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Index of Cleared Science Reviews

Index for Metribuzin (Pc Code 101101)

August 17, 1972. Memorandum. 13 Pages.
William Parkin. Toxicology Branch.
Request for a Residue Tolerance of 0.1 ppm 4-amino-6-tert-
butyl-3-(methylthio)-as-triazin-5(4H)-one (Sencor, BAY
94337) in or on Soybeans.
Tox review 001146.

May 7, 1973. Memorandum. 7 Pages.
Robert Schmidt. Toxicology Branch.
Sencor - Request for a temporary tolearnce residues for
(4-amino-6-(1,1-dimethylethyl)-3-(methylthio)-1,2,4-triazin-
5(4H)-one & its triazinone metabolites in or on potatoes at
0.3 ppm. Tox Review No. 001147.

October 18, 1974. Memorandum. 9 Pages.
Robert Schmidt. Toxicology Branch.
Request for a residue tolearnce of 0.6 ppm
(4-amino-6-(1,1-dimethylethyl)-3-(methylthio)-1,2,4-triazin-
5(4H)-one (Sencor, Bay 94337) in or on potatoes.
Tox Review No. 001148. Inert Ingredient & Manufacturing
Processing info removed from page 2.

August 16, 1977. Memorandum. 3 Pages.
H.W. Spencer. Toxicology Branch.
EPA #241-243-AA. Prowl and Sencor/Lexone Sequential and
Tank Mix. American Cyanamid Herbicide. Amended
Registration.
Inert ingredient information on page 2 is not included.

September 22, 1977. Review. 21 Pages.
Lamar Windberg. Efficacy and Ecological Effects Branch.
Reg. No. 241-243. Prowl Herbicide. Use with Sencor/Lexone
Inert ingredient information on page 1 is not included.

February 5, 1979. Memorandum. 4 Pages.
John Doherty. Toxicology Branch.
Registration No. 3125-GEL to Support Registration of a New
Product on Potatoes and Soybeans. Caswell No. 33D.
Tox Review 001150.

February 9, 1979. Memorandum. 6 Pages.
Roland Gessert. Toxicology Branch.
File Symbol 352-GON. Lexone DF Weed Killer. Metribuzin.
4-amino-6-(1,1-dimethyl)-3-(methylthio)-1,2,4-triazin-5(4H)-
one. E.I. duPont de Nemours & Company, Wilmington,
Delaware. Tox Review 001145.
Inert ingredient information on page 3 is not included.

June 16, 1980. Memorandum. 4 Pages.
Deloris Graham. Fungicide-Herbicide Branch.
EPA Registration Number 3125-325. Sencor Sprayule.
Eye irritation. Page 4 removed, draft label.
Tox review 001149.

April 18, 1982. Memorandum. 12 Pages.
Roger Gardner. Toxicology Branch.
Review of IBT Replacement Data on Sencor EPA No. 3125-270.
Accn. No. 246397.
Inert Ingredient & Manufacturing Processing info removed
from page 2.

January 23, 1985. Memorandum. 284 Pages.
Stephen C. Dapson. Toxicology Branch.
Metribuzin Registration Standard; Toxicology Chapter.
MRID Nos. 00061256, 00061254, 00087796, 00061257, 00061262,
0006161. Pages 36-39, 52-57, 69-74, 82-85, 96-99, 108-
110, 118-124, 129-132 removed, registrant data.
Tox review 004262.

January 23, 1985. Memorandum. 132 Pages.
Stephen C. Dapson. Toxicology Branch.
Metribuzin Registration Standard; Toxicology Chapter.
MRID Nos. 00106161, 65018106, 00106162, 00061261, 00061260,
0061256. Pages 36-39, 52-57, 69-74, 82-85, 96-99, 108-
110, 118-124, 129-132 removed, registrant data.
Tox review 008190.

June 22, 1985. Memorandum. 6 Pages.
Arthur Schlosser. Exposure Assessment Branch.
A Copy of the Final Report of Metribuzin Addendum Dated
July 18, 1985 is Attached to this Memo.

