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Index of Cleared Science Reviews for S-Methoprene (Pc Code 105402)
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Undated. Review. 13 Page(s).
Dennis Opresko. Oak Ridge National Lab for EPA.
Frontline Plus For Cats And Kittens STUDY TYPE: Companion Animal Safety - Cat
(OPPTS 870.7200) MRID 44942009.
Document (PDF) (585 KB PDF).
May 18, 1989. Review. 3 Page(s).
Phil Hutton. Insecticide Rodenticide Branch.
IRB Product Performance Review 2724-UEU, UEA MRID 406131-01.
Document (PDF) (131 KB PDF).
August 26, 1991. Review. 3 Page(s).
Phil Hutton. Insecticide Rodenticide Branch.
IRB Product Performance Review 2724-UEA MRID 418951-00
Inert ingredient information on page 1 is not included.
Document (PDF) (154 KB PDF).
April 13, 1992. Review. 3 Page(s).
Phil Hutton. Insecticide Rodenticide Branch.
IRB Product Performance Review 2724-UEA MRID U.A.
Inert ingredient information on page 1 is not included.
Document (PDF) (141 KB PDF).
July 22, 1992. Memorandum. 2 Page(s).
Byron Backus. Toxicology Branch.
Protocol for Domestic Animal Safety Testing of a Methoprene-Containing Collar for Dogs.
Document (PDF) (81 KB PDF).
December 29, 1999. Efficacy Review. 2 Page(s).
Vern McFarland. Insecticide Branch.
File or Reg. No. 65331-L Provide performance data in support of claims for killing
of adult fleas, flea eggs & larvae for new combination of active ingredients.
MRID 44942105 & -06; D261554.
Document (PDF) (181 KB PDF).
April 12, 2000. Memorandum. 14 Page(s).
Masih Hashim. Technical Review Branch.
EPA Reg. No: 65331-U Frontline Plus for Cats. DP Barcodes: D261563.
Case No: 066318. MRID 44942009.
Document (PDF) (716 KB PDF).
May 03, 2000. Memorandum. 4 Page(s).
Virginia Dobozy. Reregistration Branch 1 HED.
Secondary Review of DER for Companion Animal Safety Study DP Barcode: D265179
MRID: 44942009.
Document (PDF) (168 KB PDF).
May 05, 2000. Memorandum. 16 Page(s).
Byron Backus. Technical Review Branch.
EPA File Symbol: 65331-L FRONTLINE PLUS FOR DOGS DP Barcode:
D261551 Animal safety study on beagle puppies. MRID 44942104.
Document (PDF) (1726 KB PDF).
August 10, 2001. Memorandum. 102 Page(s).
Virginia Dobozy. Registration Branch I.
Review of Incident Data for Four Hartz Mountain Flea & Tick Control Products
(2596-146, -147, -148 & -150). MRID Nos. 45410906, 45435901, 44864007C, 450064-02C,
450064-03C45410901, 45410902, 45410903, 45410904 & 45410905.
Document (PDF) (5438 KB PDF).
Attachment(s) Following:
September 04, 2001. DER.
Virginia Dobozy. Reregistration Branch I.
Companion Animal Safety/Cats & Kittens [OPPTS 870.7200].
DP Barcode D276263. MRID No. 44864007C.
September 04, 2001. DER.
Virginia Dobozy. Reregistration Branch I.
Companion Animal Safety/Dogs [OPPTS 870.7200].
DP Barcode D276262. MRID No. 450064-03C.
September 04, 2001. DER.
Virginia Dobozy. Reregistration Branch I.
Companion Animal Safety/Kittens [OPPTS 870.7200]. MRID No. 45410906.
September 04, 2001. DER.
Virginia Dobozy. Reregistration Branch I.
Companion Animal Safety/Puppies [OPPTS 870.7200].
DP Barcode D276262. MRID No. 450064-02C.
September 10, 2001. DER.
Virginia Dobozy. Reregistration Branch I.
Acute Dermal Toxicity - Rabbit [OPPTS 870.1200 (Sec 81-2)];
DP Barcode D276701. MRID No. 45410902.
September 10, 2001. DER.
Virginia Dobozy. Reregistration Branch I.
