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Index of Cleared Science Reviews for Profenofos (Pc Code 111401)
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Undated. Memorandum. 62 Page(s).
William Woodrow. Toxicology Branch.
EPA Reg. #100-EUP-AT, 9H5231, 9G2234 (Curacron 6E Insecticide -
Soybeans), 100-LOI, 8F2057, 8H5177 (Curacon - Growing Cotton...
Impurity, inert ingredient, and commercial financial information
on pages 1, 4 and 5 is not included. Tox review 000821.
Document (PDF) (9006 KB PDF).
April 24, 1978. Review. 12 Page(s).
Phil Hutton. Efficacy & Ecological Effects Branch.
Reg. No. 100-200 Acc. 096859 thru 096863 New Compound - Cotton
Expedited Review.
Document (PDF) (487 KB PDF).
May 26, 1978. Review. 64 Page(s).
Ronald Ney. Efficacy & Ecological Effects Branch.
File or Reg. No. 100-LOO. Registration on Cotton.
Document (PDF) (2888 KB PDF).
October 15, 1978. Review. 5 Page(s).
Ronald Ney. Environmental Fate Branch.
Data Response to Review of 5/26/78 and Telephone
Conversation of 10/16/78.
Document (PDF) (237 KB PDF).
November 01, 1978. Profile. 3 Page(s).
David Ritter. Toxicology Branch.
Curacron, Toxicology Profile. Tox review 000823.
Document (PDF) (486 KB PDF).
November 27, 1978. Review. 5 Page(s).
Ronald Ney. Environmental Fate Branch.
Reg. /File No: 100-LOI. Preparation for Meeting.
Document (PDF) (139 KB PDF).
October 01, 1979. Review. 17 Page(s).
Efficacy and Ecological Effects Branch.
FILE OR REG. NO. 100-LOO, LOI. Resubmission with Data.
Document (PDF) (902 KB PDF).
October 01, 1979. Review. 5 Page(s).
Henry Craven. Ecological Effects Branch.
Profenofos on Cotton.
Document (PDF) (295 KB PDF).
March 25, 1980. Review. 5 Page(s).
R. W. Cook. Environmental Fate Branch.
Data for Review Photo Study to Determine Value for Regulatory Decision.
Document (PDF) (213 KB PDF).
April 08, 1980. Memorandum. 3 Page(s).
Gary Burin. Toxicology Branch.
Validation Review of IBT Study 623-7924 Reproduction Study with CGA-15324
(Curacron) in Albino Rats. Tox review 000822.
Document (PDF) (452 KB PDF).
March 18, 1981. Memorandum. 1 Page(s).
D. B. Davies. Government of Canada.
Audit and Validation of the IBT Study: "Cholinesterase Activity Study with
CGA 15324 Technical in Beagle Dogs". Tox review 002536.
Document (PDF) (103 KB PDF).
May 04, 1981. Memorandum. 1 Page(s).
H. M. Cunningham. Government of Canada.
Audit and Validation of "90-Day Subacute Oral Toxicity Study with CGA
15324 Technical in Beagle Dogs". (Revision of Report of May 16, 1979 to
Mr. D.J. Clegg). Tox review 002536.
Document (PDF) (103 KB PDF).
June 16, 1981. Memorandum. 1 Page(s).
D. B. Davies. Government of Canada.
Audit and Validation of the IBT Study: "42-Day Neurotoxicity Study with
CGA-15324 Technical in Adult Chickens". Tox review 002536.
Document (PDF) (147 KB PDF).
December 02, 1981. DER. 6 Page(s).
Dennis J. McLane. Ecological Effects Branch.
Invertebrate life cycle test - Mysidopsia bahia. Acute and chronic toxicity
of profenofos to mysid shrimp (Mysidopsia bahia). MRID No.: 00085963.
Document (PDF) (342 KB PDF).
December 08, 1981. DER. 4 Page(s).
Dennis J. McLane. Ecological Effects Branch.
Eggs and fry fathead minnow (Pimephales promelas). The toxicity of CGA-15324
to fathead minnow (Pimephales promelas) eggs and fry. MRID No.: 00085958.
Document (PDF) (185 KB PDF).
December 10, 1981. DER. 4 Page(s).
Dennis J. McLane. Ecological Effects Branch.
Invertebrate life cycle test - Daphnia magna. The chronic toxicity of CGA-15324
to the water flea (Daphnia magna). MRID No.: 00085964.
Document (PDF) (165 KB PDF).
January 29, 1982. Review. 4 Page(s).
Willa Garner. Environmental Fate Branch.
EXAMS Model Determinations for Aquatic Systems Adjacent to Cotton.
Document (PDF) (176 KB PDF).
March 15, 1982. Review. 22 Page(s).
Willa Garner. Environmental Fate Branch.
