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Index of Cleared Science Reviews for Prodiamine (Pc Code 110201)

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June 27, 1980. Data Eval. Rec. 19 Page(s).
Clayton Bushong. Ecological Effects Branch.
Fish Acute LC50; Rainbow Trout, Bluegill Sunfish, Channel Catfish. Avian
Acute Oral LD50; Bobwhite Quail,Mallard Duck. Bioaccumulation Study;
Channel Catfish. Invertebrate LC50; Daphnia magna.
Document (PDF) (1411 KB PDF).

November 21, 1986. Memorandum. 16 Page(s).
Francis Suhre. Residue Chemistry Branch.
Prodiamine: Product Chemistry Data. Pages 7-16 removed, inert
ingredient information, product manufacturing process and quality control
procedure info.
Document (PDF) (358 KB PDF).

January 09, 1987. Review. 70 Page(s).
Allen Vaughan. Ecological Effects Branch.
Proposed Registration of New Technical Chemical and End-Use
Formulations for Use on Turf, Ornamentals, and Tree and Vine Crops.
Pending registration info on page 1 & Commercial/Financial info on pages
2-5 not included. Pages 32-70 removed, draft label.
Document (PDF) (1531 KB PDF).

January 12, 1987. Memorandum. 80 Page(s).
Winnie Teeters. Toxicology Branch.
Registration of Endurance 65 WDG Herbicide. Accession 263378,
260680, 263739, 26372. Pages 15, 21-22, 27-28, 33-34, 42, 44, 46-47,
50-55, 59, 63-65, 67-69, and 71-78 removed, registration data. Tox
review 005656.
Document (PDF) (3098 KB PDF).

March 27, 1989. Memorandum. 5 Page(s).
Freshteh Toghrol. Dietary Exposure Branch.
55947-UE (Endurance 65WDG Herbicide) on Non-bearing Orchards of
Fruit, Nuts and Vines crops; 55947-UG (Prodiamine 65WDG Herbicide)
for use on Turf and Ornamentals; Response to Product Chemistry
Review of Prodiamine 11/26/86.
Document (PDF) (246 KB PDF).
Attachment(s) Following:

March 27, 1989. Memorandum. 5 Pages.
Freshteh Toghrol. Dietary Exposure Branch.
(continued) Product impurity information on page 3 is not included.
(MRID # 402293-13 ; DEB # 4957 and 4958).

*End of Attachments*

May 05, 1989. Review. 20 Page(s).
James Akerman. Ecological Effects Branch.
Resubmission with data to support proposed registration of new
chemical for use on turf and non-bearing trees, nuts and vines. Privacy
act data on page 1 is not included. Pages 11-12 removed, registrant data.
Document (PDF) (1074 KB PDF).

August 18, 1989. Review. 103 Page(s).
Emil Regelman. Environmental Fate & Ground Water Branch.
Submission of data -- hydrolysis, aerobic soil metabolism,
leaching/adsorption/desorption, dissipation, fish bioaccumulation. Pages
7-24, 27-37, 40-73, 75-80, 82-103 removed, registrant data. MRID
406091-01, 40593423, 24, -25, -26, 405238-01.
Document (PDF) (854 KB PDF).

December 06, 1989. Review. 19 Page(s).
John Chen. Toxicology Branch.
Review of the Registrant's Response to the Previous Review Comments
Concerning the Rat Teratology Study with Prodiamine (Toxicology
Branch Memorandum of 1/12/87, Winnie Teeters). Tox Review No.
007660.
Document (PDF) (2319 KB PDF).

December 20, 1989. Memorandum. 5 Page(s).
Emil Regelman. Environmental Fate & Ground Water Branch.
Submission of data -- hydrolysis in salt water. MRID 411872-01.
Document (PDF) (238 KB PDF).

January 04, 1990. Memorandum. 69 Page(s).
John Chen. Toxicology Branch.
1. Review and assessment of the submitted toxicological studies with
technical prodiamine. 2. Review of Registrants responses to previous
review comments... MRID 405934-21, -22, 409859-01 thru 09. Tox
Review No. 007660.
Document (PDF) (2764 KB PDF).

