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Index of Cleared Science Reviews for 1-Bromo-3-chloro-5,5-dimethylhydantoin (Pc Code 006315)
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September 26, 1980. DER. 35 Page(s).
James Felkel. Ecological Effects Branch.
Aquatic invertebrate 48-hour LC50. Test Species: Daphnia magna. Acc. 243015.
Document (PDF) (1581 KB PDF).
Attachment(s) Following:
September 04, 1980. DER.
James Felkel. Ecological Effects Branch.
Fish acute 96-hour LC50. Test Species: Rainbow trout, Fathead minnows.
Acc. 243015.
October 16, 1980. DER.
James Felkel. Ecological Effects Branch.
Acute toxicity (96-hour) to estuarine and marine organisms. Test Species:
Juvenile sheepshead minnow, Grass shrimp, American oyster. Acc. 243015.
October 21, 1980. DER.
James Felkel. Ecological Effects Branch.
Acute toxicity to estuarine and marine organisms. Test Species: Juvenile
sheepshead minnow, Grass shrimp, American oyster. Acc. 243015.
October 23, 1980. DER.
James Felkel. Ecological Effects Branch.
96-hour fish and 48-hour aquatic invertebrate LC50. Test Species: Rainbow trout,
Fathead minnows, Daphnia magna. Acc. 243015.
*End of Attachments*
October 24, 1980. Review. 40 Page(s).
James Felkel. Ecological Effects Branch.
File Nos. 1729-REE, -REG. Spa Brom Mini-Pak; Spa Brom Feeder Sticks.
Incremental Risk Assessment for Proposed Conditional Registration of Uses in Spas
and Hot Tubs.
Document (PDF) (1910 KB PDF).
Attachment(s) Following:
October 24, 1980. Review. 40 Pages.
James Felkel. Ecological Effects Branch.
Manufacturing process info. and product ingredient source info. on pp. 1-2, 6, 11-
13, 16-17, and 23-27 not included.
*End of Attachments*
July 28, 1981. Review. 3 Page(s).
Willa Garner. Environmental Fate Branch.
Reg./File No. 1729-REE, 1729-REG. Use in spas - incremental exposure.
Document (PDF) (133 KB PDF).
May 09, 1983. Review. 3 Page(s).
James Wilson. Disinfectants Branch.
Technical Support Section Toxicology Review I - New Application.
Document (PDF) (109 KB PDF).
October 21, 1983. Memorandum. 23 Page(s).
Toxicology Branch.
Spa-Brom; Review of Toxicity Studies on Dimethylhydantoin.
Document (PDF) (886 KB PDF).
April 13, 1984. Review. 10 Page(s).
Samuel Creeger. Exposure Assessment Branch.
Reg./File No. 38906-RE. Registration of new chemical for use in recirculating cooling
towers. Hydrolysis, photolysis, biodegradability. Acc. 252642.
Document (PDF) (430 KB PDF).
April 13, 1984. Review. 6 Page(s).
Curtis Laird. Ecological Effects Branch.
File or Reg. No. 38906-RE. Proposed registration of various cooling tower uses
including lagoons.
Document (PDF) (307 KB PDF).
April 18, 1984. Review. 23 Page(s).
Curtis Laird. Ecological Effects Branch.
File or Reg. No. 38906-T. Submission of data to support registration. Acc. 252094.
1/13/84 Avian acute oral LD50; page 8. 1/13/84 Eight-day dietary LC50; page 11.
1/16/84 Eight-day dietary LC50; page 13. 96-hour LC50; page 15. 96-hour LC50;
page 18.
Document (PDF) (789 KB PDF).
April 26, 1984. Review. 1 Page(s).
Anna Skapars. Disinfectants Branch.
Dantobrom RW.
Document (PDF) (53 KB PDF).
April 26, 1984. Review. 3 Page(s).
James Wilson. Disinfectants Branch.
New Application (Dantobrom RW). Pending registration information on page 3 is not
included.
Document (PDF) (101 KB PDF).
July 16, 1984. Efficacy Review. 1 Page(s).
Disinfectants Branch.
Dantobrom P.
Document (PDF) (39 KB PDF).
July 18, 1984. Review. 9 Page(s).
Curtis Laird. Ecological Effects Branch.
File or Reg. No. 38906-RU. Proposed registration of uses in spas, swimming pools,
recirculating water systems, pulp & paper mfg, and in oil recovery systems.
Acc.
252719.