Reg. No. : 100-LOO Reevaluation of drift and runoff data
Pages 4-22 removed, registrant data.
Document (PDF) (148 KB PDF).
March 22, 1982. Report. 1 Page(s).
Gary Burin. Toxicology Branch.
IBT Validation Report, IBT No. 623-07924, Three-Generation
Reproduction Study with CGA-15324 Technical in Albino Rats
Tox review 001629.
Document (PDF) (61 KB PDF).
March 25, 1982. Memorandum. 4 Page(s).
Gary Burin. Toxicology Branch.
Review of Validated IBT Rat Reproduction Study of Curacron (CGA-15324),
IBT No. 623-07924, Tox. Chem. 266A Tox review 001573.
Document (PDF) (418 KB PDF).
April 19, 1982. Memorandum. 41 Page(s).
William Woodrow. Toxicology Branch.
EPA Reg. #100-599, 100-598, PP#8F2057, 9H5231, and FAP 8H5177 -
Profenofos (Curacron) on Growing Cotton. Caswell #266AA, Acc. Nos. 070513,
245718, 245717... Impurity and inert ingredient information on
pages 2 and 5 not included. Tox review 001783.
Document (PDF) (5676 KB PDF).
Attachment(s) Following:
Undated. ADI printout.
Toxicology Branch.
ADI printout for cottonseed use.
*End of Attachments*
April 22, 1982. Memorandum. 7 Page(s).
William Woodrow. Toxicology Branch.
EPA Reg. No. 100-599, 100-598, PP#8F2057, 9H5231, and FAP 8H5177 -
Profenofos (Curacron) on Growing Cotton. Manufacturing process
information on page 2 is not included. Tox review 002535.
Document (PDF) (703 KB PDF).
May 28, 1982. Memorandum. 2 Page(s).
Gary Burin. Toxicology Branch.
Addendum to Validation and Review of Additional Histopathology Data for
IBT Three-Generation Reproduction Study of Curacron in Albino Rats;
IBT No. 623-07924, Accession No. 247456 Tox review 003001.
Document (PDF) (239 KB PDF).
October 19, 1982. Memorandum. 5 Page(s).
Gary Burin. Toxicology Branch.
Review of Acute Toxicology Studies for Curacron, Accession No. 247933
Tox review 002238.
Document (PDF) (508 KB PDF).
October 21, 1982. Memorandum. 3 Page(s).
Gary Burin. Toxicology Branch.
Comments on Curacron Neurotoxicity Including the Evaluation of a
Validated Acute Neurotoxicity Study in Chickens, IBT #8580-111870
Tox review 002236.
Document (PDF) (188 KB PDF).
October 26, 1982. Memorandum. 7 Page(s).
Gary Burin. Toxicology Branch.
Review of Curacron Teratology Studies; 100-598, 599; PP#8F2057,
8H5177. Caswell #266AA, Acc. Nos. 247784-7, 247919, 070884.
Tox review 002247.
Document (PDF) (868 KB PDF).
December 10, 1982. Memorandum. 4 Page(s).
Gary Burin. Toxicology Branch.
Re-Evaluation of Validated IBT Study of Curacron; Acute Delayed
Neurotoxicity in Chickens, Study #8580-10426. Inert ingredient
information on pages 2 and 3 not included. Tox review 002331.
Document (PDF) (282 KB PDF).
December 13, 1982. Memorandum. 2 Page(s).
Orville Paynter. Toxicology Branch.
Re-Evaluation of Validated IBT Study of Curacron; Acute Delayed
Neurotoxicity in Chickens, Study #8580-10426. Tox review 002929.
Document (PDF) (145 KB PDF).
October 21, 1983. Memorandum. 3 Page(s).
Gary Burin. Toxicology Branch.
Review of Curacron Rabbit Teratology Study, Accession Number 250451.
Tox review 003323.
Document (PDF) (369 KB PDF).
May 23, 1984. Review. 17 Page(s).
Carolyn Offutt. Exposure Assessment Branch.
Reg. No. : 100-599. Runoff. study review to satisfy a conditional
registration requirement.
Document (PDF) (645 KB PDF).
April 10, 1985. Review. 11 Page(s).
Carolyn Offutt. Exposure Assessment Branch.
Reg. /File No. : 100-599. 1984 Pond Monitor Survey Study to Satisfy for Full
Registration Requirement.
Document (PDF) (469 KB PDF).
November 17, 1985. Memorandum. 2 Page(s).
Gary Burin. Toxicology Branch.
Response to Comments on Review of Curacron Rabbit Teratology
Study. Acc. No. 254648. Caswell #266AA. Tox review 004780.
Document (PDF) (177 KB PDF).
December 05, 1986. Review. 6 Page(s).
Emil Regelman. Exposure Assessment Branch.
