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Index of Cleared Science Reviews for Malathion (Pc Code 057701)
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Undated. DER. 14 Page(s).
Brian Dementi. Toxicology Branch.
DER #13a; Malathion: 2-Week (Range-finding)
Inhalation Study in Sprague-Dawley Rats.
MRID No. 44554301; 82-4.
Document (PDF) (684 KB PDF).
Undated. DER. 17 Page(s).
Toxicology Branch.
DER #4. Malathion: 1-Year Chronic Oral Toxicity Study in Dogs.
Tegeris Laboratories. 1987.
MRID 40188501. HED Doc. No. 006349.
Document (PDF) (931 KB PDF).
Undated. DER. 18 Page(s).
Toxicology Branch.
DER #17; Malathion: Metabolism Study in Sprague-Dawley Rats.
Midwest Research Institute. 1989.
MRID No. 41367701. HED Doc No. 007791.
Registration Data removed from pages 10-18.
Document (PDF) (489 KB PDF).
Undated. DER. 22 Page(s).
Brian Dementi. Toxicology Branch.
Special Study, Effects on Cholinesterase in Adult & Juvenile CD Rats,
Companion Study to Development Neurotoxicity Study 870.6300.
Tox Review No. 0050550. MRID No. 45566201.
Document (PDF) (1655 KB PDF).
Undated. DER. 22 Page(s).
Toxicology Branch.
DER #12; Malathion: 21-Day Dermal Toxicity Study in Rabbits.
Research Laboratories. 1988.
MRID No. 41054201. HED Doc Nos. 008714 & 009385.
Document (PDF) (1064 KB PDF).
Undated. DER. 22 Page(s).
Toxicology Branch.
DER #8; Malathion: Acute Delayed Neurotoxicity Study in Hens.
Bio-Life Associates. 1988.
MRID No. 40939301. HED Doc Nos. 007524, 008026.
Document (PDF) (1238 KB PDF).
Undated. DER. 26 Page(s).
Toxicology Branch.
DER #13; Malathion: 13-Week Subchronic Inhalation Toxicity Study
in Sprague-Dawley Rats. Bio-Research Laboratories (Canada). 1994.
MRID No. 43266601. HED Doc No. 011516.
Document (PDF) (1798 KB PDF).
Undated. DER. 26 Page(s).
Toxicology Branch.
DER #7a. Malathion: Range-Finding Developmental Toxicity Study in Rabbits.
Food & Drug Research Laboratories. 1985. MRID No. 00152569.
HED Doc. No. 007376. Registration Data removed from pages 6-26.
Document (PDF) (173 KB PDF).
Undated. DER. 28 Page(s).
Toxicology Branch.
DER #5. Malathion: 2-Generation Reproduction Study in Sprague-Dawley Rats.
Bio/dynamics. 1990.
MRID 41583401. HED Doc. No. 009365.
Document (PDF) (1306 KB PDF).
Undated. DER. 28 Page(s).
Toxicology Branch.
DER #6. Malathion: Developmental Toxicity Study in Sprague-Dawley
Rats. Argus Research Laboratory. 1989.. MRID No. 41160901. HED
Doc. No. 008384. Registration Data removed from pages 13-28.
Document (PDF) (673 KB PDF).
Undated. DER. 7 Page(s).
Toxicology Branch.
DER #7. Malathion: Developmental Toxicity Study in Rabbits.
Food & Drug Research Laboratories 1985.
MRID No. 00152569, 40812001. HED Doc. No. 007376.
Document (PDF) (353 KB PDF).
Undated. DER. 78 Page(s).
Toxicology Branch.
DER #2. Malathion: 18-Month Carcinogenicity Study in B6C3F1 Mice.
International Research & Developmental Corp. 1994.
MRID No. 43407201. HED Doc. No. 011455.
Registration Data removed from pages 45-48 & 66-78.
Document (PDF) (3847 KB PDF).
Undated. Letter. 2 Page(s).
Carmelita White. SRRD.
Review of a 6(a)(2) and Follow-Up Data Submitted for Developmental
Neurotoxicity and Acetylcholinesterase Studies in Rats [re malathion;
see 12/14/2000 & 4/19/2001].
Document (PDF) (72 KB PDF).
Undated. Memorandum. 4 Page(s).
J. G. Cummings. Petitions Evaluation Branch, FDA.
Recommended International Tolerances for Pesticide Residues.
Document (PDF) (246 KB PDF).
July 23, 1970. Memorandum. 2 Page(s).
O. G. Fitzhugh. Office of Pesticides, FDA.
Recommended International Tolerances for Pesticide Residue (Mr. Cummings Memo of 7/9).
Document (PDF) (145 KB PDF).
September 28, 1970. Memorandum. 1 Page(s).
J. G. Cummings. Petitions Evaluation Branch, FDA.
PP #1E1039. (HCN) Codex Alimentarius International Tolerances.
Document (PDF) (83 KB PDF).
February 09, 1978. Memorandum. 3 Page(s).
William Dykstra. Toxicology Branch.
Ortho Malathion 50 Insect Spray. EPA Registration No. 239-739. Caswell #535 (Malathion).
Document (PDF) (141 KB PDF).
September 01, 1978. Summary. 4 Page(s).
Toxicology Branch.
Preliminary Toxicology Profile - Malathion.
Document (PDF) (309 KB PDF).
November 01, 1978. Memorandum. 6 Page(s).
Carlos A. Rodriguez. Toxicology Branch.
Requests to Amend CFR 40, Section 180.11, Malathion; From Preharvest
Application: 50 ppm in or on Almond Hulls; and from Post-Harvest
Application: 50 ppm in or on Almond Shells. Petition No. 8E2114.
Inert ingredient information on pages 2-3 is not incl.
Document (PDF) (376 KB PDF).
November 15, 1978. Memorandum. 2 Page(s).
Carlos A. Rodriguez. Toxicology Branch.
Summary - Request to Amend CFR 40, 180.11, Malathion; From Preharvest
Application: 50 ppm in or on Almond Hulls; and from Post-Harvest
Application: 50 ppm in or on Almond Shells. Petition No. 8E2114.
Document (PDF) (772 KB PDF).
December 12, 1980. Memorandum. 71 Page(s).
William Dykstra. Toxicology Branch.
EPA Reg. No. 241-110; 241-208.
Malathion: NCI Cancer Bioassays of Malathion and Malaoxan.
