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Index of Cleared Science Reviews
Index for Pay-Off (Pc Code 118301)
Undated. Memorandum. 5 Pages.
Herbert Manning. Environmental Fate Branch.
Environmental Fate Profile and Calculation of Estimated
Environmental Concentrations in Water and Hydrosoil for
the Insecticide Pay-Off (AC 222, 705).
Undated. Review. 7 Pages.
Herbert Manning. Environmental Fate Branch.
1. Introduction...
Trade Name: PAY-OFF
This submission is an application to register new pesticide
(chemical) for use on cotton
Acc. 099383.
July 19, 1979. Memorandum. 1 Page.
Albin Kocialski. Toxicology Branch.
Toxicology Review of 241-EUP-OU on a Crop Destruct Basis.
Acute Studies Reviewed Only.
September 4, 1979. Review. 10 Pages.
R.W. Cook. Environmental Fate Branch.
File No. 241-EUP-OU, 9G2211. AC 222, 705 2.5 EC. Cotton.
September 18, 1979. Memorandum. 1 Page.
Herbert Harrison. Insecticide-Rodenticide Branch.
Request for Expeditious Consideration of Toxicology and
Residue Chemistry Review for Pesticide Petition No. 9G2211.
September 28, 1979. Memorandum. 5 Pages.
A. Rathman. Residue Chemistry Branch.
PP #9G2211. AC 222,705 on Cotton. Evaluation of Analytical
Method and Residue Data.
Manufacturing process information on pages 2 and 3 is not
included. Inert ingredient information on page 3 and quality
control procedure information on page 4 are not included.
October 1, 1979. Memorandum. 38 Pages.
Albin Kocialski. Toxicology Branch.
Review of Submitted Data Regarding AC 222,705. Request for
an Experimental Use Permit and Temporary Tolerance on Cotton
Seed by American Cyanamid.
Quality control procedure information on page 3, and inert
ingredient information on page 4 are not included.
October 2, 1979. Memorandum. 2 Pages.
Edwin Budd. Toxicology Branch.
PP 9G2211. AC 222,705 in or on Cotton Seed.
8-Point Free-Standing Summary.
October 2, 1979. Memorandum. 4 Pages.
Edwin Budd. Toxicology Branch.
Additional Toxicological Opinion on PP 9G2211. Request for
a Temporary Tolerance of 0.05 ppm in or on Cotton Seed for
Residues of AC 222,705.
October 26, 1979. Memorandum. 3 Pages.
A. Rathman. Residue Chemistry Branch.
PP #9G2211. AC 222,705 on Cotton. Amendment Dated 10/15/79.
November 28, 1979. Letter. 2 Pages.
Douglas Campt. Registration Division.
AC 222,705.
November 28, 1979. Memorandum. 1 Page.
Albin Kocialski. Toxicology Branch.
AC 222,705. Requirement for a Six-Month Dog Study in
Partial Fulfillment for Obtaining a Permanent Tolerance.
February 21, 1980. Memorandum. 7 Pages.
Albin Kocialski. Toxicology Branch.
The February 15 Meeting Between EPA and the Representatives
of American Cyanamid Regarding AC 222,705.
May 27, 1980. Memorandum. 3 Pages.
Albin Kocialski. Toxicology Branch.
(1) PP #9G2211/FAP #0H5262. A Pesticide Petition Proposing
a Temporary Tolerance of 0.10 ppm for the Residues of
Pay-Off Insecticide (AC 222,705) in or on Cottonseed and a
FAP #0H5262 Requesting a Food Additive Tolerance of 0.2 ppm
in Refined Cottonseed Oil. (2) A Request for the Renewal..
May 28, 1980. Memorandum. 4 Pages.
Residue Chemistry Branch.
PP #9G2211. AC 222,705 on Cottonseed. Amendment of 3/14/80.
June 25, 1980. Notice. 5 Pages.
Office of Pesticide Programs. Environmental Protection Agency.
Pesticides Contaminated with N-nitroso Compounds; Proposed
Policy. Federal Register Notice, Vol. 45, No. 124,
Pages 42854-42858.
July 25, 1980. Memorandum. 10 Pages.
Albin Kocialski. Toxicology Branch.
AC 222,705 (Pay-Off). Thyroid Function Study.
