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Index of Cleared Science Reviews for Isoxaflutole (Pc Code 123000)
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Undated. Memorandum. 4 Page(s).
James Breithaupt. Environmental Risk Branch II.
Drinking Water Assessment for Isoxaflutole.
Document (PDF) (365 KB PDF).
Undated. Memorandum. 5 Page(s).
David Wells. Environmental Risk Branch II.
Study Site Selection for Isoxaflutole Ground Water Studies.
Document (PDF) (241 KB PDF).
Undated. Memorandum. 7 Page(s).
Robert Zendzian. Health Effects Branch.
Isoxaflutole, dermal absorption in the rat. MRID 440447-02. Tox review 012255.
Document (PDF) (343 KB PDF).
January 11, 1995. Memorandum. 8 Page(s).
Renee Costello. Environmental Risk Characterization Br.
Data review for Isoxaflutole (D219142, Chemical #123000...) Acute toxicity
to the Freshwater Blue-green Algae MRID 435732-45.
Document (PDF) (383 KB PDF).
May 30, 1995. DER. 10 Page(s).
Michael Davy. Environmental Risk Branch 2.
14 Day Acute Oral LD50 Study in Bobwhite Quail. MRID No. 43573231.
Registration Data information removed from pages 6-10.
Document (PDF) (293 KB PDF).
May 30, 1995. DER. 10 Page(s).
Michael Davy. Environmental Risk Branch 2.
8 Day Acute Dietary LC50 Study in Bobwhite Quail. MRID No. 435732-33.
Registration Data information removed from pages 6-10.
Document (PDF) (311 KB PDF).
May 30, 1995. DER. 11 Page(s).
Michael Davy. Environmental Risk Branch 2.
14 Day Acute Oral LD50 Study in Mallard Ducks. MRID No. 43573232.
Registration Data information removed from pages 6-11.
Document (PDF) (293 KB PDF).
May 30, 1995. DER. 8 Page(s).
Michael Davy. Environmental Risk Branch 2.
8 Day Acute Dietary LC50 Study in Mallard Ducklings. MRID No. 435732-34.
Registration Data information removed from pages 5-8.
Document (PDF) (314 KB PDF).
June 12, 1995. DER. 11 Page(s).
Michael Davy. Environmental Risk Branch 2.
RPA 201772 - Acute Toxicity to Bluegill Sunfish (Lepomis macrochirus) Under
Flow-Through Conditions. MRID No. 435732-35. Registration Data information
removed from pages 7-11.
Document (PDF) (435 KB PDF).
June 12, 1995. DER. 11 Page(s).
Michael Davy. Environmental Risk Branch 2.
RPA 201772 - Acute Toxicity to Daphnids (Daphnia magna) Under Flow-Through
Conditions. MRID No. 435732-37. Registration Data information removed from pages 7-11.
Document (PDF) (446 KB PDF).
June 12, 1995. DER. 11 Page(s).
Michael Davy. Environmental Risk Branch 2.
RPA 201772 - Acute Toxicity to Rainbow Trout (Onchorhynchus mykiss) Under
Flow-Through Conditions. MRID No. 435732-36. Registration Data information
removed from pages 7-11.
Document (PDF) (457 KB PDF).
June 13, 1995. Memorandum. 10 Page(s).
S. E. Oonnithan. Registration Support Branch.
EPA File Symbol: 000264-EUP-00; 123000 (Isoxaflutole, RPA 201772);
EXP31130A, 75% Water Dispersible Granule MRID Nos. 435732-25, 26, 27, 28, 29, & 30.
Document (PDF) (517 KB PDF).
June 14, 1995. DER. 27 Page(s).
J. Breithaupt. Environmental Fate & Ground Water Branch.
Data Evaluation Record 3 Degradation - Photodegradation on Soil.
Pages 5-27 removed, registrant data. MRID 43588005.
Document (PDF) (283 KB PDF).
June 14, 1995. DER. 27 Page(s).
J. Breithaupt. Environmental Fate & Ground Water Branch.
Data Evaluation Record 5 Metabolism - Anaerobic Aquatic.
Pages 5-27 removed, registrant data. MRID 43588007.
Document (PDF) (317 KB PDF).
June 14, 1995. DER. 28 Page(s).
J. Breithaupt. Environmental Fate & Ground Water Branch.
Data Evaluation Record 1 Degradation - Hydrolysis.
Pages 4-28 removed, registrant data. MRID 43573254.
Document (PDF) (183 KB PDF).
June 14, 1995. DER. 33 Page(s).
J. Breithaupt. Environmental Fate & Ground Water Branch.
Data Evaluation Record 6 Unaged Mobility - Leaching and Adsorption/Desorption.
Pages 8-33 removed, registrant data. MRID 43588009.
Document (PDF) (415 KB PDF).
June 14, 1995. DER. 35 Page(s).
J. Breithaupt. Environmental Fate & Ground Water Branch.
Data Evaluation Record 4 Metabolism - Aerobic Soil.
Pages 7-35 removed, registrant data. MRID 43588006.
Document (PDF) (321 KB PDF).
