August 30, 2002 Agenda
August 27, 2002 FIFRA SCIENTIFIC ADVISORY PANEL (SAP)
OPEN MEETING
FRIDAY, AUGUST 30, 2002
FIFRA SAP WEB SITE https://www.epa.gov/scipoly/sap/
OPP Docket Telephone: (703)305-5805
Sheraton Crystal City Hotel
1800 Jefferson Davis Highway
Arlington, VA 22202
(703) 486-1111
- 8:30 AM Introduction of Panel Members -Stephen M. Roberts,
Ph.D. (FIFRA SAP Session Chair)
- 8:35 AM Administrative Procedures by Designated Federal Official
- Ms. Olga Odiott
- 8:40 AM Welcome - Ms. Sherell A. Sterling (Acting Director,
Office of Science Coordination and Policy, Office of Prevention,
Pesticides and Toxic Substances, EPA)
- 8:45 AM Opening Remarks - Mr. Jack Housenger (Acting Associate Director, Antimicrobials Division, Office of Pesticide Programs, EPA)
STOCHASTIC HUMAN EXPOSURE AND DOSE SIMULATION MODEL (SHEDS)
System Operation Review of a Scenario Specific Model (SHEDS-Wood)
to Estimate Children's Exposure and Dose to Wood Preservatives from
Treated Playsets and Residential Decks Using the SHEDS Probabilistic
Model
- 9:00 AM Introduction and Background - Mr. Norm Cook (Antimicrobials Division, Office of Pesticide Programs, EPA)
- 9:10 AM Model Development Efforts
Office of Pesticide Programs Model Development Efforts - Mr. Francis (Bart) Suhre (Health Effects Division,Office of Pesticide Programs, EPA)
Office of Research and Development Model Development Efforts - Halûk Özkaynak, Ph.D. (National Exposure Research Laboratory, Office of Research and Development, EPA)
- 9:40 AM SHEDS Model Methodology for the Wood Preservative Exposure
Scenario -Valerie Zartarian, Ph.D. (National Exposure Research
Laboratory, Office of Research and Development, EPA)
- 10:30 AM Break
- 10:45 AM Demonstration of Model Interface for the Wood Preservatives Exposure Scenario - Valerie Zartarian, Ph.D., and Jianping Xue, M.D., M.P.H. (National Exposure Research Laboratory, Office of Research and Development, EPA)
- 11:15 PM Public Comments
Catherine Petito Boyce, S.M., Gradient Corporation, on behalf of Osmose Chemical Company, Arch Wood Protection, and Chemical Specialties, Inc.
Barbara D. Beck, Ph.D., Gradient Corporation, on behalf of Osmose Chemical Company, Arch Wood Protection, and Chemical Specialties, Inc.
Leila M. Barraj, Ph.D., Senior Managing Scientist at Exponent, Inc., on behalf of American Forest & Paper Association (AF&PA)
Ms. Jane Houlihan, on behalf of Environmental Working Group
- 12:00 PM Lunch
- 1:00 PM Questions to the Panel
Documentation and Operation of SHEDS-Wood
Question 1 The User's Manual for SHEDS-Wood provides installation
and operational instructions for the software. The Panel is requested
to comment on the clarity and completeness of the User's Manual
and the organization and user-friendliness of the model interface.
Does the Panel have any suggestions for improving the User's Manual
or the model interface?
Lead discussants: Sally Powell, M.S. and Lauren Zeise, Ph.D.
Question 2 The Technical Manual for the SHEDS-Wood model provides
an overview of the model construct and detailed descriptions of
key model components. The Panel is requested to comment on the clarity,
completeness and usefulness of this document with respect to describing
the model construct and scientific principles underlying the model.
Does the Panel have any suggestions for improving the Technical
Manual?
Lead discussants: Harvey Clewell, M.S. and Sally Powell, M.S.
