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Index of Cleared Science Reviews for Lindane (Pc Code 009001)

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July 21, 1981. Memorandum. 6 Page(s).
Janice Jensen. Environmental Fate Branch.
Lindane Dietary Exposure Analysis - PD 4.
Document (PDF) (191 KB PDF).

August 01, 1982. Report. 82 Page(s).
Committee on Toxicology. National Research Council.
An Assessment of the Health Risks of Seven Pesticides Used for Termite Control.
Tox review 4831.
Document (PDF) (5368 KB PDF).

June 17, 1983. Memorandum. 32 Page(s).
Krystyna Locke. Toxicology Branch.
Lindane: Subchronic Oral Dosing (Rat) Study and a Metabolic Study (Mouse).
Acc. 250340-250342, 250339.
Document (PDF) (1879 KB PDF).

July 22, 1983. Memorandum. 2 Page(s).
John Chen. Toxicology Branch.
Lindane 20954-Q: Review of Protocol for the In Vivo Sister Chromatid Exchange
Assay in CFI-Mouse Bone Marrow Cells (RCC Draft Protocol, Itingen/Schweiz).
Caswell #527.
Document (PDF) (103 KB PDF).

December 27, 1983. Memorandum. 8 Page(s).
Herman Gibb. Carcinogen Assessment Group.
Review of the Gilbert et al. Study of Wood Treaters in Hawaii.
Document (PDF) (424 KB PDF).
Attachment(s) Following:

September 16, 1983. Memorandum.
Charles Ris. Carcinogen Assessment Group.
1981 Hawaii Epidemiology Study Submitted to the Office of Solid Waste by
Reichhold and Vulcan Companies for Section 3001 Dioxin Docket.

September 16, 1983. Memorandum.
David Bayliss. Carcinogen Assessment Group.
1981 Hawaii Epidemiology Study, July 1983 (Effects of Chemical Preservatives
on the Health of Wood Treating Workers in Hawaii, 1981).

*End of Attachments*

September 25, 1984. Memorandum. 7 Page(s).
Irving Mauer. Toxicology Branch.
Lindane: Review of Mutagenicity Data in Response to Lindane PD-4 and 3(c)(2)(B)
Letter of June 6, 1984. Accession #253997/EPA Reg. Nos. 359-686, 359-687,
21137-3 and 40083-1. Pages 4-7 removed, registrant data.
Document (PDF) (158 KB PDF).

September 27, 1984. Memorandum. 8 Page(s).
Irving Mauer. Toxicology Branch.
Lindane - Mutagenicity Data in Response to PD-4 on Lindane. Accession
#254504/EPA Reg. Nos. 359-686, 359-687, 40083-1 and 21137-3. Caswell No. 527.
Pages 5-8 removed, registrant data.
Document (PDF) (193 KB PDF).

November 09, 1984. Review. 2 Page(s).
Frank Davido. Exposure Assessment Branch.
Lindane. Review Indoor Air Monitoring Study.
Document (PDF) (90 KB PDF).

May 12, 1985. Data Eval. Recs. 30 Page(s).
Ann Stavola. Ecological Effects Branch.
Package of data evaluation records concerning the toxicity of lindane.
Document (PDF) (1419 KB PDF).

May 16, 1985. Final Report. 67 Page(s).
Dynamac Corporation. Environmental Fate & Ground Water Branch.
Task 1: Review and Evaluation of Individual Studies.
Document (PDF) (2689 KB PDF).

May 30, 1985. Memorandum. 15 Page(s).
Hudson Boyd. Exposure Assessment Branch.
Data for Registration Standard - Lindane.
Document (PDF) (790 KB PDF).

June 03, 1985. Memorandum. 7 Page(s).
Richard M. Lee. Ecological Effects Branch.
Lindane Registration Standard (Beneficial Insects Portion).
Document (PDF) (222 KB PDF).

June 06, 1985. Data Eval. Rec. 1 Page(s).
Ann Stavola. Ecological Effects Branch.
Handbook of Toxicity of pesticides to wildlife.
Document (PDF) (65 KB PDF).

June 06, 1985. Data Eval. Rec. 13 Page(s).
Ann Stavola. Ecological Effects Branch.
Toxicity of Some Insecticides to Four Species of Malacostracan Crustaceans.
Document (PDF) (985 KB PDF).

June 06, 1985. Data Eval. Rec. 14 Page(s).
Ann Stavola. Ecological Effects Branch.
Residues in Fish, Wildlife, and Estuaries.
Document (PDF) (2570 KB PDF).

June 06, 1985. Data Eval. Rec. 2 Page(s).
Ann Stavola. Ecological Effects Branch.
Handbook of Acute Toxicity of Chemicals to Fish and Aquatic Invertebrates.
Document (PDF) (142 KB PDF).

June 06, 1985. Data Eval. Rec. 2 Page(s).
Ann Stavola. Ecological Effects Branch.
Lethal Dietary Toxicities of Environmental Pollutants to Birds: Special
Scientific Report.
Document (PDF) (188 KB PDF).

June 06, 1985. Data Eval. Rec. 2 Page(s).
Ann Stavola. Ecological Effects Branch.
The Acute Oral Toxicity of 369 Pesticidal, Pharmaceutical and Other Chemicals
to Wild Birds.
Document (PDF) (166 KB PDF).

June 06, 1985. Data Eval. Rec. 2 Page(s).
Ann Stavola. Ecological Effects Branch.
Toxicity of Pesticides to the Crustacean "Gammarus iacustris".
Document (PDF) (154 KB PDF).

June 06, 1985. Data Eval. Rec. 4 Page(s).
Ann Stavola. Ecological Effects Branch.
The Effects on Birds of Certain Chlorinated Insecticides Used as Seed Dressings.
Document (PDF) (167 KB PDF).

June 06, 1985. Data Eval. Rec. 6 Page(s).
Ann Stavola. Ecological Effects Branch.
Pesticide Toxicities to Tadpoles of the Western Chorus Frog "Pseudacris triseriata"
and Fowler's Toad "Bufo woodhousii fowleri".
Document (PDF) (326 KB PDF).