Acute Oral Toxicity - Rat [OPPTS 870.1100 (Sec 81-1)];
DP Barcode D276701. MRID No. 45410901.
September 10, 2001. DER.
Virginia Dobozy. Reregistration Branch I.
Companion Animal Safety/Kittens [OPPTS 870.7200].
DP Barcode D276274. MRID No. 45435901.
September 10, 2001. DER.
Virginia Dobozy. Reregistration Branch I.
Primary Dermal Irritation - Rabbit [OPPTS 870.2500 (Sec 81- 5)];
Barcode D276701. MRID No. 45410904.
September 10, 2001. DER.
Virginia Dobozy. Reregistration Branch I.
Primary Eye Irritation - Rabbit [OPPTS 870.2400 (Sec 81-4)];
Barcode D276701. MRID No. 45410903.
September 12, 2001. DER.
Virginia Dobozy. Reregistration Branch I.
Dermal Sensitization - Guinea Pig [OPPTS 870.2600 (Sec. 81-6)];
Barcode D276701. MRID No. 45410905.
*End of Attachments*
May 09, 2002. Efficacy Review. 4 Page(s).
Vern McFarland. Insecticide Branch.
File or Reg. No. 65331-5 Provide performance data in support of claims for chewing
lice and sarcoptic mange mites on dogs with standard label rate of subject product.
MRID 44628201, 45612701, 45620501, -04, -05, -06.
Document (PDF) (491 KB PDF).
September 23, 2002. Memorandum. 21 Page(s).
Byron T. Backus. Technical Review Branch.
Product Name: FRONTLINE PLUS FOR CATS. EPA Reg. No.: 65331-4.
DP Barcode: D282326. Case No: 066318. Submission: S613512.
MRID 45618502.
Document (PDF) (820 KB PDF).
September 24, 2002. Memorandum. 2 Page(s).
Byron T. Backus. Technical Review Branch.
Product Name: FRONTLINE® TOP SPOT® FOR CATS. EPA Reg. No.: 65331-2.
DP Barcode: D282329. Case No: 046906. Submission: S613891.
MRID 44942009, 45618502.
Document (PDF) (273 KB PDF).
October 21, 2002. Memorandum. 33 Page(s).
Masih Hashim. Technical Review Branch.
Product name: FRONTLINE PLUS FOR DOGS EPA Reg. No.: 65331-5
DP Barcode: D282205 Dog safety and safety/tolerance/reproduction.
MRID 45612702, 45620507.
Document (PDF) (3574 KB PDF).
July 02, 2003. Efficacy Review. 3 Page(s).
Kevin Sweeney. Insecticides Branch.
EPA Registration No. 65331-5 Efficacy of Frontline Plus to control mosquitoes
MRID 45866901, -02.
Document (PDF) (343 KB PDF).
October 21, 2003. Efficacy Review. 2 Page(s).
Kevin Sweeney. Insecticides Branch.
EPA Registration No. 65331-2, 3, 4 and 5 Decision Nos. 329453, 200325, 333158,
213526. Determine if products kill adult mosquitoes.
MRID 45866901, -02, 46019201 and -02.
Document (PDF) (262 KB PDF).
April 12, 2004. Memorandum. 11 Page(s).
William Dykstra. Reregistration Branch 4 HED.
Hartz Flea and Tick Treatment for Cats (EPA Reg. Nos. 2596-148, 2569-151);
Incident Data Reviews I014030, I014303, I014641, and I014665. Tox review 0052290.
Document (PDF) (909 KB PDF).
January 18, 2006. Efficacy Review. 4 Page(s).
Kevin Sweeney. Insecticides Branch.
EPA Reg. No. 2724-LNU. Registrant: Wellmark International. Dec # 355865.
DP#: 316838. Product Name: RF2004 (CCSO). OPPTS Guideline: 810.3300.
MRID Nos. 46513410, 46513411, 46513412, 46513413, 46513414, 46513415.
Document (PDF) (154 KB PDF).
January 18, 2006. Memorandum. 3 Page(s).
Byron Backus. Technical Review Branch.
EPA File Symbol: 2724-LNU RF2004 (CCSO). DP Barcode: D325415.
