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Index of Cleared Science Reviews

Index for Benomyl (Pc Code 099101)

Undated. Review. 143 Pages.
Health Effects Division.
Benomyl Reference Dose for Chronic Oral Exposure (RfD).
DER #1 through DER #17 attached. MRIDs 00088333, 00097284,
00096514, 00151267, 00061618, 00081913, 0097305, 00097318,
00097326, 41887901, 00066773, 00148393, 00115674, 00126522,
43788301, 35352, 66771, 99130, 41607903, 42817003, 43277901.

Undated. Memorandum. 4 Pages.
Melba Morrow. Toxicology Branch I.
ID No. 283750, Metabolite (1-Butyl Isocyanate) from
Aqueous Benlate.

October 23, 1968. Review. 6 Pages.
L.B. Dale. Toxicology Branch.
Methyl-1-(butylcarbamoyl)-2-benzimidazole carbamate.
100-66
Acute, subacute, 90-day feeding, dermal tox, skin irritation
Tox review 004678 excerpt.

March 25, 1970. Memorandum. 13 Pages.
Mary Quaife. Division of Toxicology, FDA.
Benomyl... Requested Tolerances: At 1 ppm on Bananas,
of Which Not More Than 0.2 ppm Shall Be In Pulp After Peel
Is Removed and Discarded (PP No. OFO-906)... Inert info.
on pages 2, 3, 11 and manufacturing process info. on page 2
are not included. Tox review 004678 excerpt.

April 27, 1971. Memorandum. 2 Pages.
George Whitmore. Toxicology Branch.
Memorandum of conference between du Pont and Tox Branch.
Benomyl.
Pesticide Petitions - 906, 1000, 1010, 1045, 1145.
... effect upon the reproduction organs of the test dogs.

May 5, 1971. Memorandum. 12 Pages.
Mary Quaife. Toxicology Branch.
Benomyl... A Fungicide. Requests for Tolerances as Follows:
PP No. 0F0906, 1 ppm on Bananas, of Which No More Than 0.2
ppm Will Be in Pulp; PP No. 0F1000, 15 ppm in or on Plums,
Peaches, Nectarines, Apricots, Cherries, and Prunes...
Inert info on 5, 7 not included. Tox review 004678 excerpt.

June 18, 1971. Letter. 1 Page.
Drew Baker. Petitions Control Branch.
Letter to Mr. Taylor W. Hanavan, E.I. du Pont Company.
petitions... will require a detailed histopathology
examination and report...

July 20, 1971. Memorandum. 2 Pages.
Mary Quaife. Toxicology Branch.
Memorandum of conference between du Pont and Tox Branch.
2-year feeding study on benomyl in dogs.
Benomyl, Pesticide Petitions including No. 0F0906.

October 29, 1971. Memorandum. 4 Pages.
William Boodee. Chemistry Branch.
PP #1F1033. Benomyl on Apples, Pears. Comments on
Amendment of 7/14/71 with Changes in Sections B and F, and
Additional Residue Data.

January 17, 1973. Memorandum. 4 Pages.
Robert Coberly. Toxicology Branch.
Registration No. 352-EXP-73G.
Inert ingredient information on pages 1-3 not included.
Tox review 004678 excerpt.

February 23, 1973. Memorandum. 6 Pages.
Robert Coberly. Toxicology Branch.
Registration No. 352-354. Benlate Benomyl Fungicide.
Acute tox. Inert ingredient information on pages 2-3, and
manufacturing process information on page 2 not included.
Tox review 004678 excerpt.

April 12, 1973. Memorandum. 8 Pages.
Robert Hummel. Chemistry Branch.
PP #2F1218 (FAP #2H5004). Benomyl on Grapes.
Amendment of 1/31/73.

August 14, 1973. Memorandum. 3 Pages.
Robert Hummel. Chemistry Branch.
PP #2F1218 and FAP #2H5004. Benomyl on Grapes.
Amendment of 6/12/73.