Caswell #5385; Accession Nos. 242903, 76252, 248179.
Tox review 000314.
Document (PDF) (3991 KB PDF).
July 10, 1981. Memorandum. 6 Page(s).
Minnie Sochard. Toxicology Branch.
Malathion Mutagenicity and Teratogenicity Report from J. Wassom, Oak Ridge, Tenn.
Document (PDF) (381 KB PDF).
February 17, 1983. Memorandum. 3 Page(s).
R. Bruce Jaeger. Toxicology Branch.
CYTHION Malathion, EPA Reg. No. 241-208; Two-Year Rat Feeding Study.
Acc. No. 76252.
Tox review 002504.
Document (PDF) (175 KB PDF).
June 11, 1984. Memorandum. 1 Page(s).
William Burnam. Toxicology Branch.
Malathion Data Call-In Notice.
Document (PDF) (39 KB PDF).
November 07, 1984. DER. 15 Page(s).
Paul Wennerberg. Toxicology Branch.
The evaluation of the chronic toxicity effects of Cythion ad ministered
in the diet to Spraue-Dawley Rats for 24 consecutive months. (No. 5436)
Tox Review 004208.
Document (PDF) (693 KB PDF).
August 15, 1986. Review. 4 Page(s).
Phil Hutton. Insecticide Rodenticide Branch.
TSS/IRB Precautionary Labeling Review [Reg. No] 04787-00005
Acute toxicity studies Acc. 263072, 263073.
Document (PDF) (166 KB PDF).
August 21, 1986. Profile. 3 Page(s).
George Ghali. Toxicology Branch.
Reference Doses (RFDs) for Oral Exposure - Malathion.
Document (PDF) (125 KB PDF).
July 21, 1987. DER. 7 Page(s).
Brian Dementi. Toxicology Branch.
A Teratology Study with AC6, 601 in rabbits.
MRID: 152569. Tox Review 007376.
Document (PDF) (398 KB PDF).
October 05, 1987. DER. 10 Page(s).
Brian Dementi. Toxicology Branch.
One-year oral toxicity study in purebred beagle dogs with AC6601.
MRID 40188501. Tox review 006349.
Document (PDF) (675 KB PDF).
January 28, 1988. Memorandum. 10 Page(s).
Harry Craven. Ecological Effects Branch.
Fish and Wildlife Risk Assessment for the Disposal of Treated
Seeds by Exaggerated Planting Rates.
Document (PDF) (500 KB PDF).
July 27, 1989. Memorandum. 29 Page(s).
Brian Dementi. Toxicology Branch.
American Cyanamid Company Response to Malathion Registration Standard.
Document (PDF) (2503 KB PDF).
August 30, 1989. DER. 6 Page(s).
Brian Montague. Ecological Effects Branch.
96 hour Acute Flow-through on Estuarine Fish, Cyprinodon Variegatus.
Accn. No. 41174301.
Document (PDF) (451 KB PDF).
August 31, 1989. Memorandum. 10 Page(s).
Anne Lindsay. Registration Division.
Section 18 - Quarantine Exemption for the Use of Malathion to Control Fruit
Flies in California - Action Memorandum.
Document (PDF) (654 KB PDF).
October 02, 1989. Memorandum. 13 Page(s).
Brian Dementi. Toxicology Branch.
EPA Indentification No. 241-76 -
Acute Delayed Neurotoxicity of Malathion in the Hen.
MRID 40939301, 41371401 Tox Review 007524.
Document (PDF) (901 KB PDF).
January 03, 1990. Memorandum. 4 Page(s).
Susan Hummel. Dietary Exposure Branch.
89-CA-26 Amendment of Section 18 Quarantine Exemption for the Use of
Malathion to Eradicate Fruit Flies on Numerous Raw Agricultural Commodities.
[No MRID No. , HED No. 0-0277, DEB No. 6059].
Document (PDF) (298 KB PDF).
March 01, 1990. Memorandum. 14 Page(s).
Robert P. Zendzian. Toxicology Branch.
Malathion, Metabolism Study in Rats MRID 413677-01.
Pages 6-14 removed, Registration Data.
Tox review 007791.
Document (PDF) (327 KB PDF).
March 06, 1990. Review. 4 Page(s).
Catherine Eiden. Exposure Assessment Branch.
Correspondence Control #16-752. Malathion.
Request that Spray Drift Studies Be Set Aside.
Document (PDF) (201 KB PDF).
March 16, 1990. Memorandum. 5 Page(s).
Charles Trichilo. Non-Dietary Exposure Branch.
Malathion incidents related to Medfly spraying in 1981.
Document (PDF) (317 KB PDF).
March 16, 1990. Memorandum. 8 Page(s).
Sheila Moats. Registration Support Branch RD.
EPA Reg. No. /File Symbol 9779-GNU. Acute toxicity.
MRIDs 40955102 thru 44955107.
Document (PDF) (678 KB PDF).
March 26, 1990. Memorandum. 2 Page(s).
Brian Dementi. Toxicology Branch.
Cholinesterase Peer Review Committee Meeting of 3/1/90 on Malathion
Chronic Dog Study. (Note - Peer Review of Malathion, ToxR 008386,
twenty-seven pages is not attached. See the separate cleared peer
review dated April 12, 1990. ).
Document (PDF) (159 KB PDF).
March 30, 1990. Memorandum. 44 Page(s).
Robert Zendzian. Science Analysis & Coordination Branch.
Malathion: Allergic and Ocular Effects.
Document (PDF) (4163 KB PDF).
April 12, 1990. Memorandum. 27 Page(s).
Kerry Dearfield. Science Analysis & Coordination Branch.
Peer Review of Malathion. Tox review 008386.
Document (PDF) (2171 KB PDF).
April 12, 1990. Memorandum. 8 Page(s).
Brian Dementi. Toxicology Branch.
Malathion Ocular Effects.
Document (PDF) (446 KB PDF).
April 18, 1990. Memorandum. 23 Page(s).
Irving Mauer. Toxicology Branch.
Malathion- Tox Data Submitted under MRID No. 41389301.
EPA ID No. 241-208. Pages 7-23 removed, Registration Data.
Tox review 007864.
Document (PDF) (378 KB PDF).
May 04, 1990. Memorandum. 16 Page(s).
Brian Dementi. Toxicology Branch.
