memorandum. 8 Page(s).
Carlos A. Rodriguez. Toxicology Branch.
Request for a tolerance of the fungicide thiabendazole... in or on wheat grain at 0.2
ppm and wheat straw at 1.0 ppm. Inert info on page 3 not included. Tox review 001978.
Document (PDF) (218 KB PDF).

March 19, 1979. Review. 2 Page(s).
Ronald Ney. Environmental Fate Branch.
Reg./File No.: 618-75. Protocols.
Document (PDF) (35 KB PDF).

March 29, 1979. Review. 11 Page(s).
Ronald Ney. Environmental Fate Branch.
Reg./File No.: 618-7501, 8F2108. New use on wheat.
Document (PDF) (135 KB PDF).

April 17, 1979. Memorandum. 19 Page(s).
Edwin Budd. Toxicology Branch.
ODEX proposal for thiabendazole: Tolerances for residues of 0.2
ppm in or on raw grain crops. Caswell #849A. Tox review 002852.
Document (PDF) (967 KB PDF).

August 29, 1979. DER. 10 Page(s).
R. W. Matheny. Ecological Effects Branch.
Avian Reproduction 22 Week. Test species: Bobwhite quail.
Acc. 235974.
Document (PDF) (171 KB PDF).

September 06, 1979. DER. 7 Page(s).
R. W. Matheny. Ecological Effects Branch.
Avian Reproduction. Test species: Mallard duck.
Acc. 235974.
Document (PDF) (110 KB PDF).

September 10, 1979. Review. 4 Page(s).
Raymond Matheny. Ecological Effects Branch.
File or Reg. No. 618-75. Submission of avian acute oral
tests and 48-hour LC50 for Daphnia magna. Acc. 235633.
Document (PDF) (82 KB PDF).
Attachment(s) Following:

May 21, 1979. Memorandum.
H. T. Craven. Ecological Effects Branch.
Memo to the file: EPA 618-IU. "two avian acute oral studies
conducted by Wildlife International are acceptable...".

*End of Attachments*

October 25, 1979. Memorandum. 4 Page(s).
S. A. Sterling. Fungicide Herbicide Branch.
EPA File Symbol: 239-EUTU Orthocide Plus; Caswell #159, 849A.
Tox review 007217.
Document (PDF) (101 KB PDF).

January 25, 1980. Review. 2 Page(s).
Ronald Cook. Environmental Fate Branch.
Extension of experimental use program for another year XX.
Document (PDF) (38 KB PDF).

February 20, 1980. Memorandum. 2 Page(s).
Carlos A. Rodriguez. Toxicology Branch.
PP No. 8G2078 Thiabendazole on rice.
Request for exension of experimental use permit and temporary tolerances.
Tox review 001974.
Document (PDF) (61 KB PDF).

March 24, 1980. Review. 6 Page(s).
Ronald Cook. Environmental Fate Branch.
Reg. /File No.: 239-EUTU. New mixture.
Document (PDF) (105 KB PDF).

March 31, 1980. Review. 11 Page(s).
Ronald Cook. Environmental Fate Branch.
Reg./File No.: 618-75, 9F2216. Rice.
Document (PDF) (187 KB PDF).

April 29, 1980. Memorandum. 7 Page(s).
William Dykstra. Toxicology Branch.
EPA Reg.#618-75; Thiabendazole, Lifetime Carcinogenic Study in Mice.
Tox review 001980.
Document (PDF) (224 KB PDF).

May 30, 1980. Memorandum. 7 Page(s).
Carlos A. Rodriguez. Toxicology Branch.
Request for a tolerance of the fungicide Mertect 340 F be established in or [on]
White Rice at 0.25 ppm, Rice Bran at 2.5 ppm, Rice Polishings at 2.5 ppm, Rice Hulls
at 8.0 ppm, Rice straw at 10 ppm. Inert info on page 2 not included.
Tox review 001979.
Document (PDF) (182 KB PDF).

September 25, 1980. Memorandum. 4 Page(s).
Sherell Sterling. Toxicology Branch.
EPA File Symbol: 43410-E - Fungicide T EPA File Symbol: 43410-T - Fungicide 4T.
Tox review 000859.
Document (PDF) (105 KB PDF).

November 24, 1980. Review. 2 Page(s).
Enviro Control, Inc..
Task 5. Development of Chemical/Physical Profile: Thiabendazole.
Document (PDF) (22 KB PDF).

December 29, 1980. Memorandum. 4 Page(s).
Sherell Sterling. Fungicide Herbicide Branch.
Thiabendazole Concentrate EPA File Symbol 43410-U. Tox review 000453.
Document (PDF) (79 KB PDF).

March 23, 1981. Memorandum. 4 Page(s).
Sherell Sterling. Fungicide Herbicide Branch.
Fungicide T EPA File Symbol: 43410-E. Fungicide 4T EPA File Symbol: 43410-T.
Tox review 001239.
Document (PDF) (106 KB PDF).

