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Index of Cleared Science Reviews

Index for Cyromazine (Pc Code 121301)

October 9, 1979. Review. 6 Pages.
R.W. Cook. Environmental Fate Branch.
Larvicide on Poultry, Beef Cattle, Sheep and Hog Manure.

November 9, 1979. Memorandum. 20 Pages.
Robert Jaeger. Toxicology Branch.
100-EUP-75 and 66, PP#9G2230, CGA 72662... foodtrough larvicide in poultry; topical for poultry, beef cattle, sheep and hog manure (including feedlots).
MRID 00135433 (Acc. 098385).
Tox review 002687.

November 9, 1979. Memorandum. 20 Pages.
Robert Jaeger. Toxicology Branch.
100-EUP-65 & 66, PP#9G2230, CGA 72662 (N-Cyclopropyl-3-1, 3, 5-triazine-2,4,6,-triamine) feedtrough larvacide in poultry; topical for poultry, beef cattle, sheep & hog manure (including feedlots).

April 29, 1980. Memorandum. 7 Pages.
Robert Jaeger. Toxicology Branch.
100-EUP-66 & 100-EUP-65, PP#9G2230, CGA 72662... foodtrough larvicide in poultry; topical for poultry, beef cattle, sheep and hog manure (including feedlots). DATA submittal in response to Tox Branch review of 11/9/79. MRID 00027488.
Tox review 002700.

September 20, 1982. Review. 22 Pages.
John Bascietto. Ecological Effects Branch.
Proposed Full Registration of Formulation Use Label and Fly Control Around Poultry Use Labels.
Inert ingredient information on pages 2-3 is not included.

September 21, 1982. DER. 3 Pages.
John Bascietto. Ecological Effects Branch.
Study Type: 96-hr. LC50 - freshwater fish.
Test Species - Bluegill sunfish.
Accession No. 070912.

September 22, 1982. DER. 4 Pages.
John Bascietto. Ecological Effects Branch.
Study Type: 96-hr. LC50.
Test Species - Channel Catfish.
Accession No. 070912.

September 22, 1982. DER. 3 Pages. John Bascietto. Ecological Effects Branch. Study Type: 96-hr. LC50 - freshwater fish. Test Species - Rainbow Trout. Accession No. 070912.

October 1, 1982. Review. 81 Pages.
Sam Creeger. Environmental Fate Branch.
Reg./File No.: 100-AGR and 100-AGE.
Registration for Fly Control in Chicken Manure.
Pages 19 and 53 removed, registrant data.

October 13, 1982. Memorandum. 24 Pages.
William Butler. Toxicology Branch.
PP#2F2707/2H5355; Larvadex (Cyromazine) in eggs, meat, poultry, fat and meat byproducts of poultry.
Inert, manufacturing process info on pages 2-3 not included.
MRID 103193, 103196, 103197 (Acc. 070919, 070920, 070921).
Tox review 002664.

October 18, 1982. Review. 52 Pages.
Dynamac Corporation for EFGWB.
CYROMAZINE.
Task 1: Review and Evaluation of Individual Studies.
Accumulation in Bluegill sunfish, Hydrolysis, 17 more.
Acc. No. 070914, 070915.

November 8, 1982. Memorandum. 1 Page.
Clinton Fletcher. Environmental Fate Branch.
EFB Review 10/1/82, Cyromazine. Ciba-Geigy Request for Information.
January 18, 1983. Review. 4 Pages.
Emil Regelman. Environmental Fate Branch.
Review of Extension of Section 18 - Address Rotational Crop
Question.

February 23, 1983. Memorandum. 14 Pages.
Phillip Errico. Residue Chemistry Branch.
PP#2F2707/FAP#2H5355 Cyromazine use in Poultry Feed.
Review of Analytical Method, and Metabolism and
Feeding Studies. Manufacturing process info and inert
ingredient information on page 3 not included. MRID 103204, 103205, 103207, 103208.

March 21, 1983. Memorandum. 7 Pages.
William Butler. Toxicology Branch.
PP#2F2707; Larvadex (Cyromazine) on poultry and eggs,
Conditional New Chemical Registration, Accession No.
071185-071193, Study No. 382-081; 382-082.
[oncogenicity - rats]
Tox review 002617.

April 26, 1983. Memorandum. 2 Pages.
Stephanie

April. Toxicology Branch.
PP #2F2707/2H5355: Free Standing Summary; Larvadex
(Cyromazine) in Eggs, Meat, Fat and Meat Byproducts of
Poultry.

April 29, 1983. Memorandum. 2 Pages.
William Butler. Toxicology Branch.
PP #2F2707/2H5355; Larvadex (Cyromazine) in Eggs, Meat,
Poultry, Fat and Meat Byproducts of Poultry.
Inert ingredient information on page 2 is not included.