Reg. /File # 100-599. Amend to Add Application on Soybeans. Profenofos
Is Currently Registered for Cotton.
Document (PDF) (246 KB PDF).
February 03, 1987. Review. 3 Page(s).
George Ghali. Health Effects Division.
Reference Doses (RFDs) for Oral Exposure Chemical:
Curacron/Profenofos Ciba-Geigy Limited 1981 6-Month Dog Feeding Study.
Document (PDF) (147 KB PDF).
June 18, 1991. Data Eval. Rec. 10 Page(s).
Richard Felthousen. Ecological Effects Branch.
Study Type: Avian Single dose Oral LD50 Test. Species Tested: Mallard duck.
MRID No. 416273-01.
Document (PDF) (479 KB PDF).
June 18, 1991. Data Eval. Rec. 12 Page(s).
Marise Robbins. KBN Engineering for EEB.
Study Type: Avian Dietary LC50 Test. Species Tested: Bobwhite quail.
MRID No. 416273-03.
Document (PDF) (596 KB PDF).
June 18, 1991. Data Eval. Rec. 12 Page(s).
Richard Felthousen. Ecological Effects Branch.
Study Type: Avian Dietary LC50 Test. Species Tested: Mallard duck.
MRID No. 416273-02.
Document (PDF) (613 KB PDF).
June 19, 1991. Data Eval. Rec. 11 Page(s).
Mark Mossler. KBN Engineering & Applied Sciences Inc.
Profenofos. Chetram, R.S. 1990. Tier 2 Seedling Emergence Nontarget
Phytotoxicity Study Using Profenofos Technical (Curacron).
MRID No. 416273-07.
Document (PDF) (533 KB PDF).
June 19, 1991. Data Eval. Rec. 6 Page(s).
Mark Mossler. KBN Engineering & Applied Sciences Inc.
Profenofos. Chetram, R.S. 1990. Tier 2 Seed Germination Nontarget
Phytotoxicity Study Using Profenofos Technical (Curacron).
MRID No. 416273-06.
Document (PDF) (306 KB PDF).
June 19, 1991. Data Eval. Rec. 8 Page(s).
Louis Rifici. KBN Engineering & Applied Sciences Inc.
Profenofos. Bellantoni, D.C. 1990. Profenofos Technical: A 48-Hour Static
Acute Toxicity Text with the Cladoceran (Daphnia magna). MRID No. 416273-04.
Document (PDF) (397 KB PDF).
June 19, 1991. Data Eval. Rec. 8 Page(s).
Mark Mossler. KBN Engineering & Applied Sciences Inc.
Profenofos. Winter, P.A. 1990. Profenofos: An Acute Contact Study with
the Honey Bee. MRID No. 416273-08.
Document (PDF) (2241 KB PDF).
September 02, 1992. Review. 6 Page(s).
Richard Felthousen. Ecological Effects Branch.
Curacron. Review Registrant Rebuttal to EEB Review of Avian Dietary
Studies. Profenofos.
Document (PDF) (322 KB PDF).
November 06, 1992. Data Eval. Rec. 10 Page(s).
Richard Felthousen. Ecological Effects Branch.
Profenofos. Chetram, R.S. 1990. Tier 2 Vegetative Vigor Nontarget
Phytotoxicity Study Using Profenofos Technical (Curacron).
MRID No. 461273-05.
Document (PDF) (501 KB PDF).
March 14, 1995. Memorandum. 11 Page(s).
Catherine Eiden. Chemistry Branch II.
Profenofos. Nature of the Residue in Cotton. Case No. 2540. Chemical
No. 111401. MRID No. 43186801. DP Barcode: D201827. CBRS No. 13539.
Radiovalidation data. MRID No. 43203501. DP Barcode: D203218. CBRS No. 13725.
Document (PDF) (692 KB PDF).
February 06, 1996. Memorandum. 11 Page(s).
George Ghali. Health Effects Division.
RfD/Peer Review Report of Profenofos (Curacron)...
Document (PDF) (729 KB PDF).
May 09, 1996. Memorandum. 11 Page(s).
Brian Steinwand. Science Analysis Branch.
Dietary Exposure Aanalysis for Profenofos in Support of the
Reregistration Eligibility Decision.
Document (PDF) (716 KB PDF).
June 17, 1996. Memorandum. 25 Page(s).
David Farrar. Environmental Fate & Effects Branch.
EFED Text Proposed for the Profenofos RED (List B; Case 2540; PC Code 111401).
Document (PDF) (1726 KB PDF).
June 18, 1996. Memorandum. 49 Page(s).
Kathleen Martin. Risk Characterization & Analysis Branch.
The HED Chapter of the Reregistration Eligibility Decision Document
(RED) for Profenofos.
Document (PDF) (2912 KB PDF).