March 24, 1981. Memorandum. 3 Page(s).
Sherell Sterling. Fungicide Herbicide Branch.
Thiabendazole Concentrate EPA File Symbol: 43410-U.
Page 3 removed draft label. Tox review 001237.
Document (PDF) (70 KB PDF).

April 28, 1981. Review. 4 Page(s).
Willa Garner. Environmental Fate Branch.
Reg./File No.: 618-75.
Review an anaerobic aquatic metabolism study (preharvest use on rice).
Document (PDF) (56 KB PDF).

January 22, 1982. Review. 4 Page(s).
Willa Garner. Environmental Fate Branch.
Reg. /File No.: 618-75. Use on wheat and potatoes.
Pages 3-4 removed-draft label.
Document (PDF) (45 KB PDF).

May 07, 1982. Memorandum. 4 Page(s).
Deloris Graham. Fungicide Herbicide Branch.
EPA Registration Number: 43410-2 Fungicide T.
Tox review 002831.
Document (PDF) (152 KB PDF).

May 24, 1982. Memorandum. 5 Page(s).
Deloris Graham. Fungicide Herbicide Branch.
EPA Registration Number 618-67 Thiabendazole Microfine MSD Acute toxicity studies.
Accession Number 247279. MRID 00100706. Tox review 002825.
Document (PDF) (125 KB PDF).

May 24, 1982. Memorandum. 5 Page(s).
Deloris Graham. Fungicide Herbicide Branch.
EPA Registration Number 618-67 Thiabendazole Microfine MSD. Tox review 002825.
Document (PDF) (110 KB PDF).

May 28, 1982. Review. 30 Page(s).
Clayton Bushong. Ecological Effects Branch.
File or Reg. No. 618-75. Submission of Data to Support Proposed Use on Rice.
Mertect 340-F. 48-hour freshwater invertebrate bioassay, daphnia; 30-day embryo-
larvae study, fathead minnow.
Document (PDF) (725 KB PDF).

July 13, 1982. Memorandum. 14 Page(s).
Irving Mauer. Toxicology Branch.
Caswell No.: 849A. Mutagenicity Studies With Thiabendazole,
Active Ingredient of "Mertect 340-F": Review and Evaluation.
Acc. No 247112. Tox review 002154.
Document (PDF) (346 KB PDF).

March 28, 1983. Memorandum. 5 Page(s).
David Ritter. Toxicology Branch.
Thiabendazole (Mertect-340F) - New Mutagenicity Study and Supplemental Data.
Acc. No. 247112. Tox review 002619.
Document (PDF) (110 KB PDF).

May 27, 1983. Memorandum. 4 Page(s).
Deloris Graham. Fungicide Herbicide Branch.
EPA Registration Number: 10445-31 TK-100 Liquid Concentrate.
Page 4 removed, draft label. Tox review 005453.
Document (PDF) (72 KB PDF).

May 31, 1983. Memorandum. 4 Page(s).
Deloris Graham. Fungicide Herbicide Branch.
EPA Registration Number: 10445-32; 10445-30 TK-100 Liquid Concentrate;
Metasol TK-100 Dispersion W. Pages 3, 4 removed, draft labels.
Tox review 005454.
Document (PDF) (58 KB PDF).

June 03, 1983. Memorandum. 5 Page(s).
Irving Mauer. Toxicology Branch.
Additional Data in Support of Mutagenicity Studies with Thiabendazole, (TBZ)
Active ingredient of "Mertect 340-F". Accession No. 249845. EPA Reg. No. 618-75.
Tox review 002916.
Document (PDF) (125 KB PDF).

June 06, 1983. Memorandum. 6 Page(s).
Irving Mauer. Toxicology Branch.
Additional Data in Support of Mutagenicity Studies with Thiabendazole, (TBZ)
Active Ingredient of "Mertect 340-F" Accession No. 249845. EPA Reg. No. 618-75
/Action Code 571. MRID 00125297.
Document (PDF) (222 KB PDF).

November 10, 1983. Review. 8 Page(s).
Richard Moraski. Exposure Assessment Branch.
Reg./File No.: 10445-30. Add new uses. Page 3 removed, confidential statement of formula.
Pages 4-8 removed, draft label.
Document (PDF) (53 KB PDF).

January 05, 1984. Memorandum. 5 Page(s).
Deloris Graham. Fungicide Herbicide Branch.
EPA File Symbol: 618-OE. Pages 4-5 removed, draft label.
Tox review 005269.
Document (PDF) (107 KB PDF).

January 20, 1984. Memorandum. 5 Page(s).
Deloris Graham. Fungicide Herbicide Branch.
EPA File Symbol: 10445-TA Calgon Thiabendazole Dispersion W.
Pages 4-5 removed, draft label. Tox review 005270.
Document (PDF) (96 KB PDF).

