2013 Level III Scientific and Technological Achievement Awards (STAA) Awarded Nominations

Level III awards - are for those who have accomplished an unusually notable research or technological effort. The awards are for a substantial revision or modification of a scientific/technological principle or procedure, or an important improvement to the value of a device, activity, program, or service to the public. Awarded research relates to a mission or organizational component of the EPA, or significantly affects a relevant area of science/technology.

    

Nominations Recommended for a Level III Award -- Total of Twenty-Eight
Nom. ID	Publication Title & Full Citation	Eligible/Ineligible Authors	Lab/Office/Institution	Citation
S13ER0008	(1) Metabolite Profiling and a Transcriptional Activation Assay Provide Direct Evidence of Androgen Receptor Antagonism by Bisphenol A in Fish Environmental Science & Technology, 46:9673-9680 (2012) (2) Use of Chemical Mixtures to Differentiate Mechanisms of Endocrine Action in a Small Fish Model Aquatic Toxicology, 99:389-396 (2010)	Gerald T. Ankley Drew R. Ekman Elizabeth J. Durhan Kathleen M. Jensen Michael D. Kahl Daniel L. Villeneuve Mary C. Cardon David M. Skelton Timothy W. Collette L. Earl Gray, Jr. Phillip C. Hartig Elizabeth A. Makynen Quincy Teng Jenna E. Cavallin (Non-EPA) Nathan D. Mueller (Non-EPA) Leah C. Wehmas (Non-EPA) Dalma Martinovic (Non-EPA)	NHEERL, Duluth, MN	Innovative Use of Multiple Lines of Evidence to Establish an Anti-Androgenic Mode of Action for Bisphenol A in Fish
S13ER0011	(1) Structural and Functional Characteristics of Natural and Constructed Headwater Channels Draining a Reclaimed Mountaintop Removal and Valley Fill Coal Mine Journal of the North American Benthological Society, 29(2):673-689 (2010) (2) An Assessment of Cellulose Filters as a Standardized Material for Measuring Litter Breakdown in Headwater Streams Ecohydrology, 4(3):469-476 (2011)	Ken M. Fritz Stephanie Fulton Brent R. Johnson Roger A. Burke Christopher D. Barton (Non-EPA) Jeffrey D. Jack (Non-EPA) David A. Word (Non-EPA)	NERL, Cincinnati, OH	Providing Science to Inform Decisions on Compensatory Mitigation of Headwater Streams Affected by Surface Mining
S13ER0014	Watershed and Lake Influences on the Energetic Base of Coastal Wetland Food Webs Across the Great Lakes Basin Journal of Great Lakes Research, 38(3):418-428 (2012)	Michael E. Sierszen John C. Brazner Anne M. Cotter John A. Morrice Gregory S. Peterson Anett S. Trebitz	NHEERL, Duluth, MN	Identifying Ecosystem Interactions that Support Great Lakes Coastal Food Webs
S13HE0017	(1) Evaluation of Two Different Metabolic Hypotheses for Dichloromethane Toxicity Using Physiologically Based Pharmacokinetic Modeling for In Vivo Inhalation Gas Uptake Exposure in Female B6C3F1 Mice Toxicology and Applied Pharmacology, 244(3):280-290 (2010) (2) Physiologically Based Pharmacokinetic (PBPK) Modeling of Metabolic Pathways of Bromochloromethane in Rats Journal of Toxicology, 2012(629781):1-14 (2012)	Marina V. Evans Jane C. Caldwell Christopher R. Eklund William S. Cuello (Non-EPA) Tyler A. Janes (Non-EPA) Jill M. Jessee (Non-EPA) Melissa A. Venecek (Non-EPA) Megan E. Sawyer (Non-EPA)	NHEERL, Research Triangle Park, NC	Testing of a Mechanistic Hypothesis for Volatile Methanes Using Computational Modeling and Sensitivity Analyses
