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Index of Cleared Science Reviews for Assure (PC Code 128711)

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May 24, 1983. Data Eval Rec. 20 Pages.
Dennis J. McLane. Ecological Effects Branch.
Avian acute LD50 for both mallard duck and bobwhite quail.
MRID No. 00128210
Pages 2 - 12 deleted - registrant data.
Document (PDF) (505 KB PDF).

July 19, 1983. Review. 21 Pages.
Richard Moraski. Exposure Assessment Branch.
Data to Support New EUP Use on Fallow Land.
Pages 10-21 are not included - draft label
MRID No. 00128213.
Document (PDF) (303 KB PDF).

October 6, 1983. Review. 24 Pages.
Thomas Edwards. Toxicology Branch.
352-EUP-RRE. DPX-Y6202, New Chemical.
Experimental Use Permit for Use Under Cereal Fallow.
Acc. 250071, 250072, 250073, 250554.
Tox review 004589.
Document (PDF) (1,161 KB PDF).

January 26, 1984. Review. 26 Pages.
Samuel Creeger. Exposure Assessment Branch.
Data to Support EUP: Use on Soybeans.
Pages 7-26 are not included - draft label and
registrant data.
Document (PDF) (340 KB PDF).

March 1, 1984. Review. 3 Pages.
Samuel Creeger. Exposure Assessment Branch.
Response to Previous Review.
Document (PDF) (112 KB PDF).

March 6, 1984. Memorandum. 6 Pages.
Thomas Edwards. Toxicology Branch.
Comments Relating to Correspondence on DPX-Y6202 from
DuPont Dated 1-11-84.
Tox review 003683.
Document (PDF) (254 KB PDF).

April 19, 1984. Memorandum. 8 Pages.
John M. Worthington. Residue Chemistry Branch.
PP No. 4g2977. Assure on cotton. Evaluation of the
analitical methods and residue data, including the amendment
of 4/4/84. Accession nos. 072023, 072024, 250071 and 252848
Inert information deleted from page 3.
Document (PDF) (857 KB PDF).

September 17, 1984. Review. 5 Pages.
Samuel Creeger. Exposure Assessment Branch.
Data to Support Modification of Rotational Crop Restriction.
Document (PDF) (234 KB PDF).

March 5, 1985. Review. 17 Pages.
Samuel Creeger. Exposure Assessment Branch.
Data to Support EUP Use on Fallow Land, Cotton and Soybeans.
Pages 7-17 removed, registrant data.
Document (PDF) (300 KB PDF).

August 23, 1985. Review. 5 Pages.
John Jordan. Exposure Assessment Branch.
EUP: Use on Cotton and Soybeans (Resubmission).
Document (PDF) (180 KB PDF).

September 25, 1985. Memorandum. 24 Pages.
Michael Firestone. Residue Chemistry Branch.
PP #5F3252 [RCB #1127]. DPX-Y6202 (Assure) Herbicide on
Cotton and Soybeans. Evaluation of Analytical Methodology
and Residue Data (Accession Nos. 073529 and 073547).
Manufacturing process info on pages 2 and 5 not included.
Page 24 removed, confidential statement of formula.
Document (PDF) (1,157 KB PDF).

October 16, 1985. Memorandum. 1 Page.
Michael Firestone. Residue Chemistry Branch.
PP #5F3252 [RCB #1351]. DPX-Y6202 (Assure) Herbicide on
Cotton and Soybeans. Evaluation of Amendment Dated
August 6, 1985 (Accession No. 073773).
Document (PDF) (59 KB PDF).

November 19, 1985. Memorandum. 1 Page.
Carolyn Gregario. Toxicology Branch.
Petitioner's Submission of Historical Control Data
18 Month Mouse Study (DPX-Y6202).
Acc. 073822.
Document (PDF) (48 KB PDF).

November 29, 1985. Memorandum. 7 Pages.
Michael Firestone. Residue Chemistry Branch.
PP #5F3252/FAP #6H5479 [RCB Numbers 123 and 124].
DPX-Y6202 (Assure) Herbicide on Cotton and Soybeans.
Evaluation of Amendment Dated September 19, 1985
(Accession Number 073908).
Document (PDF) (371 KB PDF).

December 23, 1985. Review. 7 Pages.
Emil Regelman. Exposure Assessment Branch.
Registration on Cotton and Soybeans
Acc. 073548.
Attachment(s) following:
Document (PDF) (2,135 KB PDF).

September 18, 1985. Report. 57 Pages.
Dynamac Corporation.
DPX-Y6202. Final Report.
Task 1: Review and Evaluation of Individual Studies.
Task 2: Environmental Fate and Exposure Assessment.

