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Index of Cleared Science Reviews for Bladex (Pc Code 100101)

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March 17, 1971. Memorandum. 3 Page(s).
G. E. Whitmore. FDA.
Bladex (SD 15418) on corn (sweet corn kernels, corn grain popcorn,
forage and straw) 0.1 ppm PESTICIDE PETITION NO. OFO-998 Tox review 000811.
Document (PDF) (1004 KB PDF).

December 06, 1977. Review. 12 Page(s).
Ronald Ney. Efficacy & Ecological Effects Branch.
EUP for Corn, Alone and in Combination with Bladex, Banvel,
AAtrex, Paraquat and Roundup.
Document (PDF) (444 KB PDF).

January 31, 1978. Memorandum. 4 Page(s).
S-L Chan. Toxicology Branch.
EPA #100-EUP-59, An EUP for Dual 8E and Tank Mixes.
Inert ingredient information on page 1 is not included.
Document (PDF) (203 KB PDF).

February 09, 1978. Memorandum. 2 Page(s).
Larry Anderson. Toxicology Branch.
EPA (HED) Review of IBT Validation Report. TXR No. 000813.
Document (PDF) (47 KB PDF).

April 04, 1978. Memorandum. 4 Page(s).
Carlos Rodriguez. Registration Division (Toxicology).
Request for Experimental Use Permit to Ship and Use a Pesticide for Experimental
Purpose Only. Bladex/Atrazine (2:1) 4 Herbicide for Preemergence Application for
the Control of Weeds in Field Corn. EPA File Symbol 201-EUP-61. Caswell #188C and 63.
Document (PDF) (228 KB PDF).

May 18, 1978. Memorandum. 9 Page(s).
Krystyna Locke. Toxicology Branch.
Bladex/Atrazine (2:1) 80W Herbicide. Caswell Nos. 63, 188C. EPA Reg. No. 201-403 UNG.
Document (PDF) (557 KB PDF).

February 04, 1980. Memorandum. 1 Page(s).
Larry Anderson. Toxicology Branch.
Validation Review of IBT Study No. J-238 Teratogenic Study with Bladex in Albino Rabbits.
Document (PDF) (60 KB PDF).

July 17, 1981. Memorandum. 7 Page(s).
N. Platonow. Government of Canada.
Audit and Validation of the IBT Study: Teratogenic Study with SD-15418
Bladex Technical in Albino Rabbits.
Document (PDF) (262 KB PDF).

October 14, 1981. Memorandum. 3 Page(s).
William Dykstra. Toxicology Branch.
EPA Reg. No. 201-279; 201-281; Bladex Teratology Study. PP #9F2232 - Petition
Proposing a Tolerance of 0.1 ppm... Be Established to Cover Negligible Residues
in or on Soybeans. Accession No. 243335.
Document (PDF) (90 KB PDF).

February 03, 1982. Memorandum. 5 Page(s).
William Dykstra. Toxicology Branch.
EPA Reg. No. 201-279; 201-281; Bladex Rat Teratology Study. PP #9F2232 -
Petition Proposing a Tolerance of 0.1 ppm... Be Established to Cover Negligible
Residues in or on Soybeans.
Document (PDF) (246 KB PDF).

May 23, 1982. Memorandum. 3 Page(s).
William Dykstra. Toxicology Branch.
Bladex; PP#9F2232; Bladex in/on Soybeans; 2-Year Mouse Oncogenicity Study
Accession Nos.: 247295-298 Tox review 001884.
Document (PDF) (215 KB PDF).

August 17, 1982. Memorandum. 2 Page(s).
William Dykstra. Toxicology Branch.
Bladex; EPA Reg. No. 201-279, 201-281; PP # 9F2232; Bladex in/on Soybeans.
Document (PDF) (68 KB PDF).

January 26, 1983. Memorandum. 8 Page(s).
William Dykstra. Toxicology Branch.
EPA Reg. No. 201-279; 201-281; Bladex - Addendum to Rat Teratology Study.
PP #9F2232 Petition Proposing a Tolerance of 0.1 ppm... Be Established
in or on Soybeans. Accession No. 071285.
Document (PDF) (349 KB PDF).

April 29, 1983. Memorandum. 14 Page(s).
Amal Mahfouz. Toxicology Branch.
Bladex; EPA Reg. No. 201-279 and 201-281. A New Teratology Study in Rabbits;
PP #9F2232; Petition Proposing a Tolerance of 0.1 ppm in/on Soybeans.
Document (PDF) (787 KB PDF).

November 04, 1983. Memorandum. 2 Page(s).
Amal Mahfouz. Toxicology Branch.
Bladex Teratology Study in F344 Rats.
Document (PDF) (128 KB PDF).

November 14, 1983. Memorandum. 19 Page(s).
Amal Mahfouz. Toxicology Branch.
PP #9F2239; Bladex in/on Soybeans; EPA Reg. No. 201-279 and 201-281.
A New Teratology Study in SD CD Rats, Accession No. 071738; and an Addendum
to the Teratology Study in F344 Rats, Accession No. 071739.
Document (PDF) (1025 KB PDF).