S13HE0018	Relative Bioavailability and Bioaccessibility and Speciation of Arsenic in Contaminated Soils Environmental Health Perspectives/Peer-reviewed, 119(11):1629-1634 (2011)	Karen D. Bradham Kirk G. Scheckel David J. Thomas Clay M. Nelson Michael F. Huges Aaron Yeow Sophia M. Serda Sharon Harper Paul E. Seales (Non-EPA) Grace E. Lee (Non-EPA) Bradley W. Miller (Non-EPA) Thomas Gilmore (Non-EPA)	NRMRL, Cincinnati, OH	Assessing and Predicting the Risk of Soil Arsenic on Human Health
S13HE0021	(1) Short-term Exposure to Triclosan Decreases Thyroxine in Vivo via Upregulation of Hepatic Catabolism Toxicological Sciences, 113(2):367-379 (2010) (2) Developmental Triclosan Exposure Decreases Maternal and Neonatal Thyroxine in Rats Environmental Toxicology and Chemistry, 29(12):2840-2844 (2010) (3) Developmental Triclosan Exposure Decreases Maternal, Fetal, and Early Neonatal Thyroxine: A Dynamic and Kinetic Evaluation of a Putative Mode-of-Action Toxicology, 300(1-2):31-45 (2012)	Kevin M. Crofton Joan M. Hedge Michael J. DeVito Katie B. Paul (Non-EPA) Ruby Bansal (Non-EPA) Robert Peter (Non-EPA) R. Thomas Zoeller (Non-EPA)	NHEERL, Research Triangle Park, NC	Characterization of an Adverse Outcome Pathway for the Thyroid-Disrupting Activity of Triclosan across Life-Stages
S13HE0024	The Exposure Data Landscape for Manufactured Chemicals Science of the Total Environment, 414:159-166 (2012)	Peter P. Egeghy Elaine A. Cohen Hubal Richard Judson Sumit Gangwal Shad Mosher (Non-EPA) Doris Smith (Non-EPA) James Vail (Non-EPA)	NERL, Research Triangle Park, NC	Revealing the Paucity of Readily Accessible Human-Exposure Data on the Vast Majority of Chemicals in Commerce
S13HE0027	Approaches to Cancer Assessment in EPA's Integrated Risk Information System Toxicology and Applied Pharmacology, 254(2):170-180 (2011)	Martin W. Gehlhaus, III Jeff Gift Karen Hogan Leonid Kopylev Paul Schlosser Abdel Kadry	NCEA, Washington, DC	Contributions to the Improved Transparency of Carcinogen Risk Assessment within IRIS Human-Health Assessments
S13HE0032	(1) Subchronic Pulmonary Pathology, Iron Overload, and Transcriptional Activity after Libby Amphibole Exposure in Rat Models of Cardiovascular Disease Environmental Health Perspectives, 120(1):85-91 (2012) (2) The role of iron Libby amphibole-induced acute lung injury and inflammation Inhalation Toxicology, 23(6):313-323 (2011) (3) Transcriptional activation of inflammasome components by Libby amphibole and the role of iron Inhalation Toxicology, 24(1):60-69 (2012)	Urmila P. Kodavanti Matte C. Schladweiler Stephen H. Gavett Andrew J. Ghio Beena D. Vallanat William O. Ward John K. McGee Debora Andrews Judy E. Richards Jonathan H. Shannahan (Non-EPA) Mark Cesta (Non-EPA) Abraham Nyska (Non-EPA)	NHEERL, Research Triangle Park, NC	Unraveling the Role of Iron in Asbestos Toxicity and Susceptibility of Those with Disease-Related Iron Overload