June 06, 1985. Data Eval. Rec. 7 Page(s).
Ann Stavola. Ecological Effects Branch.
Acute Toxicities of Insecticides to Marine Decapod Crustaceans.
Document (PDF) (256 KB PDF).

June 06, 1985. Data Eval. Rec. 7 Page(s).
Ann Stavola. Ecological Effects Branch.
Acute Toxicity of Some Organic Insecticides to Three Species of Salmonids and to
the Threespine Stickleback.
Document (PDF) (525 KB PDF).

June 06, 1985. Data Eval. Rec. 7 Page(s).
Ann Stavola. Ecological Effects Branch.
Toxicity of Seed-dressing Products for Partridge and Pheasant.
Document (PDF) (348 KB PDF).

June 06, 1985. Data Eval. Rec. 8 Page(s).
Ann Stavola. Ecological Effects Branch.
Relative Toxicity of Ten Chlorinated Hydrocarbon Insecticides to Four Species of Fish.
Document (PDF) (606 KB PDF).

June 12, 1985. Memorandum. 21 Page(s).
Ann Stavola. Ecological Effects Branch.
Lindane Registration Standard.
Document (PDF) (1109 KB PDF).

July 05, 1985. Memorandum. 12 Page(s).
Irving Mauer. Toxicology Branch.
Lindane - Appraisal of CIEL Response, January 16, 1985, in re: CIEL mutagenicity
Tests. Review of mutagenicity assay (i.p. in vivo SCE) in response to PD-4.
Registration Data information removed from pages 6-12. Tox Review No. 004524.
Document (PDF) (296 KB PDF).

July 11, 1985. Memorandum. 53 Page(s).
John Doherty. Toxicology Branch I.
Submission of the Toxicology Branch Chapter of the Registration Standard for
Lindane. Tox Review No. 004704.
Document (PDF) (3567 KB PDF).

July 11, 1985. Science Chapter. 14 Page(s).
John Doherty. Toxicology Branch.
Submission of the Toxicology Branch Chapter of the Registration Standard for
Lindane. Tox Chem. No. 527.
Document (PDF) (903 KB PDF).

July 23, 1985. Memorandum. 3 Page(s).
Robert McGaughy. Carcinogen Assessment Group.
Re-evaluation of the Oncogenicity of Lindane.
Document (PDF) (165 KB PDF).

July 25, 1985. Memorandum. 6 Page(s).
Ann Stavola. Ecological Effects Branch.
Addendum to the Ecological Effects Branch's Chapter and Data Table for
the Lindane Standard.
Document (PDF) (335 KB PDF).

August 13, 1985. Memorandum. 2 Page(s).
Allan Reiter. Residue Chemistry Branch.
EPA Reg. No. 239-2363. Amended Use, Lindane on Tomatoes (No Accession
Number. RCB No. 1163).
Document (PDF) (92 KB PDF).

August 14, 1985. Memorandum. 1 Page(s).
John Doherty. Toxicology Branch.
Lindane Registration Standard: Addendum - Requirement for Additional
Metabolism Data.
Document (PDF) (61 KB PDF).

August 22, 1985. Memorandum. 7 Pages.
John Doherty. Toxicology Branch I.
Lindane Registration Standard - Addendum to the Toxicology Branch Chapter -
Review of Metabloism in Mammals Data. Tox Review No. 004629.
Document (PDF) (378 KB PDF).

August 26, 1985. Memorandum. 7 Page(s).
John Doherty. Toxicology Branch.
Lindane Registration Standard - Addendum to the Toxicology Branch Chapter -
Review of Metabolism in Mammals Data. Tox Review No. 004629.
Document (PDF) (330 KB PDF).

October 11, 1985. Report. 3 Page(s).
Toxicology Branch.
90-Day Rat Feeding (Guideline). (Best Available Copy) Tox Review No. 004566.
Document (PDF) (123 KB PDF).

February 12, 1986. Memorandum. 5 Page(s).
John Doherty. Toxicology Branch.
Lindane - Special Review - Response to the Letter from Mr. C.A. O'Connor and Ms.
M.K. Tandy Dated October 22, 1985; Reply to Comments Made by Dr. M. Herbst
Related to Interpretation of the Rat Kidney Pathology; Review of Selected Papers…
Document (PDF) (272 KB PDF).

March 10, 1986. Review. 7 Page(s).
Joseph C. Reinert. Exposure Assessment Branch.
Rebuttal to Exposure Assessment.
Document (PDF) (337 KB PDF).

March 24, 1986. Memorandum. 7 Page(s).
Cynthia Deyrup. Residue Chemistry Branch.
Lindane Dermal Application Metabolism Study Protocol. RCB #514.
No RD Accession Number.
Document (PDF) (511 KB PDF).

April 02, 1986. Review. 2 Page(s).
Joseph C. Reinert. Exposure Assessment Branch.
Exposure Study Protocol.
Document (PDF) (135 KB PDF).

April 23, 1986. Memorandum. 15 Page(s).
John Doherty. Toxicology Branch I.
Lindane - Special Review: Review of a rat Subchronic Inhalation Toxicity Study with
Lindane. Tox Review No. 005059.
Document (PDF) (1007 KB PDF).

April 25, 1986. Memorandum. 15 Page(s).
John Doherty. Toxicology Branch.
Lindane - Special Review: Review of a Rat Subchronic Inhalation Toxicity Study
with Lindane. Tox review 005059.
Document (PDF) (871 KB PDF).

April 25, 1986. Memorandum. 5 Page(s).
Richard Felthousen. Ecological Effects Branch.
CIEL/Lindane Registration Standard - Protocol Review.
Document (PDF) (239 KB PDF).

June 13, 1986. Review. 6 Page(s).
Richard Felthousen, et. al. Ecological Effects Branch.
Registrant Request for Waiver of 7-Day Feeding Study with Bobwhite Quail and Red-
winged Blackbirds.
Document (PDF) (270 KB PDF).

