Index of Cleared Science Reviews for Dichlorvos (Pc Code 084001)
You will need Adobe Reader to view some of the files on this page. See EPA's PDF page to learn more.
Undated. Data Eval. Rec. 4 Pages.
Duncan Turnbull. Clement Associates.
Interaction of Dichlorvos and Anticholinesterases
on the In Vivo Inhibition of Human Blood Cholinesterases.
Document (PDF) (153 KB PDF).
Undated. Data Eval. Rec. 6 Pages.
Jack Kalin. Southern Research Institute.
The Effect of Acute Intoxication by Dichlorvos and
Trichlorfon on the Activities of Some Rat Brain Esterases.
Document (PDF) (201 KB PDF).
September 27, 1974. Memorandum. 6 Pages.
Andrew Rathman. Chemistry Branch.
FAP #4H5046. DDVP Premise Use. Evaluation of
Analytical Methods and Residue Data and Ltr. of 3/13/74.
Inert ingredient information on page 2 is not included.
Document (PDF) (418 KB PDF).
December 12, 1974. Memorandum. 2 Pages.
Andrew Rathman. Chemistry Branch.
FAP #4H5046. DDVP in Food Handling Establishments.
Comments on Amendment of 11/12/74, Including Revised Sections B and F.
Inert ingredient information on page 1 is not included.
Document (PDF) (85 KB PDF).
January 30, 1976. Memorandum. 1 Page.
Diana Reisa. Toxicology Branch.
16% Carbaryl Flea Collar for Dogs
Registration # 2724-ETG. Cholinesterase inhibition in dogs.
Document (PDF) (47 KB PDF).
January 30, 1976. Memorandum. 2 Pages.
Diana Reisa. Toxicology Branch.
8.5% Carbaryl Flea Collar for Cats
Registration # 2724-272. Rate of release of carbaryl...
Document (PDF) (76 KB PDF).
August 15, 1978. Memorandum. 2 Pages.
Roland Gessert. Toxicology Branch.
Toxicity of Dog and Cat Flea Collars on Exposed Animals
and Humans; Inquiry from Florida Student.
Document (PDF) (91 KB PDF).
April 8, 1980. Review. 7 Pages.
R.S. Van Denburgh. Insecticide-Rodenticide Branch.
File No. 4822-RAO. Raid Indoor Fogger. Registration.
Document (PDF) (235 KB PDF).
January 22, 1981. Memorandum. 5 Pages.
Cheryl Peterson. Insecticide-Rodenticide Branch.
EPA Registration No. 4822-169. Raid Indoor Fogger. Acute oral...
Product ingredient source information on page 1 not included.
Document (PDF) (253 KB PDF).
March 27, 1981. Memorandum. 6 Pages.
B.T. Backus. Insecticide-Rodenticide Branch.
EPA File Symbol 2724-EOG. Zoecon RF-184 House & Kennel Fogger.
Acute oral... Pages 5-6 removed, draft label.
Tox review 000341.
Document (PDF) (304 KB PDF).
July 20, 1981. Memorandum. 7 Pages.
M. Nelson. Residue Chemistry Branch.
PP #1E2510/FAP #1H5309. DDVP in or on Figs.
Evaluation of Analytical Methodology and Residue Data.
Manufacturing process and inert ingredient information on page 2 are not included.
Document (PDF) (398 KB PDF).
August 5, 1981. Memorandum. 3 Pages.
Lynn Bradley. Residue Chemistry Branch.
81-CA-29. Section 18 Exemption for DDVP on Figs in CA.
Document (PDF) (146 KB PDF).
July 25, 1983. Data Eval. Rec. 2 Pages.
Irving Mauer. Toxicology Branch.
Potentiative and Synergistic Effects.
MRID 00058650.
Document (PDF) (59 KB PDF).
July 26, 1983. Data Eval. Rec. 1 Page.
Irving Mauer. Toxicology Branch.
Mutagenicity Review. Mutagenicity of Dichlorvos and its Minor Impurities.
MRID No. 00058647.
Document (PDF) (39 KB PDF).
January 4, 1984. Review. 4 Pages.
Phil Hutton. Insecticide-Rodenticide Branch.
422-EAT. Raid Wasp & Hornet Killer IV.
Accession #251660. TSS/IRB Safety Review. Acute oral...
Inert ingredient information on page 1 is not included.
Document (PDF) (147 KB PDF).
July 01, 1986. DER. 1 Page.
John Noles. Ecological Effects Branch.
