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Index of Cleared Science Reviews for Pyrethrins (Pc Code 069001)

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January 20, 1966. Memorandum. 3 Page(s).
J. Wolff. Pesticides Control Branch.
FAP #6H1946. Synergized pyrithrins in food-storage and food- processing areas.
Prefile review.
Document (PDF) (196 KB PDF).

February 24, 1966. Memorandum. 4 Page(s).
G. E. Whitmore. Petitions Review Branch.
Pyrethrins, Piperonyl Butoxide, MGK 264 (N-octylbicycloheptane dicarboximide).
Food Additive Petition No. 6H1946 MGK rat reproduction study
Document (PDF) (173 KB PDF).

October 19, 1966. Memorandum. 5 Page(s).
J. Wolff. Pesticides Branch.
FAP #5H1740. Residues on cereal milling fractions from use of piperonyl butoxide
pyrethrins sprays. Evaluation of analytical methods and residue data.
Document (PDF) (742 KB PDF).

October 20, 1966. Memorandum. 11 Page(s).
J. Wolff. Pesticides Control Branch.
FAP #6H1946. Synergized pyrethrins in food processing and food storage areas.
Evaluation of analytical methods and residue data.
Document (PDF) (690 KB PDF).

January 30, 1967. Memorandum. 2 Page(s).
D. Duffy. Petitions Control Branch.
FAP #6H1946. Combined maximum residues of piperonyl butoxide and pyrethrins
from existing and proposed usages.
Document (PDF) (110 KB PDF).

March 09, 1967. Memorandum. 1 Page(s).
Harry Hays. Pesticides Regulation Division.
Food Additive Petition No. 6H1946. Your memorandum of Febuary 20, 1967.
Document (PDF) (38 KB PDF).

May 01, 1967. Memorandum. 1 Page(s).
Drew Baker. Pesticides Control Branch.
Food Additive Petition No. 6H1946 -- MGK 264.
Document (PDF) (119 KB PDF).

October 06, 1971. Memorandum. 1 Page(s).
J. Wolff. Pesticides Control Branch.
FAP #2H2662. Synergized pyrethrins in food processing and food storage areas.
Comments on proposal.
Document (PDF) (68 KB PDF).

December 20, 1971. Memorandum. 1 Page(s).
J. Wolff. Pesticides Control Branch.
FAP #2H2662. Synergized pyrethrins in food processing and food storage areas.
Comments on petitioner's letter dated 11/16/71.
Document (PDF) (74 KB PDF).

February 02, 1972. Memorandum. 1 Page(s).
P. C. Williams. Standards Branch.
Opinion on Usefulness Food Additive Petition 2H2662.
Document (PDF) (43 KB PDF).

March 15, 1972. Memorandum. 1 Page(s).
George Whitmore. Toxicology Branch.
Request to amend FAR 121.1074 and 121.1075 Piperonyl Butoxide and Pyrethrins.
Document (PDF) (71 KB PDF).

September 05, 1974. Memorandum. 1 Page(s).
George Whitmore. Toxicology Branch.
Request to Amend FAP No. 0H2530 Piperonyl butoxide pyrethrins.
Document (PDF) (62 KB PDF).

August 14, 1975. Memorandum. 2 Page(s).
Diana Reisa. Toxicology Branch.
Dog Guard Flea and Tick Insecticide and Mosquito Repellant.
Document (PDF) (141 KB PDF).

October 20, 1975. Review. 2 Page(s).
Jack Edmundson. Efficacy & Ecological Effects Branch.
File or Reg. No. 4816-178 Birds - 8 day dietary study... mallard duck
[no MRID]... acceptable.
Document (PDF) (354 KB PDF).

August 27, 1978. Memorandum. 5 Page(s).
Larry Anderson. Toxicology Branch.
Ortho Hi-Power Indoor Insect Fogger (Active Ingredients: Pyrethrins, Piperonyl
Butoxide, N-Octyl bicycloheptene dicarboximide, Petroleum Distillate) - Amendment
(Label Revision) with Data, EPA Reg. No. 239-2429...
Inert ingredient info. on page 1 deleted.
Document (PDF) (285 KB PDF).

