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Index of Cleared Science Reviews for Thiophanate-methyl (Pc Code 102001)

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Undated. One-Liner. 3 Page(s).
Ecological Effects Branch.
EEB Chemical Profile - Thiophanate-methyl.
Document (PDF) (105 KB PDF).
Attachment(s) Following:

October 21, 1983. Review. 3 Page(s).
Carolyn Offut. Exposure Assessment Branch.
Reg. No. 4581-322. Topsin M. EEC on Wheat.

*End of Attachments*

July 21, 1980. Memorandum. 3 Page(s).
Deloris Graham. Fungicide Herbicide Branch.
EPA File Symbol 4581-GUR. Decoo Salt No. 22. Caswell Nos. 311, 375A.
Tox review 000038.
Document (PDF) (96 KB PDF).

August 04, 1980. Memorandum. 21 Page(s).
Alfred Smith. Residue Chemistry Branch.
PP #9F2274/FAP #9H5241: Thiophanate-methyl in Sugar Cane, Pineapples,
Almonds, Apples, Beans, Peanuts, Soybeans, and Sugarbeets.
Evaluation of Analytical Method and Residue Data, and Amendment of 2/1/80.
Document (PDF) (1263 KB PDF).

December 22, 1980. Memorandum. 4 Page(s).
Deloris Graham. Fungicide Herbicide Branch.
EPA Registration No. 4581-341. Decco Salt #22. Caswell Nos. 311, 375A.
Page 4 removed, draft label. Tox review 000471.
Document (PDF) (149 KB PDF).

November 30, 1982. Memorandum. 10 Page(s).
R. W. Cook. Residue Chemistry Branch.
PP #2F2729/FAP #2H5364. Thiophanate-Methyl on Cucumbers, Melons, Pumpkins,
Summer Squash, Winter Squash, Grapes, Pineapples, and Rice. Amended Use on
Celery and Stone Fruits. Evaluation of Analytical Methods and Residue Data.
Document (PDF) (468 KB PDF).

October 24, 1985. Memorandum. 3 Page(s).
Linda Kutney. Residue Chemistry Branch.
PP #4E3058. Thiophanate-methyl on Cabbage, Lettuce, Eggplant, and Tomato.
Amendment of 8/8/85. RCB #1403. (No Accession Number). Page 3 not included,
confidential statement of formula.
Document (PDF) (31 KB PDF).

March 13, 1986. Memorandum. 2 Page(s).
Joel Garbus. Residue Chemistry Branch.
EPA No. 4581-322. Thiophanate-methyl (Topsin M), Amended Registration to Permit
Application to Curcurbits. (Supplemental Information). Accession No. 261152. RCB #516.
Document (PDF) (32 KB PDF).

April 24, 1986. Memorandum. 29 Page(s).
Cynthia Deyrup. Residue Chemistry Branch.
PP #6F3343/6H5486. (RCB #519, 509) Thiophanate-methyl in/on Rice and Grapes,
Milk, the Kidney and Liver of Cattle, Goats, Hogs, Horses, and Sheep, and Poultry
Liver. Evaluation of the Analytical Method and Residue Data. Accession No. 260822.
Document (PDF) (392 KB PDF).

July 31, 1986. Memorandum. 8 Page(s).
Mary Waller. Fungicide Herbicide Branch.
EPA File Symbol 11273-LT. Ditek 80DF Fungicide. Acc. 263488.
Pages 7-8 removed, draft label. Tox review 005998.
Document (PDF) (147 KB PDF).

August 25, 1986. Memorandum. 4 Page(s).
Michael Metzger. Residue Chemistry Branch.
4581-322. Protocol for Processing Study for Potatoes Treated with Thiophanate-methyl
(Topsin M 70W). RCB #1304.
Document (PDF) (50 KB PDF).

September 22, 1986. Review. 3 Page(s).
Samuel Creeger. Exposure Assessment Branch.
Reg. No. 4581-322. Topsin M. New Uses on Grapes and Rice.
Document (PDF) (52 KB PDF).