Decision No.: 355865. PC Codes: 128965, Etofenprox (40%); 105402,
S-Methoprene (3.6%). MRID No. 46725801.
Document (PDF) (108 KB PDF).
April 24, 2006. DER. 4 Page(s).
Angela Gonzales. Health Effects Division.
Waiver Requests for Acute Mammalian Toxicity Data
Inert ingredient info on pages 2, 3, 4 not included. MRID 46763209.
Document (PDF) (175 KB PDF).
September 26, 2006. Efficacy Review. 14 Page(s).
Mark Suarez. Insecticides Branch RD.
EPA Reg. No.: 2517-IN, 2517-ON. Product name: Sergeant's Cyphenothrin...[2517-IN],
Sergeant's Cyphenothrin...[2517-ON]. DP Barcode 305945, 307614 , 319065.
MRIDs 46346601, 46039501, 46041303, 46166109, 46298501-02, 42614501,
45086801, 44948301, 44546601.
Document (PDF) (760 KB PDF).
November 07, 2006. Efficacy Review. 10 Page(s).
Mark Suarez. Insecticides Branch.
EPA Reg. Number: 2517-IL, 2517-IN, 2517-ON. Registrant: Seargeant's Pet Care
Products, Inc. DP Barcode: 305952, 305945, 307614, 358246. Sites: dogs; puppies.
Pests: fleas (adult, eggs, larvae); ticks; mosquitoes; Deer Ticks.
Document (PDF) (529 KB PDF).
Attachment(s) Following:
November 07, 2006. Efficacy Review.
Mark Suarez. Insecticides Branch.
(continued) MRIDs 46346601, 46039501, 46041303, 46166109, 46298501,
46298502, 42604501, 45086801, 44948301, 44546601, 46166110.
*End of Attachments*
November 07, 2006. Memorandum. 31 Page(s).
Mark Suarez. Insecticides Branch.
Product Performance/Efficacy Review. Sergeant's Cyphenothrin Squeeze-On for
Dogs [2517-IL], Sergeant's Cyphenonothrin+IGR Squeeze-On for Dogs [2517-IN]
& Sergeant's Cyphenothrin+ Methoprene Squeeze-On for Dogs [2517-ON].
Reg. Nos. 2517-IL, 2517-IN & 2517-ON.
Document (PDF) (1425 KB PDF).
Attachment(s) Following:
November 07, 2006. Memorandum.
Mark Suarez. Insecticides Branch.
DP Barcode Nos. 305952 [2517-IL], 305945 [2517-IN], 307614 [2517-IN]
& 319065 [2517-ON]. MRID Nos. 46346601, 46039501, 46041303, 46166109,
46298501, 46298502, 42614501, 45086801, 44948301, 44546601 & 46166110.
*End of Attachments*
December 05, 2007. Efficacy Review. 6 Page(s).
Mark Suarez. Insecticides Branch.
EPA Reg. No.: 2517-80, 2517-85, 2517-90. Product name(s): Sergeant's
Cyphenothrin + IGR...[2517-80], Sergeant's Cyphenothrin Squeeze...[2517-85], Sergeant's
Cyphenothrin + Methoprene...[2517-90]. DP Barcode 342540, 342541, 342544.
MRID Nos. 47163701-02.
Document (PDF) (315 KB PDF).
December 22, 2008. Memorandum. 4 Pages.
Sadaf Shaukat. Biochemical Pesticides Branch.
Science Review in Support of the Registration of Z112-011, Containing 8.62% (S)-
Methoprene [Isopropyl (2E,4E,7S)-11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate])
As Its Active Ingredient. MRID Nos. 47511301, 47511302, 47225801, 47225802, 47225803.
Document (PDF) (71 KB PDF).
Attachment(s) Following:
December 22, 2008. Memorandum.
Sadaf Shaukat. Biochemical Pesticides Branch.
(continued)...EPA Reg. Number: 63823-57.
Inert ingredient information on pages 2, 3, and 4 not included.
*End of Attachments*
February 04, 2009. Memorandum. 15 Page(s).
Eugenia McAndrew. Technical Review Branch.
Name of Pesticide Product: RF2042[CDSO]. EPA Reg. No./File Symbol: 2724-TOA.