June 14, 1995. DER. 35 Page(s).
J. Breithaupt. Environmental Fate & Ground Water Branch.
Data Evaluation Record 7 Aged Mobility - Leaching and Adsorption/Desorption.
Pages 7-35 removed, registrant data. MRID 43588008.
Document (PDF) (350 KB PDF).
June 14, 1995. DER. 39 Page(s).
J. Breithaupt. Environmental Fate & Ground Water Branch.
Data Evaluation Record 2 Degradation - Photodegradation in Water.
Pages 4-39 removed, registrant data. MRID 43588004.
Document (PDF) (222 KB PDF).
June 29, 1995. Memorandum. 19 Page(s).
James Breithaupt. Environmental Risk Branch II.
Experimental Use Permit for Isoxaflutole on Corn.
Document (PDF) (994 KB PDF).
September 15, 1995. Memorandum. 116 Page(s).
Sanjivani Diwan. Toxicology Branch II.
RPA 201772 (Isoxaflutole Herbicide): Request for Experimental Use
Permit to ship RPA 201772 WDG Herbicide to the Growers for Use on Field Corn.
Registration Data information removed from pages 32-55. Tox Review No. 0011675.
Document (PDF) (3651 KB PDF).
October 23, 1995. Letter. 2 Page(s).
Philip Errico. Chemistry Branch I.
[Forwarding Multiresidue Method 9MRM) test information for updating PAM-I].
Document (PDF) (63 KB PDF).
October 23, 1995. Memorandum. 9 Page(s).
Elizabeth Leovey. Environmental Risk Characterization Branch.
Data review for Isoxaflutole (D219146...) Acute toxicity to mysid shrimp
MRID 435732-40.
Document (PDF) (373 KB PDF).
October 24, 1995. Memorandum. 7 Page(s).
Elizabeth Leovey. Environmental Risk Characterization Branch.
Data review for RPA 203328 - degradate of Isoxaflutole Acute toxicity to Daphnids
MRID 435732-41.
Document (PDF) (447 KB PDF).
November 06, 1995. DER. 14 Page(s).
Sanjivani Diwan. Toxicology Branch.
A metabolism study in rats, using 14C-RPA 201772. MRID 435732-24. Tox review 012255.
Document (PDF) (857 KB PDF).
December 07, 1995. Memorandum. 44 Page(s).
Philip Errico. Chemistry Branch I.
264-EUP-00/PP#5G4484. Proposed temporary Tolerance For Isoxaflutole
in/on Field Corn Grain. Evaluation of Analytical Method and Residue Data.
MRID 43573201 thru 08, -49, -50, -53, 43588003, 43573251.
Document (PDF) (2072 KB PDF).
February 14, 1996. Memorandum. 4 Page(s).
G. F. Kramer. Chemistry Branch I.
PP#5G04484 & PP#6F04664. Proposed Temporary Tolerance Request for
Isoxaflutole in/on Field Corn Grain. Request for Petition Method Validation.
MRID# 435732-51.
Document (PDF) (253 KB PDF).
February 14, 1996. Memorandum. 7 Page(s).
Renee Costello. Environmental Risk Characterization Br.
Data review for Isoxaflutole (D219144. ..) Toxicity to Freshwater Green Alga
MRID 435732-43.
Document (PDF) (333 KB PDF).
February 14, 1996. Memorandum. 9 Page(s).
Renee Costello. Environmental Risk Characterization Br.
Data review for Isoxaflutole (D219141...) Toxicity to Duckweed MRID 435732-46.
Document (PDF) (422 KB PDF).
February 20, 1996. Memorandum. 9 Page(s).
Renee Costello. Environmental Risk Characterization Br.
Data Review for Isoxaflutole (D219140...) Acute toxicity to the marine diatom
MRID 435732-47.
Document (PDF) (394 KB PDF).
February 22, 1996. DER. 5 Page(s).
Renee Costello. Environmental Fate & Effects Branch.
Acute Contact Toxicity Test with the Honey Bee. MRID No. 435732-48.
Document (PDF) (268 KB PDF).
February 22, 1996. Memorandum. 12 Page(s).
Renee Costello. Environmental Risk Characterization Br.
Data Review for RPA 201772 - Isoxaflutole (D219143. ..) Acute toxicity to the
freshwater diatom Navicula pelliculosa MRID 435732-44.
Document (PDF) (612 KB PDF).
March 12, 1996. Memorandum. 2 Page(s).
Renee Costello. Environmental Fate & Effects Branch.
EFED Screen for Isoxaflutole.
Document (PDF) (118 KB PDF).
June 14, 1996. Memorandum. 5 Page(s).
G. F. Kramer. Chemistry Branch I.
PP# 6F04664. Isoxaflutole in/on Field Corn and Animal RACs. Request for Petition
Method Validation. MRID#s 439048-32 and -33.
Document (PDF) (268 KB PDF).
July 09, 1996. Memorandum. 6 Page(s).
Renee Costello. Environmental Risk Characterization Br.
Isoxaflutole data review (D219139. ..) Acute toxicity to Sheepshead Minnow MRID 435732-38.