January 26, 1984. Memorandum. 6 Page(s).
Deloris Graham. Toxicology Branch.
EPA File Symbol: 10445-TA Calgon Thiabendazole Dispersion W acute toxicity studies.
Accession Number 251706. MRID 00042268. Tox review 005270.
Document (PDF) (204 KB PDF).

December 21, 1984. Memorandum. 2 Page(s).
Deloris Graham. Fungicide Herbicide Branch.
EPA File Symbol: 10445-TA Calgon Thiabendazole Dispersion W. Tox review 005820.
Document (PDF) (36 KB PDF).

April 12, 1985. Memorandum. 6 Page(s).
Carlos A. Rodriguez. Toxicology Branch.
Thiabendazole (TBZ)-PP #3F2882. Tox review 004399.
Document (PDF) (169 KB PDF).

August 28, 1985. Memorandum. 7 Page(s).
Deloris Graham. Fungicide Herbicide Branch.
EPA File Symbol: 8203-UR Agrosol Pour-on Acc. 254673.
Pages 4-7 removed, draft label. Tox review 006323.
Document (PDF) (68 KB PDF).

October 10, 1985. Review. 5 Page(s).
Carlos A. Rodriguez. Toxicology Branch.
Merck, Sharp and Dohme requests a temporary tolerance for the use of thiabedazole
fungicide to treat Aspergillus spp. and Penicillium spp. on stored corn grain at 20 ppm.
Document (PDF) (139 KB PDF).

October 10, 1985. Review. 5 Page(s).
Carlos A. Rodriguez. Toxicology Branch.
Registration No(s): 618-75 (Mertect 340-F) Pesticide Petition No(s): 5G3258 + 618-EUP-RR
requests a temporary tolerance for use to treat Aspegillus spp. on stored corn
MRID 00147905.
Document (PDF) (186 KB PDF).

October 31, 1985. Memorandum. 13 Page(s).
Charles Trichilo. Residue Chemistry Branch.
PP#5G3258/618-EUP-RR. RCB Non-concurrance Re: Use of Thiabendazole on Stored Corn....
we have reevaluated our position and find we could recommend favorably... corn...
for animal feed... Manufacturing process information on page 4 not included.
Document (PDF) (589 KB PDF).
Attachment(s) Following:

September 10, 1985. Memorandum.
Leung Cheng. Residue Chemistry Branch.
PP#5G3258. Thiabendazole on Stored Corn. Evaluation of Analytical Method
and Residue Data. Accession Number 073589. RCB Number 1229. MRID 00147905.

September 09, 1986. Memorandum.
Joel Garbus. Residue Chemistry Branch.
EPA No. 618-EUP-11: Tiabendazole; Revised Protocol for Anmal Feeding Study.
No Accession Number RCB No. 1222.

*End of Attachments*

May 05, 1986. Memorandum. 28 Page(s).
Nancy Dodd. Residue Chemistry Branch.
PP #6F3355 (RCB# 481). Thiabendazole (TBZ 060101-3) in or on Peanuts.
Evaluation of Analytical Methods and Residue Data (Accession No. 261110).
MRID 155575.
Document (PDF) (1033 KB PDF).

November 26, 1986. Memorandum. 27 Page(s).
Carlos A. Rodriguez. Toxicology Branch.
Thiabendazole - EPA Registration No. 618-75. Tox review 005601.
Document (PDF) (502 KB PDF).

April 28, 1987. Memorandum. 12 Page(s).
Mary Waller. Fungicide Herbicide Branch.
EPA File Symbol 100-ATE Apron T69 Fungicide.
Pages 7-12 removed, draft label. Tox review 006208.
Document (PDF) (139 KB PDF).

October 16, 1987. Memorandum. 8 Page(s).
Mary Waller. Fungicide Herbicide Branch.
EPA File Symbol 100-ATE Apron T69 Fungicide MRID 402939-01.
Pages 4-8 removed, draft label. Tox review 006412.
Document (PDF) (66 KB PDF).

January 11, 1988. Memorandum. 12 Page(s).
Judith Hauswirth. Toxicology Branch.
Thiabendazole - Dermal Sensitization Study in Guinea Pigs & Tolerance Petition for
the Establishment and Revocation of Certain Tolerances submitted by Merck and Co.,Inc.
July 15, 1987. EPA ID No 7-1109. Acc. No 40271701, 40271707. Tox review 006548.
Document (PDF) (246 KB PDF).

July 29, 1988. Memorandum. 19 Page(s).
Jerry Stokes. Residue Chemistry Branch.
PP#7F3553/FAP#7H5541. Thiabendazole in/on Stored Corn Grain.
Evaluation of Analytical Method and Residue Data.
(MRID#'s 40271702, -05, -06, and -07, RCB#'s 2777 and 2778).
Page 18 removed, registrant data.
Document (PDF) (919 KB PDF).