*End of attachments*

February 21, 1986. Memorandum. 11 Pages.
Michael Firestone. Residue Chemistry Branch.
PP #5F3252/FAP #6H5479 [RCB Nos. 487 and 488] -
DPX-Y6202 (Assure) Herbicide on Cotton and Soybeans.
Evaluation of a Goat Metabolism Study Protocol
Dated February 5, 1985 (No Accession Number).
Manufacturing process information on page 5 is not included.
Document (PDF) (539 KB PDF).

March 25, 1986. Memorandum. 30 Pages.
Whang Phang. Toxicology Branch.
Toxicology Studies on Assure Reviewed by Carolyn Gregorio.
Pages 9-13, 15-18, 24-25, 30 removed, registrant data.
Acc. 073548.
Tox review 005013.
Document (PDF) (950 KB PDF).

April 4, 1986. Data Eval Rec. 34 Pages.
I. Cecil Felkner. Dynamic Corporation.
Data Evaluation Record Assure; Chronic Feeding Study in
Dogs.
Pages 14-34 removed, registration data.
Acc. No 073536. MRID 00146683.
Tox review 005030.
Document (PDF) (968 KB PDF).

April 8, 1986. Data Eval Rec. 18 Pages.
I. Cecil Felkner. Dynamac Corporation.
Data Evaluation Record Assure (NC-302) Repeated Dose/21-Day
Dermal Toxicity Study in Rabbits.
Pages 9-18 removed, registrant data.
Acc. 072530. MRID 00146677.
Tox review 005031.
Document (PDF) (977 KB PDF).

June 24, 1986. Memorandum. 2 Pages.
Michael Firestone. Residue Chemistry Branch.
March 26, 1986 Meeting with Representatives from
E.I. du Pont de Nemours and Company, and Associates
from Nissan Chemical Industries re: DPX-Y6202 (Assure)
Herbicide on Cotton and Soybeans (PP #5F3252/FAP #6H5479).
Document (PDF) (88 KB PDF).

June 24, 1986. Memorandum. 2 Pages.
Michael Firestone. Residue Chemistry Branch.
June 20, 1986 Meeting with Representatives from
E.I. du Pont de Nemours and Company re: DPX-Y6202
(Assure) Herbicide on Cotton and Soybeans
(PP #5F3252/FAP #6H5479).
Document (PDF) (74 KB PDF).

October 20, 1986. Review. 4 Pages.
Emil Regelman. Exposure Assessment Branch.
Registrants Response to an EAB Review of a 1984 Aerobic
Soil Metabolism Study.
Document (PDF) (150 KB PDF).

October 20, 1986. Memorandum. 34 Pages.
Whang Phang. Toxicology Branch.
Assure (NC-302; ethyl 2-[4-(6-chloro-2-quinoxalinylOxy)
phenoxy]propionate): Evaluation of oncogenicity study
in mice
Pages 21-34 removed, registrant data.
Tox review 005541.
Document (PDF) (875 KB PDF).

October 21, 1986. Memorandum. 35 Pages.
Whang Phang. Toxicology Branch.
Assure Evaluation of Chronic Feeding Study in Dogs.
Pages 15-35 removed, registrant data.
Acc. 073536.
Tox review 005543.
Document (PDF) (1,581 KB PDF).

October 21, 1986. Memorandum. 67 Pages.
Whang Phang. Toxicology Branch.
Assure: Evaluation of 2-generation reproduction study in
rats.
Pages 24-67 removed, registrant data.
Acc. 074017. MRID 00153351.
Tox review 005547.
Document (PDF) (2,067 KB PDF).

October 21, 1986. Memorandum. 183 Pages.
Whang Phang. Toxicology Branch.
Assure: Evaluation of metabolism studies of NC-302 in rats.
Pages 28-31, 43-51, 66-72, 86-89, 106-109, 122-126, 128-135,
152-155, 169-173 removed, registrant data.
Acc. 073456.
Tox review 005546.
Document (PDF) (13,822 KB PDF).

October 21, 1986. Review. 19 Pages.
Whang Phang. Toxicology Branch.
Assure (NC-302; ethyl 2-[4-(6-chloro-2-quioxalingy10xy)
phenoxylopropionate): Evaluation of repeated dose/21-day
dermal toxicity study in rabbits.
Acc. No. 073530.
Tox review 005544.
Document (PDF) (480 KB PDF).

October 21, 1986. Memorandum. 41 Pages.
Whang Phang. Toxicology Branch.
Assure... Evaluation of Chronic oncogenicity study in rats.
Acc. No. 073531-5.
Pages 24-41 removed, registrant data.
Tox review 005545.
Document (PDF) (1,171 KB PDF).