May 18, 1983. Review. 5 Pages.
Richard Moraski. Exposure Assessment Branch.
Review Information Submitted in Response to Previous Review.

June 29, 1983. Memorandum. 1 Page.
Philip Errico. Residue Chemistry Branch.
PP #2F2707/FAP #2H5355. Results of the Cyromazine Method
Try-Out Request.

July 12, 1983. Memorandum. 1 Page.
John Bascietto. Ecological Effects Branch.
EEB Review of Cyromazine - Submission of Control Mortality
Response of Daphnia in 48-Hour Acute Toxicity Test.

August 11, 1983. Review. 5 Pages.
Richard Moraski. Exposure Assessment Branch.
Review Rotational Crop Study Relative to Section 18 Issues.

October 6, 1983. Review. 4 Pages.
Richard Moraski. Exposure Assessment Branch.
Review Response to Previous EAB Review.

March 2, 1984. Memorandum. 7 Pages.
Clinton Fletcher. Exposure Assessment Branch.
Comment on Leaching of the Cyromazine and Metabolite Melamine.

March 6, 1984. Memorandum. 2 Pages.
Philip Errico. Residue Chemistry Branch.
PP #2F2707/2H5355, Cyromazine in Poultry Feed.

March 8, 1984. Memorandum. 2 Pages.
Philip Errico. Residue Chemistry Branch.
PP #2F2707/2H5355, Results of Cyromazine Method Try-Out.

June 11, 1984. Review. 6 Pages.
Samuel Creeger. Exposure Assessment Branch.
Response to Previous EAB Review.

June 28, 1984. Memorandum. 1 Page.
Neil Chernoff. Developmental Biology Division, EPA.
Review of Teratology Studies on CGA-72662 Technical.

June 29, 1984. Memorandum. 3 Pages.
Quang Bui. Toxicology Branch.
Re-Evaluation of Teratogenic Studies with Technical
CGA 72662 in Rabbits.

July 11, 1984. Memorandum. 18 Pages.
Stephen Dapson. Insecticide and Rodenticide Branch.
Rereview of Rat Teratology and Rat Range Finding Study
of CGA-72662 Technical. Pages 5-6, 15-18 removed,
registrant data. MRID 00027488 (Acc. 099272).
Tox review 003873.

August 16, 1984. Memorandum. 2 Pages.
Edwin Budd. Toxicology Branch.
Larvadex (Cyromazine). Re-Evaluation of Mouse Oncogenicity
Study.

August 16, 1984. Memorandum. 19 Pages.
Edwin Budd. Toxicology Branch.
Larvadex (Cyromazine). Re-Evaluation of Mouse Oncogenicity
Study. Pages 3-9 removed, registrant data.
MRID 43068901, 43068902.
Tox review 004123.

December 20, 1984. Memorandum. 5 Pages.
Edwin Budd. Toxicology Branch.
PP 2F2707/FAP 2H5355. Cyromazine (Larvadex). Review of
Additional Information and Comments Submitted by Ciba-Geigy.
Tox review 004127.
January 10, 1985. Memorandum. 2 Pages.
Edwin Budd. Toxicology Branch.
PP 2F2707/FAP 2H5355. Cyromazine (Larvadex).
Addendum to Previous Review, Dated 12/17/84 Re:
Review of Additional Information and Comments
Submitted by Ciba-Geigy. (MRID 43068901, 02)
Tox review 004217.
v January 18, 1985. Review. 5 Pages. Samuel Creeger. Exposure Assessment Branch.
Reg./File No.: 100-EUO-IT
EUP for use on mushrooms
MRID 103145.

February 5, 1985. Review. 7 Pages.
Samuel Creeger. Exposure Assessment Branch.
Registration of New Chemical for Use on Celery and Lettuce.

February 5, 1985. Memorandum. 14 Pages.
Quang Bui. Toxicology Branch.
Review of a Rabbit Teratology with Larvadex (Cyromazine).
EPA # 100-AGR. Accession No. 256348.
Tox review 004263.

February 7, 1985. Review. 7 Pages.
John Bascietto. Ecological Effects Branch.
Proposed Registration - Celery and Lettuce.
Pending registration information on pages 1-2, 4-5, and 7 is not included.

February 8, 1985. Memorandum. 16 Pages.
Cynthia Deyrup. Residue Chemistry Branch.
PP #5F3180. (RCB) #331) Cycromazine in/on lettuce &
celery. Evaluation of the analytical method & residue data.
Accn. No. 073084.

