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Index of Cleared Science Reviews for Fortress (PC Code 129006)

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February 13, 1989. DER. 2 Page(s).
Sanford W. Bigelow. Toxicology Branch I.
Primary Skin Irritation - Rabbit (81-5). MRID No. 408837-18. Tox review 007112.
Document (PDF) (104 KB PDF).

February 13, 1989. DER. 48 Page(s).
Sanford W. Bigelow. Toxicology Branch I.
Acute Oral Toxicity - Rat (81-1). Page 22 removed FIFRA Reg. data. MRID Nos.
408837-12, 13, 14, 17, 19 & 408987-02 & 408837-24, 25, 21, 15,16, 22, 20, 11, and 23.
Tox review 007112.
Document (PDF) (2413 KB PDF).

May 15, 1989. Memorandum. 2 Page(s).
Sanford W. Bigelow. Health Effects Division.
Fortress: Response to Registrant's Submission Regarding the Toxicity and Potential
for Cholinesterase Inhibition of Diethylphosphate (DEP) and Diethylthiophosphate
(DETP). EPA Record No. 244011.
Document (PDF) (136 KB PDF).

January 17, 1990. Data Eval. Rec. 8 Page(s).
Jeffrey Bigler. Ecological Effects Branch.
Avian Dietary LC50, Mallard Duck. Acc. # 408837-38. Pages 5-8 removed-registrant
data.
Document (PDF) (190 KB PDF).

February 06, 1990. Data Eval. Rec. 13 Page(s).
Jeffrey Bigler. Ecological Effects Branch.
Avian Reproduction Study. Species Tested: Mallard duck. Accession 408837-40.
Pages 10-12 removed-registrant data.
Document (PDF) (648 KB PDF).

May 02, 1990. DER. 3 Page(s).
M. Elba Morrow. Toxicology Branch I.
Primary Dermal Irritation - Rabbits. MRID No. 412906-25. Tox review 008330.
Document (PDF) (165 KB PDF).

May 04, 1990. DER. 6 Page(s).
Melba Morrow. Toxicology Branch I.
Primary Eye Irritation- Rabbits. MRID No. 412906-24. Tox review 008330.
Document (PDF) (274 KB PDF).

May 04, 1990. DER. 6 Page(s).
Melba S. Morrow. Toxicology Branch I.
Dermal Sensitization- Guinea Pigs. MRID No. 412906-26. Tox review 008330.
Document (PDF) (345 KB PDF).

March 28, 1991. Data Eval. Rec. 3 Page(s).
Melba Morrow. Toxicology Branch I.
Acute oral - Rats Guideline 81-1 MRID No. 412906-22.
Document (PDF) (248 KB PDF).

March 28, 1991. DER. 32 Page(s).
Karen L. Hamernik. Toxicology Branch I.
Teratogenicity - Rabbits 83-3. Pages 21-22 removed, registrant data. Inert ingredient
information on pages 26-27 not included. MRID Nos. 412906-33, 412906-23.
Tox review 008330 and 011376.
Document (PDF) (2476 KB PDF).

March 28, 1991. Memorandum. 2 Page(s).
Henry Spencer. Toxicology Branch I.
Change of Core Classification of Inhalation Study on the Technical Fortress (In 43898)
MRID No. 408837-16. Tox review 008310.
Document (PDF) (63 KB PDF).

January 14, 1993. Review. 278 Page(s).
Dynamac Corporation. Environmental Fate & Ground Water Branch.
Chlorethoxyphos (DPX-43898) Task 1: Review and Evaluation of Individual Studies
MRID 41736821 thru 41736829, 41290603, 41290605, 42559238, 42559239,
41290609, 41290612. Pages 9-22, 29-42, 49-60, 67- 78, 87-104, 107-140, 145-152, 164-
221...(continued).
Document (PDF) (4418 KB PDF).
Attachment(s) Following:

January 14, 1993. Review. Page(s).
Dynamac Corporation. Environmental Fate & Ground Water Branch.
(continued) 225-254, 260-265, 270-272 removed-registrant data.

*End of Attachments*

July 28, 1993. Data Eval. Rec. 3 Page(s).
Pia Lindstrom. Clement International Corporation.
Acute Dermal Toxicity (Rabbit); Guideline 81-2 MRID 425592-07.
Document (PDF) (138 KB PDF).

July 28, 1993. Data Eval. Rec. 5 Page(s).
Pia Lindstrom. Clement International Corporation.
Acute Inhalation Toxicity (Rat); Guideline 81-3 MRID 417368-32.
Document (PDF) (294 KB PDF).

August 09, 1993. DER. 4 Page(s).
Marion Copley. Toxicology Branch I.
Primary Dermal Irritation (Rabbit); Guideline 81-5. MRID No. 425592-08.
Document (PDF) (119 KB PDF).

