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Index of Cleared Science Reviews

Index for Harvade (Pc Code 118901)

July 7, 1976. Review. 5 Pages.
R. Felthousen. Efficacy and Ecological Effects Branch.
Exp. Permit No. 400-EUP-53. Harvade. EUP (Cotton).

July 12, 1976. Review. 5 Pages.
W. Greear. Toxicology Branch.
Registration Human Safety Review - Harvade. 400-EUP-53.
Tox Review 003861.
Pages 3-5 are not included - draft label.

September 9, 1976. Review. 7 Pages.
Ronald Ney. Efficacy and Ecological Effects Branch.
Exp. Permit No. 400-EUP-53. Harvade. EUP on Cotton.

May 13, 1977. Review. 7 Pages.
R.W. Felthousen. Efficacy and Ecological Effects Branch.
Exp. Permit No. 400-EUP-53. Harvade.
EUP (Cotton) (Amendment) & Potatoes.

June 17, 1977. Review. 5 Pages.
Ronald Ney. Efficacy and Ecological Effects Branch.
Reg. No. 400-EUP-53. Petition No. 7G1938. Harvade.
EUP on Cotton and Potatoes.

June 30, 1978. Review. 4 Pages.
Robert Carsel. Efficacy and Ecological Effects Branch.
Reg. No. 400-EUP-53. Harvade. Revised Report -
Hydrolysis and Status Report.

July 28, 1978. Review. 3 Pages.
Robert Carsel. Environmental Fate Branch.
Reg. No. 400-EUP-53. Harvade. Submission of Revised
Supplemental Report and Current Status Report on the
Experimental Use Permit.

August 8, 1978. Efficacy Review. 6 Pages.
Sami Malak. Efficacy and Ecological Effects Branch.
Exp. Permit No. 400-EUP-53. Harvade.
Review of Second Quarterly Report Containing Drift Study.

August 11, 1978. Review. 10 Pages.
Robert Holst. Efficacy and Ecological Effects Branch.
Exp. Permit No. 400-EUP-53. Harvade. Review of Second
Quarterly Report Containing Drift Study and 48-Hr. LC50
in Daphnia.

May 13, 1980. Review. 2 Pages.
Robert Holst. Ecological Effects Branch.
Exp. Permit No. 400-EUP-53. Harvade 5F.
Review of Spray Drift Protocol.

August 13, 1980. Memorandum. 7 Pages.
Nancy Dodd. Residue Chemistry Branch.
PP #7G1939. Harvade on Potatoes and Cottonseed.
Amendment of 3/3/80.
Inert ingredient information on pages 1-3 is not included.

May 11, 1981. Review. 11 Pages.
Willa Garner. Environmental Fate Branch.
Reg. No. 400-EUP-53. Harvade. Request to Change Crop
Rotation Restriction from 12 Months to 6 Months.
Pages 10-11 are not included - draft label.

September 23, 1981. Review. 6 Pages.
Robert Holst. Ecological Effects Branch.
Harvade 5F (Liquid). Phototoxicity Study - Greenhouse -
Vegetative Vigor. Accession No. 070239.

September 25, 1981. Review. 9 Pages.
Daniel Rieder. Ecological Effects Branch.
File No. 400-RLL. Harvade 5F.
Proposed Full 3 (c)(5) Registration of Cotton and Potato
Uses.

December 1, 1981. Review. 107 Pages.
Willa Garner. Environmental Fate Branch.
File No. 400-RLL. Harvade 5F.
New Chemical - Use on Cotton and Potatoes.

February 3, 1982. Memorandum. 28 Pages.
William Dykstra. Toxicology Branch.
Harvade in/on Cotton and Potatoes; PP #1F2560, 1H5317.
Caswell #472AA; Accession Nos. 070235, 070237, -8.
Tox Review 001417.
Page 3 reemoved, confidential statement of formula.

February 22, 1982. Memorandum. 5 Pages.
William Dykstra. Toxicology Branch.
Harvade in/on Cotton and Potatoes. PP #1F2560, 1H5317.
Caswell #472AA. Accession #070684.
Rat reproduction study.
Tox review 001472.

March 9, 1982. Memorandum. 12 Pages.
Alfred Smith. Residue Chemistry Branch.
PP #1F2560/FAP #1H5317: Harvade on Cotton and Potatoes.
Evaluation of Residue Data, Analytical Method, and
Amendment of 1/20/82.
Manufacturing process information on pages 3-4, and inert
ingredient information on page 4 are not included.

April 12, 1982. Review. 18 Pages.
Willa Garner. Environmental Fate Branch.
File No. 400-RLL. Harvade. Response to EFB Review.
Pages 6-18 removed, registrant data.

August 6, 1982. Memorandum. 2 Pages.
R.S. Quick. Residue Chemistray Branch.
PP #1F2560/FAP #1H5317: Harvade on Various Commodities.
Amendment of 7/22/82 and Comments on Method Trial.

September 29, 1982. Memorandum. 2 Pages.
Alfred Smith. Residue Chemistry Branch.
PP #2F2737: Harvade in Potatoes. Evaluation of Analytical
Method and Residue Data.

November 2, 1982. Memorandum. 4 Pages.
Deloris Graham. Fungicide-Herbicide Branch.
EPA Registration No. 400-155. Harvade 5F.
Acute inhalation; acute dermal toxicity studies.
Pages 3-4 removed, draft label.
Tox review 004959.

November 12, 1982. Review. 7 Pages.
Samuel Creeger. Evironmental Fate Branch.
Reg. No. 400-155. Harvade. Provide Toxicology Branch with
Applicator Exposure Assessment - Expedited Request.

December 15, 1982. Memorandum. 2 Pages.
William Dykstra. Toxicology Branch.
Harvade; Request for Additional Data. Caswell #472AA.

