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Index of Cleared Science Reviews for Azadirachtin (PC Code 121701)

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June 25, 1982. Memorandum. 2 Pages.
William Woodrow. Toxicology Branch.
EPA#GEE-Q. Request for waiver of Biorational Biochemical
Tier 1 Testing for Neem Extract; components of Neem Nuts are
supposed to repel insects.
Document (PDF) (91 KB PDF).

February 4, 1983. Memorandum. 9 Pages.
Douglas Urban. Ecological Effects Branch.
EEB Review of Avian Data Submitted for Margosine-O, EPA Reg.
No. 100-AN, Due RD 2/5/83.
Inert ingredient information on pages 2, 5, and 8 is not
included.
Document (PDF) (358 KB PDF).

February 8, 1983. Memorandum. 14 Pages.
Douglas Urban. Ecological Effects Branch.
EEB Review of Aquatic Data Submitted for Margosine-O,
EPA Reg. No. 100-10, Due Rd 2/10/83.
Inert ingredient information on page 3, 7, and 11
is not included.
Document (PDF) (615 KB PDF).

June 30, 1983. Memorandum. 2 Pages.
William Woodrow. Toxicology Branch.
EPA Reg. #45167-R. Margosine-O (Neem Extract), Application
for Registration as an Anti-Feedant Extract. Caswell #594A.
Document (PDF) (117 KB PDF).

June 30, 1983. Memorandum. 2 Pages.
William Woodrow. Toxicology Branch.
Approval of a Sample Ames Test Protocol to be Used for
Mutagenicity Screening Evaluation of Neem Extract.
Document (PDF) (89 KB PDF).

January 16, 1984. Review. 6 Pages.
Dennis McLane. Ecological Effects Branch.
File No. 45167-R. Margosan-O. Proposed Full Registration
of Lettuce, Corn, Potato, Tomato, Cabbage, Spinach, and
Chrysanthemum Uses.
Document (PDF) (301 KB PDF).

January 16, 1984. Memorandum. 8 Pages.
Dennis McLane. Ecological Effects Branch.
EEB CHEMICAL PROFILE
Acc. No. 252097
Inert ingredient information on pages 1, 2 is not included.
Document (PDF) (242 KB PDF).

January 16, 1984. Efficacy Review. 3 Pages.
Phil Hutton. Insecticide-Rodenticide Branch.
45167-1, Margosan-O. Vikwood, Ltd. Sheboygan, WI.
Manufacturing process and inert ingredient information on
page 1 are not included.
Acc. 252097.
Document (PDF) (202 KB PDF).

April 20, 1984. Memorandum. 11 Pages.
Christine Chaisson. Toxicology Branch.
EPA Reg.# 45167-1 Margosan-O (Neem Extract), used as an
insect anti-feedant extract. Acc. #252097. Caswell #594A.
Inert ingredient information on pages 3-4 is not included.
Tox review 003768.
Document (PDF) (825 KB PDF).

January 14, 1985. Memorandum. 2 Pages.
Fred Betz. Science Integration Staff.
Classification of Azadirachtin.
Document (PDF) (105 KB PDF).

May 14, 1985. Memorandum. 2 Pages.
Robert Pilsucki. Ecological Effects Branch.
Mode of Action of Margosan-O.
Document (PDF) (106 KB PDF).

June 17, 1985. Memorandum. 1 Page.
Douglas Campt. Registration Division.
Request for Expeditious Review Update of Data Submitted by
Vikwood Ltd. on Neem Extract (Azadirachtin).
Document (PDF) (77 KB PDF).

June 25, 1985. Memorandum. 2 Pages.
Robert Pilsucki. Ecological Effects Branch.
Re: Toxicity of Margosan-O to Aquatic Organisms and Birds.
Document (PDF) (84 KB PDF).

August 7, 1985. Memorandum. 2 Pages.
Robert Pilsucki. Ecological Effects Branch.
Update on Margosan-O.
Document (PDF) (115 KB PDF).

December 11, 1985. Memorandum. 4 Pages.
William Woodrow. Toxicology Branch.
EPA Registration No. 45167-1, 5F3255. Margosan-O (Neem
Extract), Used as an Insect Antifeedant Extract for
Lepidopterous Insects. Accession No. 252097. Caswell
No. 594A. Inert ingredient information on page 4 is not
included.
Document (PDF) (198 KB PDF).

March 12, 1990. Memorandum. 7 Pages.
J. Thomas McClintock. Science Analysis & Coordination Branch.
Classification of Tetrahydroazadirachtin as a Biochemical
Pesticide.
Attachment(s) following:
Document (PDF) (287 KB PDF).

February 16, 1990. Memorandum.
J. Thomas McClintock. Science Analysis & Coordination Branch.
Classification of Azadirachtin and Tetrahydroazadirachtin as
Conventional Chemicals or Biochemical Pesticides.

*End of attachments*

October 29, 1990. Memorandum. 1 Page.
J. Thomas McClintock. Science Analysis & Coordination Branch.
Tetrahydroazadirachtin: Supplemental Information to Further
Support the Classification of Subject Compound as a
Biochemical Pesticide.
Document (PDF) (72 KB PDF).

January 17, 1991. Memorandum. 1 Page.
J. Thomas McClintock. Science Analysis & Coordination Branch.
Margosan-O Product Label Amendment: Addition of Greenhouse
Use and Targeted Pests.
Document (PDF) (61 KB PDF).