Question 3 The Source Code Directory on the CD provides annotated code for the exposure and dose algorithms used in the SHEDS-Wood model. Are these algorithms consistent with the descriptions in the SHEDS-Wood Technical Manual?
Lead discussants: Peter Macdonald, D. Phil and Kenneth Portier, Ph.D.
Model Design
Question 4 SHEDS is a probabilistic model that simulates exposure
and dose for population cohorts and chemicals of interest. The model
simulates individuals from the user-specified population cohorts
by selecting daily sequential time-location-activity diaries from
the EPA Consolidated Human Activity Database (CHAD). For this particular
application of the SHEDS-Wood model, the user-specified population
cohort chosen by OPP, is children 1 to 6 years of age who contact
playsets and/or home decks. The Panel is requested to comment on
whether this approach appropriately considers demographic factors
and statistical representativeness for the scenario selected, given
sample size considerations for each cohort. Can the Panel recommend
alternative(s) approaches to simulate a population cohort for estimating
wood preservative exposure to children?
Lead discussants: Steven Heeringa, Ph.D., John Kissel, Ph.D., and Natalie Freeman, Ph.D.
- 3:00 PM Break
- 3:15 PM Questions to the Panel (continuation)
Question 5 The SHEDS-Wood model simulates longitudinal activity patterns for individuals by constructing a 365-day profile using 8 CHAD diaries from the same age-gender cohort. These eight diaries consist of two from each of the four seasons, one sampled on a weekend and the other on a weekday. The Panel is requested to comment on the appropriateness of this approach, given sample size considerations and availability of longitudinal activity data. Does the approach provide a reasonable and realistic construct with respect to temporal variability in magnitude and frequency for children's exposure to wood preservatives from treated decks and playsets?
Lead Discussants: Kenneth Portier, Ph.D., Natalie Freeman, Ph.D., and Dale Hattis, Ph.D.
Input Parameters
Question 6 The Panel is requested to comment on the Agency's selection
of the (non-chemical specific) input values shown in Appendices
2 and 3 of the Technical Manual, especially the dermal transfer
coefficient (TC) and days per year for outdoor playing, for which
no data are currently available. Does the Panel have recommendations
concerning the following:
A) Are there existing research (which the Agency may have missed) or recommended approaches or studies which could also be used for developing the input parameters for which few or no data are available (e.g., dermal transfer coefficient and days per year a child spends on/around treated playsets and home decks)?
B) Are the variability and uncertainty distributions assigned to these non-chemical specific input parameters appropriate?
C) Is the bootstrap approach [Frey et al. (2002)] for fitting uncertainty distributions appropriate or are there alternative approaches which are preferable?
Lead discussants: Dale Hattis, Ph.D., Steven Heeringa, Ph.D., Peter
Macdonald, D. Phil, Kenneth Portier, Ph.D., Natalie Freeman, Ph.D.,
and Lauren Zeise, Ph.D.
Model Results and Applications
Question 7 The Panel is requested to comment on the statistical
diagnostic tools used by SHEDS for analyzing model results (e.g.,
variability analyses, sensitivity analyses, uncertainty analyses)
and on the model capabilities for displaying results (e.g., summary
statistics tables, pie charts, CDFs). Are there additional analyses
or outputs that would be useful?
Lead discussants: Peter Macdonald, D. Phil, Thomas L. Potter, Ph.D., Harvey Clewell, M.S., and Dale Hattis, Ph.D.
Question 8 Does the Panel recommend any additional refinements or modifications to the model (e.g., equations, assumptions, or algorithms) in order to make it more relevant to this particular application?
Lead discussants: John Kissel, Ph.D., Thomas L. Potter, Ph.D., and Harvey Clewell, M.S.
- 5:30 PM Adjournment
Please be advised that agenda times are approximate. For further information, please contact the Designated Federal Official for this meeting, Ms. Olga Odiott, via telephone: (202) 564-8378 fax: (202) 564-8382; or email:odiott.olga@epa.gov.