February 13, 1985. DER. 2 Pages.
Roy Sjoblad. Toxicology Branch.
STUDY TYPE Dermal sensitization; guinea pig
EPA Accession No. 073074
MRID 151813.

February 13, 1985. DER. 1 Page.
Roy Sjoblad. Toxicology Branch.
STUDY TYPE Primary Dermal Irritation; Rabbit
EPA Accession No. 073074
MRID 151141.

February 13, 1985. DER. 2 Pages.
Roy Sjoblad. Toxicology Branch.
STUDY TYPE Acute Dermal LC50; Rabbit
EPA Accession No. 073074
MRID 151138.

February 13, 1985. DER. 2 Pages.
Roy Sjoblad. Toxicology Branch.
STUDY TYPE Acute Inhalation LC50; Rat
EPA Accession No. 073074
MRID 151139.

February 13, 1985. DER. 1 Page.
Roy Sjoblad. Toxicology Branch.
STUDY TYPE Acute Oral LD50; Rat
EPA Accession No. 073074
MRID 151137.

February 13, 1985. DER. 1 Page.
Roy Sjoblad. Toxicology Branch.
STUDY TYPE Primary Eye Irritation; Rabbit
EPA Accession No. 073074
MRID 151140.

February 14, 1985. Review. 4 Pages.
Ken Clark. Ecological Effects Branch.
File or Reg. No. 100-ALA
Petition 5F3177
Proposed registration of mushrooms use
MRID 151136.

February 28, 1985. Memorandum. 21 Pages.
Edwin Budd. Toxicology Branch.
PP 2F2707/FAP 2H5355. Cyromazine (Larvadex).
Final Review of the Mouse Oncogenicity Study on
Larvadex (IRDC Study No. 382-082).
MRID 43068901, -02.
Tox review 004313.
Attachment(s) following:

February 27, 1985. Memorandum. Bertram Litt. Toxicology Branch. Statistical Evaluation of Lymphoma Data from Mouse Oncogenicity Study of Larvadex.

February 26, 1985. Memorandum. Louis Kasza. Toxicology Branch. Evaluation of Lymphomas in Two Pathology Reports. Mouse Oncogenicity Study on Larvadex.

*End of attachments*

April 5, 1985. Memorandum. 4 Pages.
Carole Kimmel. Reproductive Effects Assessment Group.
Review of Rabbit Teratology Study on Larvadex.

April 24, 1985. Memorandum. 7 Pages.
Quang Bui. Toxicology Branch.
Ciba-Geigy's Response to EPA's Review of a Rabbit Teratology
Study with Larvadex (Cyromazine). EPA Reg. No. 100-ALU.
Accession No. 257064. Tox Review 004410.

April 25, 1985. Memorandum. 5 Pages.
Robert Zendzian. Toxicology Branch.
Cyromazine (Larvadex), Review of Dermal Absorption Study
in Rats. Tox Review 004407.

May 16, 1985. Memorandum. 3 Pages.
Nancy Dodd. Residue Chemistry Branch.
PP #5F3180. Cyromazine on Lettuce. Evaluation of Method
Trial Report Dated May 8, 1985.

May 23, 1985. Memorandum. 1 Page.
Alfred Smith. Residue Chemistry Branch.
PP #2F2707/FAP #2H5355: Cyromazine in Poultry Tissues.
Report on Method Trials.

June 6, 1985. Memorandum. 3 Pages.
Alfred Smith. Residue Chemistry Branch.
PP #2F2707 (Accession No. 257065; RCB No. 784): Cyromazine
(Larvadex) in Poultry. Amendment of 3/7/85.

June 13, 1985. Memorandum. 4 Pages.
E.T. Haeberer. Residue Chemistry Branch.
PP#5F3177 Cyromazine on Mushrooms
Review and Evaluation of of Supplemental Section D
Submission Dated March 18, 1985.
(Accession No. 073406)
MRID 153795.

July 12, 1985. Memorandum. 7 Pages.
Quang Bui. Toxicology Branch.
Protocol review for Larvadex in rabbits EPA Reg. No. 2F2707/2H 5355.

August 16, 1985. Memorandum. 5 Pages.
Richard Loranger. Residue Chemistry Branch.
EPA Reg. No. 100-631. Cyromazine (Larvadex) Feed-Through
for Poultry. Label Revision in Response to FR Notice.
[RCB No. 1110].

September 25, 1985. Review. 7 Pages.
Carolyn Offutt. Exposure Assessment Branch.
Reg. /File No.: 100-ALU
Data for estimation of fieldworker exposure to residues
of Cyromazine after application of Trigard 75W to lettuce or clery. Data presented at meeting on 9/18/85.
MRID 00147379. Acc# 073647.