April 09, 1987. Review. 3 Page(s).
Emil Regelman. Exposure Assessment Branch.
Reg. No. 4581-280. Thiophanate-methyl. Review of Protocols for Fish Residue
Accumulation Studies.
Document (PDF) (63 KB PDF).

April 15, 1987. Memorandum. 34 Page(s).
Roger Gardner. Toxicology Branch.
Teratology Study in Rabbits with Thiophanate-methyl (EPA Reg. No. 4581-280).
Tox Proj. No. 7-0502. Tox Chem. 375A. Pages 11-20, 28-34 removed, registrant data.
Tox review 005840.
Document (PDF) (411 KB PDF).

May 01, 1987. Review. 4 Page(s).
Emil Regelman. Exposure Assessment Branch.
Reg. No. 4581-280. Thiophanate-methyl. Topsin M 4.5 Flowable.
Review of Protocols for Field Rotational Crop Studies.
Document (PDF) (78 KB PDF).

October 29, 1987. Memorandum. 17 Page(s).
Roger Gardner. Toxicology Branch.
Additional Mutagenicity Data Resubmitted in Support of the Registration
of Thiophanate-methyl (EPA Reg. No. 4581-322). Tox Proj. No. 7-1019.
Tox Chem. No. 375A. MRID 40095504, 40095503. Tox review 006400.
Document (PDF) (379 KB PDF).

November 04, 1987. Memorandum. 6 Page(s).
Michael Metzger. Residue Chemistry Branch.
Thiophanate-methyl (Topsin M 70W, EPA Reg. No. 4581-322; Topsin M 4.5F,
EPA Reg. No. 4581-352) on Wheat. Amended Registration Allowing Application
in an Increased Geographical Area and an Additional Application.
No Accession Number/No MRID Number.
Document (PDF) (84 KB PDF).

February 11, 1988. Memorandum. 6 Page(s).
Charles Frick. Science Integration Staff.
An Interim Assessment Analysis of Oncogenic Dietary Risk on the Chemical Thiophanate-methyl.
Document (PDF) (78 KB PDF).

February 18, 1988. Memorandum. 2 Page(s).
William Anthony. Residue Chemistry Branch.
Thiophanate-methyl (Topsin 70% WP) 24(c) on Beans in the State of Idaho. SLN #ID-870010.
RCB #3253. Acc.: None.
Document (PDF) (41 KB PDF).

February 18, 1988. Memorandum. 2 Page(s).
William Anthony. Residue Chemistry Branch.
Thiophanate-methyl (Topsin M 4.5F Fungicide) 24(c) on Beans in the State of Idaho.
SLN #ID-870011. RCB #3265. Acc.: None.
Document (PDF) (42 KB PDF).

November 15, 1988. Memorandum. 12 Page(s).
Roger Gardner. Toxicology Branch.
Dose Selection for an Oncogenicity Study in Mice with Thiophanate-methyl.
Tox Proj. No. 8-1053. Tox Chem. 375A. Tox Review 006923.
Document (PDF) (340 KB PDF).

May 03, 1989. Memorandum. 2 Page(s).
Debra Edwards. Dietary Exposure Branch.
Anticipated Residues of MBC on Food and Feed Commodities Resulting from
Registered Use of Benomyl and Thiophanate-methyl (RD Record No. 240751,
HED Project No. 9-0954, DEB No. 4991).
Document (PDF) (28 KB PDF).

November 16, 1990. DER. 4 Pages.
Allen Vaughan. Ecological Effects Branch.
Aquatic invertebrate acute toxicity test Species tested: daphnia carinata.
Acc. No. 400955-05.
Document (PDF) (33 KB PDF).

January 31, 1991. DER. 10 Pages.
S. Termes. Environmental Fate & Ground Water Branch.
STUDY 2. Thiophanate-methyl. 161-2. STUDY ID 41482806. Thiophanate-methyl -
Photodegradation in water. STUDY ID 92186017. Phase 3 summary of existing study
MRID 41482806; thiophanate-methyl - Photodegradation in water.
Document (PDF) (110 KB PDF).