Memorandum of Dr. Robert Zendzian "Malathion: Allergic and Ocular Effects",
March 30, 1990. ATTACHMENT.
Document (PDF) (885 KB PDF).
Attachment(s) Following:
March 30, 1990. Memorandum.
Reto Engler. Science Analysis & Coordination Branch.
Malathion: Allergic and Ocular Effects.
*End of Attachments*
May 07, 1990. Memorandum. 2 Page(s).
Jane Smith. Dietary Exposure Branch.
89-CA-26. Amendment. Section 18 Quarantine Exemption for the Use
of Malathion to Eradicate Fruit Flies on Numerous Raw Agricultural
Commodities. No Accession Number / No
MRID Number. DEB #6622.
Document (PDF) (92 KB PDF).
June 04, 1990. Memorandum. 7 Page(s).
Irving Mauer. Toxicology Branch.
Malathion---Toxicology Data Submitted under MRID 41451201,
EPA ID# 57875. Pages 5-7 removed, Registration Data.
Tox review 007965.
Document (PDF) (289 KB PDF).
June 12, 1990. Memorandum. 8 Page(s).
Brian Dementi. Toxicology Branch.
EPA ID No. 89-CA-26. Amendment to Section 18 Quarantine Exemption for the
Use of Malathion in California to Include All Crops Which Grow in Treatment Areas.
Document (PDF) (496 KB PDF).
July 11, 1990. Review. 6 Page(s).
Clyde Houseknecht. Ecological Effects Branch.
Reg. No. 89-CA-26. Various Malathion Products.
Review of Request to Amend Malathion Quarantine Exemption.
Document (PDF) (337 KB PDF).
July 12, 1990. Memorandum. 10 Page(s).
Irving Mauer. Toxicology Branch.
Malathion- Mutagenicity Data Submitted Under MRID 409393-02.
Pages 6-10 deleted, Registration Data. Tox review 008032.
Document (PDF) (277 KB PDF).
July 16, 1990. Memorandum. 7 Page(s).
Brian Dementi. Toxicology Branch.
EPA Identification No. 57875 Additional Information Concerning NCI's 1978
B6C3F1 Mouse Study "Bioassay of Malathion for Possible Carcinogenicity".
Document (PDF) (420 KB PDF).
July 24, 1990. Memorandum. 6 Page(s).
Alfred Smith. Product Chemistry Review Section.
Product Chemistry Reviews of Fyfanon Technical (EPA Reg. No.4784-5) and
Fyfanon ULV (EPA Reg. No. 4787-8) Pages 5-6 removed, Confidential appendix.
MRID 409666-03.
Document (PDF) (177 KB PDF).
August 13, 1990. Memorandum. 4 Page(s).
Charles Trichilo. Non-Dietary Exposure Branch.
Malathion Incidents Involving the Homeless.
Document (PDF) (221 KB PDF).
August 13, 1990. Memorandum. 8 Page(s).
Penelope Fenner-Crisp. Health Effects Division.
Amendment to the Section 18 Quarantine Exemption for the use of
malathion in California (89-CA-26) -- incremental risk assessment.
Document (PDF) (408 KB PDF).
Attachment(s) Following:
Undated. Memorandum.
Rita Briggs. Science Analysis & Coordination Branch.
Malathion Dietary Incremental Risk Assessment.
August 08, 1990. Memorandum.
Michael Firestone. Non-Dietary Exposure Branch.
California Malathion Section 18 Amendment - Incremental
Occupational and Residential Exposure Risk (HED #Indra 0073).
*End of Attachments*
August 15, 1990. Memorandum. 2 Page(s).
Brian Dementi. Toxicology Branch.
EPA ID No. 57875 Malathion, May 23, 1990 Letter of Understanding
from American Cyanamid Company Concerning the April 12, 1990 Meeting
Between Company and OPP Representatives.
Document (PDF) (96 KB PDF).
August 15, 1990. Review. 13 Page(s).
James Akerman. Ecological Effects Branch.
Review Mysid Shrimp Study. MRID No. 41474501.
Pages 9, 11 removed, registrant data.
Document (PDF) (754 KB PDF).
Attachment(s) Following:
August 13, 1990. DER.
Kimberly Rhodes. KBN Engineering for EEB.
Estuarine Invertebrate Acute Toxicity Test.
Species Tested: Mysid shrimp (Mysidopsis bahia).
MRID No. 414745-01.
August 13, 1990. Memorandum.
James Akerman. Ecological Effects Branch.
Review of toxicity data for Malathion (057701-5).
*End of Attachments*
August 15, 1990. Review. 4 Page(s).
James Akerman. Ecological Effects Branch.
Reg. No. 89-CA-26. Various Malathion Products.
Section 18 - Review CDFA's Proposed Amendments to Label.
Document (PDF) (247 KB PDF).
October 05, 1990. Memorandum. 4 Page(s).
Robert Zendzian. Health Effects Branch.
Malathion, Case of Juan Macias.
Document (PDF) (252 KB PDF).
October 16, 1990. Review. 4 Page(s).
Hank Jacoby. Environmental Fate & Ground Water Branch.
Malathion Reregistration Task Force and the Spray Drift Task Force.
Document (PDF) (174 KB PDF).
December 12, 1990. Memorandum. 4 Page(s).
William Dykstra. Toxicology Branch.
EPA Reg.241-110; 241-208, Malathion; NCI Cancer Bioassays
of Malathion and Malaoxon. CASWELL 535; Accession 242903.
Tox review 000314.
Document (PDF) (197 KB PDF).
February 08, 1991. Memorandum. 4 Page(s).
Jerome Blondell. Occupational & Residential Expos. Branch.
Preliminary Review of Japanese Studies of Ocular Impairment
Due to Exposure to Organophosphates.
Document (PDF) (264 KB PDF).
February 13, 1991. Memorandum. 10 Page(s).
Brian Dementi. Toxicology Branch.
Malathion Chronic Toxicity/Oncogenicity Testing Protocols.
Document (PDF) (598 KB PDF).
Attachment(s) Following:
September 17, 1990. Memorandum.
Brian Dementi. Toxicology Branch.
Summary of Malathion Reregistration Data Requirements
for Purposes of Data Call-In.
March 12, 1991. Memorandum.
Joanne Edwards. SRRD.
Meeting to Discuss Malathion Protocols.