Document (PDF) (404 KB PDF).
July 26, 1984. Review. 14 Page(s).
Curtis Laird. Ecological Effects Branch.
File or Reg. No. 38906-RE, 38906-RG, 38906-RU. Submission of Data to Support
Proposed Registrations of Microbicide Uses. 96-hour LC50 (Bluegill, page 6) (Trout,
page 9). 48-hour LC50 Daphnia magna, page 12. Acc. 252074, 252072.
Document (PDF) (506 KB PDF).
August 13, 1984. Review. 3 Page(s).
Samuel Creeger. Exposure Assessment Branch.
Reg./File No. 8959-UN. registration in spas and hot tubs. EAB has not received any
environmental fate data for review in this submission.
Document (PDF) (141 KB PDF).
August 17, 1984. Review. 1 Page(s).
Anna Skapars. Disinfectants Branch.
Dantobrom S.
Document (PDF) (42 KB PDF).
September 05, 1984. Review. 1 Page(s).
Anna Skapars. Disinfectants Branch.
Dantobrom P. Commercial/financial information is not included.
Document (PDF) (58 KB PDF).
September 12, 1984. Efficacy Review. 3 Page(s).
William Campbell. Disinfectants Branch.
New Product Registration.
Document (PDF) (100 KB PDF).
September 12, 1984. Review. 10 Page(s).
Samuel Creeger. Exposure Assessment Branch.
Reg./File No. 38906-RL use in swimming pools. Discussion of Data. The three active
ingredients in the product were... previously reviewed (13 April 1984).
Page 6 removed, confidential statement of formula.
Document (PDF) (644 KB PDF).
September 12, 1984. Review. 3 Page(s).
Samuel Creeger. Exposure Assessment Branch.
Use in Swimming Pools.
Document (PDF) (131 KB PDF).
September 27, 1984. Review. 4 Page(s).
Samuel Creeger. Exposure Assessment Branch.
Response to Data Requirements.
Document (PDF) (176 KB PDF).
November 06, 1984. Review. 24 Page(s).
Curtis Laird. Ecological Effects Branch.
File No. 8959-UU. Brominating Compounds. Proposed Registration of Uses in Spas
and Hot Tubs.
Document (PDF) (879 KB PDF).
November 13, 1984. Review. 3 Page(s).
Samuel Creeger. Exposure Assessment Branch.
Reg./File No. 8959-UN. Request for waiver from the aqueous photolysis study.
Document (PDF) (129 KB PDF).
February 26, 1985. Review. 3 Page(s).
Samuel Creeger. Exposure Assessment Branch.
Review Protocols (Hydrolysis Study).
Document (PDF) (120 KB PDF).
March 12, 1985. Memorandum. 2 Page(s).
Robert Zendzian. Toxicology Branch.
Dantobrom, Dantobrom S, & Dantobrom P Data Requirements for Use in Spas and
Swimming Pools - Glycol.
Document (PDF) (76 KB PDF).
July 11, 1985. Review. 2 Page(s).
Leslie Touart. Ecological Effects Branch.
8622-EL Submission of data to support proposed microbicide uses Acc. 258164.
Document (PDF) (83 KB PDF).
July 15, 1985. Review. 3 Page(s).
James Wilson. Disinfectants Branch.
8622-EL New Application Acute Oral, Acute Dermal, Skin Irritation, Eye Irritation
Acc. 258165.
Document (PDF) (125 KB PDF).
October 31, 1985. Memorandum. 4 Page(s).
Joycelyn Stewart. Toxicology Branch.
Dantobrom, EPA Registration No. 38906-14. Dantobrom P, EPA File Symbol 38906-
RL. Data Requirements for Use in Spas and Swimming Pools. Manufacturing
process information on page 2 is not included.
Document (PDF) (296 KB PDF).
November 26, 1986. Review. 3 Page(s).
James Wilson. Disinfectants Branch.
Resubmission - Tox Data.
Document (PDF) (149 KB PDF).
January 12, 1987. Memorandum. 10 Page(s).
Joycelyn Stewart. Toxicology Branch.
Bromochloro-5,5,dimethylhydantoin; 1-bromo- 3-chloro-5,5-dimethylhydantoin
EPA ID# 8622-EL Mutagenicity. Acc. 264468. Tox review 005654
Document (PDF) (585 KB PDF).
February 17, 1987. Review. 4 Page(s).
James Adams. Exposure Assessment Branch.
