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Framework for Inorganic Metals Risk Assessment (External Review Draft)

Note: EPA no longer updates this information, but it may be useful as a reference or resource.

Risk Assessment Forum
Federal Register Notices

Public comments on this document may be viewed using EPA's https://www.epa.gov/edocket/. Select "search" and key in the Docket Number ORD-2004-0017. Per the December 20, 2004 Federal Register Notice, all comments submitted by Tuesday, January 18, 2005 were provided to the EPA Science Advisory Board for consideration during their review of the draft framework.

The Agency recognizes that inorganic metals and metal compounds present unique issues and the added challenge of addressing the complexity of these issues in a consistent manner across the Agency's programs. The draft Framework for Metals Risk Assessment (Framework) reflects an EPA effort to develop cross-agency internal guidance for assessing metals. The overarching goals of the framework are to outline key metal-specific scientific principles and consistent approaches for conducting metals risk assessment, based on the best currently available science.

Given the complexity of issues surrounding metals risk assessment, EPA commissioned recognized scientific experts to develop papers on key scientific issues related to risk assessment of metals. These issues included environmental chemistry, exposure, human health effects, ecological effects, and bioavailability and bioaccumulation. The draft framework relies heavily on these issue papers. Development of the framework has also involved extensive consultation with the scientific community, stakeholders, and intended users, including risk assessors in other federal agencies, in different regions, and in the states. Throughout the development process, the Agency has held stakeholder meetings and made the issue papers open for public comment. After peer review deliberation by EPA's Science Advisory Board (SAB) is complete and the framework is finalized, EPA program offices will be in a position to review their current practices against the recommendations of the metals framework and incorporate adjustments as necessary, consistent with the principles of the framework.

Contact: Risk Assessment Forum Staff, 202-564-6483, or risk.forum@epa.gov


Downloads/Related Links

Related Link(s)


Framework for Inorganic Metals Risk Assessment (External Review Draft). U.S. Environmental Protection Agency, Washington, D.C., EPA/630/P-04/068B, 2004.

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