January 18, 1991. Memorandum. 3 Pages.
Zig Vaituzis. Ecological Effects Branch.
Request for Label Amendments to Margosan-O by W.R. Grace
and Co.
Reg. No. 11688-5.
Document (PDF) (109 KB PDF).

April 25, 1991. Memorandum. 7 Pages.
Michael Metzger. Chemistry Branch 2.
Azadirachtin Biochemical Pesticide. Product
Chemistry Data in Support of Registartion.
MRID Nos. 416264-01, -18; 416269-01, -19; 416263-01, -13
Tox review 008393.
Confidential Appendix is not included.
Document (PDF) (341 KB PDF).

May 30, 1991. Memorandum. 127 Pages.
J. Thomas McClintock. Science Analysis and Coor. Branch.
Registration of Azadirachtin Biochemical Pesticide: SACB...
062552-R, 062552-G, and 062552-E; MRID Nos. 416264-01
through -21, 416269-01 through -19, 416263-01 through -13.
Manufacturing process info on pages 107, 112 not included.
Tox review 008393. (continued).
Attachment(s) following:
Document (PDF) (3,359 KB PDF).

May 30, 1991. Memorandum.
J. Thomas McClintock. Science Analysis and Coor. Branch.
Pages 11-13, 21-23, 30-32, 40-43, 50-54, 62-64, 70-73,
79-81, 83-86, 92-94, 101-103, 114-120, and 122-127 removed,
registrant data.
Tox review 008393.

*End of attachments*

September 23, 1991. Memorandum. 9 Pages.
David Bays. Ecological Effects Branch.
62552-R; -E; -G
Data Accession No(s). 416264-22, 23, -24, -25
Section 3 Registration.
Document (PDF) (493 KB PDF).

November 12, 1991. Memorandum. 33 Pages.
Michael Metzger. Chemistry Branch 2.
Azadirachtin Biochemical Pesticide. Response to
Product Chemistry Data Deficiencies.
MRID Nos. 419232-00 to -14.
Quality control procedure information page 10 not included.
Pages 16-33 removed-inert info., manufacturing process & QCP.
Document (PDF) (1,003 KB PDF).

December 13, 1991. Memorandum. 4 Pages.
J. Thomas McClintock. Science Analysis and Coordination Branch.
Registration of Azadirachtin Biochemical Pesticide: SACB
Review of Supplemental Information for Product Chemistry
Data and Toxicity Studies (HED Project Nos. 1-17171 and 1-
2399; I.D. No. 000275-AO; MRID Nos. 419232-01 through -
20, Caswell No. 594A).
Document (PDF) (283 KB PDF).

August 26, 1992. Memorandum. 7 Pages.
Michael Metzger. Chemistry Branch II.
Azadirachtin Biochemical Pesticide. Product
Chemistry Data. EPA Reg. No. 62552-3. MRID No.
420865-01 to -11. DP Barcode D173864. CBRS Nos.
9959, 9960
Task 4; Product Chemistry Data in Support of Registration.
Document (PDF) (560 KB PDF).

October 8, 1992. Memorandum. 1 Page.
J. Thomas McClintock. Science Analysis Branch.
Petition for Exemption for the Requirement of a Tolerance
for Azadirachtin Applied to Seeds, Cuttings, Transplants
and Plants
PP# 2F4046
Inert ingredient information on page 2 is not included.
Document (PDF) (59 KB PDF).

July 1, 1993. Memorandum. 2 Pages.
Cindy Schaffer. Science Analysis & Coordination Branch.
SAB Review of an Acute Oral Toxicity Study on Azatin
Technical Grade, a Biochemical Pest Control Agent Submitted
by AgriDyne Technologies.
MRID 424636-01.
Document (PDF) (117 KB PDF).

November 18, 1993. Memorandum. 32 Pages.
J. Thomas McClintock. Science Analysis Branch.
SAB Review of Acute Mammalian Toxicology Studies to Support
the Registration of Neem Concentrate, a Biochemical
Pesticide Containing Azadirachtin as a Technical ...
Inert ingredient info on pages 5, 9, 14, 23, 32 not included
Tox review 010668. MRID Nos. 425383-02 thru 06.
Document (PDF) (1,711 KB PDF).

February 23, 1994. Review. 8 Pages.
Anthony Maciorowski. Ecological Effects Branch.
Azatin EC: Review of follow-up data for conditional
registration. Acute contact toxicity to honeybee.
MRID 424636-02.
Document (PDF) (357 KB PDF).

March 6, 1996. Memorandum. 44 Pages.
Sheryl Reilly. Biopesticides & Pollution Prevention Div.
Review of Mammalian Toxicology Studies Submitted by AgriDyne
Technologies, Inc. in Support of the Registration of
Azadirachtin End-Use Products, Azatin EC, Azatin-Plus EC,
and Azatin Technical (ID# 62552-1, 62552-2, and 62552-3.
MRID No. 43113001.
Document (PDF) (2,285 KB PDF).

October 4, 1996. Data Eval. Rec. 12 Pages.
Paul Zubkoff. Biopesticides & Pollution Prevention Div.
72-3 [151-13] Acute Toxicity for Nontarget Organisms -
Marine Fish. Pages 6-9 removed, registrant data.
MRID 42694605.
Document (PDF) (421 KB PDF).

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