April 08, 1980. Review. 7 Page(s).
R. S. Van Denburgh. Insecticide Rodenticide Branch.
File No. 4822-RAO. Raid Indoor Fogger. Registration.
Document (PDF) (241 KB PDF).

August 26, 1980. Memorandum. 4 Page(s).
Cheryl Peterson. Insecticide Rodenticide Branch.
EPA Registration No. 39159-2. A-200 Pyrinate Liquid. Caswell Nos. 715, 670.
Document (PDF) (244 KB PDF).

December 05, 1980. Memorandum. 4 Page(s).
Cheryl Peterson. Insecticide Rodenticide Branch.
EPA Registration No. 4816-482. Pyrenone Garden Spray Concentrate.
Caswell Nos. 715, 670, 646 Tox review 000295.
Document (PDF) (211 KB PDF).

January 22, 1981. Memorandum. 5 Page(s).
Cheryl Peterson. Insecticide Rodenticide Branch.
EPA Registration No. 4822-169. Raid Indoor Fogger. Caswell #s 715, 328.
Product ingredient source information on page 1 is not included.
Document (PDF) (275 KB PDF).

February 13, 1981. Memorandum. 3 Page(s).
B. T. Backus. Insecticide Rodenticide Branch.
EPA File Symbol 4822-RIN. Raid Indoor Fogger II.
Caswell #s 844, 652B, 715, 670, 613.
Document (PDF) (165 KB PDF).

March 12, 1981. Efficacy Review. 6 Page(s).
R. S. Van Denburgh. Insecticide Rodenticide Branch.
File No. 4822-RIN. Raid Indoor Fogger II. Registration. Inert ingredient and product
ingredient source information on pages 1-2 are not included.
Document (PDF) (254 KB PDF).

August 28, 1981. Memorandum. 2 Page(s).
D. Ritter. Toxicology Branch.
FAP #1H5303 - Pyrethrins, Piperonyl Butoxide and Diatomaceous Earth in Food and
Feed Handling Establishments. Amended Registration (#6300-1AA; Perma-Guard
Household Insecticide D-20). Inert ingredient information on page 2 is not included.
Document (PDF) (96 KB PDF).

March 19, 1982. Review. 2 Page(s).
R. S. Van Denburgh. Insecticide Rodenticide Branch.
Raid Indoor Fogger II. Registration. Product ingredient source information
on page 1 is not included.
Document (PDF) (77 KB PDF).

July 21, 1983. Memorandum. 5 Page(s).
B. T. Backus. Insecticide Rodenticide Branch.
EPA Reg. No. 432-664. Foliafume Insecticide with Rotenone/Pyrethrins. Caswell
#725, 715. In 06-27-83; Record No. 98167. Pages 4-5 removed, draft label.
Tox review 003117.
Document (PDF) (198 KB PDF).

November 01, 1983. Memorandum. 2 Page(s).
B. T. Backus. Insecticide Rodenticide Branch.
EPA Reg. No. 1021-340 Pyrocide Intermediate No. 5192 Inhalation LC50 - Rat
Acc. 251314.
Document (PDF) (75 KB PDF).

November 01, 1983. Memorandum. 3 Page(s).
William Dykstra. Toxicology Branch.
Pyrocide Intermediate 5192 EPA Registration # 1021-340 Resubmission with DATA
[Acute] Toxicity Studies (Biosearch Inc., July 1, 1975).
Document (PDF) (152 KB PDF).

March 22, 1984. Memorandum. 6 Page(s).
Deloris Graham. Fungicide Herbicide Branch.
EPA Registration Number 2724-298. Zoecon RF-200 Pressurized Spray.
Document (PDF) (392 KB PDF).