September 16, 1985. Review. 6 Pages.
Elizabeth Zucker. Ecological Effects Branch.
EPA Reg. No. 3125-270. EEB Evaluation of Acute Toxicity
Data on Freshwater Fish Submitted to Support the
Registration of Metribuzin. Accession # 257920.

November 5, 1985. Review. 10 Pages.
Emil Regelman. Exposure Assessment Branch.
EPA Reg. No. 3125-270. Metribuzin. Response to
Registration Standard.

November 15, 1985. Memorandum. 26 Pages.
Stephen C. Dapso. Toxicology Branch.
Review of additional data on a chronic feeding study in
rats... submitted by Mobay in Support of the Registration
Standard... EPA ID #3125-270; Accession # 258756 & 258757.
Pages 26-30 removed, registrant data.
Tox review 004767.

December 10, 1985. Memorandum. 11 Pages.
Stephen C. Dapson. Toxicology Branch.
Metribuzin reregistration data package: a 9 week study to
establish dose-time effect on the thyroid in rats.
Acc. No. 257924. Pages 11-16 removed, registrant data.
Tox review 004850.

February 6, 1986. Memorandum. 5 Pages.
Mary Waller. Fungicide-Herbicide Branch.
EPA File Symbol 3125-GAA. Gemini 8 Emulsifiable Concentrate
Herbicide.

May 30, 1986. Review. 2 Pages.
Emil Regelman. Exposure Assessment Branch.
EPA Reg. No. 3125-270. Metribuzin (Sencor) - Herbicide.
Study Accession No. 262229 (unreviewed).

June 26, 1986. Memorandum. 5 Pages.
Stuart Z. Cohen. Exposure Assessment Branch.
Metribuzin Ground-Water Monitoring Study.
Page 5 removed, commercial/financial information.

July 9, 1986. Memorandum. 4 Pages.
Nancy Dodd. Residue Chemistry Branch.
EPA Reg. Nos. 3125-270 and 3125-305. Metribuzin on
Sugarcane. Sugarcane Processing Study Submitted for
Reregistration.

December 11, 1986. Review. 8 Pages.
John Noles. Ecological Effects Branch.
EPA Reg. No. 3125-270. EPA Accession No. 262228: Avian
Acute Dietary LC50 Study: Mobay Chemical Corporation:
Metribuzin Registration Standard. Submission of Data in
Response to Registration Standard.

February 3, 1987. Memorandum. 38 Pages.
Stephen Dapson. Toxicology Branch.
Review of 2 Acute Inhalation Studies and 2 Mutagenicity
Studies with Metribuzin (Sencor) Submitted as Part of Data
Call-In for the Metribuzin Registration Standard...
Pages 6-9, 13-16, 20-27, 31-38 removed, registation data.
Tox review 005709.

February 17, 1987. Memorandum. 5 Pages.
W. T. Chin. Residue Chemistry Branch.
PP #4E3112. Metribuzin (Sencor) in or on Carrots.
Amendment of 8/1/86. (Acc. #264192, RCB #1345).

May 26, 1987. Memorandum. 7 Pages.
Deloris Graham. Fungicide-Herbicide Branch.
EPA Reg. No. 352-448. DuPont Preview Herbicide.
Pages 6-7 removed, draft label.

July 2, 1987. Review. 19 Pages.
Carolyn Offutt. Exposure Assessment Branch.
Alachlor and Alternatives. Review of 1985 Surface and
Ground Water Screening Results for Selected Herbicides for
PD4.

October 9, 1987. Review. 4 Pages.
Matthew Lorber. Exposure Assessment Branch.
EPA Reg./File No. 203831. Metribuzin (Sencor). Selection
of Countries for Retrospective Field Studies for Potatoes.

October 21, 1987. Review. 4 Pages.
Matthew Lorber. Exposure Assessment Branch.
Metribuzin. Ground Water Data Call-In.

February 29, 1988. Review. 8 Pages.
Patrick Holden. Exposure Assessment Branch.
Reg. No. 3125-270. Metribuzin. Submission of Revised
Small-Scale Retrospective Ground Water Monitoring Protocol.