Acute Toxicity of Some Organophosphorus Pesticides against Fish
& Aquatics: Sumithion. MRID No. 126904.
Document (PDF) (241 KB PDF).
February 2, 1987. Memorandum. 23 Pages.
Byron Backus. Toxicology Branch.
Sergeant's Flea and Tick Collar (9% Baygon, 7% DDVP).
Inert ingredient information on page 4 is not included.
Acute tox, dermal sensitization, cholinesterase inhibition. Acc 263653.
Tox review 005704.
Document (PDF) (1,950 KB PDF).
August 11, 1987. Memorandum. 13 Pages.
C. Frick. Residue Chemistry Branch.
Dichlorvos (DDVP) - Tolerance Assessment/Quantitative Risk Assessment.
Addendum to the Registration Standard.
Document (PDF) (944 KB PDF).
September 25, 1987. Memorandum. 12 Pages.
Judith Hauswirth. Toxicology Branch.
Peer Review of Dichlorvos.
Document (PDF) (682 KB PDF).
February 16, 1988. Memorandum. 1 Page.
Francis Suhre. Residue Chemistry Branch.
DDVP/Naled/Trichlorfon; Request for Updated Market Share Data;
No MRID No.; No RCB No.
Document (PDF) (47 KB PDF).
March 16, 1988. Memorandum. 3 Pages.
Judith Hauswirth. Toxicology Branch.
Second Peer Review of Dichlorvos - Reevaluation Following
the September 23, 1987, Science Advisory Panel Review.
Document (PDF) (157 KB PDF).
May 3, 1988. Memorandum. 4 Pages.
Francis Suhre. Residue Chemistry Branch.
DDVP Dietary Exposure Assessment; Availability of Residue
Chemistry Data; No MRID No., RCB Nos. 3718, 3719, and 3720.
Document (PDF) (211 KB PDF).
May 15, 1988. Memorandum. 4 Pages.
Debra Edwards. Residue Chemistry Branch.
Response to Questions Regarding Residue Chemistry Data
Requirements Listed in the Dichlorvos (DDVP) Registration
Standard (RD ID No. 0054810, RD Record No. 219493,
RCB No. 3636).
Document (PDF) (245 KB PDF).
June 8, 1988. Memorandum. 5 Pages.
Francis Suhre. Residue Chemistry Branch.
RCB's Response to Public Comments on the PD-1 for DDVP;
ID No. 084001; RCB No. 3873.
Document (PDF) (226 KB PDF).
August 17, 1988. Memorandum. 5 Pages.
Judith Hauswirth. Toxicology Branch.
Third Peer Review of Dichlorvos - Reevaluation Following
the April 18, 1988, Meeting of the NTP Panel of Experts.
Document (PDF) (230 KB PDF).
September 22, 1988. Memorandum. 30 Pages.
Francis Suhre. Dietary Exposure Branch.
Dietary Exposure Assessment for 2,2 dichlorovinyl dimethylphosphate (DDVP)
from Registered Uses of Naled and Trichlorfon (PHIs < 7 Days);
No MRID No.; DEB Nos. 3727 and 4056.
Document (PDF) (1,308 KB PDF).
September 18, 1989. Memorandum. 13 Pages.
George Ghali. Toxicology Branch.
Fourth Peer Review of Dichlorvos (DDVP).
Document (PDF) (690 KB PDF).
October 13, 1989. Memorandum. 37 Pages.
William Greear. Toxicology Branch.
Dichlorvos (DDVP) - Submission of Drinking Water
Oncogenicity Studies in the Rat and Mouse.
**Identity of product impurities on pages 4, 16 not included.
Pages 12-14, 31-37 removed, registrant data.
MRID # 41041801, -02. Tox review 007543.
Document (PDF) (1,269 KB PDF).
January 10, 1990. Memorandum. 4 Pages.
Elizabeth Haeberer. Dietary Exposure Branch.
Follow-up to the Naled Registration Standard; Review of
Method Validation Report for Chevron Chemical Co.'s Method
RM-3G-4 with Addendum (Determination of Naled and DDVP
Residues in Crops, MRID No. 405064-01), 12/1/89.
Document (PDF) (210 KB PDF).
January 25, 1990. Memorandum. 3 Pages.
R.B. Perfetti. Dietary Exposure Branch.
Dichlorvos (DDVP) Registration Standard.
Document (PDF) (147 KB PDF).
April 13, 1990. Memorandum. 1 Page.