February 15, 1990. Memorandum. 8 Page(s).
Radames Lozada. Registration Support Branch.
Product Chemistry Review on Technical Prodiamine and the end
products Produamine 65WDG and Endurance 65WDG. Inert ingredient
information on page 3 is not included. MRID Nos. 402293-01C, -02C,
405934-01, -02, -03.
Document (PDF) (373 KB PDF).

June 11, 1990. Memorandum. 3 Page(s).
John Chen. Toxicology Branch.
Review of the Registrant's Response to the Previous Toxicology Branch
II Comments concerning the Acute Rat Inhalation Study with Prodiamine
65WDG, the L5178Y Mouse Lymphoma Mutation Assay... Rat
Production... Acute Tox... Tox Review 007973.
Document (PDF) (185 KB PDF).

June 22, 1990. Review. 21 Page(s).
Emil Regelman. Environmental Fate & Ground Water Branch.
Response to previous reviews - hydrolysis, aerobic soil metabolism,
leaching/adsorption/desorption, and dissipation. Pages 12-14, 18-21
removed, registrant data. MRIDs 413594-01. 02, 03, 04, 05.
Document (PDF) (621 KB PDF).

July 24, 1990. Memorandum. 11 Page(s).
Radames Lozada. Registration Support Branch.
Product Chemistry Review on Technical Prodiamine and Prodiamine
65WDG. MRID No. 414067-01. Product impurity information on page 4 is
not included. Pages 8-11 removed, product manufacturing process and
quality control procedure information.
Document (PDF) (408 KB PDF).

August 24, 1990. Memorandum. 29 Page(s).
J. Bailey. Ecological Effects Branch.
Review and comment on registrant's Aquatic Risk Assessment. Attached
Memorandum: Review of Sandoz Corp Estimated Environ mental
Concentration (Acc. 414516-01, 8/1/90) and Review of Modeling
(7/18/90).
Document (PDF) (681 KB PDF).
Attachment(s) Following:

August 24, 1990. Memorandum.
J. Bailey. Ecological Effects Branch.
(Continued) Pages 11, 14 removed, confidential statement of formula.
Pages 16-28 removed, draft labeling.

*End of Attachments*

August 30, 1990. Review. 6 Page(s).
Henry Nelson. Envirnomental Fate & Ground Water Branch.
Submission of Preliminary Co-solvent Test Results and Protocol for Fish
Bioaccumulation Study.
Document (PDF) (371 KB PDF).

December 27, 1990. Memorandum. 43 Page(s).
John Chen. Toxicology Branch.
Review and assessment of the acute toxicity studies... and the mouse
lymphoma forward mutation assay... Accession 256549. MRID 415581-
01. Pages 10-16 removed, registration data. Tox review 008210.
Document (PDF) (1969 KB PDF).

March 18, 1991. Memorandum. 53 Page(s).
John Chen. Toxicology Branch.
Review and evaluation of the subchronic oral toxicity study with
prodiamine in rats and the metabolism sutdy with prodiamine in rats.
Pages 10-11, 14-16, 18-19, 21-22, 28-33 removed, registrant data. MRID
416084-02. Tox review 008290.
Document (PDF) (1963 KB PDF).

April 18, 1991. Memorandum. 2 Page(s).
Timothy McMahon. Toxicology Branch.
Prodiamine technical and Prodiamine 75WP; Review of Additional
Information submitted by the Registrant. Tox Review No. 008337.
Document (PDF) (95 KB PDF).

June 10, 1991. SAP Package. 179 Page(s).
Gary Burin. Toxicology Branch.
Peer Review Document on Prodiamine.
Document (PDF) (8594 KB PDF).

June 27, 1991. Memorandum. 14 Page(s).
Radames Lozada. Registration Support Branch.
Product Chemistry Review on Barricade T Herbicide. Manufacturing
process information on page 3 not included. Pages 7-14 removed,
registration data. MRID 417688-01 through 417688-19.
Document (PDF) (345 KB PDF).