October 18, 1985. DER. 7 Pages.
Thomas Armitage. Ecological Effects Branch.
Study Type: Fish Early Life Stage Toxicity Test.
Species Tested: Fathead Minnow.
Accession No. 073085.

February 7, 1986. Review. 7 Pages.
Samuel Creeger. Exposure Assessment Branch.
Reg./File No.: 100-ALU
Submission of calculations estimating cyromazine dissipation in mushroom compost.
Accession 257689.
MRID: 146845.

April 8, 1986. Review. 11 Pages.
Samuel Creeger. Exposure Assessment Branch.
Reg./File No.: 100-ALU.
Field data supporting use on lettuce, celery and chrysanthemums. [four field dissipation studies].

June 2, 1986. Memorandum. 3 Pages.
W.T. Chin. Residue Chemistry Branch.
PP #2F2707/FAP #2H5355: Cyromazine Use in Poultry Feed.
Method Trial Request.

November 21, 1986. Memorandum. 43 Pages.
Quang Bui. Toxicology Branch.
Review of a breeding study in rabbits and a developmental
toxicity study with Cyromazine in rabbits.
EPA No. 100-631. Pages 32-43 removed, registrant data.
MRID 40728601.
Tox review 005594.

September 12, 1988. Memorandum. 18 Pages.
Phillip Errico. Residue Chemistry Branch.
PP#8F3633. Cyromazine Surface Application in Swine Tissues. Evaluation of Residue Data and Analytical
Method (MRID#'s 40593200, -01, -02, -03 and -04)
RCB#3733.
Attachment(s) following:

April 5, 1988. Letter. Haney Camp. Ciba-Geigy. -Technical Cyromazine, EPA Reg. No. 100-632 -Amended application for registration, Larvadex 2SL (EPA File Symbol 100-AAE), New use in swine operations -Petition to establish tolerances for swine meat, fat ...

*End of attachments*

September 12, 1988. Memorandum. 11 Pages.
Freshteh Toghrol. Residue Chemistry Branch.
PP#8F3633. Cyromazine Surface Application in Swine
Tissues.Evaluation of Residue Data and Analytical
Method (MRID#'s 40593200, -01, -02, -03, -04).
RCB#3733.
January 27, 1989. Memorandum. 2 Pages.
Kenneth Dockter. Dietary Exposure Branch.
EPA Reg. No. 100-632. Nitrosamine Analysis for Ciba- Geigy's technical cyromazine. MRID No. 40942101.
Branch No. 4784.

June 29, 1989. Review. 6 Pages.
Emil Regelman. Environmental Fate & Groundwater Branch.
Reg./File #: 100-ALA
fate in field soil amended w/ compost containing cyromazine.
MRID 40944001.

July 26, 1989. Review. 39 Pages.

Patrick Holden. Environmental Fate & Groundwater Branch. Response to meeting with registrant for cyromazine on ground-water monitoring study requirements.
Aerobic/anaerobic soil metabolism, CGA-72662. Project
Number 84-E-016. Pages 8-39 removed, registrant data.

November 6, 1989. Memorandum. 27 Pages.
Stephen Dapson. Insecticide-Rodenticide Branch.
Review Submission of "Weight-Of-Evidence" Evaluation of Cyromazine Potential to Cause Developmental Effects,
from Ciba-Geigy. Comment on the worker safety in using
the subject products according to the provided labels. Attachment(s) following:

November 6, 1989. Memorandum. Stephen Dapson. Insecticide-Rodenticide Branch. continued. EPA ID No. 100-631, 100-Ak?, 100-ALA and 100-AAE; EPA Record No. 236828, 251360, 251361 and 251373; NRID # 409376-01; Caswell No. 167B; HED Project No. 9-0588 & 9-2104 Tox review 007603.

*End of attachments*

February 22, 1990. Memorandum. 10 Pages.
Luis Rodriguez. Dietary Exposure Branch.
PP#9E3791. Cyromazine in/on Chinese Mustard.
Evaluation of Analytical Methods and Residue Data.
MRID 41193000, -01.

April 2, 1990. Memorandum. 3 Pages.
Luis Rodriguez. Dietary Exposure Branch.
PP#9E3791. Cyromazine in/on Chinese Mustard.
Amendment of March 12, 1990.
DEB No. 6499; RD Record No. 261515,
HED Project No. 0-0946. No MRID No.