*End of Attachments*
January 30, 1991. DER. 9 Page(s).
Henry T. Craven. Ecological Effects Branch.
Fish early life stage toxicity test. Species Tested: Rainbow trout
(Oncorhynchus mykiss, previously Salmo gairdneri). MRID No. 414224-01.
Document (PDF) (596 KB PDF).
February 28, 1991. Memorandum. 2 Page(s).
Curt Lunchick. Occupational & Residential Expos. Branch.
Qualitative Assessment of the Incremental Exposure to Humans Resulting from
the Proposed Uses of Malathion and Diazinon under the Aphis Section 18 for
Fruit Fly Eradication. HED Project No.s 1-0635 and 1-0635A.
Document (PDF) (104 KB PDF).
March 05, 1991. Review. 5 Page(s).
Clyde Houseknecht. Ecological Effects Branch.
Reg. No. 91-DA-0002. Various Malathion Products.
Sec. 18 - Emergency Exemption for Use in Fruit Fly Eradication.
Document (PDF) (313 KB PDF).
March 27, 1991. Memorandum. 2 Page(s).
Brian Dementi. Toxicology Branch.
Malathion Chronic Toxicity (Ocular Effects) Testing in the Dog
'to revise malathion testing requirements'.
Document (PDF) (103 KB PDF).
March 28, 1991. Memorandum. 42 Page(s).
R. B. Perfetti. Chemistry Branch II.
Response to the Malathion Reregistration Standard: Product Chemistry Data
(MRID's 4094401 [40944102]-40944108, 40966602, 40966603, and 40335801. CBRS # 7469. )
Pages 31-42 removed, manufacturing process info. & quality control procedure information.
Document (PDF) (735 KB PDF).
April 18, 1991. Memorandum. 3 Page(s).
Mark I. Dow. Occupational & Residential Expos. Branch.
"Exposure Estimation" in: California Department of Health Services'
"Health Risk Assessment of Aerial Application of Malathion-Bait".
Document (PDF) (184 KB PDF).
April 19, 1991. Memorandum. 4 Page(s).
Henry Spencer. Toxicology Branch I.
California Health Risk Assessment of Aerial Application of Malathion-Bait.
Document (PDF) (280 KB PDF).
April 24, 1991. Memorandum. 13 Page(s).
Penelope Fenner-Crisp. Health Effects Division.
Review of the Health Risk Assessment of Aerial Application of Malathion-Bait
submitted by California Department of Health Services.
Document (PDF) (774 KB PDF).
Attachment(s) Following:
August 08, 1990. Memorandum.
Michael Firestone. Non-Dietary Exposure Branch.
California Malathion Section 18 Ammendment - Incremental
Occupational and Residential Exposure Risk (HED #Indra 0073).
April 18, 1991. Memorandum.
Penelope Fenner-Crisp. Health Effects Division.
"Exposure Estimation" in: California Department of Health Services'
"Health Risk Assessment of Aerial Application of Malathion Bait".
April 23, 1991. Memorandum.
Brian Dementi. Toxicology Branch I.
California Health Risk Assessment of Aerial Application of Malathion-Bait.
*End of Attachments*
May 03, 1991. Memorandum. 2 Page(s).
Mark Dow. Occupational & Residential Exposure Br.
Malathion Exposure Data Gaps (Subpart U Reregistration).
Document (PDF) (102 KB PDF).
May 30, 1991. Memorandum. 23 Page(s).
Brian Dementi. Product Chemistry Review Section.
EPA Identification No. 057701-5 Development Toxicity Study with
AC6601 (Malathion) in Rats Pages 8-23 removed, Registration Data.
MRID 41160901. Tox review 008384.
Document (PDF) (497 KB PDF).
June 05, 1991. Memorandum. 3 Page(s).
Brian Dementi. Toxicology Branch.
Malathion Chronic/Oncogenicity and Ocular Effects Testing Requirements.
Document (PDF) (171 KB PDF).
June 05, 1991. Note. 2 Page(s).
Jerome Blondell. Occupational & Residential Exposure Br.
I cannot concur with the RfD/Peer Review Committee document
"Occular Effects of Organophosphates".
Document (PDF) (112 KB PDF).
June 14, 1991. Review. 33 Page(s).
Reto Engler. Science Analysis & Coordination Branch.
HED Section 18 Analysis Summary - Malathion and Diazinon.
USDA (APHIS) - 91-DA-02.
Document (PDF) (1789 KB PDF).
June 16, 1991. Review. 8 Page(s).
George Ghali. Science Analysis & Coordination Branch.
Peer Review of a Document Entitled "Ocular Effects of Organophosphates".
Document (PDF) (393 KB PDF).
July 02, 1991. Memorandum. 3 Page(s).
Brian Dementi. Toxicology Branch.
Addendum to the 6/3/91 Memorandum of Brian Dementi to Joanne Edwards on
"Malathion Chronic/Oncogenicity and Ocular Effects Testing Requirements".
Document (PDF) (86 KB PDF).
October 16, 1991. Memorandum. 23 Page(s).
Anne Lindsay. Registration Division.
Section 18 - USDA Quarantine Exemptions for Use of Malathion and Diazinon
to Eradicate Exotic Fruit Fly Species in Florida - Action Memorandum.
Document (PDF) (1839 KB PDF).
October 18, 1991. Memorandum. 17 Page(s).
Brian Dementi. Toxicology Branch.
21-Day Dermal Toxicity Study with Malathion in Rabbits.
MRID 41054201. Tox Review 008714.
Document (PDF) (735 KB PDF).
November 07, 1991. Memorandum. 3 Page(s).
Mark I. Dow. Occupational & Residential Expos. Branch.
California Department of Health Services' Malathion Exposure Studies from Medfly Sprays.
Document (PDF) (161 KB PDF).
March 17, 1992. Memorandum. 23 Page(s).
Henry Spencer. Toxicology Branch.
Review of Two-generation Reproduction Toxicity in rats with AC 6601 (Malathion).
MRID 415834-01. Tox review 009365.
Document (PDF) (1240 KB PDF).
April 07, 1992. Memorandum. 19 Page(s).
Douglas Urban. Ecological Effects Branch.
Review of Freshwater Invertebrate Life-Cycle Chronic Toxicity Test.
Registration Data information removed from pages 9-12.
Document (PDF) (862 KB PDF).
Attachment(s) Following:
April 07, 1992. DER.