February 6, 1987. Memorandum. 11 Pages.
John Quest. Toxicology Branch.
Peer Review of Assure.
Document (PDF) (709 KB PDF).

February 11, 1987. Review. 41 Pages.
Emil Regelman. Exposure Assessment Branch.
Addendum to an Application for Full Registration.
Document (PDF) (1,620 KB PDF).

June 11, 1987. Review. 8 Pages.
Whang Phang. Toxicology Branch.
Evaluation of the Comments of DuPont on the Peer Review of
EPX-Y6202 (Assure).
MRID Nos. 401480-03, 401480-01.
Document (PDF) (541 KB PDF).

December 18, 1987. Review. 20 Pages.
Emil Regelman. Exposure Assessment Branch.
Review of a Confined Accumulation on Rotational Crops
Study and an EAB Response Concerning the Anaerobic
Aquatic Soil Metabolism Requirement.
Pages 9-20 are not included - registrant data.
Document (PDF) (441 KB PDF).

December 18, 1987. Memorandum. 38 Pages.
Gary Otakie. Residue Chemistry Branch.
PP#5F3252/FAP#6H5479 Quizalofop Ethyl (Assure) on
Soybeans (RCB Nos. 2806, 2807, 2810, and 2811)
Amendment Dated August 31, 1987 - MRID Nos. 403224-01
through 403224-13, 403362-01 and 403371-01.
Document (PDF) (2,685 KB PDF).

December 21, 1987. Memorandum. 16 Pages.
Whang Phang. Toxicology Branch.
Assure (NC-302): Response to Registrant's Comments and
Summaries of Evaluations for the Additional Toxicology Data.
Tox Review 006529.
Document (PDF) (987 KB PDF).

December 22, 1987. Memorandum. 4 Pages.
Whang Phang. Toxicology Branch.
Assure: Reevaluation of the uterine affects seen in
6-months feeding study in dogs.
Tox Review 006538 - Acc. 250553, replacement for 250074.
Document (PDF) (216 KB PDF).

January 5, 1988. Review. 15 Pages.
Emil Regelman. Exposure Assessment Branch.
Review of a Proposed Label for Assure for Use on Soybeans.
Pages 5-15 are not included - draft label.
Document (PDF) (152 KB PDF).

January 5, 1988. Review. 53 Pages.
Emil Regelman. Exposure Assessment Branch.
Review of a Photodegradation on Soil Study and a
Terrestrial Field Dissipation Study.
Pages 8-29 and 35-53 removed, registrant data.
MRID 403360-01, 403360-02.
Document (PDF) (619 KB PDF).

February 9, 1988. Memorandum. 28 Pages.
Whang Phang. Toxicology Branch.
Assure: Review of Dose-Range Finding Teratology
Study and Final Teratology Study with Rabbits
MRID No. 403705-01, -02
Pages 26-28 removed-registrant data.
Tox review 006598.
Document (PDF) (889 KB PDF).

March 17, 1988. Memorandum. 4 Pages.
John Quest. Toxicology Branch.
Reevaluation of Classification of Carcinogenicity of Assure
Following Science Advisory Panel (SAP) Review of Data.
Tox Review 007706.
Document (PDF) (227 KB PDF).

April 4, 1988. Review. 8 Pages.
Emil Regelman. Exposure Assessment Branch.
Expedited Review of Du Pont's Response to EAB's
Reviews Dated 12/18/87 and 1/5/88.
Document (PDF) (332 KB PDF).

May 18, 1988. Memorandum. 5 Pages.
Robert Tomerlin. Residue Chemistry Branch.
Dietary Exposure Analysis of Assure, PP #3F3532
and FAP #6H5479.
Document (PDF) (231 KB PDF).

May 23, 1988. Memorandum. 1 Page.
Emil Regelman. Exposure Assessment Branch.
Data Requirements for Conditional Registration of
Quizalofop-methyl (Assure Herbicide).
Document (PDF) (69 KB PDF).

June 27, 1988. Memorandum. 5 Pages.
Gary Otakie. Residue Chemistry Branch.
PP #3F3252/FAP #6H5479 (No RCB Number... (Quizalofop Ethyl
on Soybeans, Liver, and Milk - Results from EPA Method
Validation Dated May 25, 1988.
MRID 403224-10, 403224-03, 403224-08.
Document (PDF) (243 KB PDF).

July 15, 1988. Memorandum. 4 Pages.
Charles Frick. Residue Chemistry Branch.
Summary of Tolerance Assessment System RFD/TMRC
Comparison Conducted to Date.
Document (PDF) (95 KB PDF).