November 21, 1983. Memorandum. 4 Page(s).
Amal Mahfouz. Toxicology Branch.
PP # 9F2232; Bladex/Soybeans; EPA Reg. No. 201-279 and 201-281. Historical
Data for the Teratology Study in the New Zealand Strain of Rabbits.
Document (PDF) (219 KB PDF).

November 04, 1984. Memorandum. 5 Page(s).
Quang Bui. Toxicology Branch.
Evaluation of additional data pertaining to the teratology study with Bladex
in SD-CD Rats. PP#9F2232; Accession # 072838 Tox review 004077.
Document (PDF) (286 KB PDF).

January 10, 1985. Memorandum. 26 Page(s).
Christine Chaisson. Toxicology Branch.
EPA Reg. No. 201-298; Cyanazine (Bladex): Oncogenicity in Rats. Acc. No. 251954,
251955, 251956; 251949, 251950, 251951, 251952, 251953. Tox review 004221.
Document (PDF) (1872 KB PDF).

May 29, 1985. Memorandum. 20 Page(s).
Quang Bui. Toxicology Branch.
Review of Pilot Teratology Study with Bladex (Cyanazine) in Fischer 344 and
Sprague Dawley Rats. EPA Reg. No. 201-298. EPA Accession Nos. 256693 Through 256696.
Pages 9-20 are not included - registrant submission.
Document (PDF) (426 KB PDF).

June 05, 1985. Memorandum. 1 Page(s).
Quang Bui. Toxicology Branch.
Review of a Developmental Toxicology Study and a Subchronic Study with Bladex (Cyanazine).
EPA Reg. No. 201-298. EPA Accession No. 257867 and 257868.
Document (PDF) (49 KB PDF).

June 05, 1985. Memorandum. 31 Page(s).
Quang Bui. Toxicology Branch.
Review of a Developmental Toxicology Study and a Subchronic Study with Bladex (Cyanazine).
EPA Reg. No. 201-298. EPA Accession No. 257867 and 257868.
Pages 25-31 are not included - registrant submission.
Document (PDF) (1255 KB PDF).

June 05, 1985. Memorandum. 6 Page(s).
Quang Bui. Toxicology Branch.
Overview of the Teratogenic Potential of Bladex (Cyanazine).
Document (PDF) (345 KB PDF).

June 27, 1985. Memorandum. 1 Page(s).
Robert Zendzian. Toxicology Branch.
Bladex, 21-Day Dermal Study in Rabbits and Teratology Study in Rats.
Action Returned Studies Previously Reviewed by Dr. Bui.
Document (PDF) (43 KB PDF).

April 23, 1986. Memorandum. 39 Page(s).
Quang Bui. Toxicology Branch.
Review of Toxicology Data of Bladex (Cyanazine). EPA No. 100-101. EPA No. 201-298.
Project Nos. 1096 and 1596. Pages 20-27 and 33-39 are not included - registrant submissions.
Document (PDF) (1426 KB PDF).

August 06, 1986. Memorandum. 20 Page(s).
Quang Bui. Toxicology Branch.
Expedite review of a dermal developement toxicology study with Bladex 4L in rabbits.
EPA No. 201-208 Project No.2116 Caswell No.1660 Pages 11-20 removed, registration data.
Tox. Review 005331.
Document (PDF) (827 KB PDF).

March 18, 1987. Review. 27 Page(s).
Emil Regelman. Exposure Assessment Branch.
Reg. No. 201-298. Bladex. Partial Response to Groundwater Data Call-In.
Hydrolysis, Aerobic and Anaerobic Soil Metabolism and Leaching Data.
Document (PDF) (1126 KB PDF).

June 19, 1987. Memorandum. 5 Page(s).
Theodore Farber. Toxicology Branch.
Peer Review Committee on Cyanazine (Bladex). Tox review 008049.
Document (PDF) (276 KB PDF).

June 23, 1987. Review. 7 Page(s).
Carolyn Offutt. Exposure Assessment Branch.
Reg. No. 352-475. Bladex. Review of Ground Water Monitoring Study.
Document (PDF) (391 KB PDF).

October 07, 1987. Memorandum. 26 Page(s).
Stephen Dapson. Toxicology Branch.
Review of a one-year chronic dog study with Cyanazine and amendment to the final
report. EPA ID # 352-475, EPA Accession #'s 400819-01 and 402290-01; Pages 7-8,
16-26 removed, registration data. Tox review 006350.
Document (PDF) (1112 KB PDF).

February 16, 1988. Memorandum. 32 Page(s).
Sidney Stolzenberg. Toxicology Branch.
Review of a Two-Generation Reproduction Study of Technical Bladex (Cyanazine)
in Rats (Sprague-Dawley) 325-475 Acc. 403600-01 Tox review 006597.
Document (PDF) (1723 KB PDF).