Louis Rifici. Ecological Effects Branch.
Freshwater Invertebrate Life-Cycle Chronic Toxicity Test.
Species Tested: Daphnia magna. MRID No. 417184-01.
Registration Data information removed from pages 9-12.
*End of Attachments*
April 28, 1992. Analysis. 17 Page(s).
Stephen Schaible. Science Analysis & Coordination Branch.
RfD Exceeders Project: Dietary Exposure Analysis for Malathion.
Document (PDF) (1285 KB PDF).
October 09, 1992. Memorandum. 3 Page(s).
Brian Dementi. Toxicology Branch.
Malathion Registration Standard: Dose Level Proposal
for Malaoxon Chronic Toxicity/Oncogenicity Study.
Document (PDF) (146 KB PDF).
November 02, 1992. Memorandum. 1 Page(s).
Brian Dementi. Toxicology Branch.
28-Day Dietary Range-Finding Study of Malathion in the Rat.
Document (PDF) (67 KB PDF).
December 15, 1992. Data Eval. Rec. 11 Page(s).
L. Parsons. Environmental Fate & Ground Water Branch.
Malathion GDLN 161-4 Study 4. MRID 40969301. Vapor phase
photolysis of malathion. Pages 6-11 removed, registrant data.
Document (PDF) (417 KB PDF).
December 15, 1992. Data Eval. Rec. 19 Page(s).
L. Mickley. Environmental Fate & Ground Water Branch.
Malathion GDLN 163-1 Study 6. MRID 41345201. Adsorption/desorption studies -
batch equilibrium for malathion. Pages 4-19 removed, registrant data.
Document (PDF) (276 KB PDF).
December 15, 1992. Data Eval. Rec. 25 Page(s).
C. Cooke. Environmental Fate & Ground Water Branch.
Malathion GDLN 161-3 Study 3. MRID 41695501 Determination of the photolysis
rate on the surface of soil with malathion. Pages 6-25 removed, registrant data.
Document (PDF) (427 KB PDF).
December 15, 1992. Data Eval. Rec. 27 Page(s).
C. Cooke. Environmental Fate & Ground Water Branch.
Malathion GDLN 161-2 Study 2. MRID 41673001
Determination of the photolysis rate of C14-malathion in pH-4 aqueous solution.
Pages 6-27 removed, registrant data.
Document (PDF) (414 KB PDF).
December 15, 1992. Data Eval. Rec. 39 Page(s).
Richard Mahler. Environmental Fate & Ground Water Branch.
Malathion GDLN 163-2 Study 12. MRID 42015201. The volatization of malathion
from soil (A laboratory study). Pages 5-39 removed, registrant data.
Document (PDF) (352 KB PDF).
December 15, 1992. Data Eval. Rec. 43 Page(s).
L. Mickley. Environmental Fate & Ground Water Branch.
Malathion GDLN 162-1 Study 5. MRID 41721701. Aerobic soil
metabolism study of malathion. Pages 6-43 removed, registrant data.
Document (PDF) (428 KB PDF).
December 15, 1992. Data Eval. Rec. 54 Page(s).
L. Mickley. Environmental Fate & Ground Water Branch.
Malathion GDLN 164-1 Study 7. MRID 41727701. Terrestrial field dissipation
for malathion in cotton (California). Pages 6-54 removed, registrant data.
Document (PDF) (457 KB PDF).
December 15, 1992. Data Eval. Rec. 58 Page(s).
Richard Mahler. Environmental Fate & Ground Water Branch.
Malathion GDLN 164-2 Study 8. MRID 42058401. Combined aquatic
sediment field dissipation and irrigated crop accumulation study...
Pages 8-58 removed, registrant data.
Document (PDF) (635 KB PDF).
December 15, 1992. Data Eval. Rec. 9 Page(s).
C. Cooke. Environmental Fate & Ground Water Branch.
Malathion GDLN 161-1 Study 1. MRID 40941201 Additional information
for the malathion (AC 6,601): hydrolysis study.
Document (PDF) (368 KB PDF).
December 23, 1992. Memorandum. 2 Page(s).
Karen Hamernik. Toxicology Branch.
Malaoxon: Chronic Toxicity/Oncogenicity Study in Rats [dose levels].
Document (PDF) (81 KB PDF).
May 09, 1993. DER. 22 Page(s).
Brian Dementi. Toxicology Branch.
DER #10; Malathion: 13-week (Subchronic) Neurotoxicity Study
in Sprague-Dawley Rats. Wil Research Laboratories. 1994.
MRID No. 43269501. HED Doc No. (None).
Registration Data removed from pages 21-22.
Document (PDF) (1180 KB PDF).
May 13, 1993. Review. 10 Page(s).
Toxicology Branch.
Malathion: Registrant's Response to Residue Chemistry Data Requirement.
MRID No. 42581401.
Document (PDF) (849 KB PDF).
July 12, 1993. Memorandum. 3 Page(s).
Brian Dementi. Toxicology Branch.
Malathion Rat Chronic/Oncogenicity Study - Change of Dosage
Level for the Low Dose Group.
Document (PDF) (1832 KB PDF).
February 17, 1994. Memorandum. 7 Page(s).
R. B. Perfetti. Chemistry Branch II.
Response to the Malathion Reregistration Standard: Radiovalidation
of method in plants. MRID No. 42894601.
Document (PDF) (399 KB PDF).
April 07, 1994. Memorandum. 8 Page(s).
Anthony Maciorowski. Ecological Effects Branch.
Review of Mallard Duck Reproduction Study (Guideline 71-4) Submitted
by Cheminova Agro A/S in Support of Malathion Reregistration.
Document (PDF) (608 KB PDF).
Attachment(s) Following:
March 22, 1994. DER.
Charles Nace. Ecological Effects Branch.
71-4. Avian Reproduction Study. Species Tested: Mallard duck
(Anas platyrhynchos). MRID No. 427821-01.
*End of Attachments*
May 26, 1994. Memorandum. 21 Page(s).
R. B. Perfetti. Chemistry Branch II.
Response to the Malathion Reregistration Standard: Confined
Rotational Crop Study. (Case No. 0248, Chemical I.D. No. 057701)
MRID No. 42785501.
Document (PDF) (1341 KB PDF).
August 26, 1994. Note. 1 Page(s).
Bill Burnam. Health Effects Division.