November 28, 1988. Memorandum. 1 Page(s).
Judith Hauswirth. Toxicology Branch.
Thiabendazole - Data Waiver Request for a Delayed Neurotoxi- city Study
in the Hen, Submitted by Merck Sharp and Dohme August 15, 1988.
Tox review 006934.
Document (PDF) (29 KB PDF).

December 08, 1988. Memorandum. 5 Page(s).
Judith Hauswirth. Toxicology Branch.
Thiabendazole - Submission of Two Acute Studies Submitted June 17, 1988
by Merck Sharp and Dohme. EPA ID No.: 060101. Tox review 006961.
Document (PDF) (120 KB PDF).

December 15, 1988. Review. 23 Page(s).
Paul Mastradone. Environmental Fate & Ground Water Branch.
Review 135-day response to the Comprehensive Data Call-In
Pages 15, 16, 20 removed, draft label.
Document (PDF) (511 KB PDF).

February 02, 1989. Review. 5 Page(s).
Paul Mastradone. Environmental Fate & Ground Water Branch.
Review request for 9-month extension to submit reports
on three fate studies for Comprehensive Data Call In.
Document (PDF) (147 KB PDF).

February 27, 1989. Memorandum. 4 Page(s).
Susan Hummel. Dietary Exposure Branch.
Maneb, Thiabendazole, and Lindane. EPA Reg. Nos.: 8203-38 Granox Plus Flowable
Cereal Seed Treatment Fungicide 8203-39 Granox Plus Cereal Seed Treatment Fungicide
8203-36 Granol Plus Flowable Insecticide and Fungicide Cereal Seed Treatment..
Document (PDF) (69 KB PDF).

April 21, 1989. Memorandum. 8 Page(s).
Kenneth Dockter. Dietary Exposure Branch.
Id. No. 060101. Thiabendazole Data Call-In.
Merck's Product & Residue Chemistry responses of 8/15/88 & 9/29/88.
MRID Nos. 40789801, -14 & 40835501. Branch Nos. 4564 thru 467 & 4591.
Pages 6-8 removed, registrant data.
Document (PDF) (186 KB PDF).

June 13, 1989. Memorandum. 2 Page(s).
Maxie Jo Nelson. Dietary Exposure Branch.
EPA Reg. No. 618-67. Thiabendazole. [RD Data Review Record ID No.: 060101]
63-13 Data Submitted in Response to DCI. DEB#: 5187 HED#: 9-1223
MRID#: 41025001.
Document (PDF) (69 KB PDF).

June 23, 1989. Memorandum. 10 Page(s).
John Whalan. Toxicology Branch.
Thiabendazole. Review of Three Acute Studies MRID 00100705, 402717-01.
Tox review 007308.
Document (PDF) (232 KB PDF).

July 10, 1989. Review. 43 Page(s).
James Akerman. Ecological Effects Branch.
Submission of data in response to comprehensive DCI of 3/24/88. Merck and
Company. Pages 10, 19-20, 26, 32-34 and 40-42 removed, registrant data.
Avian dietary LC50, coldwater fish LC50, warmwater fish LC50 studies.
MRIDs 41025002, -03, -04, -05, -06.
Document (PDF) (680 KB PDF).

July 17, 1989. Memorandum. 2 Page(s).
Gobind Makhijani. Dietary Exposure Branch.
Thiabendazole - Comprehensive Data Call-In Notice - Merck and Company -
EPA Registration No. 618-67. MRID No.: 41083501. Product Chemistry Data.
Document (PDF) (61 KB PDF).

July 25, 1989. Memorandum. 3 Page(s).
Maxie Jo Nelson. Dietary Exposure Branch.
EPA Reg. No. 618-67. Thiabendazole. 63-8, -10, -16 Data Submitted in Response to DCI.
MRID#: 40835502, 40947301, -02. solubility, dissociation constant, explosibility.
Document (PDF) (95 KB PDF).

October 13, 1989. Memorandum. 35 Page(s).
Irving Mauer. Toxicology Branch.
Thiabendazole _ Mutagenicity Study Submitted in Response to Data Call-In Notice
(MRID No. 41170103) EPA ID No. 618-67. Pages 8-35 removed, registrant data.
Tox revieww 007541.
Document (PDF) (125 KB PDF).

October 18, 1989. Memorandum. 8 Page(s).
Jerry Stokes. Dietary Exposure Branch.
PP#7F3553/FAP#7H5541. Thiabendazole in/on Stored Corn Grain.
Amendment dated June 9, 1989 (MRID#'s 41125701 and -02, DEB#'s 5449 and 5450).
Document (PDF) (398 KB PDF).

January 04, 1990. Memorandum. 2 Page(s).
Bruce Kitchens. Environmental Fate & Ground Water Branch.
Determination of the Photolysis Rate of C14- Thiabendazole on the Surface of Soil
(Draft Report).
Document (PDF) (28 KB PDF).