Pages 6-8 are not included - registrant data.
August 7, 1980. Memorandum. 3 Pages.
Martha Bradley. Residue Chemistry Branch.
PP #0F2347/0H5257. AC 222,705 on Cottonseed. Evaluation of
Analytical Method and Residue Data.
December 22, 1980. Review. 2 Pages.
Willa Garner. Environmental Fate Branch.
File No. 241-ELO. Pay-Off. Data Evaluation.
April 3, 1981. Memorandum. 2 Pages.
Albin Kocialski. Toxicology Branch.
PP #9G2211/241-EUP-94/Accession No. 099909/Casw. No. 2AA.
The American Cyanamid Company Has Requested an Extension and
Expansion for Their Experimental Use Permit - the Use of
Pay-Off on Cotton.
October 26, 1981. Memorandum. 10 Pages.
Alfred Smith. Residue Chemistry Branch.
PP #0F2347/FAP #0H5257. Pay-Off (CL 222,705) on Cotton.
Amendments of 6/4/81 and 7/23/81.
Inert ingredient information on page 1 is not included.
Pages 2-6 are not included - registrant data.
October 26, 1981. Review. 86 Pages.
Toxicology Branch.
Pay-Off.
November 3, 1981. Review. 11 Pages.
Willa Garner. Environmental Fate Branch.
File No. 241-ELO. Pay-Off. Data to Support Cotton Use.
November 3, 1981. Memorandum. 2 Pages.
Alfred Smith. Residue Chemistry Branch.
PP #0F2347/FAP #0H5257. Pay-Off (CL 222,705) on Cotton.
Addendum of 10/30/81.
November 4, 1981. Memorandum. 1 Page.
Alfred Smith. Residue Chemistry Branch.
PP #0F2347/FAP #0H5257. Pay-Off (CL 222,705) on Cottonseed.
Method Trial Request.
November 6, 1981. Memorandum. 2 Pages.
Albin Kocialski. Toxicology Branch.
PP #0F2347/FAP #0H5257. Pay-Off (CL 222,705) on Cotton.
The Toxicological Significance of 3 Metabolites Found as
Residues in/on Cottonseed. Accession No. 070146.
Manufacturing process information on page 2 is not included.
November 13, 1981. Memorandum. 8 Pages.
Albin Kocialski. Toxicology Branch.
The American Cyanamid Company Proposes that the Following
Permanent Tolerance (PP #0F2347) Be Established for the
Pesticide... Pay-Off in or on... Cottonseed at 0.1 ppm.
Quality control procedure information on page 2, and
inert ingredient information on page 3 are not included.
November 13, 1981. Memorandum. 4 Pages.
Albin Kocialski. Toxicology Branch.
PP #0F2347/FAP #0H5257. A Pesticide Petition Proposing a
Permanent Tolerance of 0.1 ppm for Residues of Pay-Off
in/on Cottonseed and a Food Additive Tolerance of 0.2 ppm in
Refined Cottonseed Oil. 8-Point Free Standing Summary.
EPA File Symbol No. 241-ELO.
November 20, 1981. Memorandum. 3 Pages.
Franklin Gee. Insecticide-Rodenticide Branch.
Consideration of Conditional Registration for Use of the
New Synthetic Pyrethroid Pay-Off... on Cotton.
December 21, 1981. Review. 8 Pages.
Willa Garner. Environmental Fate Branch.
Removal of One-Year Crop Rotation Restriction.
Pages 6-8 are not included - draft label.
February 23, 1982. Review. 5 Pages.
Willa Garner. Environmental Fate Branch.
EUP - Use on Apples.
Pages 4-5 are not included - draft label.
February 23, 1982. Review. 5 Pages.
Willa Garner. Environmental Fate Branch.
EUP - Use on Pears.
Pages 4-5 are not included - draft label.
February 25, 1982. Review. 3 Pages.
Willa Garner. Environmental Fate Branch.
Data to Support Removal of Crop Rotation Restriction.
March 11, 1982. Memorandum. 4 Pages.
R. Loranger. Residue Chemistry Branch.
PP #2G2621 and PP #2G2622. AC 222,705 (Pay-Off) on Pears
Apples, Respectively. Evaluation of Analytical Method and
Residue Data.
March 16, 1982. Review. 1 Page.