Document (PDF) (430 KB PDF).
July 09, 1996. Memorandum. 7 Page(s).
Renee Costello. Environmental Risk Characterization Br.
Isoxaflutole data review (D216391. ..) Acute toxicity to Eastern Oyster MRID 435732-39.
Document (PDF) (438 KB PDF).
July 23, 1996. Memorandum. 26 Page(s).
Everett Greer. Analytical Chemistry Branch.
PP#5G04484 & PP#6F4664. Report on Method Validation of Isoxaflutole in/on Corn
Fodder, Forage and Grain.
Document (PDF) (976 KB PDF).
July 31, 1996. DER. 4 Page(s).
Virginia Dobozy. Toxicology Branch.
An acute oral toxicity study of rats receiving RPA 202248 in 0.5% methylcellulose.
MRID 43904810 Tox review 012255.
Document (PDF) (226 KB PDF).
July 31, 1996. DER. 4 Page(s).
Virginia Dobozy. Toxicology Branch.
An acute oral toxicity study of rats receiving RPA 203328 in 0.5% methylcellulose.
MRID 43904812 Tox review 012255.
Document (PDF) (216 KB PDF).
August 14, 1996. Memorandum. 45 Page(s).
G. F. Kramer. Chemistry Branch I.
PP# 6F04664. Isoxaflutole in/on Field Corn and Animal RACs. Evaluation of
Residue Data and Analytical Methods. MRID#s 439048-01, -02, -27 thru -37 and -39.
Document (PDF) (2208 KB PDF).
August 20, 1996. Memorandum. 13 Page(s).
G. F. Kramer. Chemistry Branch I.
PP# 6F04664. Isoxaflutole in/on Field Corn. Results of Petition Method Validation (PMV).
MRID# 435732-51.
Document (PDF) (582 KB PDF).
August 22, 1996. DER. 7 Page(s).
Sanjivani Diwan. Toxicology Branch.
Salmonella typhimurium reverse mutation assay (Ames Test); MRID 43904814 Tox review 012255.
Document (PDF) (344 KB PDF).
August 27, 1996. DER. 7 Page(s).
Sanjivani Diwan. Toxicology Branch.
Salmonella typhimurium reverse mutation assay (Ames Test); MRID 43904811 Tox review 012255.
Document (PDF) (381 KB PDF).
September 05, 1996. DER. 27 Page(s).
Stephen Dapson. Toxicology Branch.
Study of Embryo-Foetal Toxicity in the Rabbit by oral (gavage) administration.
Pages 16-27 removed, registration data. MRID 43904808 Tox review 012255.
Document (PDF) (702 KB PDF).
September 11, 1996. Memorandum. 59 Page(s).
Renee Costello. Environmental Risk Characterization Br.
Data review for Isoxaflutole (D229696) GDLN Nos: 123-2, 72-4, 72-1, 72-2, 72-3, 72-1.
MRIDs 439048-21 thru -26.
Document (PDF) (2977 KB PDF).
September 17, 1996. Memorandum. 3 Page(s).
Dallas Wright. Analytical Chemistry Branch.
Pre-Review of Request for Petition Method Validation of Isoxaflutole in/on Field Corn
and Animal RACs (PP#6F04664).
Document (PDF) (146 KB PDF).
October 04, 1996. Memorandum. 2 Page(s).
G. F. Kramer. Chemistry Branch I.
PP# 6F04664. Isoxaflutole in/on Field Corn and Animal RACs. Results of Petition
Method Validation (PMV) Pre-Review MRID#s 439048-32 and -33. Chemical 123000.
Document (PDF) (101 KB PDF).
November 12, 1996. DER. 11 Page(s).
Timothy McMahon. Toxicology Branch.
Comparative One-Week Tyrosine Tolerance Study in the Rat. MRID 43904817
Tox review 012255.
Document (PDF) (543 KB PDF).
November 12, 1996. DER. 15 Page(s).
Sanjivani Diwan. Toxicology Branch II.
Mechanistic Study for Thyroid Effects-Rats Nonguideline. Tox Review No. 012255.
MRID No. 43904818.
Document (PDF) (793 KB PDF).
November 13, 1996. DER. 12 Page(s).
Sanjivani Diwan. Toxicology Branch.
Qualitative comparison of metabolism of tyrosine following a single oral administration
of RPA 201772 in the rat and in the mouse. MRID 43904815 Tox review 012255.
Document (PDF) (698 KB PDF).
December 05, 1996. DER. 4 Page(s).
Jess Rowland. Toxicology Branch.
An acute oral toxicity study of rats receiving RPA 202248 in aqueous
methylcellulose. MRID 44044701. Tox review 012255.
Document (PDF) (215 KB PDF).
December 20, 1996. DER. 36 Page(s).
Mary Menetrez. Health Effects Division.
83-2; Oncogenicity study by dietary administration to CD-1 mice for 78 weeks.
Pages 29-36 removed, registration data. MRID 43904807 Tox review 012255.
Document (PDF) (1557 KB PDF).
December 20, 1996. DER. 58 Page(s).
Mary Menetrez. Health Effects Division.