8622-EL Registration for use in indoor and outdoor swimming pools and spas
Hydrolysis and Photodegradation in Water. Acc. 264468.
Document (PDF) (230 KB PDF).
May 01, 1987. Review. 8 Page(s).
Akiva Abramovitch. Exposure Assessment Branch.
Reg./File No. 3377-EG, 3377-EE, 3377-EU. Registration for use in swimming pools.
Document (PDF) (356 KB PDF).
May 12, 1987. Review. 4 Page(s).
Akiva Abramovitch. Exposure Assessment Branch.
Registration for Use in Indoor and Outdoor Swimming Pools and Spas.
Document (PDF) (206 KB PDF).
May 13, 1987. Review. 4 Page(s).
Akiva Abramovitch. Exposure Assessment Branch.
Reg./File No. 8959-44. Registration for use in indoor and outdoor swimming pools.
Both the hydrolysis and the aqueous photodegradation studies should be repeated
with a purified material... Acc. # 265455 and 265456.
Document (PDF) (192 KB PDF).
May 14, 1987. Memorandum. 17 Page(s).
Joycelyn Stewart. Toxicology Branch.
Dantobrom S, EPA ID No. 38906-13 and Dantobrom P, EPA ID No. 38906-15.
Commercial/financial information on page 1 is not included Tox review 005876.
Document (PDF) (890 KB PDF).
June 30, 1987. Memorandum. 19 Page(s).
Joycelyn Stewart. Toxicology Branch.
Dantobrom S. EPA ID No. 38906-13 and Dantobrom P, EPA ID No. 38906-15
Document (PDF) (666 KB PDF).
July 07, 1987. Review. 4 Page(s).
James Wilson. Disinfectants Branch.
Resubmission (Skin Irritation and Eye Irritation Data).
Document (PDF) (139 KB PDF).
July 17, 1987. Review. 24 Page(s).
Curtis Laird. Ecological Effects Branch.
File or Reg. No. 3377-EG, 3377-EE, 3377-EU. Data Review for Technical. Avian
acute oral LD50, Bobwhite quail, page 5. Eight-day dietary LC50, Bobwhite, p.9;
Mallard, p.12. 96-hour LC50, Bluegill, Fathead, p.15; Trout, p.18. 48-hour LC50 p.22.
Document (PDF) (815 KB PDF).
March 03, 1988. Memorandum. 3 Page(s).
Joycelyn Stewart. Toxicology Branch.
5,5-Dimethylhydantoin and 5-ethyl, 5-methylhydantoin. EPA ID # 38906-3, -4, -7, -9, -
12, -13, -14, -15. Tox Chem Nos. 366D, 568E, 309C. Product formulation information
on page 1 is not included.
Document (PDF) (155 KB PDF).
May 04, 1988. Memorandum. 8 Page(s).
Joycelyn Stewart. Toxicology Branch.
Dantobrom S and Dantobrom P. EPA ID Nos. 6836-116; 6836-118. Acc. Nos.
403313-01 and 403313-07 Tox review 006687.
Document (PDF) (542 KB PDF).
June 02, 1988. Memorandum. 14 Page(s).
Joycelyn Stewart. Toxicology Branch.
Dantobrom S and Dantobrom P. EPA ID #s 6836-116 and 6836-118. Acc. Nos.
403313-01 and 403313-07.
Document (PDF) (654 KB PDF).
April 05, 1989. Review. 10 Page(s).
Curtis Laird. Ecological Effects Branch.
File or Reg. No. 5785-IU. Proposed registration of uses in brewery pasteurizers and
recirculating cooling water systems.
Document (PDF) (516 KB PDF).
Attachment(s) Following:
May 04, 1988. Memorandum.
Emil Regelman. Exposure Assessment Branch.
Data Requirements for Dantobrom BTB.
May 04, 1988. Review.
Curtis Laird. Ecological Effects Branch.
File or Reg. No. 6336-RGL. New chemical screen for three hydantoin compounds
proposed for use in recirculating cooling water systems and airwashers.
May 13, 1988. Memorandum.
Curtis Laird. Ecological Effects Branch.
Data Requirement for Dantobrom BTB.
*End of Attachments*
August 23, 1989. Memorandum. 3 Page(s).
Joycelyn Stewart. Toxicology Branch.
Dantobrom S; EPA ID # 6836-116; Record No. 245107. MRID #s 410889-01, -02
Tox review 007447.
Document (PDF) (144 KB PDF).
