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Index of Cleared Science Reviews
Index for Chemical Name (PC Code 911508)
Undated. Memorandum. 1 Page.
Anne Lindsay. Registration Division.
Establishment of a Tolerance for CGA-154281 -- Request
for Expedited Review.
Undated. Memorandum. 7 Pages.
Rita Briggs. Science and Coordination Branch HED.
Dietary Exposure Analysis for CGA-154281.
inert ingredient... proposed to be used in formulations
of metolachlor.
March 17, 1987. Memorandum. 1 Page.
Reto Engler. Toxicology Branch.
CGA-154281, Protocol for Dermal Absorption.
April 13, 1987. Review. 36 Pages.
Emil Regelman. Exposure Assessment Branch.
7E3489. Clearance under 180.1001 all categories.
EPA Acc. No. 400288-30, 400288-31, 400288-32, 400288-33,
400288-34. Pages 5-10, 12-13, 16-22, 24-27 and 30-36
removed, registrant data.
May 7, 1987. Review. 2 Pages.
John Chen. Toxicology Branch.
Acute Rabbit Dermal Toxicity. Guideline 81-2. 7E3489.
Tox review 006239.
Attachment(s) following:
May 7, 1987. Review. 2 Pages.
John Chen. Toxicology Branch.
Acute Rat Oral Toxicity. Guideline 81-1. 7E3489.
Tox review 006239.
May 7, 1987. Review. 2 Pages.
John Chen. Toxicology Branch.
Acute Rat Inhalation Toxicity. Guideline 81-3. 7E3489.
Tox review 006239.
May 7, 1987. Review. 2 Pages.
John Chen. Toxicology Branch.
Primary Rabbit Eye Irritation. Guideline 81-4. 7E3489.
Tox review 006239.
May 7, 1987. Review. 2 Pages.
John Chen. Toxicology Branch.
Primary Rabbit Dermal Irritation. Guideline 81-5. 7E3489.
Tox review 006239.
May 7, 1987. Review. 2 Pages.
John Chen. Toxicology Branch.
Skin Sensitization in Guinea Pigs. Guideline 81-6. 7E3489.
Tox review 006239.
August 21, 1987. Review. 5 Pages.
John Chen. Toxicology Branch.
Subchronic Toxicity Study with CGA 154281 Technical in Dogs.
MRID 400288-13. Guideline 82-1. Tox review 006239.
May 15, 1987. Review. 6 Pages.
John Chen. Toxicology Branch.
90-Day Oral Toxicity Study with CGA-154281 Technical in Dogs
MRID 400288-13. Guideline 82-1. Tox review 006239.
August 21, 1987. Review. 7 Pages.
John Chen. Toxicology Branch.
90-Day Subchronic Toxicity Study in Rats
MRID 400288-12. Guideline 82-2. Tox review 006239.
May 7, 1987. Review. 5 Pages.
John Chen. Toxicology Branch.
21-Day Dermal Toxicity Study in Rabbits
7E3489. Guideline 82-2. Tox review 006239.
May 7, 1987. Review. 6 Pages.
John Chen. Toxicology Branch.
Metabolism Study in the Rat
7E3489. Guideline 85-1. Tox review 006239.
May 7, 1987. Review. 3 Pages.
John Chen. Toxicology Branch.
DNA Damage.
7E3489. Guideline 84-2. Tox review 006239.
*End of attachments*
May 7, 1987. DER. 4 Pages.
John Chen. Toxicology Branch.
84-2 Chinese Hamster - Micronucleus Test.
Study Type: Cytogenic Analysis.
Study Number: 860109.
Tox review 006239.
May 7, 1987. DER. 4 Pages.
John Chen. Toxicology Branch.
84-2 Unscheduled DNA Synthesis in Rat Hepatocytes.
Study Type: DNA Damage.
Study Number: 860177.
Tox review 006239.
May 7, 1987. DER. 4 Pages.
John Chen. Toxicology Branch.
84-2 Salmonella Mutagenicity Test.
Study Type: Gene Mutation in Bacteria.
Study Number: 860840.
Tox review 006239.
May 7, 1987. DER. 3 Pages.
John Chen. Toxicology Branch.
84-2 Salmonella Mutagenicity Test.
Study Type: Gene Mutation in Bacteria.
Study Number: 86076 (MIN 862200).
Tox review 006239.
May 11, 1987. Review. 49 Pages.
James Akerman. Ecological Effects Branch.
Ecological Effects Review of the Inert Chemical
MRID 400288-26, 400288-27, 400288-28, 400288-29.
Pages 24-29 removed, confidential statement of formula
and registrant data.
August 21, 1987. DER. 7 Pages.
John Chen. Toxicology Branch.
83-3 Rat - Teratogenicity.
Study Number: 483-287.
Pages 5-7 removed, registrant data.
MRID 40028815.