Albin Kocialski. Toxicology Branch.
Apples at 1.0 ppm.
March 16, 1982. Review. 1 Page.
Albin Kocialski. Toxicology Branch.
Pears at 0.05 ppm.
March 22, 1982. Memorandum. 9 Pages.
Richard Loranger. Residue Chemistry Branch.
PP #2G2621 and PP #2G2622. AC 222,705 (Pay-Off) on Pears
and Apples, Respectively. Evaluation of Analytical Method
and Residue Data.
Manufacturing process and inert ingredient information on
page 3 are not included.
May 3, 1982. Review. 9 Pages.
Willa Garner. Environmental Fate Branch.
Soil Data to Support Crop Rotation Data.
Pages 7-9 are not included - draft label.
October 21, 1982. Memorandum. 14 Pages.
Albin Kocialski. Toxicology Branch.
Pay-Off (Flucythrinate). PP #0F2347. Assay for Total
Residue of Parent.
Pages 2-10 are not included - registrant data.
November 3, 1982. Memorandum. 5 Pages.
Albin Kocialski. Toxicology Branch.
Pay-Off 2.5 EC. EPA Reg. No. 241-259. Dermal Sensitization
Studies. Accession No. 070145.
Commercial/financial information, and inert ingredient
information on page 4 are not included.
November 22, 1982. Review. 10 Pages.
Emil Regelmen. Environmental Fate Branch.
Reg. No. 241-259. Pay-Off. Use on Pears.
Pages 4-10 are not included - draft label.
January 17, 1983. Review. 3 Pages.
Carolyn Offutt. Environmental Fate Branch.
Opinion of EFB on Reentry Issues.
January 19, 1983. Review. 3 Pages.
Emil Regelman. Environmental Fate Branch.
Review Rotational Crop Data.
January 19, 1983. Review. 6 Pages.
Emil Regelman. Environmental Fate Branch.
Reg. No. 241-259. Pay-Off. Label Amendment, Use on Apples.
Pages 3-6 are not included - draft label.
January 25, 1983. Memorandum. 8 Pages.
Jesse Mayes. Residue Chemistry Branch.
PP #2F2754. Flucythrinate (Pay-Off) in or on Pears.
Evaluation of Residue Data and Analytical Methodology.
Manufacturing process and inert ingredient information on
page 2 are not included.
February 23, 1983. Memorandum. 4 Pages.
Albin Kocialski. Toxicology Branch.
Application for an Extension and Amendment of Experimental
Use Permit 241-EUP-99 for the Use of Pay-Off on Apples at
1.0 ppm, Grown for Fresh Market Only. PP #2G2622.
Accession No. 071376.
February 25, 1983. Memorandum. 5 Pages.
Edward Zager. Residue Chemistry Branch.
PP #3G2796. Flucythrinate Cattle Ear Tags. Evaluation of
Analytical Methods and Residue Data.
Inert ingredient information on pages 1-2, and manufacturing
process information on page 3 are not included.
February 28, 1983. Memorandum. 5 Pages.
Albin Kocialski. Toxicology Branch.
Pay-Off. PP #3F2806/FAP #3H5381, Accession No. - Not Given.
A Request for Permanent Tolerances in/on Apples (1.0 ppm);
A Food Additive Tolerance for Cattle Meat and Meat
Byproducts (0.10 ppm), the Fat of Cattle (1.0 ppm), Whole
Milk (0.3 ppm) and Milk Fat (6.0 ppm)..
March 31, 1983. Memorandum. 4 Pages.
Richard Loranger. Residue Chemistry Branch.
PP #2G2622. Flucythrinate (Pay-Off) on Apples. Request for
Extension of Temporary Tolerance.
Pages 3-4 are not included - registrant data.
May 3, 1983. Memorandum. 7 Pages.
Albin Kocialski. Toxicology Branch.
Pay-Off 2.5 EC. The American Cyanamid Company Requests an
Experimental Use Permit (241-EUP-103) and Concurrently
Petitions for a Temporary Tolerance of 0.05 ppm (PP #3G2842)
in Conjunction with the Pesticide Use on Field Corn and
Sweet Corn. (Accession No. 071429).
May 10, 1983. Memorandum. 1 Page.
Douglas Campt. Registration Division.