November 27, 1973. Memorandum. 5 Pages.
E.M. Bellet. Chemistry Branch.
PP #3F1410 and FAP #3H4033. Benomyl on Citrus.
Evaluation of Analytical Method and Residue Data.

February 1, 1974. Memorandum. 3 Pages.
E.M. Bellet. Chemistry Branch.
PP #3F1410 and FAP #3H4033. Benomyl on Citrus.
Comments on Amendments of 12/7/73.

May 10, 1974. Memorandum. 5 Pages.
Richard Beyak. Chemistry Branch.
PP #4F1452. Benomyl on Tomatoes. Evaluation of the
Analytical Method and Residue Data.
Manufacturing process and inert ingredient information
on page 2 are not included.

November 6, 1974. Memorandum. 2 Pages.
Richard Beyak. Chemistry Branch.
PP #4F1452 and FAP #5H5062. Benomyl on Tomatoes.
Comments on Amendment of 8/16/74.

May 13, 1975. Memorandum. 6 Pages.
Robert Coberly. Toxicology Branch.
Registration No. 538-RGE. Acute toxicology studies.
Inert ingredient information on pages 1 and 2 not included.
Tox review 000719; Tox review 004678 excerpt.

September 9, 1975. Memorandum. 7 Pages.
M.J. Nelson. Chemistry Branch.
PP #5F1612/FAP #5H5084. Benomyl in or on Rice.
Evaluation of Analytical Methods and Residue Data.
Manufacturing process and inert ingredient information
on page 3 are not included.

May 21, 1976. Memorandum. 10 Pages.
Mary Quaife. Toxicology Branch.
Benomyl... tolerances at 0.2 ppm each on wheat, oats,
barley and rye - grain form; at 2.0 ppm each on oats, barley
and rye - straw; and at 15 ppm on wheat straw, requested,
-human safety evaluation.
PP No. 6F1748.

September 7, 1977. Memorandum. 1 Page.
Roland Gessert. Toxicology Branch.
File Symbol 35899-EUP-2. Benomyl 0.3% in 99.7%
Dimethylformamide. Texas A & M University, College Station,
Texas.

January 24, 1978. Memorandum. 7 Pages.
Robert Jaeger. Toxicology Branch.
EPA Reg. No. 192-RET, Benomyl.
Tox review 000722.
Attachment(s) following:

April 23, 1979. Report.
Robert Kavlock. Experimental Biology Division, EPA.
Report on the Status of Teratogenicity Studies with Benomyl.

*End of attachments*

January 30, 1979. Memorandum. 4 Pages.
William Dykstra. Toxicology Branch.
Benlate. Registration #352-354; Caswell #75A (Benomyl)
Acc 236766
Tox review 000723.

October 31, 1979. Memorandum. 3 Pages.
Gary Burin. Toxicology Branch.
PP #9E2259; Request for the Establishment of a Tolerance
for Benomyl at 5 ppm on Turnip Greens.
Caswell #75A; Accession #098945
Tox Review No. 000721.

November 14, 1980. Memorandum. 52 Pages.
Sherell Sterling. Toxicology Branch.
Benlate DF Fungicide.
EPA File Symbol: 352-GOA.
Acute oral, acute dermal, eye and skin irritation.
Acc. No 243043.
Tox review 004678.
Attachment(s) following:

November 14, 1980. Memorandum.
Sherell Sterling. Toxicology Branch.
(continued)
Inert information on pages 6, 7, 13, 14, 19, 20, 28, 35,
37, 43, 44 and 45 is not included. Manufacturing process
information on pages 13 and 19 not included.
Tox review 004678.

*End of attachments*

October 14, 1981. Memorandum. 13 Pages.
Minnie Sochard. Toxicology Branch.
Toxicology Review of Benomyl.
... changes in the teratogenic NOEL and
oncogenic risk from dietary exposure.
Tox review 003728.

