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Index of Cleared Science Reviews
Index for Lactofen (Pc Code 128888)
Undated. Summary. 10 Page(s).
Ecological Effects Branch.
EEB Chemical Profile.
January 12, 1982. Memorandum. 2 Page(s).
Roger Gardner. Toxicology Branch.
Review of a 2-Year Rat Feeding Study Protocol for PPG-844.
January 31, 1983. Review. 29 Page(s).
Leslie Touart. Ecological Effects Branch.
Proposed EUP for Use on Soybeans.
Inert ingredient information on page 4 is not included.
Pages 6-11 are not included - draft label.
Pages 12-15 are not included - registrant data.
February 3, 1983. Review. 17 Page(s).
Emil Regelman. Environmental Fate Branch.
Preliminary Application for EUP with Data.
Pages 6-7, and 11 are not included - registrant data.
Pages 13-17 are not included - draft label.
April 14, 1983. Memorandum. 59 Page(s).
John H.S. Chen. Toxicology Branch.
New Chemical; PPG-844... 748-EUP-RI/3G2783; Use on Soybeans.
1. Review and assessment of toxicity studies with PPG-844
2. Herbicide for experimental use on soybeans...
Manufacturing process information on page 59 not included.
Tox review 002665.
January 19, 1984. Memorandum. 3 Page(s).
John H.S. Chen. Toxicology Branch.
Cobra Herbicide (PPG-844) 748-EUP-18: Review of Protocols
for Mutagenicity Testing. Caswell No. 704B.
March 28, 1984. Memorandum. 21 Page(s).
John H.S. Chen. Toxicology Branch.
New Chemical; PPG-844 (Cobra 2E); 748-EUP-18/3G2783;
Two-Year Extension Request for EUP and Temporary Tolerance
on Soybeans. Accession Nos. 072196, 072197, 072198,
072199, 072200, 072201, 072202, 072203.
Tox review 003724.
April 17, 1984. Memorandum. 1 Page(s).
John H.S. Chen. Toxicology Branch.
New Chemical Cobra 2E (Lactofen); 748-EUP-RO/4G3015;
Request for an Experimental Use Permit and Petition...
[redacted].
Information on pending registration action not included.
May 11, 1984. Memorandum. 2 Page(s).
John Worthington. Residue Chemistry Branch.
PP #3G2783. Extension of the Temporary Tolerance for Cobra
on Soybeans. Evaluation of Additional Metabolism Data,
Dated 11/30/83. Accession Nos. 072196 and 072027.
July 6, 1984. Memorandum. 2 Page(s).
John H.S. Chen. Toxicology Branch.
New Chemical PPG-844; 3G2783; Review and Evaluation of
the Registrant's Response to the Previous TB Review
Comments (3/28/84, J. Chen) in Toxicological Studies.
December 27, 1985. Memorandum. 30 Page(s).
Michael Firestone. Residue Chemistry Branch.
PP #5F3299 [RCB #1493]. Lactofen (Cobra) Herbicide on
Soybeans. Evaluation of Analytical Methods and Residue Data
(Accession Nos. 073855, 073860, 073853, 073843, and 073858).
Manufacturing process info on pages 2-8, 10-12, 15-18 and 20
is not included. Pages 13-14 removed, registrant data.
March 21, 1986. Review. 7 Page(s).
Elizabeth Zucker. Ecological Effects Branch.
Proposed EUP for Use in Conifer Seedbeds.
June 23, 1986. Memorandum. 93 Page(s).
Joycelyn Stewart. Toxicology Branch.
PPG-844; Lactofen; 1-(carboethoxy...
EPA ID # 5F3299; 748-ELO; 748-EAN
Acc. No. 073831-073852; 073859
Registrant data on pages 62, 63 and 71 is not included.
Tox review 005204.
June 24, 1986. Data Eval. Rec. 3 Page(s).
Allen Vaughan. Ecological Effects Branch.
Honey Bee Acute Contact LC50 - Apis mellifera
Acc 073856.
August 7, 1986. Data Eval. Rec. 6 Page(s).
John Noles. Ecological Effects Branch.
Acute Toxicity Test for Freshwater Invertebrate
Acc 073856.
August 7, 1986. Data Eval. Rec. 7 Page(s).
John Noles. Ecological Effects Branch.
96-Hour Acute LC50 for Freshwater Fish - Bluegill Sunfish
(PPG-844 Technical 77.6%).
August 7, 1986. Data Eval. Rec. 7 Page(s).
John Noles. Ecological Effects Branch.
96-Hour Acute LC50 - Freshwater Fish - Bluegill Sunfish
(22% PPG-844).
August 7, 1986. Data Eval. Rec. 8 Page(s).
John Noles. Ecological Effects Branch.
96-Hour Acute LC50 - Freshwater Fish - Rainbow Trout
(22% PPG-844).
August 7, 1986. Data Eval. Rec. 17 Page(s).
John Noles. Ecological Effects Branch.