June 24, 1986. Memorandum. 7 Page(s).
John Doherty. Toxicology Branch.
EPA ID No. 009001: Lindane: Toxicology Branch Position On Potential Toxicity Via
Inhalation to the Kidneys and Blood (Bone Marrow) as Noted in the Subchronic
(90 day) Inhalation Study Translated from German.
Document (PDF) (352 KB PDF).

July 15, 1986. Review. 4 Page(s).
Emil Regelman. Exposure Assessment Branch.
Reg. No. 359-710. Lindane HGI. Review of Proposed Protocol.
Document (PDF) (193 KB PDF).

July 22, 1986. Memorandum. 6 Page(s).
John Doherty. Toxicology Branch.
Lindane: Company Meeting to Discuss Protocols for the Rat Chronic
Feeding/Oncogenicity Study.
Document (PDF) (401 KB PDF).

August 14, 1986. Memorandum. 3 Page(s).
John Doherty. Toxicology Branch I.
Theoretical Margins of Safety for lindane exposure: Recalculation to include both
dermal & inhalation exposure for specified uses.
Document (PDF) (165 KB PDF).

August 18, 1986. Memorandum. 6 Page(s).
John Doherty. Toxicology Branch.
EPA Reg. No. 359-686 - Lindane: Review of Protocols for 90-Day Dermal Toxicity
Studies in Rats and Rabbits and 14-Week Aerosol Inhalation Study in Mice.
Document (PDF) (327 KB PDF).

September 16, 1986. Review. 3 Page(s).
Ann Stavola. Ecological Effects Branch.
Submission of Revised Protocol for Aquatic Residue Testing.
Document (PDF) (139 KB PDF).

November 18, 1986. Review. 4 Page(s).
Herbert L. Manning. Exposure Assessment Branch.
164-1 Terrestrial Field Dissipation Protocol.
Document (PDF) (150 KB PDF).

December 02, 1986. Review. 8 Page(s).
Ann Stavola. Ecological Effects Branch.
Data from Several Acute Toxicity Tests.
Document (PDF) (335 KB PDF).

December 05, 1986. Memorandum. 4 Page(s).
John Doherty. Toxicology Branch.
Lindane: Notes Related to a Company Meeting to Discuss the Revised Protocol for
the Rat Chronic Feeding/Oncogenicity Study.
Document (PDF) (207 KB PDF).

December 24, 1986. Memorandum. 27 Page(s).
John Doherty. Toxicology Branch.
EPA Reg. No. 359-686. Lindane: Review of Protocol for the Rat Chronic Feeding
and Oncogenicity Study (Life Science Research, Prepared October, 1986).
Pages 6-27 are not included - registrant data.
Document (PDF) (301 KB PDF).

December 30, 1986. Review. 6 Page(s).
Allen W. Vaughn, et. al. Ecological Effects Branch.
Submission of Honey Bee Toxicity Data to Support Registration Standard.
Document (PDF) (273 KB PDF).

December 31, 1986. Data Eval. Rec. 4 Page(s).
Ann Stavola. Ecological Effects Branch.
Avian Acute Oral Study. Bobwhite Quail (Colinus virginianus).
Document (PDF) (170 KB PDF).

December 31, 1986. Data Eval. Rec. 5 Page(s).
Ann Stavola. Ecological Effects Branch.
Fish Static Acute Toxicity Test. (Salmo gairdneri).
Document (PDF) (195 KB PDF).

December 31, 1986. Data Eval. Rec. 5 Page(s).
Ann Stavola. Ecological Effects Branch.
Fish Static Acute Toxicity Test. Bluegill - Lepomis macrochirus.
Document (PDF) (224 KB PDF).

December 31, 1986. Data Eval. Rec. 5 Page(s).
Ann Stavola. Ecological Effects Branch.
Fish Static Acute Toxicity Test. Bluegill (Lepomis macrochirus).
Document (PDF) (228 KB PDF).

December 31, 1986. Data Eval. Rec. 5 Page(s).
Ann Stavola. Ecological Effects Branch.
Fish Static Acute Toxicity Test. Bluegill Sunfish (Lepomis macrochirus).
Document (PDF) (223 KB PDF).

December 31, 1986. Data Eval. Rec. 5 Page(s).
Ann Stavola. Ecological Effects Branch.
Fish Static Acute Toxicity Test. Rainbow Trout (Salmo gairdneri).
Document (PDF) (208 KB PDF).

December 31, 1986. Data Eval. Rec. 5 Page(s).
Ann Stavola. Ecological Effects Branch.
Fish Static Acute Toxicity Test. Rainbow Trout (Salmo gairdneri).
Document (PDF) (200 KB PDF).

December 31, 1986. Data Eval. Rec. 5 Page(s).
Ann Stavola. Ecological Effects Branch.
Invertebrate Acute Toxicity Test. Daphnia Magna.
Document (PDF) (197 KB PDF).

December 31, 1986. Data Eval. Rec. 5 Page(s).
Ann Stavola. Ecological Effects Branch.
Invertebrate Acute Toxicity Test. Daphnia Magna.
Document (PDF) (208 KB PDF).

December 31, 1986. Data Eval. Rec. 5 Page(s).
Ann Stavola. Ecological Effects Branch.
Invertebrate Acute Toxicity Test. Daphnia Magna.
Document (PDF) (202 KB PDF).

December 31, 1986. Data Eval. Rec. 6 Page(s).
Ann Stavola. Ecological Effects Branch.
Oyster Embryolarvae Acute Toxicity. (Crassostrea virginica).
Document (PDF) (244 KB PDF).

January 16, 1987. Memorandum. 10 Page(s).
John Doherty. Toxicology Branch.
EPA Reg. No. 359-686. Lindane: Review of a Protocol for a 5-Day Pilot Inhalation
Study with Mice. Pages 4-10 removed, registrant data.
Document (PDF) (226 KB PDF).

