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Draft Revised Guidelines for Carcinogen Risk Assessment (External Draft, July 1999)

Risk Assessment Forum
On March 29, 2005 EPA issued final Guidelines for Carcinogen Risk Assessment, along with an associated document entitled Supplemental Guidance for Assessing Susceptibility from Early-Life Exposure to Carcinogens. Both documents are available at www.epa.gov/cancerguidelines.

EPA published its first cancer risk guidelines in 1986 (Guidelines for Carcinogen Risk Assessment (PDF)[51 FR 33992, Sept. 24, 1986]) (38 pp, 163KB, about PDF). These Guidelines set forth principles and procedures to guide EPA scientists in assessing the cancer risks from chemicals or other agents in the environment and inform the public about these procedures. EPA continues to revise its risk assessment guidelines and to develop new guidelines as experience and scientific understanding evolve. As part of that process, the Agency published Proposed Guidelines for Carcinogen Risk Assessment (PDF) (425 pp, 163KB, about PDF) in 1996 (61 FR 17960, Apr. 23, 1996). The proposed guidelines, and subsequent draft revisions to the Guidelines have been subject to extensive public comment and scientific peer review, including reviews by EPA's Science Advisory Board (SAB). EPA has also hosted scientific workshops on children's cancer risks and received input from EPA's Children's Health Protection Advisory Committee.

Supplementary Materials

In addition to the draft revised Guidelines, below are supplementary materials which mark key milestones in the development of the current draft guidelines or that will be considered as EPA completes revisions to the guidelines.These materials include:

Interim Use of 1999 Draft Revised Guidelines

The July 1999 draft revised guidelines serve as EPA's interim guidance to EPA risk assessors preparing cancer risk assessments (See Federal Register (PDF) / Vol. 66, No. 230 / Thursday, November 29, 2001 / Notices) for further information.

Contact: Technical Information Staff, 202-564-3261, or nceadc.comment@epa.gov

Downloads/Related Links

Related Link(s)


Draft Revised Guidelines for Carcinogen Risk Assessment (External Draft, July 1999). U.S. Environmental Protection Agency, Risk Assessment Forum, Washington, DC, 1999.

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