Tox review 006239.
August 21, 1987. DER. 14 Pages.
John Chen. Toxicology Branch.
83-3 Rat - Teratogenicity.
Study Number: 483-245.
Pages 8-14 removed, registrant data.
MRID 40028815.
Tox review 006239.
August 21, 1987. DER. 5 Pages.
John Chen. Toxicology Branch.
83-3 Rabbit - Teratogenicity.
Study Number: 483-246 (MIN 852163 and FL 852142).
MRID 40028816.
Tox review 006239.
August 21, 1987. DER. 7 Pages.
John Chen. Toxicology Branch.
83-3 Rabbit - Teratogenicity.
Study Number: 483-246.
MRID 40028816.
Tox review 006239.
August 27, 1987. Memorandum. 3 Pages.
Robert Jaeger. Toxicology Branch.
Inert Chemical: CGA-154281, 4-(Dichloroacetyl)-3,4-
dihydro-3-methyl-2H-1,4-benzoxazine, EPA Identifi-
cation No. 7E3489 - Used as an Inert Ingredient in
Pesticide Formulations containing Metolachlor.
Inert ingredient information on page 3 not included.
February 4, 1988. Review. 13 Pages.
R.B. Jaeger. Toxicology Branch.
Salmonella Mutagenicity Test.
Acc. No. 403888-06. Guideline 84-2.
Pages 4-13 removed, registrant data.
February 4, 1988. Review. 11 Pages.
R.B. Jaeger. Toxicology Branch.
Salmonella Mutagenicity Test.
Acc. No. 403888-04. Guideline 84-2.
Pages 4-11 removed, registrant data.
February 4, 1988. Review. 13 Pages.
R.B. Jaeger. Toxicology Branch.
Salmonella Mutagenicity Test.
Acc. No. 403888-05. Guideline 84-2.
Pages 4-13 removed, registrant data.
February 17, 1988. Review. 25 Pages.
R.B. Jaeger. Toxicology Branch.
Unscheduled DNA Synthesis in Rat Hepatocytes
Acc. No. 403888-13. Guideline 84-2.
Pages 6-25 removed, registrant data.
February 17, 1988. Review. 14 Pages.
R.B. Jaeger. Toxicology Branch.
Unscheduled DNA Synthesis in Rat Hepatocytes
Acc. No. 403888-12. Guideline 84-2.
Pages 6-14 removed, registrant data.
February 17, 1988. Review. 17 Pages.
R.B. Jaeger. Toxicology Branch.
Unscheduled DNA Synthesis in Cultured Human Fibroblasts
Acc. No. 403888-11. Guideline 84-2.
Pages 8-17 removed, registrant data.
March 3, 1988. Review. 18 Pages.
R.B. Jaeger. Toxicology Branch.
In-Vitro Chinese Hamster Cell (V79) Mutation Assay
Acc. No. 403888-07. Guideline 84-2.
Pages 6-18 removed, registrant data.
March 3, 1988. Review. 8 Pages.
R.B. Jaeger. Toxicology Branch.
Review of Registrant's Mutagenicity Overview of CGA-154281
Technical (Author- S.J. Spoede) with the Assessments of
Mutagenicity Studies Conducted with CGA-154281 Technical by
Ciba-Geigy's Consultant (Author - David Brusick, Hazleton
Labs ...) MRID 40388801 and 40388803.
March 14, 1988. Memorandum. 3 Pages.
Robert Jaeger. Toxicology Branch.
Inert Chemical: CGA-154281; EPA ID Number 7F3489;
Record Number 207038; Caswell No. 298C. Mutagenicity.
Tox review 006625.
June 17, 1988. Memorandum. 5 Pages.
Robert Quick. Residue Chemistry Branch.
PP#7F3489 CGA-154281 - Exemption from the
Requirements of a Tolerance.
Evaluation of the May 4, 1988 Amendment.
(MRID No. 406147-00 and -01) [RCB No. 3907].
September 7, 1988. Review. 3 Pages.
Paul Shuda. Environmental Fate & Groundwater Branch.
Amended report on adsorption/desorption constants.
September 10, 1988. Review. 17 Pages.
James Akerman. Ecological Effects Branch.
Submitted for review under 40 CFR 100.1001
Fish Acute Static Test, Rainbow Trout, Acc. No. 406291-01;
Freshwater Invertebrate Static Acute Test, Daphnia magna,
Acc. No. 406291-02.
Pages 8-9 and 16 have been deleted-registrant data.
September 14, 1988. DER. 19 Pages.
John Chen. Toxicology Branch.
Study Type: Salmonella/mammalian activation gene mutation...
Study Number: 881321.
Pages 6-19 removed, registrant data.
MRID 40732104.
Tox review 006928.
September 28, 1988. DER. 6 Pages.
John Chen. Toxicology Branch.
85-2 Rat - Dermal Absorption.