February 20, 1990. Review. 70 Page(s).
Emil Regelman. Environmental Fate & Ground Water Branch.
Screen/review hydrolysis, photodegradation in water, and batch-equilibrium
adsorption/desorption studies submitted as part of the Data Call-In on this chemical
MRID 41170102, 41265101, 41265301. Pages 13-23, 29-49, 54-66 removed, registrant data.
Document (PDF) (394 KB PDF).

March 09, 1990. DER. 4 Page(s).
Brian Montague. Ecological Effects Branch.
96 hour acute toxicity under flowthrough conditions with Cyprinodon variegatus.
MRID 41192003.
Document (PDF) (61 KB PDF).

March 09, 1990. DER. 5 Page(s).
Brian Montague. Ecological Effects Branch.
Acute toxicity under flow through conditions with Mysidopsis bahia.
MRID 41192002.
Document (PDF) (77 KB PDF).

March 09, 1990. DER. 6 Page(s).
Brian Montague. Ecological Effects Branch.
Acute toxicity - flow through shell deposition with Crassostrea virginica.
MRID 41192004.
Document (PDF) (97 KB PDF).

March 12, 1990. Memorandum. 8 Page(s).
William Anthony. Dietary Exposure Branch.
ID #060101,-02. Thiabendazole: Product Chemistry in response to Data Call-In.
[DEB: #6043,-44,-45] [Supplement to MRID 00047895, 00047980, 00051865, 00029108,
00125601; amendment to MRID 40789814; and 40835501); 41192001; 41258204.
Pages 4-8 removed, MP.
Document (PDF) (128 KB PDF).

May 17, 1990. Memorandum. 5 Page(s).
John Whalan. Toxicology Branch.
Review of Two Acute Toxicity Studies of Thiabendazole. MRID 412582-01, -02.
Tox review 007934.
Document (PDF) (107 KB PDF).

June 19, 1990. Memorandum. 10 Page(s).
William Woodrow. Registration Support Branch.
EPA Reg. No./File Symbol 400-UGI Vitavax-Extra. Tox review 008842.
Document (PDF) (412 KB PDF).

November 26, 1990. Memorandum. 8 Page(s).
Lucy Markarian. Registration Support Branch.
EPA Reg. No./File Symbol 2935-478 Agrosol T Flowable Systemic Soybean Treatment.
Tox review 008627.
Document (PDF) (362 KB PDF).

February 08, 1991. Memorandum. 48 Page(s).
Akiva Abramovitch. Environmental Fate & Ground Water Branch.
Phase IV review of Thiabendazole. EFGWB # 90-0808, 90-0880 and 91-0213,
Chemical 060101, Rereg. Case #2670, DP Barcode D158974 MRID 41397301, 41397302,
41559601, 416318. Pages 14-22, 26-38, 43-44 removed, registrant data.
Document (PDF) (286 KB PDF).

February 15, 1991. Review. 4 Page(s).
Judy Smith. Occupational & Residential Exposure Br..
OREB Transmittal Sheet for Phase 4 Reviews.
Document (PDF) (143 KB PDF).

September 12, 1991. Review. 8 Page(s).
Akiva Abramovitch. Environmental Fate & Ground Water Branch.
Phase IV reregistration 12 month extension request - confined rotational crop study.
Document (PDF) (122 KB PDF).

November 12, 1991. Memorandum. 13 Page(s).
Ann Clevenger. Toxicology Branch.
Review of 21-Day Dermal Toxicity Study of Thiabendazole in Rabbits.
MRID 412595-01. Tox review 008787.
Document (PDF) (240 KB PDF).

February 14, 1992. Memorandum. 2 Page(s).
Leung Cheng. Chemistry Branch II.
Thiabendazole Livestock (Goat and Poultry) Metabolism.
The Metabolism Committee Meeting Held on February 12, 1992.
Document (PDF) (46 KB PDF).

March 02, 1992. Memorandum. 9 Page(s).
Leung Cheng. Chemistry Branch II.
ID # 60101-618. Thiabendazole. Phase V Review. Goat and Poultry Metabolism Studies.
MRID # 420579-01 & 420117-01. CBRS # 8930 & 8719. DP Barcode: D170818 & D169697.
Document (PDF) (143 KB PDF).

March 11, 1992. Memorandum. 8 Page(s).
Leung Cheng. Chemistry Branch II.
ID # 60101-618. Thiabendazole Phase V Review. Metabolism Studies: Wheat,
Soybean and Sugar Beet. MRID # 418729-01, -02, -03. DP Barcode: D165718.
Document (PDF) (152 KB PDF).

May 12, 1992. Review. 8 Page(s).
Douglas Urban. Ecological Effects Branch.
Thiabendazole - 48-hour Flow Through Study for Daphnids. MRID 41709401.
Document (PDF) (171 KB PDF).