Estimate of Malathion's Cancer Potency.
Document (PDF) (48 KB PDF).
September 02, 1994. Memorandum. 3 Page(s).
Mark Dow. Occupational & Residential Exposure Br.
This memorandum is in response to your verbal request for estimates of
human "bystander" exposure to malathion bait aerially applied in urban
areas for fruit fly eradication.
Document (PDF) (140 KB PDF).
September 06, 1994. Memorandum. 26 Page(s).
R. B. Perfetti. Chemistry Branch II.
Response to the Malathion Reregistration Standard: Magnitude of the
Residue Studies. (Case No. 0248, Chemical I.D. No. 057701)
MRID Nos. 43078702, 43108201, 43078701 & 43175501.
Document (PDF) (2965 KB PDF).
October 06, 1994. Memorandum. 5 Page(s).
Robert Zendzian. Toxicology Branch.
DER #15; Malathion: Dermal Absorption Analysis; EPA Technical Report,
Protocol for Dermal Exposure Assessment, Part 6. Perculaneous Skin
Absorption Study in Humans.
Document (PDF) (187 KB PDF).
October 18, 1994. Memorandum. 22 Page(s).
R. B. Perfetti. Chemistry Branch II.
Response to the Malathion Reregistration Standard: Magnitude of
the Residue Studies. ( Case No. 0248, Chemical I. D. No. 057701,
MRID Nos. 43107601-03, CBRS No. 13691, Barcode: D203171.
Document (PDF) (833 KB PDF).
November 03, 1994. Memorandum. 3 Page(s).
Robert Zendzian. Toxicology Branch I.
Malathion, EPA Technical Report, Protocol for Dermal Exposure
Assessment, Part 6. Percutaneous Skin Absorption Study in Humans.
Tox review 011314.
Document (PDF) (168 KB PDF).
January 20, 1995. Memorandum. 3 Page(s).
Anthony Maciorowski. Ecological Effects Branch.
Letter Dated December 9, 1994 from Jellinek, Schwartz & Connolly, Inc.
(JSC) Addressing Malathion Oyster Shell Deposition Study.
MRID No. 422449901.
Document (PDF) (158 KB PDF).
March 22, 1995. Memorandum. 71 Page(s).
Edwin Budd. Toxicology Branch I.
Malathion Reregistration; Reregistration Case No. 0248; Review of
Carcinogenicity Study in Mice, Guideline 83-2(b). 6(a)(2) Issue.
MRID 434072-01. Pages 39-42, 60-71 removed, registrant data.
Tox review 011455.
Document (PDF) (3525 KB PDF).
April 18, 1995. Memorandum. 33 Page(s).
Brian Dementi. Toxicology Branch.
DER #9; Malathion: Acute Neurotoxicity Study in Sprague-Dawley Rats.
Wil Research Laboratories. 1994. MRID No. 43146701. HED Doc No. (None).
Registration Data removed from pages 16-33.
Document (PDF) (952 KB PDF).
April 27, 1995. Memorandum. 20 Page(s).
Brian Dementi. Reregistration Branch.
EPA ID# 057701 - Malathion: Review of a Series 82-4 Subchronic
(13-Week) Inhalation Study. MRID No.: 432666-01. Tox review 011516.
Document (PDF) (1369 KB PDF).
April 27, 1995. Memorandum. 64 Page(s).
David Hrdy. Chemistry Branch II.
Response to the Malathion Reregistration Standard:
Magnitude of the Residue Studies. Case No. 0248. Chem No. 057701.
MRID Nos. 43360401, 43372701, 43376801, 43372901, 43370601, 43360001,
43368301, 43362501, 43367201, 43361101, 43468201, 43479601, & 43499901.
Document (PDF) (4319 KB PDF).
September 05, 1995. Memorandum. 3 Page(s).
David Hrdy. Chemistry Branch II.
Response to the Malathion Reregistration Standard: Independent Laboratory
Validation of a Malathion Analytical Method for Crop Matrices.
MRID No. 43630301.
Document (PDF) (176 KB PDF).
October 12, 1995. Memorandum. 8 Page(s).
David Miller. Chemistry Branch II.
Malathion. Storage Stability Studies in Various Raw & Processed Commodities.
GDLN Nos. 15273 & 16257. MRID Nos. 435490-01 & 436848-01.
Document (PDF) (498 KB PDF).
June 09, 1997. Memorandum. 7 Page(s).
Brian Dementi. Toxicology Branch.
Review of the Hispathology Re-assessment of Pituitary and Uterus
Tissues for the Malathion 24-Month Oral (Dietary) Combined Toxicity/
Carcinogenicity Study in the F344 Rat. MRID 44744201. Tox review 013720.
Document (PDF) (413 KB PDF).
August 14, 1997. DER. 78 Page(s).
Brian Dementi. Toxicology Branch I.
DER #1. Malathion: 2-Year Chronic Feeding/Carcinogenicity Study in
Fischer 344 Rats. Huntingdon Life Sciences. 1996. MRID No. 43942901.
HED Doc No. (none).
Document (PDF) (5328 KB PDF).
September 02, 1997. Memorandum. 7 Page(s).
K. Dockter. Reregistration Branch.
Malathion Reregistration. Residue Chemistry: Magnitude of the Residiue
in Dates, Six-Months Storage Stability in Various Processed Commodities
& Analytical Methods for Determining Malathion & its Metabolite Malaoxon
in/on Various RACs & Processed Commodit.
Document (PDF) (432 KB PDF).
September 23, 1997. Memorandum. 10 Page(s).
William Smith. Chemistry & Exposure Branch I.
Malathion Reregistration. Chem No. 057701; Case No. 0248; Storage
Stability Studies in Various Raw & Processed Commodities; GLN 860.1380;
Cheminova Agro A/S. MRID No. 43910901.
Document (PDF) (558 KB PDF).
September 30, 1997. Memorandum. 8 Page(s).
William Smith. Chemistry & Exposure Branch I.
Malathion Reregistration. Chem No. 057701; Case No. 0248; Magnitude
of the Residue in Processed Commodities of Potatoes, GLN 860.1520;
Cheminova Agro. MRID No. 43524101.
Document (PDF) (512 KB PDF).
December 15, 1997. Memorandum. 1 Page(s).
William Dykstra. RAB1 Health Effects Division.