83-5; Combined Chronic/ Oncogenicity Study - Rats.
Pages 42-58 removed, registration data. MRID 43904806 Tox review 012255.
Document (PDF) (2259 KB PDF).
January 16, 1997. Memorandum. 4 Page(s).
G. F. Kramer. Chemistry Branch I.
PP# 6F04664. Isoxaflutole in/on Field Corn and Animal RACs. Results of Petition
Method Validation. MRID#s 441690-04& -05.
Document (PDF) (198 KB PDF).
January 27, 1997. Memorandum. 6 Page(s).
Robert Hitch. Environmental Risk Characterization Br.
Isoxaflutole Herbicide Degradate. Bobwhite Quail LC50 study. DP Barcode D224163.
Sponsor: Rhone-Poulenc Ag Company. PRAT Case No. 286745.
(The PC Code for Isoxaflutole parent is 123000) MRID 439403-02.
Document (PDF) (363 KB PDF).
February 13, 1997. Memorandum. 1 Page(s).
James Breithaupt. Environmental Risk Branch II.
Request for Review of Analytical Method for Isoxaflutole.
Document (PDF) (42 KB PDF).
February 21, 1997. DER. 24 Page(s).
Mary Menetrez. Health Effects Division.
83-lb; Chronic Toxicity to Dogs by Repeated dietary administration for 52 weeks.
MRID 43573218 Tox review 012255.
Document (PDF) (1641 KB PDF).
February 26, 1997. DER. 10 Page(s).
Robert Fricke. Toxicology Branch.
A subchronic (3-month) neurotoxicity study of RPA 201772 in the rat via dietary
administration. MRID 43904805 Tox review 012255.
Document (PDF) (598 KB PDF).
April 01, 1997. DER. 8 Page(s).
Timothy McMahon. Toxicology Branch.
Effects of dietary administration for 14 days on the Liver Enzymes of Male Sprague
Dawley CD-1 Rats. MRID 43904819.
Document (PDF) (395 KB PDF).
April 01, 1997. Memorandum. 23 Page(s).
Elizabeth Leovey. Environmental Risk Characterization Branch.
Isoxaflutole: Review of Eco-Toxicity Studies for New Chemical Registration.
Subacute LC50 Bobwhite; Seedling Emergence, Vegetative Vigor MRIDs 43940302, 43573242.
Document (PDF) (1142 KB PDF).
April 07, 1997. DER. 9 Page(s).
Timothy McMahon. Toxicology Branch.
The effect of dietary administration for 14 days on the Liver Enzymes of Male CD-1 Mice.
MRID 43904820 Tox review 012255.
Document (PDF) (452 KB PDF).
April 11, 1997. Memorandum. 3 Page(s).
Elizabeth Leovey. Environmental Fate & Effects Branch.
Isoxaflutole: Review of Eco-Toxicity Studies for New Chemical Registration.
DP Barcodes D225503, D232445. MRID No.: 43940302.
Document (PDF) (124 KB PDF).
April 16, 1997. Memorandum. 2 Page(s).
Richard Loranger. Chemistry Branch Tolerance Support.
PP#5G4484. Isoxaflutole on field corn. Minutes for 11/1/95 conference.
DP Barcode D221711... No MRID #.
Document (PDF) (102 KB PDF).
April 17, 1997. DER. 14 Page(s).
R. S. Jones. Environmental Risk Characterization Br.
Data Evaluation Record 2 Terrestrial soil dissipation; validation of method of analysis;
method confirmation; supplemental data MRIDs 43904838, 43904840, 43904841, 44092101.
Document (PDF) (1059 KB PDF).
April 22, 1997. DER. 6 Page(s).
James Breithaupt. Environmental Risk Characterization Br.
Data Evaluation Record 1 Adsorption/desorption to and from four soils; Adsorption
desorption to and from four soils and an aquatic sediment. MRIDs 43940301, 44065801.
Document (PDF) (465 KB PDF).
May 02, 1997. Memorandum. 64 Page(s).
James Breithaupt. Environmental Risk Branch II.
Transmittal of EFED's registration chapter for Isoxaflutole (Chemical No. 123000;
Case 286745; DP Barcode D225503, D223678, D231444, D232445) & EFED's recommendations
for Isoxaflutole for its use on corn.
Document (PDF) (3670 KB PDF).
May 05, 1997. DER. 10 Page(s).
Sanjivani Diwan. Toxicology Branch II.
Special Study/Rats & Mice Nonguideline. MRID No. 43904816. Tox Review No. 012255.
Document (PDF) (510 KB PDF).
May 05, 1997. Memorandum. 14 Page(s).
Lori Brunsman. Toxicology Branch II.
Isoxaflutole Qualitative Risk Assessment Bases on CD-1 Mouse & CD(SD) BR
VAF Plus Rat Dietary Studies. Tox Review No. 012714.
Document (PDF) (852 KB PDF).
May 27, 1997. DER. 10 Page(s).
Robert Fricke. Toxicology Branch.
An acute neurotoxicity study of RPA 201772 in the rat via oral gavage administration.