S13HE0033	(1) Application of WWTP Biosolids and Resulting Perfluorinated Compound Contamination in Surface and Well Water in Decatur, Alabama, USA Environmental Science & Technology, 45(19):8015-8021 (2011) (2) Determination of Perfluorinated Compounds in the Upper Mississippi River Basin Environmental Science & Technology, 44(11):4103-4109 (2010) (3) Geographical Distribution of Perfluorinated Compounds in Fish From Minnesota Lakes and Rivers Environmental Science & Technology, 44(7):2549-2554 (2010)	Andrew B. Lindstrom Mark J. Strynar E. Laurence Libelo Michael Neill Amy D. Delinsky (Non-EPA) Shoji F. Nakayama (Non-EPA) Larry McMillan (Non-EPA) Jerry Varns (Non-EPA) Patricia McCann (Non-EPA) Jessica Reiner (Non-EPA)	NERL, Research Triangle Park, NC	Research Characterizing the Transport and Fate of Persistent Perfluorinated Compounds in the Environment
S13HE0040	(1) An Integrated Imaging Approach to the Study of Oxidative Stress Generation by Mitochondrial Dysfunction in Living Cells Environmental Health Perspectives, 118(7):902-908 (2010) (2) Linking Oxidative Events to Inflammatory and Adaptive Gene Expression Induced by Exposure to an Organic Particulate Matter Component Environmental Health Perspectives, 120(2):267-264 (2112) (3) Monitoring Intracellular Redox Changes in Ozone-Exposed Airway Epithelial Cells Environmental Health Perspectives, : (2012)	James M. Samet Steven O. Simmons Robert M. Zucker Robert Silbajoris Haiyan Tong Wan-Yun Cheng (Non-EPA) Eugene Gibbs-Flournoy (Non-EPA) Philip Bromberg (Non-EPA) Thomas Hofer (Non-EPA) Evan W. Miller (Non-EPA) Christopher Chang (Non-EPA) James Remington (Non-EPA) Tobias P. Dick (Non-EPA) Jenna Currier (Non-EPA)	NHEERL, Research Triangle Park, NC	Implementation of an Advanced Molecular-Imaging Approach to the Study of Environmental Oxidant Stress
S13HE0041	(1) Simulating Quantitative Cellular Responses Using Asynchronous Threshold Boolean Network Ensembles BMC Systems Biology, 5(109): (2011) (2) Simulating Microdosimetry in a Virtual Hepatic Lobule PLoS Computational Biology, 6(4):e1000756 (2010) (3) Virtual Tissues in Toxicology Journal of Toxicology and Environmental Health B Crit Rev, 13:314-328 (2010)	Imran Shah John F. Wambaugh John Jack	NCCT, Research Triangle Park, NC	Innovations Allowing the Creation of Virtual Liver Tissues for Predicting In Vivo Effects From In Vitro Data
S13HE0043	Benchmark Dose Analysis for Bacillus anthracis Inhalation Exposures in the Nonhuman Primate Risk Analysis, An International Journal, 32(10):1750-1768 (2012)	Sarah C. Taft Stephanie A. Hines (Non-EPA)	NHSRC, Cincinnati, OH	Benchmark Dose Analysis for Bacillus Anthracis to Inform Clearance Goals
S13HE0044	Evaluation of Deltamethrin Kinetics and Dosimetry in the Maturing Rat using a PBPK Model Toxicology and Applied Pharmacology, 244(2):208-217 (2010)	Rogelio Tornero-Velez Ahmad Mirfazaelian (Non-EPA) Jeffrey W. Fisher (Non-EPA) James V. Bruckner (Non-EPA) Kyu-Bong Kim (Non-EPA) Sathanandam S. Anand (Non-EPA) Hyo J. Kim (Non-EPA) Wendy T. Haines (Non-EPA)	NERL, Research Triangle Park, NC	Accounting for Age Dependence in Pyrethroid Pharmacokinetics
S13IE0050	Near-Real-Time Combustion Monitoring for PCDD/PCDF Indicators by GC-REMPI-TOFMS Environmental Science & Technology (Sci. Journal), 46(2):923-928 (2012)	Lukas Oudejans Brian Gullett Dennis Tabor Shawn Ryan Abderrahmane Touati (Non-EPA)	NRMRL, Cincinnati, OH	Advancing State-of-the-Art Technology to Measure Diox/Furan Emmissions from Combustion Sources in Near Time