July 11, 1984. Review. 2 Page(s).
Rita Kumar. Insecticide Rodenticide Branch.
IRB/TSS Precautionary Labeling Review [Reg. No.] 1021-340 Pyrocide Intermediate
5192 Inhalation, dermal sensitization Acc. 252717, 252716, 252314.
Document (PDF) (252 KB PDF).

October 10, 1987. Review. 10 Page(s).
John Doherty. Toxicology Branch.
Pyrethrin: Review of Rat and Rabbit Teratology Studies MRID 402882-02, -03
Tox Review 006348.
Document (PDF) (531 KB PDF).

April 18, 1988. Memorandum. 7 Page(s).
John Doherty. Toxicology Branch.
EPA File Symbol 52563-R: Pyrethrins. Toxicology Branch response to the inquiry
from John W. Kennedy consultant to the U.S. Pyrethrum Culture concerning
registration of dried pyrethrum flowers grown in…Tox review 006667.
Document (PDF) (218 KB PDF).
Attachment(s) Following:

April 18, 1988. Memorandum.
John Doherty. Toxicology Branch.
continued. the USA and shipped to refineries for processing to pesticide
products. MRID 84072 (Metabolism: rats and mice) Tox review 006667.

*End of Attachments*

May 03, 1988. Review. 10 Page(s).
James Goodyear. Ecological Effects Branch.
Freshwater Fish Acute Toxicity (multiple) Rainbow trout, Bluegill sunfish, Channel
catfish, blue gillfish [sic] MRID 111966, 144750.
Document (PDF) (654 KB PDF).
Attachment(s) Following:

May 03, 1988. Review.
James Goodyear. Ecological Effects Branch.
Avian Acute Toxicity; Blue Rock Pigeon.

*End of Attachments*

May 03, 1988. Review. 8 Page(s).
James Goodyear. Ecological Effects Branch.
Avian Acute Toxicity Study type - Avian Dietary Single-dose Oral LD50 Species
Tested - Blue Rock Pigeon.
Document (PDF) (493 KB PDF).
Attachment(s) Following:

May 03, 1988. Review.
James Goodyear. Ecological Effects Branch.
Avian Acute Toxicity Study type - Avian Dietary Single-dose Oral LD50
Species Tested - House Sparrow MRID 144751.

*End of Attachments*

August 16, 1988. Review. 18 Page(s).
John Doherty. Toxicology Branch.
Pyrethrin's submission of rat and rabbit teratology range finding studies in response to
a prior request from Toxicology Branch. Assignment of Core Classification...
MRID 40603701 Tox Review 006824
Document (PDF) (904 KB PDF).

October 13, 1988. Memorandum. 12 Page(s).
John Doherty. Toxicology Branch.
EPA Identifying Number 069001. Pyretrins: Studies submitted to help resolve
problems related to completion of the plant and animal metabolism data requirements
[including MRID 084072].
Document (PDF) (392 KB PDF).

December 16, 1988. Memorandum. 7 Page(s).
Michael Flood. Dietary Exposure Branch.
Pyrethrin residue chemistry data call-in. Photolysis data submitted by Chemical
Specialities Manufacturers Association (CSMA). MRID No. 40700400, -01.
Document (PDF) (189 KB PDF).

August 21, 1989. TAS Report. 1 Page(s).
Health Effects Division.
Pyrethrin I TAS Report
Document (PDF) (67 KB PDF).

August 21, 1989. TAS Report. 4 Page(s).
Health Effects Division.
Pyrethrin I TAS Report.
Document (PDF) (226 KB PDF).

January 09, 1990. Memorandum. 8 Page(s).
Roger Gardner. Toxicology Branch.
Pyrethrin Data Call-In Submission of Preliminary Results from Long-Term Feeding
Studies in mice and Rats. MRID 41559401. Tox review 007675.
Document (PDF) (239 KB PDF).

