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Workshop Summary
The Asbestos Mechanisms of Toxicity Workshop was held June 12-13, 2003 in Chicago, Illinois. A brief summary report provided below documents areas of general agreement among the panelists or areas where a clear consensus did not exist.
All documents are provided in Adobe PDF format. Please click here for more information about PDF, or to download the Adobe Acrobat Reader.
Asbestos Mechanisms Summary (PDF 100KB)
In addition, panelists' presentations are provided below.
Thursday, June 12, 2003
Welcome and Introduction
Kim Fletcher, Facilitator
Anna Treinies, EPA OSWER
Dr. Lee Hofmann, EPA OSWER Science Advisor
Asbestos Activities in EPA (PDF 97KB)
Dr. Kevin Driscoll, Workshop Chair
Asbestos Mechanisms of Toxicity Workshop (PDF 88KB)
Panel 1 - Exposure and Dose Response Relationship
Dr. Andrew Churg, University of British Columbia
Influence of Fiber Type, Size, and Number in Human Disease: Conclusions from Fiber Burden Analysis (PDF 4.9MB)
Dr. James Lockey, University of Cincinnati
Experience with Occupational and Environmental Asbestos Exposure
(PDF 4.3MB)
Dr. Eugene McConnell, ToxPath, Inc.
Influence of Fiber Type, Size and Exposure in the Cancer and Non-Cancer Response to Asbestos Fibers (Animal Studies) (PDF 49KB)
Panel 2 - Mechanisms of Fiber-Inducing Lung and Pleural Disease
Dr. Arnold Brody, Tulane University
Interstitial Pulmonary Fibrosis (PDF 2.5MB)
Dr. Vincent Castranova, NIOSH
Mechanisms of Fiber-Induced Lung Disease (PDF 2.0MB)
Dr. Agnes Kane, Brown University
Molecular Pathogenesis of Malignant Mesothelioma (PDF 3.2MB)
Dr. Charles Hobbs, Lovelace Respiratory Research Institute (LRRI)
Fiber Durability and Biopersistence - Assessment and Role in Asbestos Toxicology (PDF 655KB)
Friday, June 13, 2003
Panel 3 - Molecular and Biochemical Mechanisms of Asbestos Fiber Toxicity
Dr. Brooke Mossman, University of Vermont
Cell Signaling and Proliferation by Asbestos (PDF 2.2MB)
Dr. Tom K. Hei, Columbia University
Genetic Effects of Asbestos Fibers (PDF 5.1MB)
Dr. Bice Fubini, University of Torino
Influence of Physico-Chemical Properties of Asbestos Fibers on their Biological Activity (PDF 1.6MB)