January 16, 1987. Memorandum. 20 Page(s).
John Doherty. Toxicology Branch.
EPA Reg. No. 359-686. Lindane: Review of Protocol for a 13-Week Dermal Toxicity
Study with Rabbits. Pages 5-20 are not included - registrant data.
Document (PDF) (226 KB PDF).

January 16, 1987. Memorandum. 20 Page(s).
John Doherty. Toxicology Branch.
EPA Reg. No. 359-686. Lindane: Review of Protocol for a 13-Week Dermal Toxicity
Study with Rats. Pages 4-20 are not included - registrant data.
Document (PDF) (178 KB PDF).

January 27, 1987. Memorandum. 16 Page(s).
John Doherty. Toxicology Branch.
EPA Reg. No. 359-686. Lindane: Review of the Protocol for a 14-Week Inhalation
Study with Mice (Bushy Run Research Center, Project No. 86-85-80201).
Pages 5-16 removed, registrant data.
Document (PDF) (204 KB PDF).

February 02, 1987. Memorandum. 10 Page(s).
John Doherty. Toxicology Branch.
EPA Data Submitter No. 52904-C. Lindane: Review of Acute Inhalation LC50,
Primary Eye Irritation, Primary Dermal Irritation, and Dermal Sensitization Studies.
Tox Review 005703.
Document (PDF) (457 KB PDF).

February 24, 1987. Memorandum. 2 Page(s).
John Doherty. Toxicology Branch.
EPA Reg. No. 359-686. Lindane: Amendment to the Protocol for the Rat Chronic
Feeding/Oncogenicity Study Concerning the 30-Day Sampling Time for Blood, Urine
and Clinical Chemistries (Life Science Research Protocol Prepared October, 1986)
Document (PDF) (77 KB PDF).

April 13, 1987. Memorandum. 3 Page(s).
Edwin Budd. Toxicology Branch.
Lindane Special Review - Reassessment of Toxicological Significance of Kidney
Lesions Observed in Rat Studies.
Document (PDF) (1476 KB PDF).
Attachment(s) Following:

September 18, 1985. Memorandum. 4 Page(s).
Kyle Barbehenn. Science Integration Staff.
Further Revision of Lindane Risks.

June 24, 1986. Memorandum. 7 Page(s).
John Doherty. Toxicology Branch.
EPA ID No. 009001: Lindane: Toxicology Branch Position on Potential
Toxicity Via Inhalation to the Kidneys and Blood (Bone Marrow) as Noted in the
Subchronic (90-Day) Inhalation Study Translated from German.
Record No. 174083.

August 14, 1986. Memorandum. 3 Page(s).
John Doherty. Toxicology Branch.
Theoretical Margins of Safety for Lindane Exposure: Recalculation to Include
Both Dermal and Inhalation Exposure for Specified Uses.

September 11, 1986. Briefing. 8 Page(s).
Carol Monroe. Special Review Branch.
Briefing on Lindane.

January 08, 1987. Memorandum. 4 Page(s).
David Jaquith. Exposure Assessment Branch.
Exposure of Workers to Lindane During Forestry and Hardwood Lumber Use.

*End of Attachments*

April 17, 1987. Memorandum. 21 Page(s).
John Doherty. Toxicology Branch.
Lindane: Toxicology Branch Comments on the Revised (March, 1987) Protocols for
Rat and Rabbit 90-Day Dermal Toxicity Studies. Pages 3-21 removed, registrant data.
Document (PDF) (119 KB PDF).

April 21, 1987. Memorandum. 27 Page(s).
John Doherty. Toxicology Branch.
EPA Reg. No. 359-686. Lindane: Review of Revised Protocol for the Rat Chronic
Feeding/Oncogenicity Study. Pages 3-27 removed, registrant data.
Document (PDF) (113 KB PDF).

April 21, 1987. Memorandum. 9 Page(s).
John Doherty. Toxicology Branch.
EPA Reg. No. 359-686. Lindane: Review of Registrants Comments on the
Protocols for the 5-Day Pilot Inhalation Study and 14-Week Inhalation Study with
Lindane.
Document (PDF) (538 KB PDF).

April 28, 1987. Memorandum. 2 Page(s).
Maxie Jo Nelson. Residue Chemistry Branch.
EPA Reg. No. 359-686. Lindane. Request for Time Extension. RCB #2184.
MRID # None.
Document (PDF) (124 KB PDF).

May 12, 1987. Review. 10 Page(s).
David Jaquith. Exposure Assessment Branch.
Applicator Exposure Study Review.
Document (PDF) (493 KB PDF).

May 27, 1987. Memorandum. 9 Page(s).
Robert Zendzian. Toxicology Branch.
Lindane, Dermal Absorption Studies in Rat and Rabbit. Tox Review 005914.
Document (PDF) (435 KB PDF).

June 24, 1987. Memorandum. 2 Page(s).
John Doherty. Toxicology Branch.
EPA Reg. No. 359-686 - Lindane. Supplementary Information Related to the Use of
Multistix Reagent Strips and Clinitest Reagent Tablets to be Used for Urine Analysis
in the Chronic Feeding Oncogenicity Study.
Document (PDF) (94 KB PDF).

July 08, 1987. Data Eval. Rec. 4 Page(s).
P. Mastradone. Exposure Assessment Branch.
Degradation - Photodegradation on Soil Acc. 265725.
Document (PDF) (161 KB PDF).

July 08, 1987. Data Eval. Rec. 8 Page(s).
P. Mastradone. Exposure Assessment Branch.
Mobility - Laboratory Volatility Acc. 265721.
Document (PDF) (410 KB PDF).

July 14, 1987. Review. 33 Page(s).
Emil Regelman. Exposure Assessment Branch.
Flagged Data in Response to Registration Standard.
Document (PDF) (1429 KB PDF).

August 20, 1987. Review. 2 Page(s).
Michael Firestone. Exposure Assessment Branch.
Review of Benefits/Use Document.
Document (PDF) (68 KB PDF).