January 16, 1990. Review. 6 Page(s).
Paul Mastradone. Chemistry Review Section.
Reg. Nos. 5785-65 and 5785-63. BromoCide Tablets, BromoCide Granules. Review
Amendment Request for Additional Use Pattern and Additional Brand Name
(BromoCide Tablets and Granules).
Document (PDF) (1002 KB PDF).
Attachment(s) Following:
February 10, 1989. Review. 17 Page(s).
Dynamac Corporation.
Dimethylhydantoin - Task 1: Review and Evaluation of Task 1: Review and
Evaluation of Individual Studies Task 2: Environmental Fate Assessment Initial
Draft Report MRIDs 408046-01 thru -07, 406852-01.
*End of Attachments*
May 21, 1990. Review. 14 Page(s).
Curtis Laird. Ecological Effects Branch.
Submission of estuarine data to support proposed label amendment for once-through
use in industrial cooling water systems. Pages 13-14 removed, registrant data.
MRID 409931-01, -02, -03.
Document (PDF) (645 KB PDF).
May 21, 1990. Review. 14 Page(s).
Curtis Laird. Ecological Effects Branch.
Submission of estuarine data to support proposed label amendment for once-through
use in industrial cooling water systems. Pages 7-8 removed, registrant data.
MRID 409931-01, -02, -03.
Document (PDF) (657 KB PDF).
January 07, 1992. Memorandum. 9 Page(s).
Melba Morrow. Toxicology Branch.
ID No.: 006836-00115, 90 Day Subchronic Oral Study in Rats with
Dimethylhydantoin. MRID 42009201. Tox review 008972.
Document (PDF) (459 KB PDF).
March 30, 1992. Memorandum. 22 Page(s).
Melba Morrow. Toxicology Branch.
ID No.: 006836-00115, Metabolism Studies with Dimethylhydantoin in Rats.
MRID 42173901. Tox review 009394.
Document (PDF) (1271 KB PDF).
August 27, 1992. Review. 48 Page(s).
Douglas Urban. Ecological Effects Branch.
Lonza Inc.; List C Phase IV. MRID 930760-02, -03, 04, 05, 20, 06, 27, 07,
22, 08, 09, 10.
Document (PDF) (1930 KB PDF).
March 20, 1993. Review. 1 Page(s).
Bernice Slutsky. Environmental Fate & Effects Division.
EFED's comments on dihalodialkylhydantoins DCI (Case 3055).
Document (PDF) (43 KB PDF).
September 27, 1993. Review. 55 Page(s).
Anthony Maciorowski. Ecological Effects Branch.
Review of data for hydantoin submitted by Lonza Inc. Flow-through life-cycle toxicity.
Daphnia magna. Early life-stage toxicity. Fathead minnow. Pages 15-22, 37-40
removed, registrant data. MRID 42721701, 42721702.
Document (PDF) (2086 KB PDF).
May 13, 1994. Memorandum. 2 Page(s).
Paul Chin. Toxicology Branch.
EPA ID # 006836: Registrant's Response to Agency Review of MEH (5-methyl-5-
ethylhydantoin) General Metabolism Study. MRID 430204-02. Tox review 010966.
Document (PDF) (130 KB PDF).
September 15, 1994. Review. 3 Page(s).
Alfred Smith. Registration Support Branch.
Product Chemistry Review of Halobrom (RR Case#3055, Phase 4) Page 3 removed,
quality control procedures.
Document (PDF) (130 KB PDF).
January 12, 1995. Letter. 2 Page(s).
Mark Wilhite. Accelerated Reregistration Branch.
Review of product chemistry and toxicology studies for the chemical 1-Bromo-3-
chloro-5, 5-dimethyllhydantoin.
Document (PDF) (115 KB PDF).
February 15, 1995. Memorandum. 4 Page(s).
Anthony Maciorowski. Ecological Effects Branch.
Review of three acute estuarine toxicity tests for Halobrom (DP Barcode D171469).
MRID 420761-02, -01, -03.
Document (PDF) (213 KB PDF).
May 12, 1995. Memorandum. 14 Page(s).
Paul Chin. Toxicology Branch.
EPA ID # 006315: 5,5-Dimethylhydantoin (DMH)- Review of 90-Day Subchronic
Dermal Toxicity Study in Rats (MRID No. 431739-01). Tox review 011544.
Document (PDF) (712 KB PDF).
May 12, 1995. Memorandum. 16 Page(s).