July 27, 1992. Memorandum. 3 Page(s).
Christine Olinger. Chemistry Branch.
6(a)(2) Data: Over-Tolerance Residues of Thiabendazole on Citrus;
Chemical No. 60101; Branch No. 10168; DP Barcode No. D179437;
MRID 42315701.
Document (PDF) (81 KB PDF).

October 23, 1992. Memorandum. 2 Page(s).
Dennis McNeilly. Chemistry Branch.
Reregistration of Thiabendazole. Product Chemistry {Guideline 63 Requirements}.
(Case No. 2670)[CBRS No.: 10704 MRID: 42490501; DP Barcode: D183292].
Document (PDF) (51 KB PDF).

December 30, 1992. Review. 37 Page(s).
Akiva Abramovitch. Environmental Fate & Ground Water Branch.
Waiver requests for 162-3,4, 164-2 and 165-3. Also, upgrading of 161-1, 161-2,
and 163-1 studies. MRID 41265301, 41265101, 41170102, 42367801, 42022701.
Pages 26-29 removed-registrant data.
Document (PDF) (577 KB PDF).

March 12, 1993. DER. 9 Page(s).
Greg Susanke. Ecological Effects Branch.
72-1. Freshwater fish static acute toxicity test. Species tested: Bluegill sunfish.
Pages 5-7 removed, registrant data. MRID 42477701.
Document (PDF) (117 KB PDF).

March 19, 1993. Review. 10 Page(s).
Douglas Urban. Ecological Effects Branch.
72-1. Freshwater fish static acute toxicity test. Species tested: Bluegill sunfish.
Pages 7-9 removed, registrant data. MRID 42477701.
Document (PDF) (122 KB PDF).

April 15, 1993. Memorandum. 11 Page(s).
R. B. Perfetti. Chemistry Branch II.
Response to the Thiabendazole Phase IV Review: Residue Chemistry Data
(MRID #'s 42515801 and -02, CBRS # 10,954, Barcode: D185173).
Document (PDF) (120 KB PDF).

May 05, 1993. Memorandum. 9 Page(s).
John Whalan. Toxicology Branch.
Thiabendazole: Review of a Mutagenicity Study. MRID 423618-01.
Tox review 010227.
Document (PDF) (201 KB PDF).

May 27, 1993. Memorandum. 7 Page(s).
John Whalan. Toxicology Branch.
Thiabendazole: Review of a Mutagenicity Study. MRID 420853-01.
Tox review 010290.
Document (PDF) (149 KB PDF).

July 12, 1993. Memorandum. 3 Page(s).
John Whalan. Toxicology Branch I.
Thiabendazole: FIFRA Sec. 6(a)(2) Report of Preliminary Positive Findings
in a Carcinogenicity Study. EPA ID# 060101-000618 Caswell File 849A.
Document (PDF) (66 KB PDF).

July 28, 1993. Memorandum. 16 Page(s).
Leung Cheng. Chemistry Branch II.
Thiabendazole. Case No. 2670. Response to Phase IV Review: Residue Chemistry Data.
MRID No. 42718401. CBRS No. 11792. DP Barcode: D190451.
Document (PDF) (172 KB PDF).

July 30, 1993. Memorandum. 20 Page(s).
John Abbotts. Chemistry Branch.
Thiabendazole, Reregistration. Magnitude of the Residue in Citrus and Citrus
Processed Commodities (MRID No. 42568001). CBRS No. 11216. DP Barcode No. D186592.
Document (PDF) (294 KB PDF).

July 30, 1993. Memorandum. 20 Page(s).
John Abbotts. Chemistry Branch II.
Thiabendazole, Reregistration. Magnitude of the Residue in Citrus and Citrus
Processed Commodities (MRID No. 42568001). CBRS No. 11216. DP Barcode No. D186592.
Document (PDF) (617 KB PDF).

August 03, 1993. Memorandum. 15 Page(s).
John Abbotts. Chemistry Branch.
Thiabendazole, Reregistration. Magnitude of the Residue in Sweet Potato
(MRID No. 42660301), Potato, and Potato processed Commodities (MRID No. 42660302).
CBRS No. 11601. DP Barcode No. D189323.
Document (PDF) (252 KB PDF).

August 03, 1993. Memorandum. 15 Page(s).
John Abbotts. Chemistry Branch II.
Thiabendazole, Reregistration. Magnitude of the Residue in Sweet Potato
(MRID No. 42660301), Potato, and Potato Processed Commodities (MRID No. 42660302).
CBRS No. 11601. DP Barcode No. D189323.
Document (PDF) (472 KB PDF).

November 18, 1993. Data Summary. 5 Page(s).
Chemistry Branch..
Thiabendazole (Case 2670/Code 060101) Unofficial Residue Chemistry Data
Summary Through 11/18/93.
Document (PDF) (140 KB PDF).