Study Number: ABR-87086.
Page 6 removed, registrant data.
MRID 40732105.
Tox review 006928.
November 15, 1988. Memorandum. 2 Pages.
Quang Bui. Toxicology Branch II.
CGA-154281: ID Number 7E03489; Record Number 229240; Action
Code 212; Caswell No. 298C
Tox Review 006928.
May 16, 1989. Memorandum. 2 Pages.
R.D. Schmitt. Dietary Exposure Branch.
PP#7E3489. CGA154281 on crops having established
metolachlor tolerances. Submission of April 6, 1989.
DEB #5310. No MRID #. HED #9-1410.
May 30, 1989. Memorandum. 3 Pages.
Donald Marlow. Analytical Chemistry Branch.
PP#7E3489 - CGA-154281 on Corn Forage
Method Validation Report.
September 5, 1989. Memorandum. 4 Pages.
Robert Quick. Dietary Exposure Branch.
PP# 7E 3489 CGA-154281 On All Crops with Tolerances
for Metolachlor (Dual).
Evaluation of the July 7 and August 21, 1989
Amendments.
(MRID No. 41208-02 and 411774-01).
September 6, 1989. Memorandum. 2 Pages.
Robert Quick. Dietary Exposure Branch.
PP#7E3489 - CGA-154281 On All Crops with Tolerances
for Metolachlor (Dual).
Evaluation of the Petition Method Validation Report.
(No MRID No.).
November 21, 1989. Memorandum. 3 Pages.
Robert Quick. Dietary Exposure Branch.
PP#7E3489 - CGA-154281 On All Crops with Tolerances
for Metolachlor (Dual).
Evaluation of the Second Petition Method Validation
(PMV) Report.
(No MRID Nos.).
May 7, 1990. Memorandum. 3 Pages.
David Van Ormer. Science and Coordination Branch HED.
SAR Analysis of a Benzoxazine Inert Ingredient.
June 9, 1992. Memorandum. 4 Pages.
Anne Lindsay. Registration Division.
Final Rule for 4-(Dichloroacetyl)-3,4-dihydro-3-
methyl-2H-1,4-benzoxazine.
Attached is a final rule that a tolerance be established for
residues...
September 12, 1995. DER. 15 Pages.
David Liem. Toxicology Branch.
Study Type: Reproductive Toxicity (Rat); Guideline 83-4.
Study Number: 380-154.
MRID Number: 42888703.
October 3, 1995. Memorandum. 105 Pages.
David Liem. Toxicology Branch.
Benoxacor: Review of a Chronic Oral Toxicity Study in Dogs
(83-1), a Carcinogenicity Study in Mice (83-2), a
Combined Chronic Toxicity/Carcinogenicity Study in Rats
(83-5), and a Reproductive Toxicity Study in Rats (83-4).
Attachment(s) following:
October 3, 1995. Memorandum.
David Liem. Toxicology Branch.
(continued)
Pages 6-21, 64-77 removed, registrant data.
MRIDs 42888701 through -04.
*End of attachments*
May 16, 1996. DER. 11 Pages.
David Liem. Toxicology Branch.
Study Type: 13-Week Feeding Toxicity Study- Mice GDLN: 82-1
Harmonized Guideline 870.3100 (rodent).
DP Barcode: D223738.
MRID#: 43337402, -03, -04.
July 25, 1996. DER. 16 Pages.
David Liem. Toxicology Branch.
Study Type: Evaluation of the Significance of Forestomach
Tumors Induced in Rodents by CGA154281 (Benoxacor).
Nonguideline.
DP Barcode: D223738. ID#: 7E03489.
MRID 42888705.
August 1, 1996. DER. 1 Page.
David Liem. Toxicology Branch.
Study Type: Evaluation of a Summary of Supplemental Toxicity
Information Supporting the Registration of CGA-154281
Technical. Nonguideline.
DP Barcode: D223738. ID#: 7E03489.
MRID 43337401.
August 29, 1996. Memorandum. 5 Pages.
David Liem. Toxicology Branch.
Benoxacor: Review of Supplementary Data Package on
Benoxacor. Barcode: D223738. ID#: 7E03489.
MRID#: 43337401 thru -05 (original submission MRID# 40028812
43337406; and 42888705).
December 11, 1996. Memorandum. 16 Pages.
William Cutchin. Risk Characterization & Analysis Branch.
PP# 7E3479 Request for Extension of Time-Limited
Tolerances for Benoxacor (CGA-154281) Used as a
Safener. Attached: Tolerance Assessment System (TAS) reports.
December 18, 1996. Memorandum. 3 Pages.
David Liem. Toxicology Branch.
Benoxacor: Review of Supplementary Data Package on
Benoxacor. Barcode: D223738. ID#: 7E03489.
MRID#: 43339501. (to supplement MRID# 40028812).