ID# 94DA0003, -0004. Three Month Renewal of Section 18 Quarantine
Exemption for Use of Malathion-Bait and Diazinon to Control Non-
Indigenous Fruit Flies, (Including Mediterranean Fruit Fly) in Florida.
Document (PDF) (61 KB PDF).
December 17, 1997. Memorandum. 53 Page(s).
Jess Rowland. Science Analysis Branch HED.
Malathion - Report of the Hazard Identification Assessment Review Committee
Tox review 012440.
Document (PDF) (3501 KB PDF).
February 18, 1998. Memorandum. 2 Page(s).
Martha Lamont. Registration Action Branch I.
DRES Analysis for Malathion '... Please perform a chronic and acute DRES
analysis for malathion using additional PDP information provided...'.
Document (PDF) (78 KB PDF).
May 26, 1998. Memorandum. 18 Page(s).
Manying Xue. Chemistry & Exposure Branch I.
Malathion: PC Code 057701. Case 0248. Magnitude of Residues of
Malathion & Malaoxon in/on Stored Grains &Processed Commodities.
(OPPTS 860.1520). MRID Nos. 436661401 & 43666801.
Document (PDF) (1256 KB PDF).
July 13, 1998. Memorandum. 8 Page(s).
Manying Xue. Chemistry & Exposure Branch I.
Malathion: PC Code 057701. Case 0248. Magnitude of Residue of Malathion
& malaoxon in/on Winter Wheat Grain & its Processed Commodities.
MRID No. 43510501.
Document (PDF) (492 KB PDF).
August 18, 1998. Memorandum. 39 Page(s).
Jerome Blondell. Chemistry & Exposure Branch.
Review of Malathion Incident Reports.
Document (PDF) (3015 KB PDF).
September 22, 1998. Memorandum. 158 Page(s).
Brian Montague. Environmental Risk Branch.
EFED RED Chapter for Malathion PC Code 057701; Case No. 818961
DP Barcodes: D238903 and D238906 and D238904.
Document (PDF) (11225 KB PDF).
November 05, 1998. Memorandum. 43 Page(s).
Manying Xue. Chemistry & Exposure Branch I.
Malathion: PC Code 057701. Registration Case 0248. Magnitude of Residues
in Alfalfa, Clover & Cottonseed (OPPTS 860.1500) Processing Studies
in Grapes, Cottonseed, Rice & Field Corn (OPPTS 860.1520).
MRID Nos. 43546101, 43545201, 43596601, 43577401, 4358.
Document (PDF) (2677 KB PDF).
December 01, 1998. Memorandum. 23 Page(s).
Brian Dementi. Toxicology Branch.
Review of Pathology Working Group Report (PWG) Peer Review of Proliferative
Lesions of the Liver in Male B6C3F1 Mice in an 18-Month Oral (Dietary)
Oncogenicity Study in Micce of Malthion. MRID 44554901. Tox Review 013721.
Document (PDF) (1865 KB PDF).
December 22, 1998. Memorandum. 152 Page(s).
Jess Rowland. Hazard Identification Assessment Review.
MALATHION: - RE-EVALUATION A Report of the Hazard Identification
Assessment Review Committee.
Document (PDF) (6574 KB PDF).
January 08, 1999. Memorandum. 55 Page(s).
Manying Xue. Chemistry & Exposure Branch I.
Malathion: PC Code 057701. Case 0248. Magnitude of Residues in/on avocados,
beans (dry), blueberries, grapes, grasses, onions (dry bulb), onions
(green), rice, spring wheat, winter wheat (OPPTS 860.1500) & an orange
processing study (OPPTS 860.1520).
Document (PDF) (3416 KB PDF).
Attachment(s) Following:
January 08, 1999. Memorandum.
Manying Xue. Chemistry & Exposure Branch I.
MRID Nos. 43383501; 43417601, 43372601, 43383401, 43362601,
43350401, 43383301, 43468101, 43414901, 43350402 & 43451701.
*End of Attachments*
February 11, 1999. Memorandum. 154 Page(s).
Brian Dementi. Toxicology Branch.
Supplemental Information for the Cancer Assessment Review Committee Meeting Scheduled
for February 24, 1999 to Resume Evaluation of the Malathion Carcinogenicity Database.
Pages 13-84, 143-149 removed, registrant data.
Document (PDF) (5513 KB PDF).
Attachment(s) Following:
November 03, 1997. Memorandum.
Jess Rowland. Health Effects Branch.
MALATHION: Request for Re-Evaluation of Tissues/Slides by
the Cancer Assessment Review Committee. Tox review 012374.
December 01, 1998. Memorandum.
Brian Dementi. Toxicology Branch I.
Review of Pathology Working Group Report (PWG) Peer Review of
Proliferative Lesions of the Liver in Male B6C3F1 Mice in an 18-Month
Oral (Dietary) Oncogenicity Study in Mice of Malathion (MRID 44554901).
*End of Attachments*
February 12, 1999. Memorandum. 276 Page(s).
Sanjivani Diwan. Health Effects Division.
Cancer Assessment Review Committee Meeting on Malathion.
Pages 187-190, 208-219 removed, registrant data. (page 2: 2/12/99; William
Burnam; Additional Malathion Information for... Cancer Peer Review; page 3:
9/8/97; Jess Rowland; Cancer Assessment...
Document (PDF) (19222 KB PDF).
May 05, 1999. Memorandum. 25 Page(s).
Brian Dementi. Toxicology Branch.
Review of Histopathology Assessment of Nasal Tissues for the Malathion 18-Month
Oral (Dietary) Carcinogenicity Study in Mice (MRID: 44733501; 44792301).
Pages 14-25 removed, registrant data. Tox review 013722.
Document (PDF) (1141 KB PDF).
May 27, 1999. Memorandum. 81 Page(s).
Brian Dementi. Toxicology Branch.
Review of the Histopathology Re-Assessment of Nasal Tissues for the
Malathion 24-Month Oral (Dietary) Combined Toxicity/ Carcinogenicity Study
in the F344 Rat (MRID 44782301). Pages 26-81 removed, registrant data.
Tox review 013719.
Document (PDF) (2348 KB PDF).
October 06, 1999. Memorandum. 15 Page(s).
Richard Griffin. Reregistration Branch II, HED.
MALATHION: Preliminary Dietary Risk Assessment.
Document (PDF) (1323 KB PDF).
November 03, 1999. Memorandum. 15 Page(s).