October 1, 1988. Review. 1 Page.
Thomas Edwards. Hazard Evaluation Division.
Revised 6-Month Dog Feeding Study.
Acc. No. 255762
Tox Review 4714.
Document (PDF) (51 KB PDF).

March 20, 1989. Review. 5 Pages.
Emil Regelman. Environmental Fate & Ground Water Branch.
Review of Protocol for Confined Accumulation Study.
Document (PDF) (266 KB PDF).

July 26, 1989. Memorandum. 5 Pages.
Francis Suhre. Dietary Exposure Branch.
Tolerances for Milk, Milk Fat, and Cheese.
Document (PDF) (293 KB PDF).

September 28, 1989. Memorandum. 8 Pages.
Michael Flood. Dietary Exposure Branch.
Part II Screen of 60 Chemicals for IR-4 to Determine
Status of Residue Chemistry Problems. DEB No. 5666.
HED No. 9-1950. RD Record No. 249,555.
Document (PDF) (496 KB PDF).

March 29, 1990. Memorandum. 10 Pages.
William J. Hazel. Dietary Exposure Branch.
Quizalofop P-ethyl [D(+) isomer]/Assure ii: DuPont
registration proposal. MRID 41224001 and 41206101 thru -03.
Ingredient source info. pages 1, 2, and 3 deleted. Product
impurity info pages 2, 3 deleted. Quality control procedure
info page 4 deleted. Pages 9-10 removed confidential append.
Document (PDF) (808 KB PDF).

May 18, 1990. Memorandum. 8 Pages.
Steven Koepke. Dietary Exposure Branch.
PP# 0F3834 Quizalofop Ethyl (Assure, DPX-Y6202) in or
on Lentils, Dry Beans and Dry Peas. Evaluation of
Analytical Methods and Residue Data.
MRID No. 413208-00, -01.
Document (PDF) (532 KB PDF).

November 13, 1990. Memorandum. 106 Pages.
Whang Phang. Toxicology Branch.
Assure: I. Review of eight acute toxicity, two subchronic
toxicity, and 3 mutagenicity studies on D+ isomer of Assure
II. Comparison of the toxicology profiles of racemate
mixture and D+ isomer of Assure. MRID 412061-04. ToxR 008154
Pages 19-26, 36-45, 57-60, 69-73, 104-106 removed, RD.
Document (PDF) (4,170 KB PDF).

May 8, 1991. Review. 11 Pages.
Emil Regelman. Environmental Fate & Groundwater Branch.
Reg. No 352-526, 352-441
To review request for addition of cotton to label.
Document (PDF) (544 KB PDF).

September 13, 1991. Memorandum. 14 Pages.
Dan Hanke. Toxicology Branch II.
Assure II Herbicide (DPX-Y6202-52 D+) Data review.
Pages 7-14 removed, registrant data.
MRID 418646-01.
Tox review 008589.
Document (PDF) (365 KB PDF).

September 10, 1992. Memorandum. 3 Pages.
Alfred Smith. Registration Support Branch.
Results of the Method Trials for the Active Ingredient
Quizalofop P-Ethyl (Assure II; D-NC-302)
Pages 2-3 removed-quality control procedure information.
Document (PDF) (74 KB PDF).

October 9, 1992. Data Eval. Rec. 18 Pages.
Nancy McCarroll. Clement International Corporation.
Study Type: Mutagenicity: Unscheduled DNA Synthesis
Assay in Primary Rat Hepatocytes
MRID 419366-02
Pages 8-18 removed-registrant data.
Document (PDF) (342 KB PDF).

October 9, 1992. Data Eval. Rec. 22 Pages.
Nancy McCarroll. Clement International Corporation.
Study Type: Mutagenicity: Gene Mutation in Cultured
Mammalian Cells (Mouse Lymphoma Cells)
MRID 419366-01
Pages 10-22 removed-registrant data.
Document (PDF) (405 KB PDF).

July 15, 1993. Memorandum. 10 Pages.
Jerry Stokes. Chemistry Branch-Tolerance Support.
Quizalofop-p ethyl ester. Comparison of the Metabolism
of DPX-79376, the R Enantiomer, Optically active
Ingredient, and DPX-Y6202, the Racemic Mixture, in
Soybeans. (MRID 24632-01, CB#10606, Barcode #D182751).
MRID 42463201.
Document (PDF) (645 KB PDF).

