TOLERANCE REASSESSMENT ADVISORY COMMITTEE
TABLE OF CONTENTS
SCIENCE GUIDANCE DOCUMENTS

Note: This information is provided for reference purposes only. Although the information provided here was accurate and current when first created, it is now outdated.

(Note: Many of these files are in PDF format and require the Acrobat Reader )

Notes on Compilation of Science Guidance Documents

Framework for Refining FQPA Science Policies-Detailed Considerations

1. Applying the FQPA 10-Fold Safety Factor

A Standard Operating Procedures for FQPA Safety Factor Committee, Draft, April 6, 1998

Presentation for FIFRA Scientific Advisory Panel by Office of Pesticide Programs, Health Effects Division on FQPA Safety Factor for Infants and Children

2. Dietary Exposure Assessment - Whether and How to Use Monte Carlo Analyses and the 99.9 percentile issue

Guidance for Submission of Probabilistic Exposure Assessments to the Office of Pesticide Programs' Health Effects Division, Draft, February 6, 1998

3. Exposure Assessment - Interpreting "No Residues Detected."

Residue Chemistry Test Guidelines, OPPTS 860.1000(see section (e), Food Use/Non-Food Use Determinations)

Determining the Need for Tolerances in Livestock Commodities, October 30, 1997

These documents will be supplemented by guidance based on the following three papers:

• a paper to better define "no expectation of finite residues" (i.e., when is zero actually zero?)

• a paper describing appropriate statistical methods for incorporating non-detectable residues into risk assessments (i.e., where zero may not be zero, what is the appropriate method for incorporating a value in the risk assessment?)

• a paper describing use of limit of detection versus limit of quantitation in dietary exposure assessment

4. Dietary Exposure Estimates

Acute Dietary Exposure Assessment, Office Policy, Draft, June 1996

Draft OPP Policy for the Use of Anticipated Residues of Pesticides in Foods for Use in Chronic Dietary Exposure Assessments (presented to SAP in June 1997)-Appendices are not provided; they are available on request due to number of pages

Comparison of the features of the DRES and DEEM dietary risk software systems

5. Drinking Water Exposures

HED SOP 97.1: Interim Guidance for Conducting Drinking Water Exposure and Risk Assessments, December 2, 1997

Evolution and Current Status of EPA's Efforts to Accurately Estimate Pesticide Concentrations in Drinking Water for Tolerance Reassessment, August 12, 1998

Background Paper: Factoring Drinking Water Exposure into Tolerance Decisions, May 1998

Index Reservoir Model for Estimating Pesticide Concentrations in Drinking Water, FIFRA SAP presentation, July 30, 1998

OPP's Interim Approach for Addressing Drinking Water Exposure in Tolerance Decisionmaking, November 1997

6. Assessing Residential Exposure

Standard Operating Procedures for Residential Exposure Assessments, Draft, December 18, 1997

7. Aggregating Exposures from all Non-Occupational Sources

HED SOP 97.2: Interim Guidance for Conducting Aggregate Exposure and Risk Assessments, November 26, 1997 (document is being updated)

8. How to conduct a cumulative risk assessment for organophosphate or other pesticides with a common mechanism of toxicity

Guidance for Identifying Pesticide Chemicals that have a Common Mechanism of Toxicity for Use in Assessing the Cumulative Toxic Effects of Pesticides, draft, undated

9. Selection of Appropriate Toxicity Endpoints (or critical effects) for Risk Assessments of Organophosphates

Office of Pesticide Programs Science Policy on the Use of Cholinesterase Inhibition for Risk Assessments of Organophosphate and Carbamate Pesticides, draft, April 30, 1997

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updated October 28, 1998