May 30, 1990. Memorandum. 12 Pages.
W.T. Chin. Dietary Exposure Branch.
PP#9E3752: Cyromazine in/on Chinese Cabbage. Amendment
of 4/30/90 (DEB #6666).
Attachment(s) following:

December 4, 1989. Memorandum.
W.T. Chin. Dietary Exposure Branch.
PP#9E3752: Cyromazine in/on Chinese Cabbage. Evaluation
of Analytical Methods and Residue Data (MRID #410492-0
and -1; DEB #5199).

*End of attachments*

December 10, 1990. Review. 10 Pages.
Michael Barrett. Environmental Fate & Ground Water Branch.
Reg. No. 100-654. Cyromazine. Review Protocol for
Small-Scale Prospective Ground Water Monitoring Study.
January 11, 1991. Memorandum. 28 Pages.
Timothy McMahon. Toxicology Branch.
N-cyclopropyl-1,3,5,-triazine-2,4,6-triamine (Trigard):
Review of a Rat Metabolism Study Submitted by the Registrant
MRID No: 41442101.
Tox review 008223.

July 15, 1992. Memorandum. 4 Pages.
Esther Rinde. Health Effects Division.
Post SAP Carcinogenicity Peer Review Meeting on
Dimethoate, Bromoxynil and Triallate
and Re-consideration of the Classification of Aliette and Cyromazine/Melamine.

August 14, 1992. Memorandum. 8 Pages.
Radames Lozada. Chemical Coordination Branch.
Exposure Assessment for the Use of Cyromazine on Mushrooms.
MRID 42238702.

December 9, 1992. Memorandum. 18 Pages.
Francis Griffith. Chemistry Branch I.
PP#1F4016 - Cyromazine (TRIGARD) on Leafy Vegetables (Except Brassica) Crop Group.
Review of Residue Data and Analytical Method.
(MRID # 41976301) [CBTS # 9817] {DP Barcode D177546}.

December 23, 1992. Memorandum. 19 Pages.
Francis Griffith. Chemistry Branch.
PP# 2F4053 - Cyromazine (Trigard) on Cucurbit Vegetables
Crop Group. Review of Residue Data and Analytical Method.
(MRID # 42116001) {DP Barcode D177550}.
January 11, 1993. Review. 52 Pages.
Elizabeth Behl. Environmental Fate & Groundwater Branch.
Reg./File 000100-00654
Prospective ground-water study final report and amended use.
Pages 22-26, 29-34, 36-38, 42-44 removed, registrant data.
MRID 42283501, -02, -03, -04, 42426401.
January 13, 1993. Memorandum. 1 Page.
Lucas Brennecke. Pathology Associates, Inc.
evaluation of the Cyromazine rat mammary gland data.
Attachment(s) following:

January 13, 1993. Memorandum. 2 Pages. Lucas Brennecke. Pathology Associates, Inc. Mammary Tumors in Cyromazine Rats.

May 31, 1992. Final Proposal. 20 Pages. P.C. Mann. Experimental Pathology Laboratories, Inc. Proliferative Lesions of the Mammary Gland in Rats.

*End of attachments*

February 22, 1993. Memorandum. 3 Pages.
Lucas Brennecke. Pathology Associates, Inc.
Additional Evaluation of Mammary Tumor Data in Cyromazine.
Rats and Mice.

March 9, 1993. Memorandum. 5 Pages.
Stephen Funk. Chemistry Branch.
Data Call-In for Hexachlorobenzene and Pentachlorobenzene
in Technical Cyromazine; Waiver Request. DP Barcode
D186546. MRID No. 42583103. CBRS No. 11192.
Pages 4-5 removed, manufacturing process.

March 24, 1993. Letter. 3 Pages.
Robert Lascola. Chemistry Branch.
Letter to Bernadette McMahon, FDA.
Enclosed is the following Multiresidue Test Information
for the updating of PAM I . . .
PP#: 6F3329, 6F3333
MRID#: 42224305.

April 2, 1993. Memorandum. 26 Pages.
Robert Lascola. Chemistry Branch I.
PP#6F3329: Cyromazine on Carrots. Amendment of 2/17/92.
CBTS# 9715. MRID# 42224301 thru -05. DP Barcode# D176914.
PP#6F3333/FAP#2H5640: Cyromazine on Tomatoes. Amendment of
2/18/92. CBTS# 9716. 9717. MRID# 42255101, -02. DP Barcode#
D176906, D176909. Pages 7 and 20-22 removed, registrant data.

July 16, 1993. Memorandum. 4 Pages.
Francis Griffith. Chemistry Branch.
PP# 1F4016- Cyromazine (TRIGARD) ON LEAFY VEGETABLES (EXCEPT BRASSICA CROP GROUP).
PP# 2F4053 -CYROMAZINE (TRIGARD) ON CUCURBIT VEGETABLES CROP GROUP.
(MRID # 42224305)... {DP Barcodes D187702 and D187707}.