March 09, 1990. Memorandum. 36 Page(s).
Stephen Dapson. Toxicology Branch.
Review additional data submitted in support of a multigeneration study
in rats with Bladex... MRID 411111-01 Tox review 007804.
Document (PDF) (2357 KB PDF).

April 30, 1990. Memorandum. 58 Page(s).
Irving Mauer. Toxicology Branch.
Cyranazine - Mutagenicity Data Submitted under MRID Nos. 00165051, 408045-02, -03,
-04, and -05. Pages 10-11, 18-22, 28-37, 43-49 and 56-58 removed, registration data.
Tox review 007893.
Document (PDF) (1569 KB PDF).

January 07, 1991. Memorandum. 5 Pages.
Henry Spencer. Toxicology Branch I.
Conclusions Drawn from Structure-Activity-Relationship (SAR) Analysis of s-Triazine
Pesticides and Related compounds from OTS.
Document (PDF) (190 KB PDF).

March 06, 1991. Memorandum. 88 Page(s).
Roger Gardner. Toxicology Branch I.
Cyanazine - EPA Registration No. 352-475 - 6(a)(2) Data - 2-Year Chronic Toxicity/Oncogenicity
Rat Study with Cyanazine Technical - Reregistration and Special Review Branchs' Referral.
Tox review 008280. Pgs 29-35, 52-88 removed, registrant data.
Document (PDF) (2231 KB PDF).

March 07, 1991. Memorandum. 78 Page(s).
Esther Rinde. Health Effects Division.
Peer review of Cyanazine.
Document (PDF) (3688 KB PDF).

April 19, 1991. Memorandum. 15 Page(s).
Esther Rinde. Science Analysis & Coordination Branch.
Health Effects Division (HED) Peer Review Committee Draft Document on CYANAZINE.
Document (PDF) (847 KB PDF).

May 13, 1991. Memorandum. 1 Page(s).
Bernice Fisher. Science Analysis & Coordination Branch.
Cyanazine (188C), Atrazine (63) and Simazine (740) Quantitative Risk Assessment
Comparisons on Malignant Mammary Gland Tumors only in Rats.
Document (PDF) (62 KB PDF).

July 08, 1991. Memorandum. 2 Page(s).
Bernice Fisher. Science Analysis & Coordination Branch.
Cyanazine (188C), Atrazine (63) and Simazine (740) Quantitative Risk Assessment
Comparisons on Malignant Mammary Gland Tumors only in Rats.
Revised Comparisons as of July, 1991.
Document (PDF) (100 KB PDF).

July 30, 1991. Memorandum. 17 Page(s).
William Dykstra. Toxicology Branch.
Peer review of Cyanazine (Bladex).
Document (PDF) (826 KB PDF).

August 20, 1991. Memorandum. 100 Page(s).
William Dykstra. Toxicology Branch.
Peer Review of Cyanazine (Bladex) Tox review 008521
Pages 68-74 are not included-registrant data.
Document (PDF) (4787 KB PDF).

March 11, 1992. Memorandum. 2 Page(s).
Roger Gardner. Toxicology Branch 1.
Cyanazine; Historical Control Data on 2-Year Rat Study; ID # 100101;
Support of Reregistration. Tox review 009353.
Document (PDF) (100 KB PDF).

August 03, 1992. Memorandum. 6 Page(s).
George Ghali. Toxicology Branch.
Cyanazine: Report of the RfD/Peer Review.
Document (PDF) (380 KB PDF).

August 07, 1992. Memorandum. 3 Page(s).
Michael S. Metzger. Chemistry Branch II.
Atrazine, Simazine, & Cyanazine. Results of the Metabolism Committee Meeting of 07/09/92.
Document (PDF) (191 KB PDF).

November 13, 1992. Memorandum. 15 Page(s).
Stephen Schaible. Science Analysis Branch.
Dietary Exposure Analysis and Carcinogenic Risk Assessment for Cyanazine and
Metabolites Using Anticipated Residues.
Document (PDF) (1044 KB PDF).

June 14, 1993. Memorandum. 2 Page(s).
Reto Engler. Health Effects Division.
Cyanazine; Quantitative Estimate of Carcinogenic Risk: Oral Slope Factor.
Document (PDF) (122 KB PDF).

July 13, 1993. Memorandum. 25 Page(s).
William Dykstra. Toxicology Branch.
Cyanazine: Reregistration Case; 0066; ID# 100101; Review of New Toxicology
Studies Submitted in Support of Reregistration. MRID 427395-01, -02, -03, -04.
Tox review 010382.
Document (PDF) (993 KB PDF).

March 07, 1994. Memorandum. 27 Page(s).
Michael Beringer. Chemical Coordination Branch.
Revised Occupational and residential Risk Assessment for the Triazines.
Document (PDF) (1550 KB PDF).

August 07, 1995. Memorandum. 4 Page(s).
George Keitt. Biological Analysis Branch.
Response to Ciba-Geigy Regarding Triazine Benefits Analysis.
Document (PDF) (208 KB PDF).

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