March 12, 1990. Review. 25 Page(s).
William Dykstra. Toxicology Branch.
SRRD/GCSB Transmittal Sheet For Part B's (page 24) summary of
MRID No. 41344501, 41344601. MRID 92158008, 92158009.
Document (PDF) (417 KB PDF).

March 23, 1990. Review. 3 Page(s).
Charles Trichilo. Non-Dietary Exposure Branch.
SRRD/GCSB Transmittal Sheet for Parts B/C/D Submitter: MGK, Fairfield America,
Roussel Bio, Pyrethrum Board.
Document (PDF) (151 KB PDF).

June 21, 1990. Memorandum. 13 Page(s).
John Doherty. Toxicology Branch.
EPA Id #69001. Pyrethrum Extract: Review of mutagenicity (Ames Test) and
chromosome aberration study and overview of mutagenicity/genotoxicity testing.
MRID 41344701. Tox review 007998.
Document (PDF) (384 KB PDF).

February 15, 1991. Review. 4 Page(s).
A. Nielsen. Occupational & Residential Exposure Branch.
OREB Transmittal Sheet for Phase 4 Reviews
Data Submitter(s): Fairfield American Corporation.
Document (PDF) (248 KB PDF).

February 15, 1991. Review. 4 Page(s).
A. Nielsen. Occupational & Residential Exposure Branch.
OREB Transmittal Sheet for Phase 4 Reviews
Data Submitter(s): Prentiss Drug & Chemical Company Inc.
Document (PDF) (250 KB PDF).

February 15, 1991. Review. 4 Page(s).
A. Nielsen. Occupational & Residential Exposure Branch.
OREB Transmittal Sheet for Phase 4 Reviews
Data Submitter(s): Pyrethrum Board of Kenya.
Document (PDF) (249 KB PDF).

February 15, 1991. Review. 4 Page(s).
A. Nielsen. Occupational & Residential Exposure Branch.
OREB Transmittal Sheet for Phase 4 Reviews
Data Submitter(s): S.C. Johnson & Son Inc.
Document (PDF) (250 KB PDF).

February 15, 1991. Review. 4 Page(s).
A. Nielsen. Occupational & Residential Exposure Branch.
OREB Transmittal Sheet for Phase 4 Reviews
Data Submitter(s): The Commonwealth Industrial Gases, Ltd.
Document (PDF) (251 KB PDF).

February 15, 1991. Review. 4 Page(s).
A. Nielsen. Occupational & Residential Exposure Branch.
OREB Transmittal Sheet for Phase 4 Reviews Mc Laughlin Gormley King Co.
Document (PDF) (247 KB PDF).

March 19, 1991. Memorandum. 6 Page(s).
John Doherty. Toxicology Branch.
EPA Id #690021. Pyrethrins: Review of an unsceduled DNA synthesis study
(Genotoxicity Category III) with rat hepatocytes. MRID 41344501. Tox review 008308.
Document (PDF) (170 KB PDF).

June 10, 1991. Efficacy Review. 1 Page(s).
Vern McFarland. Insecticide Rodenticide Branch.
Reg No. 270-251 To provide performance data in support of claim for control of deer
tick on horses and ponies, to be added to existing label for the subject product.
MRID 417939-01
Document (PDF) (67 KB PDF).

September 03, 1991. DER. 4 Page(s).
Allen Vaughan. Ecological Effects Branch.
Study Type: Honey bee acute contact LD50 Species tested: Apis mellifera
MRID 41968803.
Document (PDF) (387 KB PDF).

September 09, 1991. DER. 3 Page(s).
Richard Felthousen. Ecological Effects Branch.
Study Type: Avian Dietary LC50 Test. Species tested: Bobwhite quail
MRID 41968801.
Document (PDF) (379 KB PDF).

September 09, 1991. DER. 3 Page(s).
Richard Felthousen. Ecological Effects Branch.
Study Type: Avian Dietary LC50 Test. Species tested: Mallard Duck MRID 41968802.
Document (PDF) (374 KB PDF).