August 28, 1987. Memorandum. 3 Page(s).
David Jaquith. Exposure Assessment Branch.
Exposure Assessment for Lindane Use on Bedbugs and for Control of Clothes Moths.
Document (PDF) (155 KB PDF).

September 02, 1987. Memorandum. 5 Page(s).
Robert Zendzian. Toxicology Branch.
Lindane, MOS's for Selected Use Patterns.
Document (PDF) (239 KB PDF).

September 18, 1987. Review. 5 Page(s).
Michael Firestone. Exposure Assessment Branch.
Human Exposure Assessment.
Document (PDF) (292 KB PDF).

November 06, 1987. Review. 8 Page(s).
Emil Regelman. Exposure Assessment Branch.
Review of Laboratory Volatility Studies.
Document (PDF) (445 KB PDF).

December 17, 1987. Memorandum. 3 Page(s).
John Doherty. Toxicology Branch.
Lindane: Toxicology Branch Response to the Letter from Mr. Matthew J. McGrath
Concerning 1) Extension of the Due Date for the Mouse Inhalation Study, 2)
Evaluation of Bone Marrow Myelograms in the Mouse Inhalation Study, 3) Progress of
the Subchronic…
Document (PDF) (205 KB PDF).

February 25, 1988. Memorandum. 1 Page(s).
Cynthia Deyrup. Residue Chemistry Branch.
Partial Response (11/10/87) by Centre International d'Etudes du Lindane (CIEL) to
Data Gaps Cited in the Residue Chemistry Chapter of the 9/30/85 Lindane
Registration Standard. (RCB #3256). MRID No. 404312-09.
Document (PDF) (55 KB PDF).

March 01, 1988. Memorandum. 14 Page(s).
Laurie Lewis. Exposure Assessment Branch.
Exposure Assessment for Lindane Greenhouse Uses.
Document (PDF) (644 KB PDF).

March 03, 1988. Memorandum. 2 Page(s).
John Doherty. Toxicology Branch.
EPA Reg. No. 359-686 - Lindane: Registrant's Request to Revise the Protocol for
Rabbit 90-Day Dermal Toxicity Study. Problems Involved in Conducting a 90-Day
Dermal Toxicity at the Hazleton (UK) Laboratories.
Document (PDF) (118 KB PDF).

March 09, 1988. Review. 5 Page(s).
Paul Mastradone. Exposure Assessment Branch.
Review Fish Bioaccumulation Study.
Document (PDF) (281 KB PDF).

March 21, 1988. Review. 21 Page(s).
Michael Firestone. Exposure Assessment Branch.
Applicator Exposure Study.
Document (PDF) (696 KB PDF).

March 24, 1988. Memorandum. 12 Page(s).
John Onley. Residue Chemistry Branch.
Partial Response (July 15, 1987) by Centre International d'Etudes du Lindane (CIEL)
to Data Gap S171-4 (Nature of the Residue in Livestock Poultry) as Identified in the
Residue Chemistry Chapter of the September 30,1985..(RCB No. 3315).
MRID No. 402713-01
Document (PDF) (620 KB PDF).

March 24, 1988. Memorandum. 15 Page(s).
Nancy Dodd. Residue Chemistry Branch.
ID No. 359-686 (RCB No. 3259) - Lindane Registration Standard Followup - Residues
from Seed Treatment - MRID No. 404312-07.
Document (PDF) (871 KB PDF).

March 24, 1988. Memorandum. 17 Page(s).
Cynthia Deyrup. Residue Chemistry Branch.
Partial Response (7/21/87) by Centre International d'Etudes du Lindane (CIEL) to
Data Gap S171-4 (Nature of the Residue in Livestock Ruminants) as Identified in the
Residue Chemistry Chapter of the 9/30/85 Lindane… (RCB #3312).
MRID No. 402713-02
Document (PDF) (985 KB PDF).

March 24, 1988. Memorandum. 2 Page(s).
John Onley. Residue Chemistry Branch.
Partial Response (Cover Letter of 12/1/87) by the Law Firm of McKenna, Conner, &
Cuneo on Behalf of Centre International d'Etudes du Lindane (CIEL) Pertinent to Data
Gap S171-4 as Identified in the Residue Chemistry Chapter of the 9/30/85 Lindane…
Document (PDF) (99 KB PDF).

March 24, 1988. Memorandum. 23 Page(s).
Gary Otakie. Residue Chemistry Branch.
Partial Response (November 10, 1987) by Centre International d'Etudes du Lindane
(CIEL) to Data Gap S171-4 (Nature of the Residue in Plants as Identified in the
Residue Chemistry Chapter of the September 30, 1985...
MRID No. 404312-01, 404312-04, 404109-02.
Document (PDF) (1179 KB PDF).

March 24, 1988. Memorandum. 4 Page(s).
Nancy Dodd. Residue Chemistry Branch.
ID No. 359-686 (RCB No. 3257). Lindane Registration Standard Followup.
Analytical Methods for Plants. MRID Nos. 404312-02 and 404312-06.
Document (PDF) (196 KB PDF).

March 24, 1988. Memorandum. 4 Page(s).
Nancy Dodd. Residue Chemistry Branch.
ID No. 359-686 (RCB No. 3261) - Lindane Registration Standard Followup -
Analytical Methods for Animal Tissues, Eggs, and Milk - MRID No. 404312-08.
Document (PDF) (220 KB PDF).

March 24, 1988. Memorandum. 7 Page(s).
Nancy Dodd. Residue Chemistry Branch.
ID No. 359-686 (RCB No. 3260) - Lindane Registration Standard Followup, Storage
Stability - MRID Nos. 404312-03 and 404312-06.
Document (PDF) (317 KB PDF).

March 31, 1988. Memorandum. 3 Page(s).
Cynthia Deyrup. Residue Chemistry Branch.
Goat Metabolism Study Submitted by CIEL in Response to Lindane Registration
Standard Data Call-In. Deference to Tox on the Need for a More Adequate
Identification of Residues in Goat Liver and Kidney.
Document (PDF) (122 KB PDF).