MRID 43904804 Tox review 012255.
Document (PDF) (578 KB PDF).
May 28, 1997. DER. 26 Page(s).
Alan Levy. Toxicology Branch.
Two generation reproduction study with RPA 201772 in Rats. MRID 43904809 Tox review 012255.
Document (PDF) (1484 KB PDF).
June 03, 1997. DER. 11 Page(s).
Virginia Dobozy. Toxicology Branch.
28-Day toxicity study in the Rat by dietary administration. MRID 43904813 Tox review 012255.
Document (PDF) (641 KB PDF).
June 11, 1997. Memorandum. 22 Page(s).
Sanjivani Diwan. Toxicology Branch.
RPA 201772 (Isoxaflutole) Herbicide: Review of Toxicity Studies Submitted to
Support Registration and Permanent Tolerance Petition. Tox review 012255.
Document (PDF) (1519 KB PDF).
July 14, 1997. Memorandum. 26 Page(s).
George Kramer. Residue Analysis Branch I.
PP# 6F04664. Isoxaflutole in/on Field Corn and Animal RACs. Amendment of 12/2/96.
Revised Sections B & F, New Stability Data. MRID#s 441690-01 thru -07...
Document (PDF) (1970 KB PDF).
July 16, 1997. Memorandum. 9 Page(s).
George Ghali. Peer Review Committee.
RfD/Peer Review Report of Isoxaflutole [4- (2-methylsulphonyl-4-trifluotophmethyl-
benzoyl)-5- cyclopropyl isoxazole]. Tox Review No. 012278.
Document (PDF) (586 KB PDF).
August 06, 1997. Memorandum. 30 Page(s).
Sanjivani Diwan. Toxicology Branch.
Carcinogenicity Peer Review of Isoxsaflutole. Tox review 012300.
Document (PDF) (1700 KB PDF).
August 20, 1997. Memorandum. 4 Page(s).
George Kramer. Registration Action Branch I.
PP# 6F04664. Isoxaflutole in/on Field Corn and Animal RACs. Request for
Anticipated Residues. Barcode D237699. Chemical 123000. Case 287353.
Document (PDF) (211 KB PDF).
September 18, 1997. Memorandum. 6 Page(s).
George Kramer. Residue Analysis Branch I.
PP# 6F04664. Isoxaflutole in/on Field Corn and Animal RACs. Request for
REVISED Anticipated Residues. Barcode D238727. Chemical 123000. Case 287353.
Document (PDF) (323 KB PDF).
September 25, 1997. Memorandum. 3 Page(s).
George Kramer. Registration Action Branch.
HED Metabolism Assessment Review Committee Meeting of 9/4/97. Isoxaflutole.
PP#6F04664. Tox Review No. 012665.
Document (PDF) (137 KB PDF).
September 30, 1997. Memorandum. 2 Page(s).
Barbara Madden. Health Effects Division.
Meeting to Discuss Issues Regarding Cancer Peer Review Document for New
Chemical Isoxaflutole (123000). DP Barcode: None.
Document (PDF) (118 KB PDF).
November 04, 1997. Memorandum. 6 Page(s).
Mark Law. Analytical Chemistry Laboratory Branch.
PP# 6F04664. Tolerance Method Validation of Isoxaflutole in/on Field
Corn and Animal RACs.
Document (PDF) (309 KB PDF).
November 26, 1997. Memorandum. 7 Page(s).
George Kramer. Residue Analysis Branch I.
PP# 6F04664. Isoxaflutole in/on Field Corn and Animal RACs. Amendments of 8/12/97
& 9/25/97. Revised Sections B & F. MRID# None. Barcode D238240.
Chemical 123000. Case 287353.
Document (PDF) (343 KB PDF).
December 09, 1997. Memorandum. 4 Page(s).
James Breithaupt. Environmental Risk Branch II.
Corrections to Isoxaflutole Drinking Water Assessment Memo Dated 11/10/97.
Document (PDF) (240 KB PDF).
December 10, 1997. Memorandum. 3 Page(s).
Jess Rowland. Science Analysis Branch.
Isoxaflutole - Report of the Risk Assessment Review Committee. Tox Review No. 012434.
Document (PDF) (160 KB PDF).
December 22, 1997. Memorandum. 15 Page(s).
Jess Rowland. Science Analysis Branch.
Isoxaflutole - Reassessment of the FQPA Requirement - Report of the Hazard
Identification Assessment Review Committee. Tox Review No. 012567.
Document (PDF) (891 KB PDF).
January 27, 1998. Memorandum. 43 Page(s).
Michael Davy. Environmental Risk Branch II EFED.
Isoxaflutole: Review Phytotoxicity Studies for New Chemical Registration,
DP Barcode D240106 MRID 443999-05 thru -10.
Document (PDF) (1983 KB PDF).
February 05, 1998. Memorandum. 15 Page(s).
James Breithaupt. Environmental Fate & Ground Water Branch.
Review of Environmental Fate Studies Submitted in Response to Section 3 Review
of Isoxaflutole. Metabolism - Aerobic Aquatic, MRID 44291502 Mobility - Leaching
and Adsorption/Desorption, MRID 44291503.
