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Triadimefon Reregistration Eligibility Decision (RED) and Triadimenol Tolerance Reassessment and Risk Management Decision (TRED) Fact Sheet

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August 2006

Pesticide Reregistration

All pesticides sold or distributed in the United States must be registered by EPA, based on scientific studies showing that they can be used without posing unreasonable risks to people or the environment. Because of advances in scientific knowledge, the law requires that pesticides first registered before November 1, 1984, be reregistered to ensure that they meet today's more stringent standards.

In evaluating pesticides for reregistration, EPA obtains and reviews a complete set of studies from pesticide producers that describe the human health and environmental effects of each pesticide. To implement provisions of the Food Quality Protection Act (FQPA) of 1996, EPA considers the special sensitivity of infants and children to pesticides, as well as aggregate exposure of the public to pesticide residues from all sources, and the cumulative effects of pesticides and other compounds with common mechanisms of toxicity. The Agency develops any mitigation measures or regulatory controls needed to effectively reduce each pesticide's risks. EPA then reregisters pesticides that meet current human health and safety standards and can be used without posing unreasonable risks to human health and the environment.

When a pesticide is eligible for reregistration, EPA explains the basis for its decision in a Reregistration Eligibility Decision (RED) document. For the purpose of tolerance reassessment, EPA explains the basis for its decision in a Tolerance Reassessment Eligibility Decision (TRED) document. This fact sheet summarizes the information in the RED/TRED document for the pesticide triadimefon and the tolerance reassessment for triadimenol, case number 2700 (PC Codes 109901 and 127201).

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Regulatory History

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Health Effects

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Ecological Effects

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Risk Mitigation

The following risk mitigation measures are required for triadimefon and triadimenol to address risks of concern.

Dietary (Food and Water) Risk Mitigation:

Residential Risk Mitigation

Occupational Risk Mitigation

Environmental Risk Mitigation

A number of the mitigation measures described above will reduce exposure and risks to
mammals and birds. These include:

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Regulatory Conclusion

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Generic Data Requirements

The generic data base supporting the reregistration of triadimefon for the above eligible uses has been reviewed and determined to be substantially complete. However, the following data requirements are necessary to confirm the reregistration eligibility decision documented in the decision document:

Human Health Effects - Triadimefon

Guideline Study Name New Harmonized Test Guideline No.
Developmental Neurotoxicity Study (DNT) 870.6300

Ecological Effects - Triadimefon

Guideline Study Name New Harmonized Test Guideline No.
Estuarine/Marine Fish LC50 850.1015
Estuarine/Marine Mollusk EC50 850.1025
Estuarine/Marine Shrimp EC50 850.1035
Seedling Emergence 850.4225
Vegetative Vigor 850.4250
Aquatic Vascular Plant Growth 850.4400

There are data that must be submitted to support the continuing registration of triadimenol. These data are not expected to change the regulatory conclusions for triadimenol described in the decision document. A generic DCI will be issued and will require development and submission of these listed data in order to confirm the conclusions outlined in the decision document.

Product Chemistry - Triadimenol

Guideline Study Name New Harmonized Test Guideline No.
Stability 830.6313
pH ( H20 solutions) 830.7000
Ultraviolet/visible Absorption 830.7050
Partition Coefficient (N-octanol/water) 830.7550
Water Solubility 830.7840

Toxicology- Triadimenol

Guideline Study Name New Harmonized Test Guideline No.
Acute neurotoxicity study 870.6100
Subchronic neurotoxicity Study 870.6200

Residue Chemistry

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For More Information

Electronic copies of the Triadimefon RED and Tolerance Reassessment for Triadimenol and all supporting documents are available in the Agency’s electronic docket on the internet at http://www.regulations.gov under docket number EPA-HQ-OPP-20050258 and EPA-HQ-OPP- 2006-0038, respectively.

For more information about EPA's pesticide reregistration program, the Triadimefon RED, or reregistration of individual products containing triadimefon and triadimenol, please contact the Special Review and Reregistration Division (7508C), Office of Pesticide Programs, US EPA, Washington, DC 20460, telephone 703-308-8000.

For information about the health effects of pesticides, or for assistance in recognizing and managing pesticide poisoning symptoms, please contact the National Pesticide Information Center (NPIC). Call toll-free 1-800-858-7378, from 6:30 am to 4:30 pm Pacific Time, or 9:30 am to 7:30 pm Eastern Standard Time, seven days a week. The NPIC internet address is
http://npic.orst.edu. Exit EPA disclaimer

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