April 11, 1988. Review. 5 Page(s).
Michael Firestone. Exposure Assessment Branch.
Protocol Review for Exposure Study.
Document (PDF) (220 KB PDF).

May 19, 1988. Memorandum. 2 Page(s).
John Doherty. Toxicology Branch I.
Lindane: Toxicology Branch response to Residue Chemistry Branch inquiry
concerning more adequate identification of lindane residues in goat liver & kidney.
Document (PDF) (85 KB PDF).

June 16, 1988. Memorandum. 23 Page(s).
John Doherty. Toxicology Branch.
Lindane: Meeting with the CIEL Group to Discuss the Current Status of Toxicity
Testing and the Revised Protocol for the Rabbit 90-Day Subchronic Dermal Toxicity
Study. Pages 5-23 removed, registrant data.
Document (PDF) (299 KB PDF).

July 05, 1988. Review. 2 Page(s).
Paul Mastradone. Exposure Assessment Branch.
3 Progress Reports for 2 Forestry Dissip. Studies (GA and MT).
Document (PDF) (94 KB PDF).

July 05, 1988. Review. 8 Page(s).
Paul Mastradone. Exposure Assessment Branch.
Review Waiver Request for Terrestrial Part of Forestry Dissip.
Document (PDF) (537 KB PDF).

July 11, 1988. Memorandum. 3 Page(s).
John Doherty. Toxicology Branch.
Lindane: Toxicology Branch Response to a Letter from the Law Firm of McKenna,
Conner and Cuneo Regarding the Summary of a Meeting Held on June 9, 1988 in
which the Potential for Lindane to Induce Kidney Lesions and the Protocol for a
Subchronic Dermal…
Document (PDF) (165 KB PDF).

August 23, 1988. Memorandum. 4 Page(s).
Stephanie Willett. Dietary Exposure Branch.
ID No. 52904-C. Lindane Registration Standard Followup. Storage Stability Data.
MRID No. 406605-02. RCB No. 4035.
Document (PDF) (233 KB PDF).

August 24, 1988. Memorandum. 12 Page(s).
Gary Otakie. Residue Chemistry Branch.
Partial Response (June 9, 1988) by Centre International d'Etudes du Lindane (CIEL)
to Data Gap Section 171-4 (Magnitude of the Residue in Poultry and Eggs) as
Identified in the Residue Chemistry Chapter of the September 30, 1985 Lindane
Registration…
Document (PDF) (652 KB PDF).

August 29, 1988. Memorandum. 5 Page(s).
Stephanie Willett. Dietary Exposure Branch.
ID No. 52904-C. Lindane Registration Standard Followup. Residues in Swine.
MRID No. 406605-04. DEB No. 4038.
Document (PDF) (301 KB PDF).

August 31, 1988. Memorandum. 16 Page(s).
Martin Kovacs. Dietary Exposure Branch.
Partial Response (April 7, 1988) by Centre International d'Etudes du Lindane (CIEL)
to Data GAP Section 171-4 [Magnitude of Residue in Animals (Sheep)] as Identified
in the Residue Chemistry Chapter of the September 30, 1985 Lindane Registration…
Document (PDF) (1089 KB PDF).

September 19, 1988. Review. 21 Page(s).
Paul Mastradone. Environmental Fate & Ground Water Branch.
Review Three Leaching Studies.
Document (PDF) (921 KB PDF).

September 20, 1988. Memorandum. 22 Page(s).
Martin Kovacs. Dietary Exposure Branch.
Partial Response (December 15, 1987) by Centre International d'Etudes du Lindane
(CIEL) to Data Gap 171-4 [Magnitude of Residue in Animals (Dairy Cattle Meat and
Milk)] as Identified in the Residue Chemistry Chapter of the Sept. 30, 1985 Lindane…
Document (PDF) (1443 KB PDF).

September 30, 1988. Memorandum. 8 Page(s).
John Doherty. Toxicology Branch.
EPA ID No. 52904-C - Lindane - Review of a Subchronic (Scheduled for 13 Weeks)
Dermal Toxicity Study which was Terminated After 12 Days Because of High
Mortality.
Document (PDF) (345 KB PDF).

October 24, 1988. Report. 9 Page(s).
CDFA Medical Toxicology Branch.
Summary of Toxicology Data - Lindane.
Document (PDF) (699 KB PDF).

January 23, 1989. Memorandum. 6 Page(s).
John Doherty. Toxicology Branch.
California Department of Food and Agriculture - EPA Toxicology Review for Lindane.
Document (PDF) (418 KB PDF).

February 21, 1989. Memorandum. 3 Page(s).
Linda Propst. Dietary Exposure Branch.
52251-6. OR-CAL Colloidal Lindane. Tolerance or Label Restriction Against Using
on Turf Grass Grown for Seed. No MRID Number. DEB No. 4867.
Document (PDF) (167 KB PDF).

February 27, 1989. Memorandum. 4 Page(s).
Susan Hummel. Dietary Exposure Branch.
Maneb, Thiabendazole, and Lindane. EPA Reg. Nos.: 8203-38 Granox Plus
Flowable Cereal Seed Treatment Fungicide 8203-39 Granox Plus Cereal Seed
Treatment Fungicide 8203-36 Granol Plus Flowable Insecticide and Fungicide Cereal
Seed Treatment.
Document (PDF) (315 KB PDF).

March 15, 1989. Review. 12 Page(s).
Richard Felthousen. Ecological Effects Branch.
Submission of R-Winged Blackbird 14-Day Dietary Toxicity Study in Response to
Registration Standard.
Document (PDF) (464 KB PDF).

May 18, 1989. Memorandum. 20 Page(s).
John Doherty. Toxicology Branch.
EPA Id. No. 52904-C. Lindane: Review of a 13-Week Dermal Toxicity Study with
Rats. Tox review 007189.
Document (PDF) (1127 KB PDF).

