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Benchmark Dose Technical Guidance Document (External Review Draft)
Risk Assessment Forum
Federal Register Notices
Notice
[9/30/08] The BMDS software (version 2.0) is available for download at https://www.epa.gov/ncea/bmds.htm
The purpose of this document is to provide guidance for the Agency on the application of the benchmark dose approach in determining the point of departure (POD) for health effects data, whether a linear or nonlinear low dose extrapolation is used. The guidance includes discussion on computation of benchmark doses and benchmark concentrations (BMDs and BMCs) and their lower confidence limits, data requirements, dose-response analysis, and reporting requirements. This guidance is based on today's knowledge and understanding, and on experience gained in using this approach.
Downloads/Related Links
- Benchmark Dose Technical Guidance Document (External Review Draft) (PDF) (96 pp, 811 KB, About PDF)
- Summary Report of the 2000 Workshop to Peer Review the Benchmark Dose Technical Guidance Document (PDF) (282 pp, 1.2 MB, About PDF)
- Use of the Benchmark Dose Approach in Health Risk Assessment
- Logistical Fact Sheet (PDF) (3 pp, 18 KB, About PDF)
- Peer Review Workshop Documents - Charge to Reviewers (PDF) (2 pp, 8 KB, About PDF)
- Report on the 1996 Benchmark Dose Peer Consultation Workshop