Request for Expeditious Review of the Attached Data
Concerning Nitrosamines Contamination.
Quality control process information is not included.
May 17, 1983. Memorandum. 1 Page.
Albin Kocialski. Toxicology Branch.
Pay-Off. EPA Reg. No. 241-259. Request by D. Campt,
Division Director, Registration Division, for an Expeditious
Review of the Lifetime Risk Analysis for Exposure to Pay-Off
Insecticide Contaminated by Volatile Nitrosamines.
Manufacturing process information is not included.
May 23, 1983. Review. 3 Pages.
Richard Moraski. Exposure Assessment Branch.
Review In-House Data to Support Proposed EUP on Field
Corn and Sweet Corn.
Page 3 is not included - draft label.
May 23, 1983. Memorandum. 3 Pages.
Albin Kocialski. Toxicology Branch.
Pay-Off. EPA Reg. No. 241-259. (1) Nitrosamine
Contamination of the Technical and Formulated Product.
(2) Lifetime Risk Analysis for Exposure to Pay-Off
Insecticide Contaminated by Volatile Nitrosamines...
Manufacturing process information on pp. 1-2 is not included.
May 24, 1983. Review. 2 Pages.
Richard Moraski. Exposure Assessment Branch.
Data Submitted in Response to Review.
May 26, 1983. Memorandum. 1 Page.
Herbert Harrison. Insecticide-Rodenticide Branch.
Nitrosamine Level in Pay-Off Technical Grade of the Active
Ingredient (241-259).
May 26, 1983. Memorandum. 7 Pages.
Edward Zager. Residue Chemistry Branch.
PP #3G2842. Flucythrinate on Field and Sweet Corn.
Evaluation of Analytical Method and Residue Data.
Manufacturing process information on page 3 is not included.
June 7, 1983. Review. 23 Pages.
Richard Moraski. Exposure Assessment Branch.
Data Submitted to Fill Gaps for Registration.
Pages 12-23 are not included - registrant data.
June 7, 1983. Memorandum. 3 Pages.
Albin Kocialski. Toxicology Branch.
PP #3F2806/3H5381. Flucythrinate (Pay-Off) on Apples.
Residue Chemistry Branch Deferral as to Toxicology Branch's
Concern with Various Metabolites Found in the Milk, Kidney
and Liver of Goats.
Manufacturing process information on page 2 is not included.
Attachment(s) following:
April 28, 1983. Memorandum. 12 Pages.
Martha Bradley. Residue Chemistry Branch.
PP #3F2806/3H5381. Flucythrinate on Apples. Evaluation
of Analytical Method and Residue Data.
Manufacturing process and inert ingredient information on
page 3 is not included.
*End of attachments*
July 13, 1983. Memorandum. 11 Pages.
Sami Malak. Residue Chemistry Branch.
PP #3G2869. Flucythrinate (AC 222,705 or Pay-Off) on
Soybeans. Evaluation of Analytical Method and Residue Data.
Manufacturing process and inert ingredient information on
page 3 are not included. Commercial/financial information
on page 4 is not included.
July 13, 1983. Memorandum. 3 Pages.
Albin Kocialski. Toxicology Branch.
Pay-Off 2.5 EC. The American Cyanamid Company Requests an
Experimental Use Permit (241-EUP-RNA) and Concurrently
Petitions for a Temporary Tolerance of 0.05 ppm (PP #3G2869)
in Conjunction with the Pesticide Use on Soybeans...
Manufacturing process information on pp. 1-2 is not included.
July 13, 1983. Memorandum. 1 Page.
Albin Kocialski. Toxicology Branch.
Nitrosamine Levels in Pay-Off Technical Grade of Active
Ingredient (EPA Reg. No. 241-259). Toxicology Branch
Response to Mr. Herbert Harrison's Memorandum Dated
May 26, 1983.
Attachment(s) following:
May 27, 1983. Memorandum. 2 Pages.
Albin Kocialski. Toxicology Branch.
Nitrosamine Levels in Pay-Off Technical Grade of the Active
Ingredient (EPA Reg. No. 241-259). Toxicology Branch
Response to Mr. Herbert Harrison's Memorandum Dated
May 26, 1983.
Manufacturing process information on pp. 1-2 is not included.