Document (PDF) (1046 KB PDF).
February 05, 1998. Memorandum. 50 Pages.
Barbara Madden. Risk Characterization & Analysis Branch.
Isoxaflutole -123000: Health Effects Division Risk Characterization Document for the
First Food Use of Isoxaflutole in/on Corn (6F4664). DP Barcode Nos.: D223677, D227942,
D234214, D237697, D239590, D241042, D241043 & D241047.(MRIDs 435732-20,-21,-22,-23).
Document (PDF) (521 KB PDF).
February 25, 1998. Memorandum. 5 Page(s).
Michael Davy. Environmental Risk Branch II EFED.
Isoxaflutole: Review Phytotoxicity Studies for New Chemical Registration,
DP Barcode D240106. MRID 44399905 thru -10.
Document (PDF) (241 KB PDF).
March 12, 1998. Memorandum. 3 Page(s).
James Breithaupt. Environmental Fate & Ground Water Branch.
Calculation of Half-lives of RPA 202248 in Aerobic Soil Metabolism Study
(MRID 43588006) for Isoxaflutole and EEC's for Surface and Ground Water.
Document (PDF) (183 KB PDF).
March 18, 1998. Memorandum. 5 Page(s).
George Kramer. Residue Analysis Branch I.
PP# 6F04664. Isoxaflutole in/on Field Corn and Animal RACs. Request for
Anticipated Residues for Tier 3 Risk Assessment. DP Barcode D244004.
Document (PDF) (313 KB PDF).
March 23, 1998. Memorandum. 3 Page(s).
Alberto Protzel. Toxicology Branch I.
Isoxaflutole. PC Code 123000. Outcome of the Ad hoc Metabolism Assessment
Review Committee Meeting Held on March 23, 1998 Concerning isoxaflutole
metabolite RPA 203323. DP Barcode D244555. Tox Review No. 012662.
Document (PDF) (178 KB PDF).
April 03, 1998. Memorandum. 7 Page(s).
Jess Rowland. Science Analysis Branch.
Isoxaflutole - Report of the FQPA Safety Factor Committee. Tox Review No. 012561.
Document (PDF) (425 KB PDF).
April 15, 1998. Memorandum. 1 Page(s).
Brenda Tarplee. Health Effects Division.
Special Report of the FQPA Safety Factor Committee. Tox Review 014039.
Document (PDF) (59 KB PDF).
May 13, 1998. Memorandum. 1 Page(s).
Michael Davy. Environmental Fate & Effects Division.
Isoxaflutole: Aquatic Plant Risk Assessment.
Document (PDF) (74 KB PDF).
June 17, 1998. Memorandum. 3 Page(s).
George Kramer. Residue Analysis Branch I.
PP# 6F04664. Isoxaflutole in/on Field Corn and Animal RACs. Amendment of 4/28/98.
Revised Section F. MRID# none. DP Barcode D245872.
Document (PDF) (166 KB PDF).
June 29, 1998. Memorandum. 2 Page(s).
Michael Davy. Environmental Fate & Effects Division.
Isoxaflutole: Review of Phytotoxicity Studies for New Chemical Registration.
DP Barcode D240106 (ref. MRID 44399905).
Document (PDF) (152 KB PDF).
July 09, 1998. Memorandum. 5 Page(s).
Thuy Nguyen. Environmental Risk Branch III EFED.
Validation of Analytical Method: "Method of Analysis for Isoxaflutole and its
Metabolites in Water" MRIDs 443999-01 thru-04.
Document (PDF) (316 KB PDF).
July 10, 1998. Memorandum. 28 Page(s).
Alberto Protzel. Toxicology Branch I.
Isoxaflutole. Outcome of the review of 3 mutagenicity studies on the isoxaflutole
metabolite RPA 203328. Tox Review No. 012683. MRID Nos. 44545301, -02, & -03.
Document (PDF) (1454 KB PDF).
July 21, 1998. Memorandum. 3 Page(s).
Michael Davy. Environmental Fate and Effects Branch.
Isoxaflutole: Review of Rebuttal to Terrestrial Plant Turnip Study.
DP Barcode D246666. (ref. MRID 44399905).
Document (PDF) (222 KB PDF).
July 21, 1998. Memorandum. 30 Page(s).
Michael Davy. Environmental Risk Branch II EFED.
Isoxaflutole: Review of Rebuttal to Terrestrial Plant Turnip Study.
DP Barcode D246666 MRID 44399905.
Document (PDF) (822 KB PDF).
July 27, 1998. Memorandum. 53 Page(s).
Barbara Madden. Risk Characterization & Analysis Branch.
Isoxaflutole - 123000: Revised Health Effects Division Risk Characterization
document for the First Food Use of Isoxaflutole in/on corn (6F4664).
Tox Review No. 012694.
Document (PDF) (3805 KB PDF).
August 25, 1998. Memorandum. 3 Page(s).
Michael Davy. Environmental Risk Branch 2.
Isoxaflutole Review of Rebuttal to Phytotoxicity Risk Assessment (including Maps).
