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Transmittal Notice
UNITED STATES ENVIRONMENTAL PROTECTION AGENCY
WASHINGTON D.C. , 20460
OFFICE OF
PREVENTION, PESTICIDES AND TOXIC SUBSTANCES
August 2, 2005
MEMORANDUM
Subject: Transmission of the Preliminary Cumulative Risk Assessment for the N -Methyl Carbamate Pesticides for review by the FIFRA Scientific Advisory Panel.
To: Myrta Christian, Designated Federal Official
FIFRA SAP
Office of Science Coordination and Policy (7101C)
From: Dr. Anna B. Lowit and CAPT David J. Miller
Office of Pesticide Programs,
Health Effects Division (7509C)
Through: Dr. Tina Levine, Director
Office of Pesticide Programs,
Health Effects Division (7509C)
A meeting of the FIFRA SAP is scheduled for August 23-26, 2005 . This meeting will focus on the Preliminary Cumulative Risk Assessment for the N -Methyl Carbamate Pesticides. This memo provides a list of documents provided by EPA at this point. The charge and issue questions will be transmitted separately.
List of Documents Provided to the SAP (as of August 2, 2005 )
I. Preliminary N-Methyl Carbamate Cumulative Risk Assessment
II. Appendices
A. Introduction (None)
B. Hazard
1. Spreadsheet of RBC and whole/half brain AChE data (means, standard deviations) used in the Preliminary Cumulative Risk Assessment of the N-methyl carbamate pesticides
a. Agg Data
b. Padilla Data
2. Dose-response modeling of rat RBC and brain AChE for the Preliminary Cumulative Risk Assessment of the N-methyl carbamate pesticides
a. Dose-Time Response Modeling of Rat Brain AChE Activity: Aldicarb Gavage Dosing
b. Dose-Time Response Modeling of Rat RBC AChE Activity: Aldicarb Gavage Dosing
c. Dose-Time Response Modeling of Rat Brain AChE Activity: Carbaryl Dermal Exposure
d. Dose-Time Response Modeling of Rat RBC AChE Activity: Carbaryl Dermal Dosing
e. Dose-Time Response Modeling of Rat Brain AChE Activity: Carbaryl Gavage Dosing
f. Dose-Time Response Modeling of Rat RBC AChE Activity: Carbaryl Gavage Dosing
g. Dose-Time Response Modeling of Rat Brain AChE Activity: Carbofuran Gavage Dosing
h. Dose-Time Response Modeling of Rat RBC AChE Activity: Carbofuran Gavage Dosing
i. Dose-Time Response Modeling of Rat Brain AChE Activity: Formetanate Gavage Dosing
j. Dose-Time Response Modeling of Rat RBC AChE Activity: Formetanate Gavage Dosing
k. Dose-Time Response Modeling of Rabbit Brain AChE Activity: Methiocarb Dermal Dosing
l. Dose-Time Response Modeling of Rabbit RBC AChE Activity: Methiocarb Dermal Dosing
m. Dose-Time Response Modeling of Rat Brain AChE Activity: Methiocarb Gavage Dosing
n. Dose-Time Response Modeling of Rat RBC AChE Activity: Methiocarb Gavage Dosing
o. Dose-Time Response Modeling of Rat Brain AChE Activity: Methomyl Gavage Dosing
p. Dose-Time Response Modeling of Rat RBC AChE Activity: Methomyl Gavage Dosing
q. Dose Response Modeling of Rabbit Brain AChE Activity: Oxamyl Dermal Dosing
r. Dose Response Modeling of Rabbit RBC AChE Activity: Oxamyl Dermal Dosing
s. Dose Response Modeling of Rat Brain AChE Activity: Oxamyl Inhalation Exposure
t. Dose Response Modeling of Rat RBC AChE Activity: Oxamyl Inhalation Exposure
u. Dose-Time Response Modeling of Rat Brain AChE Activity: Oxamyl Gavage Dosing
v. Dose-Time Response Modeling of Rat RBC AChE Activity: Oxamyl Gavage Dosing
w. Dose-Time Response Modeling of Rat Brain AChE Activity: Primicarb Gavage Dosing
x. Dose-Time Response Modeling of Rat RBC AChE Activity: Pirimicarb Gavage Dosing
y. Dose-Time Response Modeling of Rabbit Brain AChE Activity: Propoxur Dermal Dosing
z. Dose-Time Response Modeling of Rabbit RBC AChE Activity: Propoxur Dermal Dosing
aa. Dose-Time Response Modeling of Rat Brain AChE Activity: Propoxur Inhalation Exposure
bb. Dose-Time Response Modeling of Rat RBC AChE Activity: Propoxur Inhalation Exposure
cc. Dose-Time Response Modeling of Rat Brain AChE Activity: Propoxur Gavage Dosing
dd. Dose-Time Response Modeling of Rat RBC AChE Activity: Propoxur Gavage Dosing
ee. Dose-Time Response Modeling of Rat Brain AChE Activity: Thiodicarb Gavage Dosing
ff. Dose-Time Response Modeling of Rat RBC AChE Activity: Thiodicarb Gavage Dosing
3. N-M-CarbamateDoseResponse (computer code, zip file)
4. R-packages (computer code, zip file)
5. Summary of AChE protocol evaluations, mixture experiments, motor activity measurements
6. Physiologically-Based Pharmacokinetic Modeling for the N-methyl carbamate cumulative risk assessment
C. Dietary
1. Processing Factors Used in Cumulative Dietary Exposure Assessment
D. Drinking Water
1. Summary of USGS NAWQA Monitoring for N-Methyl Carbamates
2. Summary of State Monitoring for N-Methyl Carbamates
3. Drinking Water Treatment Effects on N-Methyl Carbamate Pesticides
4. N-Methyl Carbamate Usage Estimates
5. Chemical-Specific Fate and Transport Properties Used for the Water Exposure Models
6. N-Methyl Carbamate Surface Water Exposure Assessment
7. N-Methyl Carbamate Ground Water Exposure Assessment
E. Residential
1. Residential Pesticide Use Inputs from REJV Survey Data
2. Residential Exposure Scenarios Appendix
F. Cumulative Risk
1. Temporal Exposure Profile Plot for Florida Central Ridge Ground Water
2. Temporal Exposure Profile Plot for North Carolina Coastal Plain Ground Water
3. Temporal Exposure Profile Plot for North Carolina Coastal Plain Surface Water
G. Model Comparison (None)
H. Risk Characterization (None)
I. Future Steps (None)
J. References (None)