January 31, 1991. DER. 4 Pages.
S. Termes. Environmental Fate & Ground Water Branch.
STUDY 1. Thiophanate-methyl. 161-1. STUDY ID 40095507. Thiophanate-methyl:
Hydrolysis. STUDY ID 92186016. Phase 3 summary of MRID 40095507;
thiophenate-methyl - Hydrolysis.
Document (PDF) (35 KB PDF).

January 31, 1991. DER. 4 Pages.
S. Termes. Environmental Fate & Ground Water Branch.
STUDY 4. Thiophanate-methyl. 162-3. STUDY ID 40061501. Thiophanate-methyl--
anaerobic aquatic metabolism. STUDY ID 92186019. Phase 3 summary of MRID 40061501:
Thiophanate-methyl anaerobic aquatic metabolism.
Document (PDF) (38 KB PDF).

January 31, 1991. DER. 5 Pages.
S. Termes. Environmental Fate & Ground Water Branch.
STUDY 3. Thiophanate-methyl. 161-3. STUDY ID 41482807. Thiophanate-methyl -
Photodegradation on soil. STUDY ID 92186018. Phase 3 summary of existing study
MRID 41482807; thiophanate-methyl - Photodegradation on soil.
Document (PDF) (49 KB PDF).

January 31, 1991. DER. 5 Pages.
S. Termes. Environmental Fate & Ground Water Branch.
STUDY 5. Thiophanate-methyl. 163-1. STUDY ID 41560902. Thiophanate-methyl
- Batch equilibrium (adsorption/desorption).
Document (PDF) (47 KB PDF).

May 02, 1995. Memorandum. 42 Page(s).
Pamela Hurley. Toxicology Branch.
625 6(A)(2). Thiophanate-methyl. Review of Chronic/Oncogenicity Feeding Study in
Rats. Attachment 1 (?)attachment to 4/14/99 Cancer Peer Review. MRID 428966-01.
Pages 40-42 removed, registrant data. Tox review 011531.
Document (PDF) (1090 KB PDF).

February 24, 1998. DER. 16 Page(s).
H. T. Borges. Chemical Hazard Evaluation Group for HED.
Special Thyroid and Liver Mechanistic Studies.
Attachment 5 (?) Attachment to 4/14/99 cancer peer review. MRID 42896601b.
Document (PDF) (401 KB PDF).

March 23, 1999. DER. 26 Page(s).
Linnea Hansen. Toxicology Branch.
Oral Carcinogenicity (18-Month Dietary) - Mouse [83-2(b)]
Attachment 3 (?)Attachment to 4/14/99 cancer peer review. MRID 42607701.
Document (PDF) (544 KB PDF).
Attachment(s) Following:

April 21, 1994. Memorandum.
Pamela Hurley. Toxicology Branch.
102001. Thiophanate-methyl. Review of 18-Month Dietary Mouse Study
as 6(A)(2) Data MRID 42607701 Tox review 010931.

*End of Attachments*

March 31, 1999. Memorandum. 12 Page(s).
Lori Brunsman. Science Analysis Branch, HED.
Thiophanate-methyl Qualitative Risk Assessment Based on Fisher 344 Rat and CD-1
Mouse Dietary Studies. Attachment 2 (?)Attachment to 4/14/99 cancer peer review
MRID 428966-01, 426077-01. Tox review 013289 excerpt.
Document (PDF) (143 KB PDF).

April 14, 1999. Memorandum. 52 Page(s).
Sanjivani Diwan. HED.
Cancer Assessment Review Committee Meeting on Thiophanate-methyl 4/9/99
Cancer Peer Review of Thiophanate-methyl attached.
Document (PDF) (700 KB PDF).

August 24, 1999. Memorandum. 48 Page(s).
Linea Hansen. HED.
Cancer Assessment Document; Evaluation of the Carcinogenic Potential of Thiophanate-methyl.
Tox review 013688.
Document (PDF) (737 KB PDF).

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