DP Barcode D246665.
Document (PDF) (210 KB PDF).
September 30, 1998. Memorandum. 2 Page(s).
James Breithaupt. Environmental Risk Branch II.
Response to 6/6/97 Rhone-Poulenc Rebuttal for Isoxaflutole.
Document (PDF) (77 KB PDF).
December 02, 1998. Memorandum. 2 Page(s).
David Wells. Environmental Risk Branch II.
Isoxaflutole Ground Water Study Protocols.
Document (PDF) (100 KB PDF).
December 17, 1998. Memorandum. 2 Page(s).
George Ghali. Science Analysis Branch.
Isoflutole (PCX Code 123000): Reconsideration of the "Food Quality Protection Act"
-Factor Previously Applied by the RfD/Hazard Identification Committee.
Tox Review No. 013022.
Document (PDF) (83 KB PDF).
January 11, 1999. Memorandum. 3 Page(s).
David Wells. Environmental Risk Branch II.
Isoxaflutole Tile Drain Water Monitoring Study.
Document (PDF) (222 KB PDF).
February 24, 1999. Memorandum. 6 Page(s).
Ian Kennedy. Environmental Risk Branch 2.
Isoxaflutole Site Selection Report for Tile Drain Monitoring Studies & Prospective
Groundwater Studies on Tile Drained Fields (447379-01). DP Barcode: D252906.
Document (PDF) (410 KB PDF).
March 25, 1999. Memorandum. 3 Page(s).
Ian Kennedy. Environmental Risk Branch 2.
Revised tile drain "grab" monitoring protocol.
Document (PDF) (171 KB PDF).
March 29, 1999. Memorandum. 6 Page(s).
Michael Davy. Environmental Risk Branch 2.
Isoxaflutole Plant Field Studies, D253375, D253213.
Document (PDF) (389 KB PDF).
April 29, 1999. Memorandum. 11 Page(s).
Michael Davy. Environmental Risk Branch 2.
Isoxaflutole: EFED's Response to Plant Field Studies Rebuttal.
DP Barcodes D255262, D255259.
Document (PDF) (699 KB PDF).
May 03, 1999. Memorandum. 2 Page(s).
Ian Kennedy. Environmental Risk Branch 2.
Notes on March 16th meeting on isoxaflutole water studies. DP Barcode: D254443.
Document (PDF) (75 KB PDF).
May 07, 1999. Memorandum. 2 Page(s).
Ian Kennedy. Environmental Risk Branch 2.
Site characterization reports for Isoxaflutole PGW studies (447939-1 & -2).
DP Barcode: D255008.
Document (PDF) (98 KB PDF).
July 13, 1999. Memorandum. 5 Page(s).
Michael Davy. Environmental Risk Branch 2.
EFED Response to Rhone Poulenc Rebuttal to EFED's Science Chapter for Isoxaflutole.
DP Barcode D236564.
Document (PDF) (361 KB PDF).
July 16, 1999. Memorandum. 2 Page(s).
Michael Davy. Environmental Risk Branch 2.
Review of Established Soybean Irrigation Studies for Isoxaflutole. DP Barcode D257679.
Document (PDF) (62 KB PDF).
August 04, 1999. Memorandum. 7 Page(s).
Ian Kennedy. Environmental Risk Branch 2.
Comments to the Meeting Notes dated 7/8/99 with Rhone- Poulenc Ag Company
Concerning Isoxaflutole Detailed Tile Drain Monitoring Studies & PGW Studies.
DP Barcode: 257682.
Document (PDF) (389 KB PDF).
October 07, 1999. Memorandum. 2 Page(s).
Ian Kennedy. Environmental Risk Branch 2.
Site Selection for Isoxaflutole PGW study. DP Barcode: 259794.
Document (PDF) (95 KB PDF).
October 12, 1999. Memorandum. 17 Page(s).
Michael Davy. Environmental Risk Branch 2.
Isoxaflutole: Review of Shrimp & Bobwhite Studies for Isoxaflutole.
MRID Nos. 446935-01 & 447188-01.
Document (PDF) (791 KB PDF).
November 02, 1999. Memorandum. 8 Page(s).
Michael Davy. Environmental Risk Branch 2.
Review of Isoxaflutole Contaminated Irrigation Studies on Five Plant Species.
Document (PDF) (374 KB PDF).
December 17, 1999. Memorandum. 2 Page(s).
Ian Kennedy. Environmental Risk Branch 2.
Status Reports on Tile Drain Monitoring Studies. DP Barcodes: 260924, 260925,
260926, 260927, 260938.
Document (PDF) (70 KB PDF).
December 20, 1999. Memorandum. 2 Page(s).
Ian Kennedy. Environmental Risk Branch 2.
Quarterly report for state water samples. DP Barcode: 260919, 259395.
Document (PDF) (65 KB PDF).
February 16, 2000. Memorandum. 3 Page(s).
Ian Kennedy. Environmental Risk Branch 2.
Isoxaflutole Tile Drain Water Monitoring Study. DP Barcode: D262235.
Document (PDF) (177 KB PDF).
