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Benchmark Dose Technical Guidance Document (External Review Draft)

Risk Assessment Forum
Federal Register Notices

[9/30/08] The BMDS software (version 2.0) is available for download at https://www.epa.gov/ncea/bmds.htm

The purpose of this document is to provide guidance for the Agency on the application of the benchmark dose approach in determining the point of departure (POD) for health effects data, whether a linear or nonlinear low dose extrapolation is used. The guidance includes discussion on computation of benchmark doses and benchmark concentrations (BMDs and BMCs) and their lower confidence limits, data requirements, dose-response analysis, and reporting requirements. This guidance is based on today's knowledge and understanding, and on experience gained in using this approach.

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