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Summary Report of the Technical Workshop on Issues Associated with Considering Developmental Changes in Behavior and Anatomy When Assessing Exposure to Children
Risk Assessment Forum
Federal Register Notices
EPA's Risk Assessment Forum (RAF) announces the availability of the final report, Summary Report of the Technical Workshop on Issues Associated with Considering Developmental Changes in Behavior and Anatomy when Assessing Exposure to Children (EPA/630/R-00/005, December 2000). The report presents information and materials from a peer involvement workshop organized by the RAF. The meeting was held in Washington, DC on July 26 and 27, 2000. The meeting discussions focused on how to consider age-related changes in behavior and physical development when assessing childhood exposures to environmental contaminants. These discussions are part of EPA's ongoing efforts to improve the assessment of risk to children.
An Agency workgroup convened under the auspices of the RAF has been exploring children's exposure assessment issues. This workgroup has concluded that a major issue facing Agency assessors is how to consider age-related changes in behavior and physiology when preparing exposure assessments for children. Children's behavior changes over time in ways that can have an important impact on exposure. Further, children's physiology changes over time in ways that can impact both their exposures and their susceptibility to certain health effects. There are two aspects to these physiological changes. First, there are anatomical changes resulting from physical growth. Second, there are changes in pharmacokinetics and pharmacodynamics that affect the absorption, distribution, excretion and effects of environmental contaminants.
The Agency is examining the pharmacokinetic/ pharmacodynamic changes in children through other efforts and future meetings on this topic are anticipated. The July 2000 workshop focused on incorporating age-related changes in behavior and anatomy into Agency exposure assessments.
Downloads/Related Links
- Summary Report (Not Including Appendices) (PDF) (NA pp, 174 KB, about PDF)
- Report Appendices a, B, C & D (PDF) (NA pp, 697 KB, about PDF)
- Report Appendix H (PDF) (NA pp, 773 KB, about PDF)
- Report Appendix F (PDF) (NA pp, 16 KB, about PDF)
- Report Appendix G (PDF) (NA pp, 94 KB, about PDF)
- Report Appendix E (PDF) (NA pp, 2 MB, about PDF)
Citation
U.S. EPA. Summary Report of the Technical Workshop on Issues Associated with Considering Developmental Changes in Behavior and Anatomy When Assessing Exposure to Children. U.S. Environmental Protection Agency, Risk Assessment Forum, Washington, DC, 630/R-00/005, 2001.