*End of attachments*
July 19, 1983. Memorandum. 4 Pages.
Martha Bradley. Residue Chemistry Branch.
PP #3F2806/3H5381. Flucythrinate on Apples.
Amendment of 5/18/83.
July 19, 1983. Review. 3 Pages.
Albin Kocialski. Toxicology Branch.
Apples at 1.0 ppm; Meat and Meat Byproducts of Cattle,
Goats, Hogs, Horses and Sheep at 0.10 ppm; Fat of
Cattle, Goats, Hogs, Horses and Sheep at 1.0 ppm;
Whole Milk at 0.10 ppm; Milk Fat at 2.0 ppm; Apple
Pomace at 10.0 ppm.
August 16, 1983. Memorandum. 9 Pages.
Albin Kocialski. Toxicology Branch.
Guardian Insecticide Cattle Ear Tags. EPA File No. 241-ETR.
Accession No. 071697. Active Ingredient is Flucythrinate.
Commercial/financial information on pages 1 and 2, and
inert ingredient information on pages 2, 3-4 (entire pages),
5, 6, and 8 are not included.
September 8, 1983. Memorandum. 1 Page.
Martha Bradley. Residue Chemistry Branch.
PP #3F2806/3H5381. Flucythrinate on Apples, Meat and Milk.
Results of Method Trial, 8/23/83.
September 14, 1983. Review. 3 Pages.
Albin Kocialski. Toxicology Branch.
2.0 ppm for Head and Leaf Lettuce and Request for Amended
Registration of 241-259.
October 7, 1983. Review. 10 Pages.
Richard Moraski. Exposure Assessment Branch.
Use on Lettuce.
Pages 3-10 are not included - draft label.
October 7, 1983. Review. 6 Pages.
Richard Moraski. Exposure Assessment Branch.
Rotational Crop Consideration.
Pages 5-6 are not included - inert ingredient information.
November 4, 1983. Memorandum. 2 Pages.
Martha Bradley. Residue Chemistry Branch.
PP #3F2806/3H5381. Flucythrinate on Apples.
Amendment of 9/8/83.
November 17, 1983. Review. 14 Pages.
Samuel Creeger. Exposure Assessment Branch.
Use of Cabbage.
Pages 3-14 are not included - draft label.
November 18, 1983. Memorandum. 8 Pages.
Martha Bradley. Residue Chemistry Branch.
PP Nos. 3F2937 and 4F2969. Flucythrinate on Lettuce and
Cabbage. Evaluation of Analytical Method and Residue Data.
Manufacturing process information on page 3, and inert
ingredient information on pages 3-4 are not included.
February 2, 1984. Review. 3 Pages.
Albin Kocialski. Toxicology Branch.
1.5 ppm in/on Cabbage and Request for Amended Registration
of 241-259.
May 31, 1984. Memorandum. 2 Pages.
Lynn Bradley. Residue Chemistry Branch.
PP #3G2842. Flucythrinate on Corn. Extension of Temporary
Tolerances. Accession No. 072381.
July 19, 1984. Memorandum. 22 Pages.
Michael Firestone. Residue Chemistry Branch.
PP #4F3077/FAP #4H5431: Flucythrinate on Field and Sweet
Corn, and Tomatoes. Evaluation of Analytical Methods...
Manufacturing process information on page 7, and pending
registration action information on pages 13 and 18 are not
included. Pages 19-20 are not included - registrant data.
July 24, 1984. Memorandum. 2 Pages.
Clinton Fletcher. Exposure Assessment Branch.
Registration Standard on a New Chemical.
August 7, 1984. Memorandum. 6 Pages.
Michael Firestone. Residue Chemistry Branch.
PP #4F3110/FAP #4H5436. Flucythrinate on Sweet and Field
Corn. Evaluation of Analytical Methods and Residue Data.
(Accession No. 072592).
August 13, 1984. Note. 4 Pages.
Clinton Fletcher. Exposure Assessment Branch.
Note to John Tice and Adam Heyward Concerning EAB Comments
on the Flucythrinate Registration Standard Package.
August 13, 1984. Memorandum. 2 Pages.
Leung Cheng. Residue Chemistry Branch.
PP #3G2869. Temporary Tolerance Extension of Pay-Off
(Flucythrinate) on Soybeans.