August 30, 1996. Memorandum. 9 Page(s).
David Farrar. Environmental Fate & Effects Branch.
EFED Risk Characterization and Recommendations for the
Reregistration of Profenofos.
Document (PDF) (615 KB PDF).
September 25, 1996. Memorandum. 20 Pages.
Ronald Parker. Environmental Fate & Ground Water Branch.
Product Name: Curacron. Common Name: Profenofos. Type of Product:
Acaracide, insecticide. Company Name: Ciba-Geigy. DP Barcode:
D222822, D222825. To provide aquatic exposure assessment for
Profenofos through PRZM-EXAMS Computer modelling.
Document (PDF) (950 KB PDF).
September 25, 1997. Memorandum. 5 Page(s).
Jess Rowland. Science Analysis Branch HED.
Profenofos - FQPA Requirement - Report of the Hazard Identification
Assessment Review Committee. Tox review 012326.
Document (PDF) (294 KB PDF).
January 21, 1998. Memorandum. 58 Page(s).
Richard Griffin. Health Effects Division.
Profenofos (PC Code 111401). FQPA Update of the HED Chapter of the
Reregistration Eligibility Decision Document. Case No. 2540.
Document (PDF) (3585 KB PDF).
February 06, 1998. Letter. 6 Page(s).
Kylie Rothwell. SRRD.
To: Robert E.M. Wurz Novartis Crop Protection, Inc. Profenofos
Reregistration; HED Chapter with FQPA Update; HED's Response to
Rebuttal on Toxicology Section.
Document (PDF) (392 KB PDF).
Attachment(s) Following:
October 29, 1997. Memorandum.
Raymond Locke. Accelerated Reregistration Branch.
HED's response to the Registrant's Rebuttal of the Toxicology
Chapter of the Draft HED RED on Profenofos.
*End of Attachments*
May 14, 1998. Memorandum. 5 Page(s).
Richard Lee. Environmental Risk Branch 4.
Summary of EFED Concerns Regarding Fish Kill Incidents Attributed
to Use of Profenofos on Cotton.
Document (PDF) (345 KB PDF).
August 12, 1998. Letter. 7 Page(s).
Jack Housenger. SRRD.
To: Robert E.M. Wurz Novartis Crop Protection, Inc. Profenofos Fish
Kills in Southern United States.
Document (PDF) (416 KB PDF).
December 01, 1998. Memorandum. 9 Pages.
Ann Stavola. Ecological Effects Branch.
EFED Response to Comments from the Registrant and the Public
Regarding the Draft Profenofos RED.
Document (PDF) (433 KB PDF).
April 22, 1999. Memorandum. 2 Pages.
Nelson Thurman. Environmental Risk Branch IV.
EFED Response to USDA/Land Grant University Comments on the
Profenofos Updated Risk Assessment; Comments Dated April 1, 1999.
Document (PDF) (84 KB PDF).
June 15, 1999. Memorandum. 22 Page(s).
Carmelita White. SRRD.
Resonse to Public Comments on Preliminary Risk Assessments for the
Organophosphate Profenofos.
Document (PDF) (1744 KB PDF).
June 16, 1999. Risk Assessment. 49 Page(s).
Denise Keehner. Environmental Fate & Effects Division.
Reregistration Eligibility Decision Environmental Risk Assessment
for Profenofos.
Document (PDF) (3455 KB PDF).
June 16, 1999. Risk Assessment. 58 Page(s).
Richard Griffin. Health Effects Division.
Human Health Risk Assessment, Profenofos.
Document (PDF) (3954 KB PDF).
June 26, 2002. Memorandum. 4 Page(s).
William Sette. Toxicology Branch.
Profenofos: Review of Acute and Repeated Exposure Comparative
Cholinesterase Study Protocols. DP Barcode: D281191. TXR #: 0050512.
Document (PDF) (129 KB PDF).
November 17, 2004. Memorandum. 4 Page(s).
Jess Rowland. Science Information Management Branch.
Secondary Review of the Developmental Neurotoxicity Studies.
(MRIDs 46025401 and 46025402). DP BARCODE: D293052. TXR#: 0052102.
Document (PDF) (2079 KB PDF).
September 20, 2005. Memorandum. 30 Pages.
Ayaad Assaad. Toxicology Branch.
PROFENOFOS: Data Evaluation Record of a Developmental
Neurotoxicity Toxicity Study. CAS # 41198-08-7
DP Barcode D293052. MRID No. 46025401 & 46025402.
TXR No. 0052102.
Document (PDF) (1523 KB PDF).
January 31, 2007. Memorandum. 1 Page.
Christopher Salice. Environmental Risk Branch IV.
Response to Profenofos freshwater fish full life cycle data waiver request.
DP Barcode: D280410.
Document (PDF) (30 KB PDF).