Gobind Makhijani. Dietary Exposure Branch.
Data Requirement - Residue Chemistry for Indoor Use of DDVP-
AMVAC EPA Reg. No. 5481-96, DEB No. 6500.
Document (PDF) (43 KB PDF).
July 20, 1990. Memorandum. 2 Pages.
Elizabeth Haeberer. Dietary Exposure Branch.
Dichlorvos (DDVP) Registration Standard: Questions Pertaining to Residue
Chemistry Data Requirements for Storage Stability Studies and Residue Data
No MRID No., HED Project No. 0-1503, DEB No. 6809).
Document (PDF) (125 KB PDF).
December 3, 1990. Memorandum. 26 Pages.
William Greear. Toxicology Branch.
Dichlorvos (DDVP) - Submission of a 12-Month Chronic Oral Study in Dogs
(EPA ID No. 5481-96) MRID No. 415931-01.
Pages 21-26 removed, registrant data.
Tox review 008178.
Document (PDF) (947 KB PDF).
February 20, 1991. Memorandum. 3 Pages.
Freshteh Toghrol. Chemistry Branch.
Response to the Residue Chemistry Chapter of the DDVP Registration Standard;
Request for Time Extension for Livestock Metabolism Studies (Dated 4/16/90).
No MRID No., CBRS #7110.
Document (PDF) (166 KB PDF).
August 14, 1991. Memorandum. 2 Pages.
Dennis McNeilly. Chemistry Branch.
Proposed Revocation of DDVP (Dichlorvos) Food Additive Tolerances.
[CB#: 8203; MRID: N/A; DP Barcode: D165988.].
Document (PDF) (134 KB PDF).
February 24, 1992. Memorandum. 17 Pages.
Joycelyn Stewart. Toxicology Branch.
Developmental Toxicity Study on Dichlorvos (DDVP).
EPA ID# 084001. Record # S 400533. MRID # 41951501
Tox review 009305.
Document (PDF) (512 KB PDF).
June 10, 1992. Memorandum. 5 Pages.
George Ghali. Science Analysis & Coordination Branch.
Report of the third RfD/Peer Review of Dichlorvos (DDVP).
Document (PDF) (444 KB PDF).
July 7, 1993. Memorandum. 6 Pages.
George Ghali. Health Effects Division.
Dichlorvos (DDVP): Reconsideration of quantification of human risk.
Document (PDF) (448 KB PDF).
July 21, 1993. Memorandum. 24 Pages.
Dennis McNeilly. Chemistry Branch II.
DDVP (dichlorvos); Goat Metabolism Study Following Dermal
Application for 3 Consecutive Days.
[CB #: 11768; MRID: 42721601; DP Barcode: D190450].
Document (PDF) (1,284 KB PDF).
July 18, 1994. Memorandum. 33 Pages.
Susan V. Hummel. Chemistry Branch II.
Dichlorvos (084001) Reregistration Case No. 0310 Processing
studies on field corn, wheat, rice, cottonseed and soybeans.
[MRID 42993501, CB No. 13296; DP Barcode D199979] Livestock
Feeding Studies: Dairy Cow and Hen [MRIDs 43037401, 43047901,
CB No. 13294, DP Barcode D199975] (subject cont.).
Attachment(s) following:
Document (PDF) (2,299 KB PDF).
July 18, 1994. Memorandum.
Susan V. Hummel. Chemistry Branch II.
(CONT.) Food Handling Establishments: Corn Processing, Oat
Manufacturing, Oat Processing, Wheat Manufacturing [MRIDS 42775901,
42878801,42878802,42910801,42910901; CB No. 13427, DP Barcode D200905].
July 18, 1994. Memorandum.
Susan V. Hummel. Chemistry Branch II.
(CONT.) Reduction of Residues: Half-Life Determination in Packaged
and Bagged Commodities. [MRID 42858201, CB No.13295 DP Barcode D199976].
July 18, 1994. Memorandum.
Susan V. Hummel. Chemistry Branch II.
(CONT.) Reduction of Residues: Uncooked and Cooked/Processed Commodities:
meat, eggs, dry beans, milk, cocoa beans, coffee beans, and tomato paste.
[MRID 42910701; CB No.13006 DP Barcode : D197522].
*End of attachments*
December 2, 1994. Memorandum. 13 Pages.
Stephen Schaible. Science Analysis Branch.
Acute and Chronic Dietary Exposure Analyses for DDVP.
Document (PDF) (1,031 KB PDF).
