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Dioxin Toxicity Equivalency Factors (TEFs) for Human Health: Final Document

Recommended Toxicity Equivalency Factors (TEFs) for Human Health Risk Assessments of Dioxin and Dioxin-Like Compounds

This document describes EPA's updated approach for evaluating the human health risks from exposures to environmental media containing dioxin-like compounds. It recommends the use of consensus TEF values for 2,3,7,8-tetrachlorodibenzo-p-dioxin and dioxin-like compounds, which were published in 2005 by the World Health Organization, and adopted by EPA in 2008 for ecological risk assessments.

The document summarizes the toxicity equivalence methodology, provides background information and assumptions on how the methodology has evolved, and provides health risk assessors with a recommended approach for application. It will assist EPA scientists in using the toxicity equivalence methodology to assess health risks from dioxins and dioxin-like compounds, as well as inform EPA decision makers, other agencies, and the public about this methodology.

The draft document was developed by the EPA's Risk Assessment Forum with extensive input from scientists throughout the Agency. The document was available for public comment and underwent external peer review in the fall of 2009.

In preparing the final document, EPA considered the public comments submitted to EPA’s docket during the public comment period and the comments and recommendations from the external peer reviewers.

The docket for this review is located on the internet at the following address:
Docket ID: EPA-HQ-ORD-2009-0605.



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