Raymond Locke. Toxicology Branch.
5,5-Dimethylhydantoin. Review of Toxicology Data. MRID 43553101. Chronic (One-
Year) Toxicity (Dog). Tox review 011546.
Document (PDF) (1011 KB PDF).
May 19, 1995. Memorandum. 33 Page(s).
Paul Chin. Toxicology Branch.
EPA ID # 006315: 5,5-Dimethylhydantoin (DMH) - -Review of Carcinogenicity Study
in Mice and Chronic Toxicity/Caarcinogenicity Study in Rats (MRID No. 433977-01
and -02). Tox review 011556.
Document (PDF) (1887 KB PDF).
July 09, 1996. Memorandum. 26 Page(s).
Raymond Locke. Toxicology Branch.
BCDMH. Review of Toxicology Data. Multigeneration Reproduction - Rat (83-4).
MRID 43290601. Tox review 011975.
Document (PDF) (1733 KB PDF).
July 24, 1996. Memorandum. 12 Page(s).
Raymond Locke. Toxicology Branch.
1-Bromo-3-chloro-5,5-dimethylhydantoin: Review of Toxicology Data. Subchronic oral
toxicity (feeding) - Dog; Range-finding study for chronic toxicity - Dog.
MRID 43553101. Tox review 011997.
Document (PDF) (794 KB PDF).
October 23, 1996. Letter. 16 Page(s).
Kathleen Depukat. Accelerated Reregistration Branch SRRD.
Review od Chronic (One-Year) Feeding Study in the Dog Supporting the
Reregistration of 1-bromo-3-chloro-5,5- dimethylhydantoin, Case # 3055, AI 006315.
Document (PDF) (969 KB PDF).
Attachment(s) Following:
September 20, 1996. Memorandum.
Raymond Locke. Toxicology Branch.
1-Bromo-3-chloro-5,5-dimethylhydantoin. Review of Toxicology Data. Chronic
(One-Year) Toxicity (Dog). MRID 43813301. Tox review 012060.
*End of Attachments*
January 29, 1997. Memorandum. 15 Page(s).
Raymond Locke. Toxicology Branch.
1-Bromo-3-chloro-5,5-dimethylhydantoin: Review of toxicology data. 18-month
oncogenicity study in mice, 83-2b. MRID 44063901. Tox review 012154.
Document (PDF) (892 KB PDF).
January 29, 1997. Memorandum. 3 Page(s).
Raymond Locke. Toxicology Branch.
1-Bromo-3-chloro-5,5-dimethylhydantoin (BCDMH). Addenda to Data Evaluation
Records (DERs). [Addenda to Doc. No. 011997 and 011546.] MRID 44111900,
44111901, 44111902. Tox review 012153.
Document (PDF) (128 KB PDF).
July 10, 1997. Memorandum. 34 Page(s).
Raymond Locke. Toxicology Branch.
BCDMH. Review of Toxicology Data. Combined chronic/oncogenicity feeding - Rat.
(83-5) MRID 44095901.
Document (PDF) (2243 KB PDF).
July 14, 1999. Memorandum. 3 Page(s).
Bruce Mann. Efficacy & Science Support Branch AD.
Efficacy Review and Label Review for "Dantabrom TBS-5B", for "Dantabrom TBS-
4A", and for "Dantabrom TBS-5A" EPA Reg. No(s) 6836-ETU, 6836-ETE and 6836-
ETG. MRID 44801904 & -05. [in-tank sanitizing data].
Document (PDF) (177 KB PDF).
August 14, 2000. Memorandum. 18 Page(s).
Timothy McMahon. Risk Assessment & Science Support Branch.
5,5-Dimethylhydantoin - Report of the Hazard Identification Assessment Review
Committee. Tox review 014292.
Document (PDF) (1239 KB PDF).
August 28, 2000. Memorandum. 18 Page(s).
Timothy McMahon. Risk Assessment & Science Support Branch.
5,5-Dimethylhydantoin - Revised Report of the Hazard Identification Assessment
Review Committee. Tox review 014298.
Document (PDF) (1207 KB PDF).
December 8, 2005. Review. 14 Page(s).
Tim Leighton. Antimicrobials Division.
Formation of Bromate Ion from Application of Dihalodialkylhydantoin Sanitizers
(BCDMH and DBDMH) into Swimming Pools and Associated Cancer Risks for Swimmers.
DP Barcode 324327.
Document (PDF) (739 KB PDF).