August 10, 2000. Memorandum. 2 Page(s).
Ian Kennedy. Environmental Risk Branch 2.
Isoxaflutole Prospective Groundwater Study. DP Barcode: D267156.
Document (PDF) (90 KB PDF).
August 22, 2000. Memorandum. 1 Page(s).
Ian Kennedy. Environmental Risk Branch 2.
Isoxaflutole PGW protocol followup. DP Barcode: D264185.
Document (PDF) (74 KB PDF).
August 28, 2000. Memorandum. 1 Page.
Ian Kennedy. Environmental Risk Branch 2.
Isoxaflutole carbon absorption study. DP Barcode: D261461. MRID No. 449264-01.
Document (PDF) (266 KB PDF).
September 19, 2000. Memorandum. 2 Page(s).
Ian Kennedy. Environmental Risk Branch 2.
Isoxaflutole state monitoring results, May through July, 2000.
DP Barcodes: D268207, D266713.
Document (PDF) (159 KB PDF).
May 07, 2001. Memorandum. 10 Pages.
William P. Eckel. Environmental Risk Branch II.
Review of Final Study Reports on Tile Drain Studies for Isoxaflutole in Bagley and
Dawson, Iowa and Galatea and New Hampshire, Ohio. DP Barcode: D273604.
Document (PDF) (290 KB PDF).
May 10, 2001. Memorandum. 11 Pages.
William P. Eckel. Environmental Risk Branch II.
Isoxaflutole State Monitoring Program: Iowa, 1999-2000. DP Barcode 271576.
Document (PDF) (793 KB PDF).
May 24, 2001. Memorandum. 4 Pages.
William P. Eckel. Environmental Risk Branch II.
Preliminary Review of Prospective Ground Water (PGW) Monitoring Studies for
lsoxaflutole (Balance™) and Registrant's Request to Terminate PGW and Indiana
Tile Drain Studies. DP Barcode: D275059. MRID Nos. 452458-02, -03 & -04.
Document (PDF) (593 KB PDF).
June 07, 2001. Memorandum. 19 Pages.
William P. Eckel. Environmental Risk Branch II.
Review of "Monitoring Terrestrial Drift and Run-off Zones for Non-target Plant
Response to a Label-rate, Pre-emergence Application of Balance WDG Herbicide to
Cornfields," MRID 451290-01, 1188 pp., dated April 28, 2000. DP Barcode: D266715.
Document (PDF) (781 KB PDF).
February 14, 2002. Memorandum. 10 Pages.
William P. Eckel. Environmental Risk Branch II.
Isoxaflutole Tile Drain Studies, Allen and Owen Counties, Indiana.
DP Barcode: D278264. MRID Nos. 454984-01, -02.
Document (PDF) (464 KB PDF).
February 14, 2002. Memorandum. 4 Pages.
William P. Eckel. Environmental Risk Branch II.
Isoxaflutole 2-year Tile Drain study, New Holland, Ohio. DP Barcode: D278258.
MRID Nos. 44931407, 44996006, 45113307, 45245805 & 45497201.
Document (PDF) (406 KB PDF).
August 22, 2002. Memorandum. 4 pages.
William P. Eckel. Environmental Risk Branch II.
Review of Final Study Report on Tile Drain Study for Isoxaflutole in New Holland, Ohio.
DP Barcode: D284037.
Document (PDF) (441 KB PDF).
November 04, 2002. Memorandum. 6 Pages.
William P. Eckel. Environmental Risk Branch II.
Monitoring Data for Isoxaflutole: Quarterly Report for Samples Analyzed April 1
to June 30, 2002 (Dated 9/9/02). MRID No. 45785001. DP Barcode 286410.
Document (PDF) (217 KB PDF).
October 22, 2003. Memorandum. 13 Pages.
William P. Eckel. Environmental Risk Branch II.
2003 Monitoring Data for Isoxaflutole. DP Barcode: D294305.
DP Barcodes covered are D294305, D294307, D294308, D294309, D294310, and D294311.
Document (PDF) (549 KB PDF).
June 05, 2008. DER. 11 Pages.
Robert J. Mitkus. Registration Action Branch 1.
Prenatal Developmental Toxicity Study - Rat; OPPTS 870.3700 [§83-3]; OECD 414.
DP BARCODE: D335563. TXR#: 0054227. MRID No. 45655906.
Document (PDF) (844 KB PDF).
June 05, 2008. DER. 4 Pages.
Robert J. Mitkus. Registration Action Branch 1.
90-Day Oral Toxicity [feeding]-[rat]; OPPTS 870.3100 [§82-1a] (rodent); OECD 408.
DP BARCODE: D335563. TXR#: 0054227. MRID No. 45655903.
Document (PDF) (187 KB PDF).
October 01, 2008. Memorandum. 39 pages.
Jess Rowland. Science Information Management Branch.
ISOXAFLUTOLE: Review of a Developmental Neurotoxicity Study. DP Barcode: D269315.
Decision No.: 174399. Registration No.: 264-566. TXR No.: 0050815. MRlD No.: 45215701.
Document (PDF) (638 KB PDF).