Dynamic Acute Toxicity to Freshwater Fish.
Species Tested: Lepomis macrochirus, Bluegill Sunfish.
Quality control procedure information on pages 4, 5 and 6
is not included.
August 7, 1986. Data Eval. Rec. 23 Page(s).
John Noles. Ecological Effects Branch.
Acute Flow-Through Fish Early Life Stage.
Species Tested: Pimephales promelas, Fathead Minnow.
Inert ingredient info on pages 1-4, 7, 8, 10, 14, 17-19 and
and 21-23 not included. Quality control procedure
information on pages 5-7 is not included.
August 11, 1986. Memorandum. 3 Page(s).
John Noles. Ecological Effects Branch.
PPG Industries' Ecological Effects Data Assigned under
EPA Accession No. 073856.
September 26, 1986. Final Report. 42 Page(s).
Dynamac Corporation.
Lactofen. Task 1: Review and Evaluation of Individual
Studies. Task 2: Environmental Fate and Exposure
Assessment.
September 26, 1986. Memorandum. 6 Page(s).
Joycelyn Stewart. Toxicology Branch.
PPG-844; Lactofen... EPA ID# 748-EUP-ER; 6G3341;
Accession Nos. 260818-260819.
September 26, 1986. Memorandum. 7 Page(s).
Joycelyn Stewart. Toxicology Branch.
PPG-844; Lactofen... EPA ID# 748-EUP-EE; 6G3340;
Accession Nos. 260820-260821.
Confidential business information on pages 1 and 2 is
not included.
September 30, 1986. Review. 6 Page(s).
S. Creeger. Exposure Assessment Branch.
File No. 748-ELO. Lactofen.
New chemical, registration request on soybeans.
November 5, 1986. Memorandum. 1 Page(s).
Joycelyn Stewart. Toxicology Branch.
Lactofen (Cobra); PPG-844. EPA ID Nos. 5F3299; 748-EAN
Review historical control data on liver tumors...
November 5, 1986. Memorandum. 12 Page(s).
David Anderson. Toxicology Branch.
The Effects of Lactofen in a Repeat Developmental Toxicity
Study in Rabbits. EPA Reg. No. 748-EAN
Tox review 005574.
January 12, 1987. Memorandum. 3 Page(s).
Joycelyn Stewart. Toxicology Branch.
Lactofen; Cobra Insecticide; PPG-844
EPA ID# 748-EAN. Acc. No. 264145.
Review mouse hepatocyteprimary culture/DNA repair assay.
Tox review 005655.
February 12, 1987. Memorandum. 4 Page(s).
Bernice Fisher. Toxicology Branch.
Lactofen (Cobra) - Mouse Study, Qualitative Risk Assessment.
February 20, 1987. Memorandum. 8 Page(s).
Laurie Lewis. Exposure Assessment Branch.
Lactofen (Cobra) Exposure Assessment.
February 20, 1987. Memorandum. 13 Page(s).
Cynthia Deyrup. Residue Chemistry Branch.
PP #5F3299. (RCB Nos. 1779 and 1897). Lactofen on
Soybeans. Amendments of 12/12/86 and 1/23/87.
MRID Nos. 400266-01, 400266-02, 400266-03, 400594-01,
400594-02, and 400594-03.
Manufacturing process info on pages 2-3 and 5-7 not included.
February 20, 1987. Memorandum. 3 Page(s).
Bernice Fisher. Toxicology Branch.
Lactofen (Cobra) - Quantitative Risk Assessment.
February 20, 1987. Profile. 3 Page(s).
Reto Engler. Toxicology Branch.
Reference Doses (RFDs) for Oral Exposure - Lactofen (Cobra).
February 22, 1987. Review. 38 Page(s).
John Noles. Ecological Effects Branch.
Registrant Response with Submission of Data Relative to
Previous EEB Review.
Inert ingredient information on pages 3, 4, 16, 18, and 21
is not included. Pages 23-38 removed, registrant submission.
February 26, 1987. Review. 11 Page(s).
James Adams. Exposure Assessment Branch.
File No. 748-ELO. Cobra. Additional Data, Responses to EAB
Review of 9/30/86.
February 27, 1987. Memorandum. 2 Page(s).
Bernice Fisher. Toxicology Branch.
Lactofen (Cobra) - Risk Characterization.
March 6, 1987. Memorandum. 4 Page(s).
Stephen Saunders. Residue Chemistry Branch.
Revised TAS Analysis of Tolerance Request for Lactofen
on Soybeans. PP #5F3299, Caswell No. 704B.
March 16, 1987. Memorandum. 3 Page(s).
Joycelyn Stewart. Toxicology Branch.
Lactofen PP #5F3299. PPG Industries Proposes that a
Permanent Tolerance be Established for the Residues of
the Herbicide... and its Associated Metabolites Containing
the Diphenylether Linkage...
Manufacturing process information on page 3 is not included.
July 15, 1987. Memo to File. 2 Page(s).
Dan Rieder. Ecological Effects Branch.