January 10, 1994. Memorandum. 31 Page(s).
Jerry B. Stokes. Chemistry Branch I.
PP33F4174. Amendment Dated 2/14/95. Chlorethoxyfos (DPX-43898) in/on Corn.
Evaluation on Analytical Method and Residue Data. MRID Nos. 412906-01 thru -06, -
35, -36, -37 Page 23-31 deleted - manufacturing process; quality control procedures on
pages 9-10 not included.
Document (PDF) (1632 KB PDF).

February 07, 1994. Review. 16 Page(s).
Akiva Abramovitch. Environmental Fate & Ground Water Branch.
000352-LLG Technical and 000352-LLE 5G Insecticide New Chemical Review
MRID 41736821 thru 41336828 and 41290605.
Document (PDF) (1275 KB PDF).

October 18, 1994. Memorandum. 3 Page(s).
David G. Anderson. Toxicology Branch I.
EPA ID 129006; Response to sponsor's comments Guinea Pig Sensitization Test
(Buehler method) (81-6) with DPX-43898-26 (Fortress 5G). MRID No. 425592-09,
412906-26.
Document (PDF) (140 KB PDF).

November 16, 1994. Review. 11 Page(s).
Karen Hamernik. Toxicology Branch.
Toxicology Endpoint Selection Document MRID 408837-14, -15, 425592-21, 417368-
33, 425592-15, 412906-27, -32, 408987-03, -04.
Document (PDF) (713 KB PDF).

December 12, 1994. Review. 12 Page(s).
Karen Hamernik. Toxicology Branch I.
Addendum to DERs for Fortress 1. Acute Neurotoxicity of DPX-43898 (Fortress Tech)
in Rats (MRID 425592-10) 2. Subchronic Neurotoxicity: 90-Day Study of DPX-43898
Feeding Study in Rats (MRID 425592-17).
Document (PDF) (798 KB PDF).

December 30, 1994. Memorandum. 30 Pages.
Karen L. Hamernik. Toxicology Branch I.
FORTRESS (CHLORETHOXYFOS; DPX-43898. IN 43898). An organophostae: 1.
Review of Additional Toxicology Studies Submitted to Support the full Registration
of Fortress Technical and Fortress 5GDP Barcode D185831. MRID Nos. 41736836,
41736837 & 42559215.
Document (PDF) (1029 KB PDF).

March 07, 1995. Memorandum. 6 Page(s).
Jerry B. Stokes. Chemistry Branch I.
Request for a Metabolism Review of Chlorethoxyfos (DPX-43898) and Determination
of Residue(s) to be Regulated.
Document (PDF) (419 KB PDF).

March 09, 1995. Memorandum. 9 Page(s).
George Z. Ghali. Health Effects Division.
RfD/Peer Review Report of Fortress [O,O-diethyl O- (1,2,2,2-tetrachloroethyl)
phosphorothioate]. Tox review 011441.
Document (PDF) (704 KB PDF).

April 14, 1995. Memorandum. 7 Page(s).
Jerry B. Stokes. Chemistry Branch I.
PP33F4174. Amendment Dated 2/14/95. Chlorethoxyfos (DPX-43898) in/on Corn.
MRID No. 435503-00 Page 7 not included - manufacturing process.
Document (PDF) (1889 KB PDF).

April 19, 1995. Memorandum. 2 Page(s).
Jerry Stokes. Chemistry Branch.
The HED Metabolism Committee Meeting Held on April 11, 1995. Chlorethoxyfos.
Document (PDF) (133 KB PDF).

May 01, 1995. Memorandum. 5 Page(s).
Brian Steinwand. Science Analysis Branch.
Dietary Exposure Analysis for Chlorethoxyfos in/on Corn. PP# 3F4174.
Document (PDF) (259 KB PDF).

May 11, 1995. Memorandum. 4 Page(s).
Charles Lewis. Special Review & Registration (& OREB).
Review of Registrants Supplemental Information for Chlorethoxyfos.
Document (PDF) (319 KB PDF).

June 25, 1995. Review. 10 Page(s).
Karen Hamernik. Health Effects Division.
Toxicology Endpoint Selection Document.
Document (PDF) (776 KB PDF).

June 29, 1995. Memorandum. 6 Page(s).
Brian Steinwand. Science Analysis Branch.
Acute Dietary Exposure Analysis for Chlorethoxyfos.
Document (PDF) (246 KB PDF).

July 13, 1995. Review. 73 Page(s).
Akiva Abramovitch. Environmental Fate & Ground Water Branch.
000352-(LLE,LLG,LTO) Du Pont Fortress 2.5G, 5G and technical. To review data to
support the registration of Fortress as well as to review supplemental (162-3) data.
MRID 43607301,43550307. Pp 14- 20, 22-27 removed-draft label. Pp 29-32, 37-67
removed-RD.
Document (PDF) (1838 KB PDF).

August 01, 1995. Review. 39 Page(s).
Anthony Maciorowski. Ecological Effects Branch.
Chlorethoxyfos (Fortress) Application for Registration (D212604, D212662) Attached
is the Ecological Effects portion of the risk assessment for Fortress...
Document (PDF) (2730 KB PDF).