December 20, 1988. Data Eval. Rec. 36 Pages.
A. Reiter. Environmental Fate & Ground Water Branch.
MRID 40577701. Metribuzin Confined Accumulation Study on
Peanuts. Lab. Proj. ID AMR-563-86. Unpublished Study
Prepared and Submitted by E.I. du Pont de Nemours and Co.
Pages 7-33 removed, registration data.

December 28, 1988. Review. 11 Pages.
Emil Regelman. Environmental Fate & Ground Water Branch.
EPA Reg./File # 235782. Metribuzin. Request for Extension
of Data Requirement.

February 7, 1989. Review. 6 Pages.
Emil Regelman. Environmental Fate & Ground Water Branch.
EPA Reg./File No. 325-270. Metribuzin (Sencor). Request
for Waiver of Fish Accumulation Study Requirement.

February 8, 1989. Memorandum. 9 Pages.
Martin F. Kovacs. Dietary Exposure Branch.
PP #2F2677 Sencor (Metribuzin) in or on Soybeans - Amendment
of July 7, 1988 to Review Additional Soybean Residue Data
Submitted in Response to the Metribuzin Registration
Standard Data Requirements (MRID No. 402779-04).

June 15, 1989. Memorandum. 2 Pages.
Linda Propst. Dietary Exposure Branch.
EPA Reg. Nos. 352-382 and 352-390. Metribuzin. Rotational
Crop Accumulation Study. Deferral from EFGWB. MRID No.
405777-01. DEB Nos. 5156 and 5157.

June 28, 1989. Memorandum. 5 Pages.
John H.S. Chen. Toxicology Branch.
Review of Mutagenicity Studies with Sencor.
EPA Registration No 3125-270
Acc. No. 251219
Tox review 003865.

July 27, 1989. Memorandum. 155 Pages.
Stephen Dapson. Toxicology Branch.
Tolerances and Revised Tolerances for Metribuzin on Food
Use Crops. ID#s: 8F3683, 8H5563, 3125-314, 3125-325, 2F2677;
MRIDs 262892, 40255503, 40347701, 263761, 265366, 40838401..
Pgs 18-27, 38-51, 56-67, 75-88, 103-109, 112-115 removed, RD
Tox review 007369.

July 28, 1989. Memorandum. 7 Pages.
Robert Zendzian. Science Analysis & Coordination Branch.
Sencor. Review of Dermal Absorption Study in Rats.
MRID 263761. Page 7 removed, registation data.
Tox 007372.

October 27, 1989. Memorandum. 55 Pages.
Michael Flood. Dietary Exposure Branch.
EPA Reg. Nos. 3125-314, 3125-325. PP #8F3683/FAP8H5563.
Sencor Herbicide (Metribuzin) In/On Alfalfa Seed, Alfalfa
Chaff, Asparagus, Barley Forage, Barley Hay... MRID Nos.
400425-01, -02; 402555-01, -02; 402779-01, -02, -03, -05;
403717-01; 403676-01, -04, -05; 408027-01. Acc. No. 262890.

November 17, 1989. Memorandum. 1 Page.
Michael Flood. Dietary Exposure Branch.
MRID #410210-01. DEB #'s 5867, 5868. PP #8F3683/FAP #
8H5563. Sencor Herbicide (Metribuzin). Multi-residue
Protocol Testing.

November 22, 1989. Memorandum. 5 Pages.
Michael Flood. Dietary Exposure Branch.
PP #8F3683, FAP #8H5563. Sencor Herbicide (Metribuzin) In/
On Alfalfa Seed, Alfalfa Chaff, Asparagus, Barley Forage,
Barley Hay, Corn Silage, Corn Cannery Waste...Storage
Stability Study -- Amendment to Our Memo Dated 10/27/89.
MRID # 410206-01.

February 23, 1990. Review. 3 Pages.
Richard Lee. Ecological Effects Branch.
Worksheet. Metribuzin (Herbicide). DCI for Plant Studies.

April 10, 1990. Memorandum. 57 Pages.
Richard Schmitt. Dietary Exposure Branch.
Metribuzin Product Chemistry and Residue Chemistry
Registration Standard Updates. Pages 16-19 removed,
manufacturing process and quality control procedure info.
MRID 40042501, -02, 40255501, -02, 40277901 thru -05,
40367601, -04, -05, 40371701, 40802701, 41020601, 41021001.