November 22, 1993. Memorandum. 10 Page(s).
David Miller. Chemistry Branch II.
Thiabendazole. Magnitude of the Residue Field Trials with Mushrooms...
MRID No. 425989-01.
Document (PDF) (193 KB PDF).

February 23, 1994. Memorandum. 2 Page(s).
John Whalan. Toxicology Branch I.
Thiabendazole: FIFRA Sec. 6(a)(2) Submission of a Specialized Protocol
Caswell File 849A.
Document (PDF) (54 KB PDF).

March 04, 1994. Memorandum. 2 Page(s).
G. F. Kramer. Chemistry Branch.
ID# 000618-00075. Review of Label Amendment for thiabendazole
(Mertect 340-F Fungicide). MRID# 42905201. Barcode D195001. Case 002896.
CBTS# 12535. [Magnitude of the residue in tobacco.].
Document (PDF) (66 KB PDF).

April 14, 1994. Memorandum. 10 Page(s).
Francis Suhre. Chemistry Branch.
Thiabendazole (ID 060101). Residue Chemistry Data Requirement 171-4(k) for bananas.
Barcode: D196149; CBRS No. 12715; MRID No.: 42868701. Case No. 2670.
Document (PDF) (216 KB PDF).

April 14, 1994. Memorandum. 10 Page(s).
Francis Suhre. Chemistry Branch II.
Thiabendazole (ID 060101). Residue Chemistry Data Requirement (171-4(k) for bananas.
Barcode: D196149; CBRS No. 12715; MRID No.: 428687-01.
Document (PDF) (318 KB PDF).

July 14, 1994. Memorandum. 2 Page(s).
Freshteh Toghrol. Chemistry Branch.
Thiabendazole Reregistration. List B Chemical No. 060101; Case No. 2670. Merck & Co.,
Requirements Regarding Stability (Guideline # 63-13). MRID No. 43172801.
Document (PDF) (60 KB PDF).

September 07, 1994. Review. 25 Page(s).
Anthony Maciorowski. Ecological Effects Branch.
Review fish early life stage toxicity study. 72-4. Freshwater fish, early life-stage, flow-
through toxicity test. Species tested: Fathead minnow. Pages 8-11 removed, registrant data.
MRID 42508901.
Document (PDF) (377 KB PDF).

December 30, 1998. Memorandum. 13 Page(s).
Sherrie Mason. Reregistration Branch.
Thiabendazole Reregistration. Residue Analytical Enforcement Methods for Milk,
Eggs and Animal Tissues and Storage Stability Studies for Residues in Milk and
Animal Tissues. MRID No.: 43251501 thru 43251505.
Document (PDF) (481 KB PDF).

January 08, 1999. Memorandum. 29 Page(s).
Sherrie Mason. Reregistration Branch.
Thiabendazole Reregistration. 860.1500 & 860.1340 - Response to Agency Reviews for
Magnitude of the Residue in Apples, Citrus, & Wheat; Analytical Method in Wheat and
ILV, Magnitude of the Residue in Citrus & Banana Following Post Harvest Dip Application.
Document (PDF) (1143 KB PDF).
Attachment(s) Following:

January 08, 1999. Memorandum.
Sherrie Mason. Reregistration Branch.
(continued) MRID No.: 43328301-43328303, 43328306, 43328307 and 43721901-43721904.

*End of Attachments*

January 12, 1999. Memorandum. 18 Page(s).
Sherrie Mason. Reregistration Branch.
Thiabendazole Reregistration. 860.1500 & 860.1340-Response to Agency Reviews
for Magnitude of the Residue in Mushrooms, Sweet Potatoes, Potatoes, & Potato
Processed Commodities; New Field Trials for Sweet Potatoes...
MRID No.: 43531001, 43531002, 43547601.
Document (PDF) (685 KB PDF).

February 03, 1999. Review. 1 Page(s).
Sami Malak. Technical Review Branch.
Product Chemistry Review of Manufacturing Use Product. Barcode No.: 252511.
REG./File Symbol No.: 618-109. MRID 44724601 & -02.
Document (PDF) (121 KB PDF).

May 06, 1999. Memorandum. 97 Page(s).
Sanjivani Diwan. Health Effects Division.
Cancer Assessment Review Committee Meeting on Thiabendazole.
Document (PDF) (1656 KB PDF).
Attachment(s) Following:

April 29, 1980. Review.
William Dykstra. Toxicology Branch.
EPA Reg. #618-75; Thiabendazole, Lifetime Carcinogenic Study in Mice.
Accession #242116. Tox review 001980.

September 11, 1997. DER.
Reto Engler. Dynamac Corporation for HED.
Study Type: 83-1b; 53-Week Oral (Capsule) Toxicity Study in Dogs.
MRID 42809701.