June 30, 1989. Memorandum. 28 Page(s).
John Doherty. Toxicology Branch I.
EPA Reg. No.: 52904-C. Lindane: Review of a fourteen week dust inhalation study
with mice. Tox Review No. 007304. Registration Data information removed from
pages 14-15, 18, & 24-25.
Document (PDF) (1679 KB PDF).

August 21, 1989. Data Eval. Rec. 23 Page(s).
Richard Mahler. Environmental Fate & Ground Water Branch.
Field dissipation study on lindane for terrestrial uses on peaches in Donalsonville,
Georgia. MRID No. 406225-02.
Document (PDF) (139 KB PDF).

August 21, 1989. Data Eval. Rec. 3 Page(s).
Richard Mahler. Environmental Fate & Ground Water Branch.
Field dissipation study on lindane for terrestrial uses on tomatoes, Porterville,
California. MRID No. 406225-03.
Document (PDF) (201 KB PDF).

August 21, 1989. Data Eval. Rec. 3 Page(s).
Richard Mahler. Environmental Fate & Ground Water Branch.
Metabolism of lindane in soil under aerobic and anaerobic conditions.
MRID No. 406225-01 (1/2).
Document (PDF) (213 KB PDF).

August 21, 1989. Data Eval. Rec. 3 Page(s).
Richard Mahler. Environmental Fate & Ground Water Branch.
Metabolism of lindane in soil under aerobic and anaerobic conditions.
MRID No. 406225-01 (2/2).
Document (PDF) (137 KB PDF).

August 21, 1989. Data Eval. Rec. 6 Page(s).
Richard Mahler. Environmental Fate & Ground Water Branch.
The volatilization of lindane from soil. MRID No. 406225-04, -05, -06.
Document (PDF) (301 KB PDF).

August 21, 1989. Review. 5 Page(s).
Paul Mastradone. Environmental Fate & Ground Water Branch.
Review Data Submitted in Response to Registration Standard.
Document (PDF) (229 KB PDF).

August 25, 1989. Review. 6 Page(s).
Richard Felthousen, et. al. Ecological Effects Branch.
Submission of Bobwhite Quail 14-Day Dietary Toxicity Study in Response to
Registration Standard.
Document (PDF) (284 KB PDF).

August 30, 1989. Memorandum. 20 Page(s).
John Doherty. Toxicology Branch.
EPA Id# 52904-C. Lindane: Review of interim report of the rat chronic
feeding/oncogenicity study with lindane (Life Sciences Research, #88/CIL002/816,
3/7/89) covering the 30 day and 26 week interim sacrifices. Confirmation that male
(continued)
Document (PDF) (1183 KB PDF).
Attachment(s) Following:

August 30, 1989. Memorandum.
John Doherty. Toxicology Branch.
rat kidney is a target organ for lindane toxicity. Request for quantitative data on
alpha 2u globulins in male kidney tissue. MRID 410914-01 Tox review 007461.

*End of Attachments*

March 20, 1990. Memorandum. 5 Page(s).
James Akerman. Ecological Effects Branch.
Aquatic Invertebrate Life-cycle Study for Daphnia magna (Accession No. 400561-06)
for Lindane Technical.
Document (PDF) (266 KB PDF).

March 20, 1990. Memorandum. 7 Page(s).
James Akerman. Ecological Effects Branch.
Early Life Stage Study for Rainbow Trout Salmo gairdneri
(Accession No. #400561-05) for Lindane Technical.
Document (PDF) (340 KB PDF).

April 10, 1990. Memorandum. 14 Page(s).
Marion Copley. Toxicology Branch.
ID 009001-9. Lindane: Evaluate Immunohistochemical Report for Localization of
Alpha 2u Globulin in Kidneys in Rats Pages 4-14 removed, registrant data.
Tox review 007859
Document (PDF) (174 KB PDF).

January 31, 1991. Memorandum. 109 Page(s).
E. Zager. Chemistry Branch II.
Lindane Product and Residue Chemistry Reregistration Standard Updates and
CBRS # 6961. Pages 11-12 removed, quality control information. Pages 25-40
removed, quality control, manufacturing process and impurity information.
Document (PDF) (6634 KB PDF).

March 18, 1991. Memorandum. 1 Page(s).
John Doherty. Toxicology Branch.
Special Neurotoxicity Testing for Lindane.
Document (PDF) (57 KB PDF).

July 09, 1991. Memorandum. 3 Page(s).
George Tompkins. Environmental Fate & Ground Water Branch.
Environmental Fate Studies to be Included in Data Call-In Notice for Lindane (009001).
Document (PDF) (136 KB PDF).

July 09, 1991. Memorandum. 6 Page(s).
Penelope Fenner-Crisp. Health Effects Division.
Reregistration Data Call In Requirements for Paraquat, Fluometuron, Trimethacarb,
Lindane, Folpet DDVP & OBPA.
Document (PDF) (288 KB PDF).

August 14, 1991. Memorandum. 3 Page(s).
Doug Urban. Ecological Effects Branch.
Lindane: List A Project. Report of Data and Study Requirements.
Document (PDF) (123 KB PDF).

September 27, 1991. Memorandum. 21 Page(s).
John Doherty. Toxicology Branch.
EPA Id. # (No Number Provided): "Technical" Lindane: Review of a 13-Week Dermal
Toxicity Study with Rabbits Including a 6-Week Recovery Phase. Study Includes
Special Assessment of the Kidney and Bone Marrow Myelograms.
Tox Review 008610.
Document (PDF) (1214 KB PDF).

October 22, 1991. Memorandum. 16 Page(s).
Linnea Hansen. Toxicity Branch I.
ID No. 009001: Lindane (technical). Evaluation of a Dominant Lethal Test in rat & a
Mammalian Cultured Cell Gene Mutation Assay (anaerobic conditions) to support
reregistration of Lindane. MRID NO. 62657. Tox Review No. 008726.
Document (PDF) (997 KB PDF).

March 22, 1992. DER. 8 Page(s).
John Doherty. Toxicology Branch I.
Tumorigenic responses to lindane in mice: potentiation by a dominant mutation.
Document (PDF) (575 KB PDF).