September 24, 1990. Review. 15 Pages.
Henry Nelson. Environmental Fate & Ground Water Branch.
EPA Reg./File No. 352-390. Metribuzin (Herbicide).
Accumulation in Confined Rotational Crops
MRID 40577701.
Attached: 8/13/90, DEB Deferral.

January 28, 1991. Memorandum. 17 Pages.
Timothy McMahon. Toxicology Branch.
SENCOR Technical: Review of a Rabbit Teratology Study
Submitted by the Registrant.
MRID 412492-01
Tox review 008251.

May 10, 1991. Memorandum. 3 Pages.
James Akerman. Ecological Effects Branch.
EEB Review of List A DCI Package for Metribuzin.
MRID Nos. 001615-02, -03.

May 20, 1991. Memorandum. 4 Pages.
Timothy McMahon. Toxicology Branch.
Metribuzin (Sencor Technical): Review of additional
information submitted by the registrant. MRID No. 418355-01
MRID 418355-01.
Tox review 008375.

May 21, 1991. Memorandum. 3 Pages.
James A. Breithaupt. Environmental Fate & Ground Water Branch.
Metribuzin List "A" Review.
Current summary of the data requirements for metribuzin.

July 25, 1991. Memorandu. 12 Pages.
Stephen C. Dapson. Toxicology Branch II.
Revised Section F Petition and additional data for
teratology study in rats with Metribuzin.
MRID No. 41551801.
Tox review 008473.

September 13, 1991. Memorandum. 18 Pages.
Douglas Urban. Ecological Effects Branch.
Review Studies of Sencor.
MRID Nos. 470234-011, -012.
Page 8-9, 14, 17-18 removed, registration data.

December 2, 1991. Review. 5 Pages.
Douglas Urban. Ecological Effects Branch.
Review avian dietary study; previous review determined
study to be unacceptable.
MRID No. 00065507.

January 2, 1992. Memorandum. 7 Pages.
Walter J. Kozumbo. Toxicology Branch II.
...DIC 1468 Technical or Metribuzin: Review of a study
on dermal sensitization in guinea pigs submitted by the
registrant.
MRID 415551-01. Pages 7-8 removed, registrant data.
Tox review 008965.

January 15, 1992. Memorandum. 16 Pages.
Anonymous. Ecological Effects Branch.
Addendum to the DER of the Shell Deposition Study.
MRID No. 42094501.
Page 9 removed, FIFRA Registration Data.

January 22, 1992. Memorandum. 2 Pages.
Douglas Urban. Ecological Effects Branch.
Data Review for Sencor.
MRID Nos. 42094501, -02.

January 29, 1992. Review. 13 Pages.
Henry Jacoby. Environmental Fate & Groundwater Branch.
Review information concerning potential ground-water
monitoring site in Missouri.

May 29, 1992. Memorandum. 57 Pages.
Stephen C. Dapson. Toxicology Branch II.
Metribuzin - Review of a teratology study in rabbits and an
in vitro cytogenetic assay in CHO cells.
MRID No. 412492-01 and 415551-02.
Pages 38-57 removed, registrant data.
Tox review 009520.

December 7, 1992. EFGWB Review. 295 Pages.
Akiva D. Abramovich. Environmental Fate & Ground Water Branch.
EFGWB review of Metribuzin; Review of 161-1,2,3, 162-1,2,
163-1, 164-1, and 165-1 studies.
MRID 40367602, 40367603 42283001, 40380901, 42236101,
40838402. Acc. 42283001. Pages 14-17, 20-28, 32-40, 45-60,
65, 67-82, 86-94, 99-114, 119, 121-132, 135, (continued).
Attachment(s) following:

December 7, 1992. EFGWB Review. 295 Pages.
Akiva D. Abramovich. Environmental Fate & Ground Water Branch.
Continued: 139-160, 167-178, 182-213, 220-231, 235-269, 276,
278-293, 295 removed, registrant data.

*End of attachments*

December 8, 1992. Review. 45 Pages.
Henry Jacoby. Environmental Fate & Groundwater Branch.
Review final report for small-scale ground-water monitoring
study.
MRID 41422001.