S13IR0054	Direct Application of Biota-Sediment Accumulation Factors Environmental Toxicology and Chemistry, 29(1):230-236 (2010)	Lawrence P. Burkhard Philip M. Cook Marta T. Lukasewycz	NHEERL, Duluth, MN	Understanding the Uncertainties in Applying Biota-Sediment Accumulation Factors at Superfund Sites
S13MM0056	Development and Evaluation of EPA Method 1615 for Detection of Enterovirus and Norovirus in Water Applied and Environmental Microbiology, 79(1):215-223 Applied and Environmental Microbiology, 79(1):215-223 (2013)	Jennifer L. Cashdollar Nichole E. Brinkman Shannon M. Griffin Brian R. McMinn Eric R. Rhodes Eunice A. Varughese G. Shay Fout Ann C. Grimm Sandhya U. Parshionikar Larry Wymer	NERL, Cincinnati, OH	Development and Evaluation of EPA Method 1615
S13MM0059	(1) Metagenome Analyses of Corroded Concrete Wastewater Pipe Biofilms Reveal a Complex Microbial System BioMed Central Microbiology, 12(122):1-14 (2012) (2) Metagenomic Analyses of Drinking Water Receiving Different Disinfection Treatments Applied and Environmental Microbiology, 78(17):6095-6102 (2012)	Jorge W. Santo Domingo Randy P. Revetta Vicente Gomez-Alvarez	NRMRL, Cincinnati, OH	Characterization of Microbial Functional Networks of Drinking Water and Wastewater Systems via Metagenome Analysis
S13OR0063	Effects from Filtration, Capping Agents, and Presence/Absence of Food on the Toxicity of Silver Nanoparticles to Daphnia magna Environmental Toxicology and Chemistry, 29(12):2742-2750 (2010)	H. Joel Allen Christopher A. Impellitteri Dana A. Macke Deborah L. Roose Helen C. Poynton James M. Lazorchak J. Lee Heckman (Non-EPA) Shekar Govindaswamy (Non-EPA) Mallikarjuna N. Nadagouda (Non-EPA)	NRMRL, Cincinnati, OH	Research Regarding the Toxicity of Silver Nanoparticles
S13OR0065	Post-processing Method to Reduce Noise while Preserving High Time Resolution in Aethalometer Real-time Black Carbon Data Aerosol and Air Quality Research (Scientific Journal, 11:539-546 (2011)	Gayle S.W. Hagler Tiffany L.B. Yelverton Ram Vedantham Anthony D.A. Hansen (Non-EPA) Jay R. Turner (Non-EPA)	NRMRL, Cincinnati, OH	A Noise-Reduction Algorithm to Improve the Utility of Black-Carbon Data - a Key Pollutant of Concern for Health and Climate
S13OR0069	Human and Rat ABC Transporter Efflux of Bisphenol A and Bisphenol A Glucuronide: Interspecies Comparison and Implications for Pharmacokinetic Assessment Toxicological Sciences, 128(2):317-325 (2012)	Christopher S. Mazur Satori Marchitti John Kenneke Mira Dimova (Non-EPA) Annie Lumen (Non-EPA) Jeff Fisher (Non-EPA)	NERL, Athens, GA	Providing Critical Pharmacokinetic Data Needed for Human-Health Risk Assessment of BPA
S13OR0072	Production and Consumption of Reactive Oxygen Species by Fullerenes Environmental Toxicology & Chemistry, 31(1):136-143 (2012)	Richard G. Zepp Lingjun Kong (Non-EPA)	NERL, Athens, GA	Creative Research on Data and Relationships for Evaluating Environmental Production of ROS by Carbon Nanoparticles
S13RA0077	Active Pharmaceutical Ingredients and Aquatic Organisms Environmental Contaminants in Biota: Interpreting Tissue Concentrations, W. Nelson Beyer and James P. Meador (Eds.), 2nd, ch. 8:287-347 (2011)	Christian G. Daughton Bryan W. Brooks (Non-EPA)	NERL, Las Vegas, NV	First Synoptic Review of Aquatic Biota Exposure to Pharmaceutical Residues: Tissue Levels and Bioconcentration