August 15, 1995. Memorandum. 9 Page(s).
Charles Lewis. Special Review & Registration (& OREB).
Estimates of Exposure for Fortress (Chlorethoxyfos).
Document (PDF) (552 KB PDF).

August 21, 1995. Memorandum. 18 Page(s).
Steve Robbins. Risk Characterization & Analysis Branch.
HED Risk Assessment for Chlorethoxyfos (Fortress).
Document (PDF) (1494 KB PDF).

August 29, 1995. Memorandum. 54 Page(s).
Henry Nelson. Envirnomental Fate & Ground Water Branch.
Review of runoff studies from corn seedbeds in Central and Western Iowa under
simulated rainfall. MRID 435503-02 and 435503-03. Pages 23-54 removed, registrant
data.
Document (PDF) (1403 KB PDF).

April 01, 1996. Memorandum. 3 Page(s).
Linnea J. Hansen. Toxicology Branch.
FORTRESS (CHLORETHOXYFOS). ID# 000352-00553. Review of Protocols for
Acute and 28-day Hen delayed Neurotoxicity Studies (81-7 and 82-6, Respectively)
and Acute Rat Neurotoxicity Screening Study (81-8SS). MRID Nos. 40898702,
42559210.
Document (PDF) (205 KB PDF).

September 30, 1996. Memorandum. 3 Page(s).
Kit Farwell. Toxicology Branch I.
Fortress (Chlorethoxyfos). Review of Protocols for Inhalation Range-finding Study,
Repeated-Dose Inhalation Toxicity Study, and Repeated-Dose Dermal Toxicity
Study.
Document (PDF) (211 KB PDF).

September 25, 1997. Memorandum. 5 Page(s).
Jess Rowland. Science Analysis Branch.
Chlorethoxyfos - FQPA Requirement - Report of the Hazard Identification Review
Committee. Tox review 012323.
Document (PDF) (335 KB PDF).

October 08, 1997. DER. 38 Page(s).
Kevin Poff. Fate & Monitoring Branch.
DER 1. Field Volatility. Pages 7-38 removed, registrant data. MRIDs 43550307,
44361301.
Document (PDF) (547 KB PDF).

October 08, 1997. Review. 8 Page(s).
Kevin Poff. Fate & Monitoring Branch.
EPA Reg. No. 000352-0053. To review additional data submitted to upgrade a
previously reviewed Field Volatility (163-3) study. MRID 44361301.
Document (PDF) (706 KB PDF).

October 16, 1998. Memorandum. 9 Page(s).
Gary Bangs. Residue Chemistry Analysis Branch.
CHLORETHOXYFOS - HED Occupational and Residential Exposure Chapter for
the HED Chapter of the Chlorethoxyfos RED. Chemical# 129006.
Document (PDF) (552 KB PDF).

October 19, 1998. Memorandum. 3 Page(s).
Jess Rowland. Health Effects Division.
CHLORETHOXYFOS - RE-EVALUATION OF Toxicology Endpoint Selection
Tox review 012910.
Document (PDF) (261 KB PDF).

November 23, 1998. Memorandum. 6 Page(s).
Robert Matzner. Fate & Monitoring Branch.
Drinking Water Assessment for Chlorethoyfos.
Document (PDF) (392 KB PDF).

January 08, 1999. Memorandum. 20 Page(s).
Steven Knizner. Health Effects Division.
CHLORETHOXYFOS. Revised Short Format HED Chapter of RED. Chemical
Number 129006. DP Barcode D 252055.
Document (PDF) (1150 KB PDF).

April 20, 1999. Memorandum. 4 Page(s).
Gary Bangs. Health Effects Division.
Response to: EPA Docket No. OPP 31470: Responses to EPA's January 1999
Preliminary Risk Assessment for the Active Ingredient , Chlorethoxyfos of Fortress
5G Insecticide in the SmartBox, Fortress 2.5 G and Fortress Technical.
Document (PDF) (227 KB PDF).

May 13, 1999. Memorandum. 10 Page(s).
Sarah Law. Health Effects Division.
CHLORETHOXYFOS: Acute and Chronic Dietary Exposure Analysis.
Document (PDF) (532 KB PDF).

May 26, 1999. Memorandum. 2 Page(s).
Roger Hawks. Health Effects Division.
CHLORETHOXYFOS - Review of a Repeated Exposure Inhalation Study and
Evaluation of That Study by the Hazard Identification Review Committee
Tox review 013393.
Document (PDF) (135 KB PDF).

July 19, 1999. Memorandum. 5 Page(s).
Deanna Scher. SRRD.
Response to "Non-Chemical Specific" Public Comments on the Preliminary Risk
Assessment for Chlorethoxyfos.
Document (PDF) (364 KB PDF).

August 06, 1999. Risk Assessment. 23 Page(s).
Gary Bangs. Health Effects Division.
Human Health Risk Assessment, Chlorethoxyfos.
Document (PDF) (1915 KB PDF).

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