January 21, 1993. Review. 10 Pages.
Anthony Maciorowski. Ecological Effects Branch.
Data review - toxicity to freswater green algae.
MRID 424383-01. Page 8 removed, registrant data.

February 17, 1993. Review. 49 Pages.
Anthony Maciorowski. Ecological Effects Branch.
Submission of fish early life-stage and aquatic invertebrate
life cycle studies under 6(a)(2) in support of
reregistration.
MRIDs 42447801, -02.
Pages 11-14, 36-38 removed, registration data.

March 8, 1993. Review. 25 Pages.
Anthony Maciorowski. Ecological Effects Branch.
Submission of non-target plant data submitted under 6(a)(2)
in support of reregistration.
MRID No. 42447803.
Pages 17-20 removed, FIFRA Registration Data.

March 30, 1993. Memorandum. 1 Page.
Norm Cook. Ecological Effects Branch.
6(a)(2) Metribuzin Data.
MRID No. 42438301.

April 21, 1993. Memorandum. 33 Pages.
Timothy F. McMahon. Toxicology Branch II.
Metribuzin: Review of Toxicology Data Submitted under FIFRA
section 6(a)(2) by the Registrant.
MRID 426725-01.
Tox review 010178.

December 13, 1993. Memorandum. 70 Pages.
Anthony Maciorowski. Ecological Effects Branch.
Metribuzin and DADK (metribuzin metabolite) Aquatic
Invertebrate Life Cycle Tests - 6(a)(2) Data.
MRID 427312-01 and 427325-01.
Pages 28-35, 52-56 removed, registration data.

April 11, 1994. Review. 2 Pages.
Anthony Maciorowski. Ecological Effects Branch.
Submission of rebuttal to previous EEB review of a fish
early life-stage study.
MRID No. 42447801.

June 6, 1994. Review. 6 Pages.
Anthony Maciorowski. Ecological Effects Branch.
Submission of Green Alga study to support reregistration of
List A, Case No. 0181, Metribuzin.
MRID 431336-01.

June 8, 1994. Memorandum. 8 Pages.
Anthony Maciorowski. Ecological Effects Branch.
Metribuzin Terrestrial Plant Data Evaluation Record.
MRID No. 432083-01.

August 17, 1994. Review. 10 Pages.
Elizabeth Behl. Environmental Fate & Ground Water Branch.
Environmental Fate & Ground Water Branch Review Action;
Metribuzin; Review request from State of Florida to amend
ground-water label advisory for metribuzin.
Reg. No 3125-325.

September 7, 1994. Memorandum. 7 Pages.
George Ghali. Health Effects Division.
RfD/Peer Review Report of Metribuzin (Sencor).

July 2, 1996. Review. 6 Pages.
Shyman Mathur. Registration Support Branch.
Product Chemistry Review.
File Symbol 279-GRTL.
Authority BL Co-Mix Formulation.
MRID 43926701, -02, -03.

June 8, 1999. Review. 6 Pages.
Paul Horng. Product Reregistration Branch.
Product Chemistry Review.
EPA REG. No. 3125-325. Sencor DF 75% Dry Flowable Herbicide.
Inert ingredient info on page 1 not included. Manufacturing
process information on page 5 not included.
MRID 44713922.

June 30, 1999. Review. 7 Pages.
Ann Hanger. Product Reregistration Branch.
Product Chemistry Review of: TGAI [X] Manufacturing-Use [X]
...Product. Barcode No.: D255489... Reg. No.: 3125-270.
MRID No. 147003, 161509, 41284401, 42890201, 156324,
41696401, 42598203, 161507, 42890202, 42425601.
Page 7 removed, description of product manufacturing process.

February 17, 2000. Review. 2 Pages.
Paul Horng. Product Reregistration Branch.
Product Chemistry Review.
EPA REG. No. 3125-325. Sencor 75 Turf Herbicide.
Inert ingredient info on page 1 not included.
MRID 45003001.

May 15, 2000. Review. 1 Page.
Anne Hanger. Product Reregistration Branch.
Product Chemistry Review.
REG. No. 3125-270. Sencor Technical, 94% Metribuzin.
MRID 45024401, 45127901.

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