March 25, 1996. DER. 21 Pages.
Rosemary Mora. KBN Engineering & Applied Sciences Inc.
FRESHWATER FISH EARLY LIFE-STAGE TEST GUIDELINE 72-4. DDVP Technical Grade:
Toxicity to Embryos and Larvae of the Rainbow Trout, Oncorhynchus mykiss,
Under Flow-Through Test Conditions. MRID No.: 437880-01. DP Barcode: D220208.
Document (PDF) (1323 KB PDF).
March 25, 1996. DER. 25 Pages.
Rosemary Mora. KBN Engineering & Applied Sciences Inc.
ESTUARINE FISH EARLY LIFE-STAGE TEST GUIDELINE 72-4. DDVP Technical Grade:
Toxicity to Embryos and Larvae of the Sheepshead Minnow (Cyprinodon variegatus)
Under Flow-Through Test Conditions. MRID No.: 437904-01. DP Barcode: D220208.
Document (PDF) (1549 KB PDF).
August 28, 1996. Memorandum. 29 Pages.
Joycelyn Stewart. Toxicology Branch I.
Fifth Carcinogenicity Peer Review od Dichlorvos.
Document (PDF) (2,056 KB PDF).
September 30, 1996. DER. 21 Pages.
Leslie Touart. Ecological Effects Branch.
AQUATIC INVERTEBRATE LIFE CYCLE TEST GUIDELINE 72-4(B). DDVP Technical Grade:
Chronic Toxicity to the Mysid (Mysidopsis bahia) Under Flow-Through Conditions.
MRID No.: 438543-01. DP Barcode: D222024.
Document (PDF) (1684 KB PDF).
March 24, 1998. Memorandum. 23 Pages.
Joycelyn Stewart. Registration Action Branch.
Review of toxicity studies on DDVP using human volunteers.
MRID 44317901, 4416201, 44248801, 44248802.
Tox review 012541.
Document (PDF) (1,599 KB PDF).
March 31, 1998. Memorandum. 10 Pages.
Jerome Blondell. Chemistry and Exposure Branch.
Review of Dichlorvos Incidents Reports.
DP Barcode D242971, Chemical #084001.
Document (PDF) (307 KB PDF).
June 3, 1998. Memorandum. 7 Pages.
Jess Rowland. Health Effects Division.
DICHLORVOS (DDVP)- RE-EVALUATION - Report of the Hazard
Identification Assessment Review Committee.
Tox review 012629.
Document (PDF) (252 KB PDF).
October 07, 1998. Review. 10 Pages.
Ibrahim Saheb. Environmental Fate & Monitoring Branch.
Purpose: Review environmental fate studies to support reregistration of DDVP.
Assess the envirionmental fate of DDVP...MRID Nos. 40034904, 41723101, 41723102,
41723103, 43326601, 43642501, 43835701, 44297701, 44386701. DP Barcodes: D239718, D199640.
Document (PDF) (1183 KB PDF).
February 16, 1999. Memorandum. 66 Pages.
Susan Hummel. Chemistry & Exposure Branch.
Revised Preliminary HED Risk Assessment for Dichlorvos.
Document (PDF) (4,999 KB PDF).
September 28, 2000. Memorandum. 3 Pages.
Sanjivani Diwan. Reregistration Branch 4 HED.
Dichlorvos: Review of Protocol for a 7-Day Oral Toxicity Study in the Rat.
Document (PDF) (138 KB PDF).
May 01, 2002. Memorandum. 4 Pages.
William Sette. Toxicology Branch.
Dichlorvos: Review of Acute and Repeated Exposure Comparative
Cholinesterase Study Protocols. DP Barcode: D281327. TXR #: 0050524.
Document (PDF) (148 KB PDF).
November 09, 2005. Memorandum. 84 Pages.
William Dykstra. Reregistration Branch 4.
Re-evaluation of DNT Studies for DDVP-Combined Studies Satisfy
Guideline Requirement for Acceptable DNT. DP Barcode: D323156.
MRID No.: 46153302, 46239801, 46487401.
Document (PDF) (3897 KB PDF).
June 09, 2006. Memorandum. 58 Pages.
Anna Lowit. Toxicology Branch.
Benchmark dose analysis of cholinesterase inhibition data in neonatal and adult rats
(MRID no. 46688914) following exposure to DDVP PC Code: 084001.
DP Barcode DP 328793. TXR No. 0054223.
Document (PDF) (1042 KB PDF).