Scientific Advisory Panel

The EPA report entitled Determination of the Appropriate FQPA Safety Factor(s) in the Organophosphorus Pesticide Cumulative Risk Assessment: Evaluation of Sensitivity and Susceptibility to the Common Mechanism of Toxicity, Acetylcholinesterase Inhibition, dated June 10, 2002 did not provide a detailed discussion on the genetic variability of sensitivity to organophosphorus (OP) pesticides. Furthermore, the EPA report refers to work ongoing in Dr. Clement E. Furlong's laboratory at the University of Washington concerning the developmental variability of A-esterase (PON1). Thus, Dr. Furlong was asked by the Office of Pesticide Programs to prepare a commentary on the genetic and developmental variability of sensitivity to OPs as influenced by PON1.

Dr. Vicki L. Dellarco
US EPA
Health Effects Division
Office of Pesticide Programs

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Attachments
•Comments on Genetic and Developmental Variability of Sensitivity to Chlorpyrifos/Chlorpyrifos oxon Exposure as Modulated by Plasma Paraoxonase, C. E. Furlong, University of Washington (PDF) (7 pp, 105K)

• PON1 Status as a Susceptibility Facor in Pesticide Toxicity (MS Powerpoint) (580K) by C.E. Furlong, University of Washington