September 30, 1991. Review. 24 Page(s).
Linnea J. Hansen. Toxicology Branch I.
ID# 57883-1. Pyrethrum extract (technical). Evaluation of a Two-Generation Rat
Reproduction Study to support reregistration of Pyrethrum Extract MRID 413275-01
Tox Review 008639.
Document (PDF) (1247 KB PDF).

March 10, 1992. DER. 3 Page(s).
Sara Ager. Ecological Effects Branch.
Study Type: Avian Acute Oral for the Bobwhite quail MRID 42010901.
Document (PDF) (408 KB PDF).

June 01, 1992. Memorandum. 2 Page(s).
Christine Olinger. Chemistry Branch.
Reregistration of Pyrethrins: Analytical Method Issues; Chemical No. 69001;
Case No. 2580... DP Barcode No. D177182 MRID 042146.
Document (PDF) (65 KB PDF).

March 30, 1993. Memorandum. 17 Page(s).
William Woodrow. Registration Support Branch.
EPA Reg./File Symbol No.: 499-GIL. PT 230 [239] Tri Die. Six acute toxicity studies.
MRID 42613702 thru 42613707.
Document (PDF) (1048 KB PDF).

November 09, 1993. Memorandum. 8 Page(s).
Bruce Kitchens. Occupational & Residential Exposure Branch.
Evaluate New Uses for the Product Cessco Accudose Insecticide Aerosol
(a.i. Pyrethrins) and Provide an Exposure Assessment.
Document (PDF) (356 KB PDF).
Attachment(s) Following:

November 09, 1993. Memorandum.
Laurie Lewis. Exposure Assessment Branch.
Pyranha Exposure Assessment.

*End of Attachments*

December 02, 1993. Memorandum. 2 Page(s).
Bruce Kitchens. Occupational & Residential Exposure Branch.
Accudose Insecticide Aerosol (DP D194705, 006959-IE).
Document (PDF) (92 KB PDF).

February 24, 1994. Review. 45 Page(s).
John Doherty. Toxicology Branch I.
EPA ID No.: 069001. Pyrethrum extract: Review of rat and mouse chronic
feeding/carcinogenicity study (IRDC 1990); Page 27 removed, registrant data.
MRID 415595-01,415594-01. Tox Review 010798.
Document (PDF) (2242 KB PDF).

March 31, 1994. Review. 14 Page(s).
John Doherty. Toxicology Branch I.
Review of a series 81-8ss acute neurotoxicity screen study. Pages 13-14 are removed
- registrant data MRID 429258-01 Tox Review 010883.
Document (PDF) (835 KB PDF).

June 22, 1994. Review. 33 Page(s).
John Doherty. Toxicology Branch I.
Pyrethrine: Review of a series 82-4 subchronic (3-month) inhalation toxicity study
in rats. MRID 424782-01 Tox Review 011068.
Document (PDF) (1597 KB PDF).

July 19, 1994. Memorandum. 6 Page(s).
Ian Blackwell. Registration Support Branch.
EPA Reg. No./File Symbol: 11540-1/ULD BP-300 Insecticide; Acute Tox One-Liner.
MRID No. 430940-1.
Document (PDF) (265 KB PDF).

October 19, 1994. DER. 13 Page(s).
D. Edelstein. Environmental Fate & Ground Water Branch.
Study 7 Laboratory Accumulation - Fish Pages 9-60 removed, registrant data.
MRID 43303201.
Document (PDF) (1092 KB PDF).

October 19, 1994. DER. 5 Page(s).
D. Edelstein. Environmental Fate & Ground Water Branch.
Study 4 Mobility - Leaching and Adsorption/Desorption Pages 5-19 removed,
registrant data. MRID 43096603.
Document (PDF) (635 KB PDF).

October 24, 1994. Review. 22 Page(s).
Akiva Abramovitch. Environmental Fate & Ground Water Branch.
Fate Data Summary Review of 161-1, 161-2, 161-3, 163-1, 163-2 and 164-2 studies for
reregistration. MRID 43188201, 43096601, -02, -03, -04, 43125701, 43195201, 43302301.
Document (PDF) (2350 KB PDF).

