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Methods for Derivation of Inhalation Reference Concentrations and Application of Inhalation Dosimetry

Risk Assessment Forum

This document describes the U.S. Environmental Protection Agency (EPA) methodology for estimation of inhalation reference concentrations (RfCs) (earlier terminology was "inhalation reference dose" or "RfD") as benchmark estimates of the quantitative dose-response assessment of chronic noncancer toxicity for individual inhaled chemicals. Noncancer toxicity refers to adverse health efects other than cancer and gene mutations. The overview chapter discusses general prinicples of dose-response assessment for noncancer assessment process. Subsequent chapters of the document discuss criteria and information to be considered in selecting key studies for RfC derivation, provide an overview of the respiratory system and its intra- and interspecies variables, and discuss areas of uncertainty and data gaps in relation to the proposed methodology.

Contact: Risk Assessment Forum Staff, 202-564-6483, or risk.forum@epa.gov

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*Please note that we are in the process of making this document accessible to those requiring assistive technology devices. A fully accessible version of this document will be posted when we complete this process. The content and general nature of the document will otherwise remain unchanged.Related Report- SAB Report: Review of the RfC Methods Case Studies. Review of Case Studies Associated with the Document Methods for Derivation of Inhalation Reference Concentrations and Application of Inhalation Dosimetry. https://www.epa.gov/sab/pdf/ehc9902.pdf

Citation

U.S. EPA. Methods for Derivation of Inhalation Reference Concentrations and Application of Inhalation Dosimetry. U.S. Environmental Protection Agency, Office of Research and Development, Office of Health and Environmental Assessment, Washington, DC, EPA/600/8-90/066F.

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