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Report on the Benchmark Dose Peer Consultation Workshop

Note: EPA no longer updates this information, but it may be useful as a reference or resource.

Risk Assessment Forum

This report includes information and materials from a peer consultation workshop organized by the EPA's Risk Assessment Forum. The meeting was held in Bethesda, Maryland, on September 10-11, 1996. The subject of the peer consultation was the document entitled Benchmark Dose Technical Guidance Document (External Review Draft, EPA/600/P-96/002A). [Note: a revised draft Benchmark Dose Technical Guidance Document that was published in 2000 is also available from EPA.] The expert panel was convened to independently comment on the draft guidance document and make recommendations that will enhance the guidance development process as well as the ultimate product.

The benchmark dose approach is one way of determining the point of departure for linear low dose extrapolation of carcinogens, calculation of a margin of exposure (MOE), or application of uncertainty factors for calculating oral reference doses (RfDs), inhalation reference concentrations (RfCs), or other exposure estimates. Following a 1990 colloquium recommendation, the Risk Assessment Forum took an active role in promoting research and discussion on benchmark dose issues. This led to the publication in 1995 of the document Use of the Benchmark Dose Approach in Health Risk Assessment and the external review draft guidance document that served as the focus of this peer consultation workshop.

Contact: Risk Assessment Forum Staff, 202-564-6483, or risk.forum@epa.gov

Downloads/Related Links

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Additional Information

Note: a complete electronic version of this document that preserves its original appearance (such as in a pdf file format) is not currently available. However, a scanned version is available in image or text format from EPA's National Environmental Publications Information System. Paper copies may be ordered from the National Technical Information Service.


US EPA. Report on the Benchmark Dose Peer Consultation Workshop. U.S. Environmental Protection Agency, Washington, DC, EPA/630/R-96/011, 1996.

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