August 21, 1984. Review. 7 Pages.
Samuel Creeger. Exposure Assessment Branch.
Add New Use on Field and Sweet Corn.
August 23, 1984. Memorandum. 6 Pages.
Martha Bradley. Residue Chemistry Branch.
PP Nos. 3F2937 and 4F2969. Flucythrinate on Lettuce and
Cabbage. Amendments of June 8 (3F2937) and 15 (4F2969),
1984.
August 29, 1984. Memorandum. 2 Pages.
Albin Kocialski. Toxicology Branch.
Pay-Off Insecticide for Use on Soybeans. PP #3G2869.
Extension of the Experimental Use Permit (241-EUP-106) to
July 18, 1985.
September 19, 1984. Review. 7 Pages.
Samuel Creeger. Exposure Assessment Branch.
Review Data - No Specific Use.
September 24, 1984. Review. 4 Pages.
Albin Kocialski. Toxicology Branch.
2.0 ppm in/on Cabbage.
September 24, 1984. Review. 3 Pages.
Albin Kocialski. Toxicology Branch.
1.0 ppm in/on Lettuce.
October 18, 1984. Memorandum. 5 Pages.
Albin Kocialski. Toxicology Branch.
Pay-Off (Flucythrinate 30.0% a.i.) PP #4F3110/4H5436.
A Request for Permanent Tolerances in/on Field Corn and
Sweet Corn.
October 31, 1984. Review. 4 Pages.
Samuel Creeger. Exposure Assessment Branch.
Reg. No. 241-259. Pay-Off. Consider Response to EAB
Question on Soil Residues.
November 19, 1984. Memorandum. 11 Pages.
Martha Bradley. Residue Chemistry Branch.
PP #3F2937. Flucythrinate on Lettuce. Amendment of 9/5/84.
December 14, 1984. Memorandum. 4 Pages.
Marion Copley. Toxicology Branch.
Review of Submitted Data Regarding AC 222,705 (Pay-Off) in
Support of Pesticide Petition Proposing a Permanent
Tolerance of 0.1 ppm of Residues in/on Cottonseed, and a
0.2 ppm Food Additive Tolerance in Refined Cottonseed Oil,
American Cyanamid Company.
December 17, 1984. Memorandum. 8 Pages.
Albin Kocialski. Toxicology Branch.
(1) Review of Acute Inhalation Study in Rats with
AC 222,705 (Pay-Off; EPA Reg. No. 241-259; 30% a.i.).
(2) Review of Additionally Submitted Data and Response to
Toxicology Branch Questions Raised in a Previous Review of
Data Submissions Associated with a Permanent Tolerance..
February 20, 1985. Memorandum. 7 Pages.
Michael Firestone. Residue Chemistry Branch.
PP #4F3110/FAP #4H5436 (RCB Nos. 598 and 599).
Flucythrinate (Pay-Off) on Field Corn. Evaluation of
Amendment Dated January 23, 1985. (Accession No. 073289).
March 7, 1985. Memorandum. 9 Pages.
Albin Kocialski. Toxicology Branch.
Pay-Off (Flucythrinate 30.0% a.i.). Revised Section F
PP #4F3110/4H5436, for Corn Grain, Corn Forage and Corn
Fodder (Stover).
Manufacturing process information on page 9 is not included.
March 25, 1985. Memorandum. 5 Pages.
William Greear. Toxicology Branch.
Guardian Insecticide Swine Ear Tag. EPA File Symbol
241-EIN. (Active Ingredient: 10% Flucythrinate).
Inert ingredient information on pages 1-2 is not included.
Pages 4-5 are not included - draft label.
May 10, 1985. Memorandum. 4 Pages.
R.W. Cook. Residue Chemistry Branch.
Accession No. 073347. (RCB No. 671). PP #4F2969:
Flucythrinate in or on Cabbage. Amended Section D,
Letter of 2/8/85.
March 31, 1986. Memorandum. 29 Pages.
William Greear. Toxicology Branch.
(1) Pay-Off Insecticide (Flucythrinate) - Submission of a
2-Year Dog Feeding Study as a Requirement for Conditional
Registration (EPA Reg. No. 241-259). Accession Nos. 257106-
257108. (2) Recalculation of the ADI Value...
Pages 20-29 are not included - registrant data.