January 26, 1995. Review. 9 Page(s).
John Doherty. Toxicology Branch.
EPA ID# 069001. Pyrethrine: Review of a series 83-1 chronic feeding study in dogs.
MRID 414695 Tox Review 011395.
Document (PDF) (531 KB PDF).

June 06, 1995. TAS Report. 1 Page(s).
Health Effects Division.
Pyrethrins TAS Report.
Document (PDF) (65 KB PDF).

June 06, 1995. TAS Report. 6 Page(s).
Health Effects Division.
Pyrethrins TAS Report.
Document (PDF) (294 KB PDF).

June 12, 1995. Memorandum. 15 Page(s).
John Doherty. Toxicology Branch.
Carcinogenicity Peer Review of Pyrethrins.
Document (PDF) (1019 KB PDF).

June 12, 1995. Review. 6 Page(s).
George Z. Ghali. Health Effects Division.
RfD/Peer Review Report of Pyrethrins. MRID No. 41496501, 42478201, 41559501,
41559401. Tox review 011579.
Document (PDF) (497 KB PDF).

September 21, 1995. Note. 2 Page(s).
John Doherty. Health Effects Division.
EPA Id# 069001. Pyrethrins: Minutes of a meeting with the registrant and their
consultant to discuss the Carcinogenicity Peer Review Report.
Document (PDF) (114 KB PDF).

August 12, 1996. Memorandum. 21 Page(s).
Carol Glascow. Registration Support Branch.
EPA File Symbol/EPA Reg. No.: 499-450/ULD BP-300 Insecticide (Acute Toxicity Studies).
Document (PDF) (1111 KB PDF).

June 11, 1997. Memorandum. 11 Page(s).
John Doherty. Toxicology Branch.
EPA Id No.: 069001. Pyrethrins: Review of a chromasome aberration study in CHO cells.
DP Barcode: D227458 MRID 43987001.
Document (PDF) (372 KB PDF).

July 17, 1997. Review. 5 Page(s).
Alfred Smith. Technical Review Branch.
Product Chemistry Review. REG./File Symbol No.: 499-GIL. Whitmire PT 239 Tri
Die Insecticide MRID 42613701.
Document (PDF) (219 KB PDF).

May 06, 1999. Memorandum. 28 Page(s).
Sanjivani Diwan. Health Effects Division.
Report of the Cancer Assessment Review Committee Tox review 013354.
Document (PDF) (1558 KB PDF).

May 07, 2003. Memorandum. 2 Page(s).
Roger Gardner. Biochemical Pesticides Branch.
Review of acute oral (MRID 45773201) and acute dermal (MRID 45773202) studies
with EU1161 (EPA File Symbol 67702-2). (S631088).
Document (PDF) (60 KB PDF).

March 15, 2004. DER. 11 Page(s).
Jose Melendez. Environmental Risk Branch.
Study 1 Aerobic Soil Metabolism Pages 9-17 removed, registrant data.
MRID 43499803.
Document (PDF) (801 KB PDF).

April 06, 2005. Memorandum. 23 Page(s).
Jerome Blondell. Chemistry & Exposure Branch.
Review of Pyrethrins Incident Reports - Revised. DP Barcode D315643,
Chemical #069001.
Document (PDF) (993 KB PDF).

August 16, 2005. Memorandum. 24 Page(s).
Jerome Blondell. Chemistry & Exposure Branch.
Review of Pyrethrins Incident Reports - Second Revision. DP Barcode D320300,
Chemical #069001.
Document (PDF) (129 KB PDF).

February 14, 2008. Memorandum. 28 Pages.
Jessica Kidwell. Cancer Assessment Review Committee.
PYRETHRINS: Fourth Report of the Cancer Assessment Review Committee.
TXR No.: 0054822.
Document (PDF) (1156 KB PDF).

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