April 22, 1992. Memorandum. 3 Page(s).
John Doherty. Toxicology Branch I.
EPA Id No.: 009001. Lindane: Review of neurotoxicity screen study protocols for
series 81-8ss (acute) & 82-7ss studies.
Document (PDF) (214 KB PDF).

December 23, 1992. Memorandum. 1 Page(s).
Marion Copley. Toxicology Branch I.
Lindane: Preparation for Cancer Peer Review.
Document (PDF) (62 KB PDF).

December 30, 1992. Memorandum. 16 Page(s).
Guruva Reddy. Toxicology Branch I.
EPA ID No. 009001: Lindane. Review of Reproduction Study in Rat.
MRID No. 422461-01. Tox Review No. 009911.
Document (PDF) (1090 KB PDF).

December 30, 1992. Memorandum. 24 Page(s).
John Doherty. Toxicology Branch I.
EPA Id# 009001. Lindane: Review of the rat chronic feeding carcinogenicity study
submitted January 1991. MRID No. 41853701. Tox Review No. 009909.
Document (PDF) (1654 KB PDF).

July 13, 1993. Memorandum. 21 Page(s).
John Doherty. Toxicology Branch I.
EPA Id No.: 009001. Lindane: Review of rat & rabbit developmental toxicity studies
conducted in 1971 & 1976. MRID Nos. 00062656, 428080-01 & 00062658.
Document (PDF) (1204 KB PDF).

August 26, 1993. Memorandum. 9 Page(s).
George Ghali. Health Effects Division.
Lindane: RfD/Peer Review Report; CASRN. 58-89-9. MRID No. 42222205.
Document (PDF) (608 KB PDF).

September 13, 1993. DER. 7 Page(s).
John Doherty. Toxicology Branch I.
Supplemental DER; Refer to HED Document No.: 009909 for initial DER; Lindane:
81-5. Chronic Feeding/Carcinogenicity - rats. MRID No. 429272-01. Registration Data
information removed from pages 5-7.
Document (PDF) (329 KB PDF).

September 24, 1993. Memorandum. 33 Page(s).
John Doherty. Toxicology Branch I.
EPA File No.: 009001. Lindane: i. Company response to the Agency's request to
provide additional information regarding the adrenal gland for the rat carcinogenicity
study; ii...MRID No. 41853701. Tox Review No. 010603. Pages 23-25 removed,
registrant data
Document (PDF) (2053 KB PDF).

October 06, 1993. Memorandum. 2 Page(s).
John Doherty. Toxicology Branch I.
EPA Id No.: 009001. Lindane: Return of overviews of the carcinogenic potential of
lindane prepared by the registrant & their consultant.
Document (PDF) (94 KB PDF).

September 01, 1994. Review. 5 Page(s).
Alfred Smith. Registration Support Branch.
Product Chemistry Review of Drexel Lindane Technical Page 5 deleted - Confidential
Statement of Formula.
Document (PDF) (292 KB PDF).

October 04, 1994. Review. 7 Page(s).
Marion Copley. Toxicology Branch I.
Toxicology Endpoint Selection Document; Dermal Absorption Data; Acute Dietary
Endpoint (One Day); Short Term Occupational or Residential Exposure (1 to 7 Days);
Intermediate Term Occupatonal or Residential (1 week…)
MRID Nos. 40056107, 42808001, 40821701.
Document (PDF) (375 KB PDF).

November 28, 1995. Memorandum. 3 Page(s).
Marion Copley. Toxicology Branch I.
Lindane: Waiver request for several toxicity studies.
Document (PDF) (174 KB PDF).

September 17, 1997. Memorandum. 6 Page(s).
John Doherty. Toxicology Branch I.
EPA Id No.: 009001. Lindane: Request for a waiver from the requirement for a series
83-2b carcinogenicity study with mice.
Document (PDF) (471 KB PDF).

July 26, 2000. DER. 31 Pages.
S. Shallal Al-Mudallal. Reregistration Branch 4.
STUDY TYPE: DEVELOPMENTAL NEUROTOXICITY - RAT [870.6300 (§83-6)].
MRID No. 45073501. Tox review No. 014282. DP BARCODE: D260975, D264799.
Page 24-31 removed, registrant data.
Document (PDF) (1214 KB PDF).

August 02, 2000. DER. 15 Page(s).
Tessa Long. Oak Ridge National Lab for HED.
Lindane (gamma HCH). Study Type: Acute Oral (Gavage) Neurotoxicity -Rat (81-8)
MRID 44769201. Tox review 014274 excerpt.
Document (PDF) (881 KB PDF).

August 02, 2000. DER. 23 Page(s).
Tessa Long. Oak Ridge National Lab for HED.
Lindane (gamma HCH). Study Type: Subchronic Oral Neurotoxicity -Rat (82-7)
MRID 44781101. Tox review 014276 excerpt.
Document (PDF) (1152 KB PDF).

August 08, 2000. DER. 24 Page(s).
Carol Forsyth. Oak Ridge National Lab for HED.
Lindane. Study Type: Developmental Neurotoxicity -Rat [870.6300] MRID 45073501.
Tox review 014282 excerpt.
Document (PDF) (1582 KB PDF).

March 11, 2002. Memorandum. 25 Page(s).
Sayed Tadayon. Chemistry Exposure Branch HED.
Assessment of Worker Exposure to a Commercial Seed Treatment in Seed-Treating
Plants. [Vitavax, Uniroyal Chemical]. MRID 44731501.
Document (PDF) (2153 KB PDF).

October 17, 2002. Letter. 7 Page(s).
Mark Howard. Special Review & Reregistration Division.
Lindane; Product Chemistry Data Evaluation Report.
MRIDs 45426601 through 45426611.
Document (PDF) (321 KB PDF).
Attachment(s) Following:

July 18, 2002. Memorandum.
Thurston Morton. Reregistration Branch 4 HED.
Lindane (009001); Reregistration Case 0315. Product Chem...

*End of Attachments*

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