Meeting with PPG Industries to Discuss Data Requirements
on Lactofen.
November 23, 1987. Review. 14 Page(s).
Patrick Holden. Exposure Assessment Branch.
Lactofen. Response to Ground Water Monitoring Request.
February 17, 1988. Memorandum. 6 Page(s).
Michael Firestone. Exposure Assessment Branch.
Worker Exposure Assessment for Lactofen.
February 26, 1988. Memorandum. 5 Page(s).
Joycelyn Stewart. Toxicology Branch.
Lactofen PP 8F3591. PPG Industries proposes that a
permanent tolerance be established for the residues
of the herbicide 1-(carboethoxy)ethyl-5-[2-chloro-4-
(trifluoro methyl)phenoxy]-2-nitrobenzoate and its
associated metabolites..peanuts and peanut hulls at 0.05 ppm.
March 21, 1988. Review. 7 Page(s).
Patrick Holden. Exposure Assessment Branch.
Lactofen. Protocol Review for the Small-Scale
Prospective Ground Water Monitoring Study.
May 6, 1988. Review. 6 Page(s).
Patrick Holden. Exposure Assessment Branch.
Ground Water Data Call-In Response for the
Small-Scale Prospective Study: Protocol.
August 19, 1988. Review. 7 Page(s).
Allen Vaughan. Ecological Effects Branch.
Incremental Risk Assessment for Proposed New Use in Southern
Pine Seedbeds.
Pages 6-7 removed, draft label.
September 19, 1988. Review. 9 Page(s).
Paul Mastradone. Environmental Fate & Ground Water Branch.
Reg. No. 748-259. Cobra. Review of Application to Amend
Registration to Include New Use on Southern Pine Seedbeds.
June 6, 1989. Review. 9 Page(s).
Allen Vaughan. Ecological Effects Branch.
Proposed Section 18 for Use on Peanuts.
Pages 6-9 removed, draft label.
June 29, 1989. Review. 4 Page(s).
Patrick Holden. Environmental Fate & Ground Water Branch.
Lactofen. Comment on Site Selection Data Submitted for
Small-Scale Prospective Ground Water Monitoring Study for
Lactofen.
October 20, 1989. One-Liner. 4 Page(s).
Environmental Fate & Ground Water Branch.
Pesticide Environmental Fate One-Line Summary - Lactofen.
November 21, 1989. Memorandum. 4 Page(s).
Joycelyn Stewart. Toxicology Branch.
Lactofen (Cobra): Request for an Experimental
Use Permit (EUP) and Temporary Tolerance for Cotton.
EPA ID #'s 748-EUP-21; 6G3341; Record #'s 244 344;
244 335. MRID # 410698-01.
February 22, 1990. Memorandum. 26 Page(s).
Gary Otakie. Dietary Exposure Branch.
PP# 9F3798 - Lactofen (Cobra) Herbicide on Cotton
(DEB No. 5741) - Evaluation of Analytical Methods,
Residue and Processing Data Dated July 24, 1989
(MRID No. 412091-01 and -02).
April 12, 1990. Memorandum. 5 Page(s).
Rita Briggs. Science Analysis and Coordination Branch.
Dietary Exposure Analysis and Carcinogenic Risk
Assessment for the Proposed Use of Lactofen on
Cottonseed, PP# 9F3798.
June 7, 1990. Review. 86 Page(s).
Joycelyn Stewart. Toxicology Branch.
Peer Review Files - Lactofen (Cobra)
Tox review 007811.
October 15, 1990. Review. 6 Page(s).
Michael Barrett. Environmental Fate & Ground Water Branch.
File No. 89-VA-09. Cobra. Evaluation of Ground Water
Contamination Potential. (Section 18 Request from State of
Virginia - Department of Agriculture).
October 29, 1990. Memorandum. 5 Page(s).
Gary Otakie. Dietary Exposure Branch.
PP# 9F3798 - Lactofen (Cobra) Herbicide on Cotton (DEB
No. 6914) - Evaluation of Goat and Chicken Metabolism
Protocols.
June 20, 1991. Memorandum. 35 Page(s).
Gary Otakie. Chemistry Branch I.
PP#9F3798 - Lactofen (Cobra) Herbicide on Cotton - DEB (DEB
No. 7488)- Evaluation of Amendments Dated November 29, 1990.
MRID Nos. 417095-01 thru 03.
September 30, 1992. Memorandum. 8 Page(s).
Gary Otakie. Chemistry Branch I.
PP#9F3798 - Lactofen (Cobra) Herbicide on Cotton -
Evaluation of Amendments Dated January 17, 1992.
MRID Nos. 421830-01 thru 03.
May 23, 1995. Memorandum. 15 Page(s).
Gary Otakie. Chemistry Branch I.
PP#9F3798 - Lactofen (Cobra) Herbicide on Cotton -
Evaluation of Amendments Dated January 21, 1994.
MRID Nos. 430950-01 & 02.
Registration Data information removed from pages 10-15.