November 20, 1997. DER.
William Sprangler. Dynamac Corporation for HED.
Study Type: 83-5a; Combined chronic/oncogenicity study with thiabendazole
in the rat. MRID 43593201.

March 01, 1999. DER.
Robert Fricke. Reregistration Branch 2 HED.
Study Type: Thyroxine Clearance Study in the Rat. MRID 43593202.

May 04, 1999. Memorandum.
Patricia Gaun. Health Effects Division.
Thiabendazole: Evaluation of Carcinogenic Potential.
Attaced is the Cancer Assessment Document for thiabendazole.

May 07, 1999. Memorandum.
Mary Marion. Science Analysis Branch.
Thiabendazole Risk Assessment Based On Sprague-Dawley Rat Dietary Study.
MRID # 43593201.

October 12, 1999. DER.
Patricia Gaunt (David Nixon). Reregistration Branch 4 HED.
Study Type: Carcinogenicity feeding in mice; OPPTS 870.3200 [83-2b].
MRID 00031447. Supplement to Document No. 001980.

*End of Attachments*

July 21, 1999. Memorandum. 23 Page(s).
Patricia Gaunt. Reregistration Branch HED.
THIABENDAZOLE -Report of the Hazard Identification Assessment Review Committee.
Tox review 013601.
Document (PDF) (690 KB PDF).

August 19, 1999. Memorandum. 2 Page(s).
Lori Brunsman. Science Analysis Branch.
Thiabendazole Quantitative Risk Assessment (Q1*) Based On Sprague-Dawley Crl:CD BR
Rat Chronic Dietary Study Using mg/kg b.w. ^3/4's/day Cross Breeding Scaling Factor.
Tox review 013689.
Document (PDF) (42 KB PDF).

August 24, 1999. Memorandum. 2 Page(s).
Lori Brunsman. Science Analysis Branch.
REVISED Thiabendazole Quantitative Risk Assessment (Q1*) Based On Sprague-
Dawley Crl:CD BR Rat Chronic Dietary Study Using mg/kg b.w. ^3/4's/day Cross
Breeding Scaling Factor. Tox review 013692.
Document (PDF) (41 KB PDF).

November 16, 1999. Memorandum. 35 Page(s).
Sanjivani Diwan. Health Effects Division.
Thiabendazole - Report of the Cancer Assessment Review Committee.
Tox Review No. 013840.
Document (PDF) (560 KB PDF).
Attachment(s) Following:

October 07, 1999. Memorandum.
Sanju Diwan. Health Effects Division.
Thiabendazole - CARC Final Report.

*End of Attachments*

February 24, 2000. Memorandum. 39 Page(s).
Sanjivani Diwan. Health Effects Division.
Thiabendazole - Report of the Cancer Assessment Review Committee.
Tox review 013840.
Document (PDF) (608 KB PDF).

August 30, 2001. Review. 10 Page(s).
Shyam Mathur. Technical Review Branch.
Product Chemistry Review of Thiabendazole Technical (MK-360). Product ingredient
source info on page 1 & 4 not included. Pages 2 removed, claimed confidential by
submitter. Pages 5-10 removed, manufacturing process info. DP Barcode D276231.
MRID 45356401.
Document (PDF) (250 KB PDF).

February 26, 2002. Memorandum. 11 Page(s).
Sanjivani Diwan. Reregistration Branch HED.
Thiabendazole (PC Code 060101) - Evaluation of Covance Statistical
Analysis of Rat Tumor Data. MRID 45591801. Tox review 050498.
Document (PDF) (283 KB PDF).
Attachment(s) Following:

August 19, 1999. Memorandum.
Lori Brunsman. Science Analysis Branch.
REVISED Thiabendazole Qualitative Risk Assessment Based On
Sprague-Dawley Crl:CD BR Rat Dietary Study. Tox review 013684.

January 30, 2002. Memorandum.
Lori Brunsman. Science Information Management Branch.
Thiabendazole: Comments to Covance Submission of 1/9/2002.

*End of Attachments*

February 26, 2002. Memorandum. 2 Page(s).
William Burnam. Health Effects Division.
Cancer Reclassification of Thiabendazole. Tox review 050523.
Document (PDF) (37 KB PDF).

March 08, 2002. Memorandum. 36 Page(s).
William Burnam. Health Effects Division.
Cancer Reclassification of Thiobendazole. Supplement to the Final Report
(TXR#013840) and the February 26, 2002 Memorandum (TXR# 005023).
Tox review 050554.
Document (PDF) (1185 KB PDF).

April 13, 2006. New Use Review. 28 Page(s).
Keara Moore. Environmental Risk Branch.
Review of New Use for Thiabendazole (Mertect 340-F) as a seed treatment on dry peas.
DP Barcode: 315436, 322581. MRIDs 43187201, -02, 41791201, 41765301, 43328305, 41170102.
Document (PDF) (1492 KB PDF).

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