November 18, 1981. Review. 6 Pages.
Louis Kasza. Toxicology Branch.
Evaluation of Pathologic Data from Two-Year Feeding Study
in Mice Treated with Benomyl, DuPont Haskell
Laboratory Study.
Tox Review 003726.

December 4, 1981. Memorandum. 7 Pages.
Louis Kasza. Toxicology Branch.
Evaluation of Pathologic Data from
Two-Year Feeding Study in Mice
Treated with INE-965, MBC (Benomyl Metabolite).
Tox review 003727.

May 4, 1982. Memorandum. 8 Pages.
Bertram Litt. Toxicology Branch.
Statistical Evaluation and Oncogenicity Risk
Assessment of Benomyl, Benlate and MBC 2-Year
Feeding Studies in Mice.

January 7, 1983. Memorandum. 8 Pages.
Edwin Budd. Toxicology Branch.
PP 6F1748. Benomyl on Small Grains, Liver and Milk.

March 11, 1983. Memorandum. 2 Pages.
Minnie Sochard. Toxicology Branch.
Benomyl - No. 352-354. Rat Teratology Study.
Accession No. 248563.
Tox Review 002578.

June 27, 1983. Memorandum. 4 Pages.
Roger Gardner. Toxicology Branch.
Benomyl, Additional Teratogenicity Data. Reg. No. 352-354.
Accession Nos. 249749 and 248563
Tox Review No. 003042.

April 24, 1984. Notes. 12 Pages.
John Melone. HED.
Chuck Tricholo, Bill Burnam. Immediate Action.
See Ed's note. We discussed this at staff today.
Teratogenic Effects. Calculation of ADI and TMRC.
(Allowable Daily Intake; Theoretical Maximum Residue
Contribution).

May 23, 1985. Memorandum. 3 Pages.
R.W. Cook. Residue Chemistry Branch.
No Accession No. (RCB No. 828) PP #7E2007. Benomyl in
or on Peppers and Eggplants. An Update of RCB's Evaluation
of PP #7E2007 is Requested.

June 21, 1985. Memorandum. 3 Pages.
Philip Errico. Residue Chemistry Branch.
PP #0E2409. Benomyl Use on Garden Beets. Amendment of
July 19, 1982 (RCB #829) (No Accession No.).

October 11, 1985. Review. 11 Pages.
Jane Harris. Toxicology Branch.
3-Generation Reproduction (rat). Haskel Lab Study No. 264-68
Tox review 004708.

October 18, 1985. Memorandum. 4 Pages.
Sami Malak. Residue Chemistry Branch.
Review of Protocols for Benomyl Bound Liver Residues in
Response to 3(c)(2)(B) Data Call-In. No Accession Number.
RCB No. 1407.

October 24, 1985. Science Chapter. 169 Pages.
Marion Copley. Toxicology Branch.
Toxicology Branch Chapter of the Registration Standard
for Benomyl. Inert ingredient info on pages 6, 27, 63, 83-85
not included. MRIDs 66771, 66785, 97287, 66773, 97284,
115674, 96514, 88333, 97305, 81913, 97318, 97326, 61618.
Tox review 004679.

November 14, 1985. Memorandum. 12 Pages.
Gobind Makhijani. Residue Chemistry Branch.
Response to Data Gaps in the Product Chemistry Chapter
of the Benomyl Registration Standard.
Quality control procedure information on page 6 is not
included. Pages 7-12 are not included - quality control
procedure and manufacturing process information.

November 22, 1985. Memorandum. 3 Pages.
William Anthony. Residue Chemistry Branch.
Benomyl Sec. 18 on Potatoes in Florida. ID #86-FL-01.
RCB #157. Acc. No.: None.

January 24, 1986. Memorandum. 6 Pages.
Michael Firestone. Residue Chemistry Branch.
PP #6E3325 (RCB #310). Benomyl on Watercress. Evaluation
of Analytical Methods and Residue Data (Accession No.
074014).

January 30, 1986. Memorandum. 7 Pages.
Karl Arne. Residue Chemistr