DP Barcode: D357271. Decision No.: 399095.
MRID Nos.: 475185-04 to -08. (MRID 47518509).
Document (PDF) (333 KB PDF).
February 05, 2009. Memorandum. 34 Page(s).
Byron Backus. Technical Review Branch.
Name of Pesticide Product: RF 2042 [CDSO]. EPA Reg. No. /File Symbol: 2724-TOA.
DP Barcodes 357272, 359984. Decision No.: 399095. Action Code: R310.
MRID Nos. 47518510, 47578401.
Document (PDF) (1219 KB PDF).
January 15, 2010. Efficacy Review. 3 Pages.
Clayton Myers. RD-IB.
EPA Reg. #: 2517-RGN, 2517-REO, 2517-RGR, 2517-RGE, 2517-REI, 2517-RET.
Products: 6 Sergeant's Pet Care Products, cyphenothrin, 20-30%.
DP #s: 370291, 370302, 370279, 370298, 370284, 370306. MRIDs: 47849701.
Document (PDF) (765 KB PDF).
September 22, 2010. Memorandum. 28 Page(s).
Byron Backus. Technical Review Branch.
Name of Pesticide Product: CERTIFECT FOR DOGS.
EPA Reg. No. /File Symbol: 65331-T. DP Barcode: DP 372058.
Decision No.: 423378. Action Code: R320.
MRID No.: 47914235.
Document (PDF) (666 KB PDF).
October 05, 2010. Memorandum. 12 Page(s).
Byron Backus. Technical Review Branch.
Name of Pesticide Product: CERTIFECT FOR DOGS.
EPA Reg. No. /File Symbol: 65331-T. DP Barcode: DP 375363.
Decision No.: 423378. Action Code: R320.
MRID No.: 47914238.
Document (PDF) (486 KB PDF).
October 05, 2010. Memorandum. 16 Page(s).
Byron Backus. Technical Review Branch.
Name of Pesticide Product: CERTIFECT FOR DOGS.
EPA Reg. No. /File Symbol: 65331-T. DP Barcode: DP 377589.
Decision No.: 423378. Action Code: R320.
MRID No.: 47914237.
Document (PDF) (252 KB PDF).
October 05, 2010. Memorandum. 23 Page(s).
Byron Backus. Technical Review Branch.
Name of Pesticide Product: CERTIFECT FOR DOGS.
EPA Reg. No. /File Symbol: 65331-T. DP Barcode: DP 377588.
Decision No.: 423378. Action Code: R320.
MRID No.: 47914236.
Document (PDF) (355 KB PDF).
November 03, 2010. Efficacy Review. 24 Pages.
Autumn Metzger.
Product: CERTIFECT. File Symbol: 65331-T. DP Barcode: 372045.
Purpose: To determine efficacy for registration of new spot-on
combination product for dogs. MRIDs: 47914207 thru 47914228.
Document (PDF) (476 KB PDF).
January 04, 2011. Memorandum. 8 Page(s).
Byron Backus. Technical Review Branch.
Acute Toxicity, Response to Second Rebuttal for Dermal Sensitization.
Name of Pesticide Product: CERTIFECT FOR DOGS. EPA Reg. No. /File Symbol: 65331-T.
DP Barcode: DP 384819. MRID No.: 48321001.
Document (PDF) (105 KB PDF).
February 01, 2011. Efficacy Review. 6 Page(s).
Autumn Metzger..
PRODUCT: CERTIFECT. FILE SYMBOL: 65331-T. DP BARCODE: DP 386346.
To determine efficacy for the label claim "Effective after exposure to sunlight"
on a new registration for a spot-on combination product for dogs.
MRIDs: 48342901, 48342902.
Document (PDF) (210 KB PDF).
February 10, 2011. Memorandum. 13 Page(s).
Byron Backus. Technical Review Branch.
Companion Animal Safety, Response to Rebuttal from Merial.
Name of Pesticide Product: CERTIFECT FOR DOGS.EPA Reg. No. /File Symbol: 65331-T.
DP Barcode: DP 384668. Decision No.: 423378. Action Code: R320.
MRIDs 47914235, 47914236, and 47914237.
Document (PDF) (400 KB PDF).