September 7, 1993. Memorandum. 3 Pages.
R.W. Cook. Chemistry Branch.
PP03834. Quizalofop ethyl... on lentils,
dried peas, dried beans.
EPA Reg. No. 352-441. duPont 'Assure' Herbicide
EPA Reg. No. 352-541. duPont 'Assure II' Herbicide.
Document (PDF) (172 KB PDF).

April 6, 1994. Review. 1 Page.
Alfred Smith. Registration Support Branch.
Revised Analytical Method for Quizalofop ethyl.
Document (PDF) (76 KB PDF).

April 21, 1994. Review. 7 Pages.
Anthony Maciorowski. Ecological Effects Branch.
000352-00541
Review of terrestrial phytotoxicity study -
Tier I seed germination and Tier 1 & 2 seedling emergence
and vegetative vigor
MRID 431253-01.
Document (PDF) (560 KB PDF).

March 30, 1995. Memorandum. 24 Pages.
Francis Griffith. Chemistry Branch.
PP# 3F4268 - Quizalofop-P Ethyl Ester (Assure II) on the
Legume Vegetables (Succulent or Dried) and foliage of ...
Review of Magnatude of the Residue Data and Residue Analyt-
ical Method and the February 22, 1995 Amendment.
MRID #s 428275-01 thru -09, 433140-01, and 424391-01.
Document (PDF) (2,172 KB PDF).

May 25, 1995. Memorandum. 4 Pages.
Francis Griffith. Chemistry Branch.
PP# 3F4268 - Quizalofop-P Ethyl ester (Assure II) in Legume
vegetables...
Tolerance Method Validation Request.
MRID #s 433140-01 and 429275-09.
Document (PDF) (241 KB PDF).

October 5, 1995. Memorandum. 4 Pages.
Francis Griffith. Chemistry Branch.
PP# 3F4268 - Quizalofop-P Ethyl Ester (assure II) on Legume
vegetable...
Response to SAB on Adequacy of Existing Tolerances for a
DRES Analysis.
Document (PDF) (276 KB PDF).

October 11, 1995. Memorandum. 4 Pages.
Francis Griffith. Chemistry Branch.
PP# 3F4268 - Quizalofop-P Ethyl Ester (assure II) on Legume
vegetables...
Evaluation of the Analytical Chemistry Laboratory Prereview
of the Tolerance Method Validations for for Quizalofop-p ...
MRID #s 433140-01 and 429275-09.
Document (PDF) (220 KB PDF).

January 26, 1996. Memorandum. 11 Pages.
Francis Griffith. Chemistry Branch.
PP# 5E4590 - Quizalofop-p Ethyl Ester (Assure II) on
Pineapples.
Review of Magnitude of the Residue Data and Residue Analyt-
ical Method.
MRID #s 437825-01.
Document (PDF) (864 KB PDF).

February 13, 1996. Memorandum. 7 Pages.
Francis Griffith. Chemistry Branch.
PP# 3F4268/5H5720 - Quizalofop-p Ethyl Ester (Assure II) on
the Legume Vegetables...
Review of the July 27, Sept. 22 and 26, 1995, Amendments.
MRID # 438041-01.
Document (PDF) (555 KB PDF).

February 21, 1996. Memorandum. 16 Pages.
Francis Griffith. Chemistry Branch.
PP# 3F4545/FAP# 6H5737 Quizalofop-p Ethyl Ester (Assure II)
on the Foliage of Legume Vegetables (Except Soybeans) Crop
Group, Canola, and Canola Processed Commodities.
Review of Magnitude of the residue Data and Residue Analyt-
ical Method. MRID #s 436957-01 and 436957-02.
Document (PDF) (1,341 KB PDF).

May 14, 1996. Memorandum. 6 Pages.
Steven Knizner. Residue Chemistry Analysis Branch.
Attachment 3. Memorandum of S. Knizner, 5/14/96, PP#6E4652
Quizalofop-ethyl - PP#6E4652. IR-4 Petition for
Tolerance in/on Mint
MRID 43917301, Reg. No 352-541.
Document (PDF) (377 KB PDF).

June 14, 1996. Memorandum. 4 Pages.
Francis Griffith. Chemistry Branch.
PP# 3F4268/5H5720 - Quizalofop-P Ethyl Ester (Assure II) on
the legume vegetables...
Review of May 23, 1996, Amendment.
Document (PDF) (269 KB PDF).

June 14, 1996. Memorandum. 4 Pages.
Francis Griffith. Chemistry Branch.
PP# 5F4545/FAP# 6H5737 - Quizalofop Ethyl Ester (Assure)
on the foliage of legume vegetables (except soybeans) crop
group, canola and canola processed commodities.
Review of May 23, 1996, Amendment.
Document (PDF) (225 KB PDF).

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