April 8, 1983. Review. 32 Pages.
Michael Rexrode. Ecological Effects Branch.
Reg. No. 400-155. Harvade 5F. Submission of Data for
Review.

April 15, 1983. Review. 18 Pages.
Richard Moraski. Exposure Assessment Branch.
Reg. No. 400-155. Harvade. Human Exposure Analysis.
Pages 6-18 removed, registrant data.

May 12, 1983. Memorandum. 1 Page.
William Dykstra. Toxicology Branch.
Harvade; Reevaluation of Slides of Chronic Mouse and Rat
Studies. Caswell No. 472AA.

June 21, 1983. Presentation. 12 Pages.
Louis Kasza. Toxicology Branch.
SAP, Harvade Meeting. Interpretation of Pathologic Changes.

June 30, 1983. Memorandum. 1 Page.
William Dykstra. Toxicology Branch.
Harvade; 3(c)(2)b Request for Additional Metabolism and
Mutagenicity Data. Caswell No. 472AA.

July 26, 1983. Memorandum. 3 Pages.
William Burnam. Toxicology Branch.
Conclusions on the Evaluation of Health Risks of Harvade.

July 27, 1983. Memorandum. 3 Pages.
William Dykstra. Toxicology Branch.
PP #1F2560/1H5317; Harvade in/on Cotton.

August 16, 1983. Memorandum. 18 Pages.
George Ghali. Toxicology Branch.
Harvade; EPA Reg. No. 400; Dermal Absorption; Interim and
Final Reports. Caswell No. 472AA, Accession No's.
249719 and 250092.
Pages 15-16 removed, registrant data.
Tox review 003152.

August 17, 1983. Memorandum. 4 Pages.
Douglas Campt. Registration Division.
Harvade.

September 7, 1983. Review. 7 Pages.
Richard Moraski. Exposure Assessment Branch.
Reg. No. 400-155. Harvade. Amend Crop Rotation Restriction.

September 27, 1983. Memorandum. 3 Pages.
Michael Rexrode. Ecological Effects Branch.
Harvade: Evaluation of Raw Data for Daphnia Study.

July 6, 1984. Memorandum. 6 Pages.
William Dykstra. Toxicology Branch.
Harvade; in vitro chromosome analysis in CHO.
Acc #072195
Tox review 002358.

March 12, 1986. Review. 3 Pages.
Reto Engler. Toxicology Branch.
Reference Doses (RFDs) for Oral Exposure -
Dimethipin/Harvade.

April 8, 1986. Review. 5 Pages.
George Ghali. Health Effects Division.
Dimethipin
Reference Dose for Chronic Oral Exposure (RfD)
Uniroyal Chemical Co., 1981a
2-Year Rat Feeding Study. MRID 00145225.

August 20, 1986. Memorandum. 2 Pages.
William Dykstra. Toxicology Branch.
Harvade; EPA Reg. No. 400-155; Subchronic Mouse Study.
Accession No. 263214
Tox Review 005371.

August 28, 1986. Memorandum. 11 Pages.
John Quest. Toxicology Branch.
Peer Review of Harvade.

May 28, 1987. Review. 2 Pages.
Carl Grable. Fungicide-Herbicide Branch.
Efficacy Review.
Reg. No. 400-155 and 400-398.
Revised labeling: tank mix rate
and rotational crop statement.

June 21, 1988. Review. 3 Pages.
Paul Mastradone. Exposure Assessment Branch.
Reg. Nos. 400-155, 400-398. Dimethipin. Review Crop
Rotation Data/Statement for Small Grains.

October 5, 1989. Memorandum. 11 Pages.
William Dykstra. Toxicology Branch.
Harvade - Submission of Uniroyal Response to Peer
Review Committee Evaluation of Harvade.

October 25, 1989. Memorandum. 6 Pages.
Bernice Fisher. Science Analysis and Coordination Branch.
Harvade - Statistical Tests on Rat (Hazleton, Squire and
EPL Evaluations) and Mouse (Hazleton and EPL Evaluations)
Data for Selected Tumors. Caswell No. 472AA.

November 21, 1989. Memorandum. 1 Page.
Reto Engler. Science Analysis and Coordination Branch.
Harvade (Dimethipin)
The HED Peer review Committee has concluded that the rat
study was not conducted at a dose high enough to adequately
evaluate the carcinogenic potential of Harvade and must
therefore be repeated.

January 5, 1990. Memorandum. 13 Pages.
Esther Rinde. Science Analysis and Coordination Branch.
Second Peer Review of Harvade.

July 31, 1990. Review. 17 Pages.
Paul Mastradone. Environmental Fate & Ground Water Branch.
Reg. No. 400-155. Dimethipin (Harvade). Label Amendments
and Response to EPA on Crop Rotation Revisions.

December 7, 1995. Memorandum. 6 Pages.
Bernard Schneider. Chemistry Branch.
ID# 000400-00155, 000400-00398. Review of label amendment
for Dimethipin (Harvade-5F, Harvade 25F Harvest Growth
Regulant) to Determine if Established Tolerances Cover the
Proposed Uses for Cotton. MRID# None. ...

February 20, 1997. Review. 1 Page.
Bruce Kitchens. Registration Support Branch RD.
Reg. No. 400-398.
data requirements... with respect to product composition
and description of materials... are satisfied.
data requirements... with respect to certified limits is
satisfied...

April 30, 2001. Memorandum. 10 Pages.
Masih Hashim. Technical Review Branch RD.
EPA Reg. No. 400-398 b.
This memo is an amendment to the last one issued 4-27-2001.
Uniroyal Company has requested a revision of the toxicology
profile for its product Harvade-25F. (Acute studies.)
MRIDs 132412 thru 132414, 441615-01, -02, 412646-04.

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