June 28, 1991. Review. 6 Page(s).
Amelia Acierto. Registration Support Branch.
Product Chemistry Review of Barricade 65WG Herbicide. Inert ingredient
and manufacturing process information is not included on pages 2, 4,
and 6. MRID 41768820 thru 41768829.
Document (PDF) (470 KB PDF).

July 25, 1991. Review. 59 Page(s).
Akiva Abramovitch. Environmental Fate & Ground Water Branch.
Reg. # 55947-UR. submission of adsorption/desorption and fish
bioaccumulation data. Pages 8-22, 26-36, 39-53 removed, registant data.
MRID 417272-01, 02, 03.
Document (PDF) (967 KB PDF).

August 08, 1991. Data Eval. Rec. 21 Page(s).
Henry Craven. Ecological Effects Branch.
Acute Toxicity Test for Freshwater Invertebrates. Species Tested:
Daphnid (Daphnia magna). Attached: Memorandum-Review of Studies
for prodiamine. DERs: Acute Toxicity Test for Freshwater Fish: Bluegill,
Rainbow Trout, Daphnia. MRID 418393-01, 418393-02, 4.
Document (PDF) (1094 KB PDF).

August 08, 1991. Memorandum. 21 Page(s).
Douglas Urban. Ecological Effects Branch.
Review of 96-Hour Flow-Through Acute Toxicity Tests with Bluegill and
Rainbow Trout and 48-Hour Flow-Through Acute Toxicity Test with
Daphnia magna MRID 418393-10, -02, -03 Pages 9, 15, 21 removed,
registration data.
Document (PDF) (1027 KB PDF).

August 13, 1991. Review. 5 Page(s).
Douglas Urban. Ecological Effects Branch.
100-series.
Document (PDF) (302 KB PDF).

September 16, 1991. Memorandum. 2 Page(s).
Edward Brandt. Biological Analysis Branch.
Review of Public Interest Documentation for Prodiamine for Control of
Grassy and Broadleaf Weeds in Turf and Ornamentals.
Document (PDF) (140 KB PDF).

October 02, 1991. Memorandum. 3 Page(s).
Bruce Jaeger. FIFRA Scientific Advisory Panel.
Transmittal of the Final FIFRA Scientific Advisory Panel Report on the
September 18, 1991, Meeting.
Document (PDF) (172 KB PDF).

October 30, 1991. Review. 3 Page(s).
Akiva Abramovitch. Environmental Fate & Ground Water Branch.
Submission of amended label for approval.
Document (PDF) (188 KB PDF).

November 05, 1991. Memorandum. 2 Page(s).
John Chen. Toxicology Branch.
Review of the Submitted CSF and Labeling of the Proposed New
Chemical Herbicide (Barricade T).
Document (PDF) (84 KB PDF).

November 05, 1991. Memorandum. 32 Page(s).
Douglas Urban. Ecological Effects Branch.
Review of studies for the new chemical Prodiamine. 21-Day Chronic
Static Renewal Toxicity of C14-Prodiamine to Daphnia magna. MRID
417873-02. Acute Toxicity of C14-Prodia- mine to Daphnia Magna. MRID
417977-01. Pages 9-12, 19-32 removed, registrant data.
Document (PDF) (825 KB PDF).

November 14, 1991. Memorandum. 3 Page(s).
John Chen. Toxicology Branch.
Review of draft EPA Fact Sheet. Data needed to determine risks
associated with the use of this new chemical. Do the risks override
conditional registration of this new chemical.
Document (PDF) (98 KB PDF).

November 27, 1991. Review. 2 Page(s).
Michael Clifford. Registration Support Branch.
New Registration for Barricade 65WG Herbicide in water soluble packs.
Inert ingredient information on page 2 not included.
Document (PDF) (184 KB PDF).

December 02, 1991. Review. 2 Page(s).
Douglas Urban. Ecological Effects Branch.
Review of Protocols for a Fish Early-Life Stage and an Avian
Reproduction Study for the New Chemical Prodiamine.
Document (PDF) (91 KB PDF).