March 15, 1994. Memorandum. 13 Pages.
Elizabeth Behl. Environmental Fate & Groundwater Branch.
ID# 000100-00654
Review addendum to Final Report for Small-Scale Ground-Water Monitoring Report of Cyromazine on Tomatoes
in Florida. Guideline 166-1.
MRID 43061200 to -03.

May 4, 1994. DER. 3 Pages.
Allen Vaughan. Ecological Effects Branch.
Honey bee acute contact LD50
MRID 43152601.

August 10, 1994. Memorandum. 5 Pages.
William Wassell. Chemistry Branch.

Cyromazine, Larvadex 1% Premix Larvacide (EPA Reg. No. 101-671). Review of 6(a)(2) data and correspondence dated 06/09/94, 06/13/94 and 06/19/94 from Ciba-Geigy Corp.
MRID No. 43277601, 43281001, 43273501;
DP Barcode: D205836, D205837, D205838.
January 6, 1995. Memorandum. 12 Pages
. Stephen Dapson. Toxicology Branch II.
Carcinogenicity Peer Review of Cyromazine (2nd).
Tox Review No. 011384.

February 13, 1995. Memorandum. 8 Pages.
Joel Garbus. Chemistry Branch.
PP#6F3332: Cyromazine: Amendment of 12/20/94 Proposing
Inadvertent Tolerances for Rotational Sweet Corn and
Radishes. Revised Section F and Responses to Deficiencies
Noted in CBTS's Review of 2/12/87. MRID 43495401.
DP Barcode D210905.

February 13, 1995. Memorandum. 7 Pages.
Jerry Stokes. Chemistry Branch.
PP#6F3333/FAP#2H5640: Cyromazine on Tomato. Amendment of 6/10/94. CBTS#'s 14906 and 15026. MRID#'s 43274201,
43274202, and 43274203. DP Barcode#'s D221239 and D211324.
PP#6F3329: Cyromazine on Carrot. Amendment of 06/10/94.
CBTS# 14906. No MRID#'s. DP Barcode# D221239.

May 3, 1995. Memorandum. 8 Pages.
William Cutchin. Chemistry Branch.
PP#5E4450, Evaluation of Analytical Method and Residue
Data. Cyromazine in/on Imported Mangoes. Chemical#
121301, DP Barcode: D212706, CBTS#: 15211, MRID#:43470301 thru -08.

May 7, 1995. Memorandum. 27 Pages.
James Wolf. Environmental Fate & Groundwater Branch.
Review of Ground-Water Issues and the Florida
Prospective Ground-Water Monitoring Study for
Cyromazine. Pages 6,8,9,11,13,15,17,18,21, 25 removed,
registrant data. DP Barcode 209089.
MRID 43421200, -01, -02.

October 18, 1995. Memorandum. 14 Pages.
Jerry Stokes. Chemistry Branch.
PP#6F3333/FAP#2H5640: Cyromazine on Tomatoes. Response
to RD Request Dated 07/25/95 to Reevaluate the Need for 409 Tolerances. Reevaluation of Need for Additional
Tolerances for Animal Commodities. CBTS# 15912. No
MRID#'s. DP Barcode# D217689.
Attachment(s) following:

May 26, 1995. Memorandum.
Jerry Stokes. Chemistry Branch.
PP#6F3333/FAP#2H5640: Cyromazine on Tomato. Amendment
05/04/95. CBTS# 15420. MRID#'s 43607700 and 43607701.
DP Barcode# D214217.

April 4, 1996. Memorandum.
Jerry Stokes. Chemistry Branch.
PP#6F3333/FAP#2H5640: Cyromazine on Tomato. Response to
FR Notice, Revised Section F, and Correction to Previous
Comment in CBTS (J. Stokes) Memorandum dated 10/18/95.
No MRID#'s. CBTS#17083. DP Barcode #D224826.
*End

*End of attachments*

February 21, 1996. Memorandum. 11 Pages. William Cutchin. Chemistry Branch.
PP#5F4546, Evaluation of Analytical Method and Residue.
Data for New Use Pattern on Lettuce. Tolerances for.
the Inadvertant Residues of Cyromazine in/on Cotton, Alfalfa and Sudangrass. Chemical# 121301, DP Barcode: .
D216971, CBTS#: 15802, MRID#: 43694401. .