Richard Griffin. Reregistration Branch II, HED.
MALATHION: Preliminary Dietary Risk Assessment (Revised).
Document (PDF) (912 KB PDF).
November 08, 1999. Memorandum. 72 Page(s).
Paula Deschamp. Reregistration Branch 2, HED.
Malathion: Preliminary Risk Assessment for the Reregistration Eligibility
Decision (RED) Document. Chemical No. 057701. Case No. 0248. Barcode D255364.
Tox review 013873.
Document (PDF) (5380 KB PDF).
November 18, 1999. Memorandum. 14 Page(s).
Brian Dementi. Toxicology Branch.
Malathion: Study Pathologist's Responses (MRIDs 44837001, 44970601,
44970501) to Health Effects Division's Questions on the Nasal Tissue
Histopathology Re-evaluation (MRID 44782301) of the Combined Chronic
Toxicity/Carcinogenicity Study in the F344 Rat...
Document (PDF) (883 KB PDF).
January 18, 2000. DER. 16 Page(s).
Toxicology Branch.
DER #14b; Malathion: Published Study; Ehrich, M. , Shell,L. , Rozum, M. ,
and Jortner, B.S. (1993) Short-term clinical & neuropathologic effects of
cholinesterase inhibitors in rats. J. Am Coll. Toxicol. 12(1), 55-68
(MRID No. 45045001) TXR0050532.
Document (PDF) (1205 KB PDF).
February 10, 2000. Memorandum. 54 Page(s).
Brian Dementi. Toxicology Branch.
Malathion - Report of the Cancer Assessment Review Committee
Attached: 2/2/2000 Final Cancer Assessment Document; Evaluation of the
Carcinogenic Potential of Malathion. MRID No. 43975201. Tox review 013991.
Document (PDF) (4245 KB PDF).
September 12, 2000. Memorandum. 8 Page(s).
Brian Dementi. Toxicology Branch.
DER #4a. Malathion: 28-day oral toxicity study in beagle dogs.
(MRID 45077703); Review of 28-Day Oral Toxicity Study of Malathion in Beagle
Dogs (MRID No. 45077703); Recommendations for Further Testing in Dogs.
Tox review No. 014336.
Document (PDF) (590 KB PDF).
December 14, 2000. Memorandum. 9 Page(s).
Brian Dementi. Toxicology Branch.
Review of FIFRA 6(a)(2) Data Submission for a Dose Range- Finding
Study in Sprague-Dawley Rats Intended to Provide Guidance for Dose
Selection for the Definitive Developmental Neurotoxicity and
Acetylcholinesterase Studies... Tox review 014413.
Document (PDF) (787 KB PDF).
April 19, 2001. Memorandum. 14 Page(s).
Brian Dementi. Toxicology Branch.
Review of a February 13, 2001 FIFRA 6(a)(2) Submission of Preliminary Data
from a Developmental Neurotoxicity Study on Malathion Performed in CD Rats.
Tox review 014544.
Document (PDF) (1106 KB PDF).
April 22, 2002. Memorandum. 9 Page(s).
Susan Makris. Toxicology Branch.
DER #7b. Malathion: Registrant Comments on Agency review of prenatal
developmental Toxicity study in rabbits (MRID No. 45626801) Supplemental
to MRID Nos. 00152569 & 40812001. Tox review No. 0050549.
Document (PDF) (672 KB PDF).
August 22, 2002. Memorandum. 100 Page(s).
Susan Makris. Toxicology Branch.
D282204. Malathion (057701) Developmental neurotoxicity data reviews:
1) developmental neurotoxicity study in rats 2) comparative cholinesterase
inhibition study in adult and juvenile rats 3) dose range-finding
developmental neurotoxicity in rats.
Document (PDF) (8159 KB PDF).
Attachment(s) Following:
August 22, 2002. Memorandum.
Susan Makris. Toxicology Branch.
(continued) MRIDs 45646401, 45566201, 45627001.
Tox review 050550.
*End of Attachments*
November 08, 2002. Memorandum. 440 Page(s).
Jack Arthur. Registration Action Branch 3.
Malathion: Updated Revised Occupational Exposure and Risk Assessment for the
Interim Reregistration Eligibility Decision (IRED) Document. (DP Barcode: D286796;
EPA MRID Nos.: 45005910, 45491901, 45138202, 45491902, 45138201, 45469501).
Document (PDF) (20173 KB PDF).
November 09, 2004. Memorandum. 13 Page(s).
Brian Dementi. Toxicology Branch.
D292658: Malathion (057701) Amendment 1 to comparative
cholinesterase inhibition study in adult and juvenile rats
(MRID 46005001). TXR No. 0052129.
Document (PDF) (546 KB PDF).
November 10, 2004. Memorandum. 9 Page(s).
Norman Birchfield. Environmental Risk Branch I.
Malathion use as a mosquitocide and potential risk to listed salmonids.
DP Barcode: 308617.
Document (PDF) (661 KB PDF).
April 11, 2005. Memorandum. 59 Page(s).
Anna Lowit. Reregistration Branch 2.
Benchmark dose analysis of brain and RBC data from the malathion
comparative cholinesterase study in juvenile and adult rats
(MRID No. 45566201). TXR No. 0053251.
Document (PDF) (151 KB PDF).
March 30, 2007. Memorandum. 19 Page(s).
Gerome Burke. Toxicology Branch.
Data Evaluation Record (DER) for Special Study: Repeat Dose Comparative
Cholinesterase Study of Malathion and Malaoxon in Juvenile Rats.
DP Barcode: D332783. TXR # 0054537. (MRID Nos. 46822201, 46821703).
Document (PDF) (694 KB PDF).
June 28, 2007. Memorandum. 9 Page(s).
Deborah Smegal. Re-Registration Branch 2.
Malathion and Malaoxon: Review of Acute Dose Comparative Cholinesterase
Study Protocol PC Code: 057701. Barcode: DP# 340518. TXR No. 0054632.
Document (PDF) (274 KB PDF).
August 21, 2007. Memorandum. 6 Page(s).
Deborah Smegal. Re-Registration Branch 2.
Malathion and Malaoxon: Follow-up Analysis of Acute Dose Comparative
Cholinesterase Study Protocol PC Code: 057701. Barcode: DP# 342339.
TXR No. 0054671.
Document (PDF) (187 KB PDF).