December 09, 1991. Memorandum. 2 Page(s).
Kenneth Dockter. Chemistry Branch.
EPA File No. 55947-UG. Nitrosamine analysis of Sandoz's Barricade 65
WG Herbicide [prodiamine] product. MRID 420547-01.
Document (PDF) (88 KB PDF).

December 11, 1991. Addendum. 8 Page(s).
Ecological Effects Branch.
Revised labeling. Turf, Landscape Ornamentals.
Document (PDF) (407 KB PDF).

December 11, 1991. Memorandum. 6 Page(s).
John Chen. Toxicology Branch.
1. Review of the proposed 6-week feeding study in rats to investigate
thyroid effects (with recovery); and 2. Review the proposed neurotoxicity
testing and the protocol submitted to determine the nature of neurotoxicity
effect(s) of prodiamine to rats.
Document (PDF) (359 KB PDF).

December 17, 1991. Memorandum. 5 Page(s).
Ameesha Mehta. Occupational & Residential Exposure Branch.
Exposure Assessment for New Chemical, Prodiamine, Using Surrogate
Data.
Document (PDF) (331 KB PDF).

December 19, 1991. Review. 17 Page(s).
Akiva Abramovitch. Occupational & Res. Exposure Branch.
Reg. # 055947-UR submission of additional fish bioaccumulation data.
MRID 405238-01. Pages 08-11 removed, registration data.
Document (PDF) (776 KB PDF).

January 03, 1992. Memorandum. 3 Page(s).
Alfred Smith. Registration Support Branch.
Results of the Method Trials for the Active Ingredient Prodiamine.
Document (PDF) (159 KB PDF).

February 07, 1992. Memorandum. 14 Page(s).
Anne Lindsay. Registration Division.
Registration of Prodiamine (Barricade T Herbicide, Barricade 65WG
Herbicide, and Barricade 65WG Herbicide in Water Soluble Packs).
Document (PDF) (693 KB PDF).

June 25, 1992. Memorandum. 16 Page(s).
William Woodrow. Registration Support Branch.
Submission of acute oral, acute dermal, an inhalation feasibility, primary
eye and skin irritation studies, and a dermal sensitization study to support
registration of Barricade F Herbicide. MRID Nos. 422088-12 through -17.
Document (PDF) (1028 KB PDF).

July 23, 1992. Memorandum. 6 Page(s).
William Woodrow. Registration Support Branch.
Company questions (Sandoz) concerning a 5/25/92 acute toxicity
studies reviewed 5/28/92. MRID No. 422088-15.
Document (PDF) (304 KB PDF).

August 13, 1992. Memorandum. 2 Page(s).
K. Dockter. Chemistry Branch.
EPA Reg. No. 55947-144. Nitrosamine analysis of Sandoz's Barricade F
Herbicide [prodiamine] product. MRID 424123-01. D181171. CBRS
10314.
Document (PDF) (93 KB PDF).

September 16, 1992. Memorandum. 2 Page(s).
Richard Loranger. Chemistry Branch Tolerance Support.
EPA ID# 55947-RUU. Prodiamine (Barricade F Herbicide). Need for
nitrosamine analysis.
Document (PDF) (146 KB PDF).

June 28, 1993. Review. 34 Pages.
Akiva Abramovitch. Environmental Fate & Ground Water Branch.
ID #: 055947-00041. Submission of leaching/adsorption/desorption data
on aged material. MRID No. 42483201. DP Barcode No. D183015. Pages
10-34 removed, Registrant Data.
Document (PDF) (1097 KB PDF).

October 02, 1996. Memorandum. 9 Pages.
James Breithaupt. Environmental Risk Characterization Br.
Upgrading of 163-1 study for Prodiamine and Status of Data
Requirements. DP Barcodes: D196316, D223873. MRID No. 42978401.
Pages 3-9 removed, Registrant Data.
Document (PDF) (109 KB PDF).

September 13, 2002. Review. 2 Page(s).
Indira Gairola. Technical Review Branch.
EPA Reg. No 600063-ER. Product chemistry. MRIDs 45716601, -02.
Document (PDF) (78 KB PDF).

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