S13RA0079	(1) U.S. Environmental Protection Agency Radiogenic Risk Models and Projections for the U.S. Population Health Physics / Print, : (2012) (2) U.S. Environmental Protection Agency Radiogenic Risk Projections: Uncertainty Analysis Health Physics / Print, : (2012)	David J. Pawel Jerome S. Puskin	ORIA, Washington, DC	Outstanding Papers on EPA's Radiogenic Cancer Risk Projections and Their Uncertainties
S13SI0088	Green Pharmacy and Pharm Ecovigilance: Prescribing and the Planet Expert Review of Clinical Pharmacology, 4(2):211-232 (2011)	Christian G. Daughton Ilene S. Ruhoy (Non-EPA)	NERL, Las Vegas, NV	Sustainable Solutions in Healthcare to Prevent Medication Waste and Environmental Contamination by Pharmaceuticals
S13SI0090	(1) Ecological Periodic Tables for Benthic Macrofaunal Usage of Estuarine Habitats in the US Pacific Northwest Estuarine, Coastal and Shelf Science, 94:36-47 (2011) (2) Ecological Periodic Table for Benthic Macrofaunal Usage of Estuarine Habits: Insights from a Case study in Tillamook Bay, Oregon, USA Estuarine, Coastal and Shelf Science, 102-103:70-83 (2012)	Steven P. Ferraro Faith A. Cole	NHEERL, Corvallis, OR	Groundbreaking Research and Development on Ecological Periodic Tables
S13TF0096	(1) Incremental Testing of the Community Multiscale Air Quality (CMAQ) Modeling System Version 4.7 Geoscientific Model Development, 3(1):205-226 (2010) (2) Model Representation of Secondary Organic Aerosol in CMAQv4.7 Environmental Science and Technology, 44(22):8553-8560 (2010) (3) Simulating Emission and Chemical Evolution of Coarse Sea-Salt Particles in Community Multiscale Air Quality (CMAQ) Model Geoscientific Model Development, 3(1):257-273 (2010)	Kristen Foley Shawn Roselle Keith Wyat Appel Prakash Bhave Ann Marie Carlton James Kelly Jonathan Pleim Golam Sarwar Robert Gilliam Christopher Nolte Sergey Napelenok Tanya Otte Jeffrey Young David Wong Rohit Mathur Alice Gilliland Edward Edney George Pouliot William Hutzell Jesse Bash Robert Pinder Deborah Luecken Russell Bullock Donna Schwede Marc Houyoux Uma Shankar (Non-EPA)	NERL, Research Triangle Park, NC	The Development and Systematic Evaluation of a Substantially Upgraded Air-Quality Modeling System
S13TF0097	Use of Spatially Explicit Physicohemical Data to Measure Downstream Impacts of Headwater Stream Disturbance Water Resources Research, 46(W09526): (2010)	Brent R. Johnson Ken M. Fritz Adam Haas (Non-EPA)	NERL, Cincinnati, OH	Predicting Effects of Headwater Stream Disturbance on Downstream Water Quality
Key to Acronyms used in the above Table OA Office of the Administrator NERL National Exposure Research Laboratory NHEERL National Health and Environmental Effects Laboratory NRMRL National Risk Management Research Laboratory OAQPS Office of Air Quality Planning and Standards OPP Office of Pesticide Programs ORIA Office of Radiation and Indoor Air OSCP Office of Science Coordination and Policy ORCR Office of Resource Conservation and Recovery *Note: The percentages given after name represent the current percent of the total level of effort as documented in the EPA nomination.