July 31, 1996. Memorandum. 47 Pages. .
William Cutchin. Chemistry Branch. .
PP#6F3422, Amendment Dated 8/9/95, Response to Review and Storage Stability Study. Amendment Dated 8/9/95, .
Withdrawing Request for Wheat and Barley Tolerances. .
Tolerances for the Inadvertant Residues of Cyromazine.
in/on Cabbage, Sugar Beets, Sweet Potatoes and Sorghum. .
Attachment(s) following:

July 31, 1996. Memorandum.
William Cutchin. Chemistry Branch.
continued.
DP Barcode: D218433 and 218863.
MRID#: 43753000 through 02.

*End of attachments*

September 12, 1996. Memorandum. 31 Pages.
Stephen Dapson. Toxicology Branch.
CYROMAZINE: Review of two acute inhalation toxicity
studies and a data waiver request for the 21 day dermal
study requirement.
MRIDs 43799901, 43799902, 44060901, 44060902.
Tox review 012046.
January 10, 1997. Memorandum. 37 Pages.
Jerry Stokes. Chemistry Branch.
Cyromazine. Revised Label for Trigard 75W Insecticide.
Spray Volume Changes Proposed For Crop Groups Leafy Vegetables (except Brassica) and Cucurbit Vegetables, and RACs Chinese Mustard, Pepper, and Tomato. No MRID's.
CBTS#17600. DP Barcode# D230105. Chemical No. 121301.
Attachment(s) following:

July 16, 1993. Memorandum.
Francis Griffith. Chemistry Branch.
Multiresidue Method (MRM) Validation Data for Cyromazine (Trigard and Larvadex)
[CBTS #s 12176 and 12177]{DP Barcodes # D192978 and D192981}
MRID # 42224305.

July 16, 1993. Memorandum.
Francis Griffith. Chemistry Branch.
PP# 1F4016 - Cyromazine (Trigard) on Leafy Vegetables Except Brassica Crop Group.
PP# 2F4053 - Cyromazine (Trigard) on Cucurbit Vegetables Crop Group.
(MRID # 42224305) [CBTS 11324 and 11327] {D187702, D187707}.

December 23, 1992. Memorandum.
Francis Griffith. Chemistry Branch I.
PP# 2F4053 - Cyromazine (Trigard) on Cucurbit Vegetables Crop Group.
Review of Residue Data and Analytical Method.
(MRID # 421160-01) [CBTS # 9816] {DP Barcode D177550}.

*End of attachments*

April 22, 1997. Memorandum. 5 Pages.
Stephen Funk. Chemistry Branch.
Cyromazine Product Chemistry: Hexachlorobenzene and Pentachlorobenzene. DP Barcode D231940. CBRS 17694.
MRID 44156001.
Pages 3-5 removed and information on pages 1-2 not included, manufacturing process and quality control procedure.

March 11, 1998. Memorandum. 57 Pages.
Andrew Rathman. Registration Action Branch HED.
Cyromazine - 121301: Health Effects Division Risk
Characterization for use of the chemical Cyromazine in/on Mangoes (5E4450), Crop Group 3: Bulb Vegetables (5F4576),
Potatoes (6F4613), Cottonseed (5F4546), Sweet corn and
Radishes (6F3332). Barcode: D242798, D242799, D242801,242802.
Attachment(s) following:

December 11, 1997. Memorandum.
Andrew Rathman. Registration Action Branch HED.
Cyromazine In/On Various Crops and Meat and Milk. Chemical #121301.

July 9, 1996. Memorandum.
Jerry Stokes. Chemistry Branch.
PP#5F4546: Cyromazine In/On Crop Group 3: Bulb Vegetables. CBTS#'s 16896, 16973, and 17150. MRID#'s 43763100 and 43763101. DP Barcode#'s D219197 and D225580. Chemical No. 121301.
MRIDs (all memos) 4376301, 43826202, 43826203, 43644401.

*End of attachments*

April 15, 1998. Memorandum. 2 Pages.
Jerry Stokes. Chemistry & Exposure Branch 2.
Cyromazine. Conclusions of the Metabolism Assessment Review
Committee at Meeting of 11/04/97. Chemical No. 121301.
DP Barcode D245214.
January 10, 1999. Memorandum. 37 Pages.
Jerry Stokes. Chemistry Branch.
Cyromazine. Revised Label for Trigard 75W Insecticide.
Spray Volume Changes Proposed for Crop Groups Leafy Vegetables (except Brassica) and Cucurbit Vegetables, and RACs Chinese Mustard, Pepper and Tomato. No MRID's.
CBTS#17600. DP Barcode# D230105.
Attachment(s) following:

July 16, 1993. Memorandum. Francis Griffith. Chemistry Branch. MULTIRESIDUE METHOD (MRM) VALIDATION DATA FOR CYROMAZINE
(TRIGARD AND LARVADEX)
[CBTS #s 12176 and 12177]{DP Barcodes #sD192978 and D192981}.

July 16, 1993. Memorandum. Francis Griffith. Chemistry Branch. PP# 1F4016- Cyromazine (TRIGARD) ON LEAFY VEGETABLES (EXCEPT BRASSICA CROP GROUP).
PP# 2F4053 -CYROMAZINE (TRIGARD) ON CUCURBIT VEGETABLES CROP GROUP.
(MRID # 42224305)... {DP Barcodes D187702 and D187707}.

December 23, 1992. Memorandum.
Francis Griffith. Chemistry Branch.
PP# 2F4053 - CYROMAZINE (TRIGARD) ON CUCURBIT VEGETABLES CROP GROUP.
Review of Residue Data and Analytical Method.
(MRID # 4211600l)(CBTS # 9816){DP Barcode Dl77550}.

*End of attachments* P>

April 5, 1999. Memorandum. 71 Pages.
Jerry Stokes. Chemistry and Exposure Branch.
Reassessment of Established Cyromazine Tolerances (40 CFR 180.414) In/On Various Crops. Barcode DP D254881.
MRID 41976301.

June 9, 1999. Memorandum. Pages.
William Wassell. Registration Action Branch HED.
PP#7E4905. Cyromazine in/on Lima Bean. Evaluation of Residue Data and Analytical Methodology.
DP Barcode: D242692.
EPA Reg. No.: 100-654.
MRID No.: 44383801.

July 27, 1999. DER. 35 Pages.
Stephen Carey. Environmental Risk Branch.
71-4 - Avian Reproduction Test Mallard duck.
MRID 44743802.

August 9, 1999. Review. 2 Pages.
Thuy Nguyen. Environmental Risk Branch.
Review of New Uses:
Cyromazine (121301): Celery, Potatoes and Bulb Vegetables.
D219201, D250731, D251321.

September 17, 1999. Memorandum. 7 Pages.
William Wassell. Registration Action Branch HED.
000100-00656. Application for amended registration of Armor,
EPA Reg. No. 100-656. Removal of Restriction Against Using
Treated Mushroom Compost as Fertilizer.
DP Barcode: D242379 MRID No: 44456701, 44456702.

October 15, 1999. Review. 4 Pages.
Daniel Rieder. Environmental Risk Branch.
Review of New Uses:
Cyromazine (121301): Lima Beans.

February 10, 2000. DER. 37 Pages.
Stephen Carey. Environmental Risk Branch.
71-4 - Avian Reproduction Test
Bobwhite quail
MRID 44743801.

May 2, 2002. Memorandum. 9 Pages.
Thuy Nguyen. Environmental Risk Branch.
Review New Uses.
Cyromazine (121301): Dry Beans.
DP Barcode: D271623.
Attachment(s) following:

May 2, 2002. Memorandum.
Thuy Nguyen. Environmental Risk Branch.
Aquatic Exposure Assessment.
Revised Tier I Estimated Surface and Ground Water Assessment of Cyromazine. DP Barcode: D271623.

*End of attachments*

July 25, 2002. Memorandum. 11 Pages.
William Wassell. Registration Action Branch HED.
PP#0E06219; Cyromazine in/on Dry Beans. Review of Residue
Data and Analytical Methodology.
DP Barcode: D271622
EPA Reg. No: 100-654
MRID No.: 45220301.

February 5, 2003. Memorandum. 15 Pages.
William Wassel. Registration Action Branch HED.
PP#2E06507; Cyromazine in/on Bulb Vegetables. Review
of residue Data and Analytical Methodology.
DP Barcode: D285751.
MRID No.: 45757601, 45757602.

August 4, 2003. Memorandum. 93 Pages.
Waheeda Mani Tehseen. Registration Action Branch HED.
CYROMAZINE (PC Code 121301).
Revised Executive Summaries and DERs of Cyromazine.
DP Barcode: D284318.
Pages 40, 57-67 removed, registrant data.
Tox review 051643.

September 25, 2003. Memorandum. 14 Pages.
Rick Whiting. Technical Review Branch.
EPA File Symbol: 75802-R. SIERRA.
Acute toxicity. MRID 45936703 thru -08.
January 27, 2004. Memorandum. 4 Pages.
William Wassell. Registration Action Branch HED.
ID# 000100-00656; Cyromazine. Removal of Restiction Against
Using Treated Mushroom Compost as Fertilizer. Review
of Field Accumulation in Rotational Crops Study. DP Barcode: 280056
MRID Nos: 45564301.
January 12, 2005. DER. 4 Pages.
Mark Suarez. Insecticide Branch.
EPA Reg. No. 75802-1; Product Name: Serene Fly Control
Pellets. MRID No. 46307801 & 46307802.

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