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Index of Cleared Science Reviews
Index for Metasystox-R (Pc Code 058702)
August 28, 1975. Memorandum. 4 Page(s).
Robert Coberly. Toxicology Branch.
Metasystox-R (S-[2-(ethylsulfinyl)ethyl]0,0-dimethyl
phosphorothioate) and its Cholinesterase Inhibiting
Metabolites. Pesticide Petition No. 3F1391. Food Additive
Petition No. 5H5096. Inert info on page 1 not included.
Tox review 000122.
September 19, 1975. Memorandum. 16 Page(s).
Robert Coberly. Toxicology Branch.
Metasystox-R (S-[2-(ethylsulfinyl)ethyl]0,0-dimethyl
phosphorothioate) and its Cholinesterase Inhibiting
Metabolites. Pesticide Petition No. 5F1643.
Inert ingredient information on pages 3-4 is not included.
Tox review 000124.
May 26, 1981. Memorandum. 2 Page(s).
Cheryl Peterson. Insecticide-Rodenticide Branch.
Letter from S.S. Song Dated 5-14-81, EPA Reg. No. 239-741
Ortho Isotox Insect Spray. Caswell Nos. 160, 93, 455.
March 30, 1984. Memorandum. 2 Page(s).
Stephen Saunders. Toxicology Branch.
Expedited Review of Metasystox-R Teratology Study.
Tox Review 003721.
September 24, 1986. Memorandum. 8 Page(s).
Quang Bui. Toxicology Branch.
Laboratory Audit Report - Miles Laboratories, Inc.,
Elkhart, Indiana 46515.
February 10, 1987. Memorandum. 4 Page(s).
Quang Bui. Toxicology Branch.
Company Response to a Review of a Two-Generation
Reproduction Study with Metasystox-R in Rats and Protocol
Review.
Inert ingredient information on pages 2-3 is not included.
Tox review 005716.
July 14, 1987. Memorandum. 1 Page(s).
Edwin Tinsworth. Registration Division.
Expedited Comparative Review of Ecological Effects of
Azodrin/Supracide/Capture and of Diazinon/Metasystox R/
Cygon.
July 23, 1987. Memorandum. 8 Page(s).
Harry Craven. Ecological Effects Branch.
Comparative Risk Assessment on Ecological Effects of
Azodrin, Supracide, Metasystox R, Furadan 4F, Capture,
Cygon, and Diazinon to Avian Species.
August 21, 1987. Memorandum. 5 Page(s).
Quang Bui. Toxicology Branch.
Review a "Six-Month Progress Report" for the Male
Reproductive Toxicity Study with Metasystox-R in Rats.
Tox Review No. 006228.
October 27, 1987. Memorandum. 2 Page(s).
Quang Bui. Toxicology Branch.
Company Response to the Agency's Request for Clarification
Relative to Oxydemeton-methyl.
Inert ingredient information on page 2 is not included.
Tox review 006396.
September 26, 1989. Memorandum. 38 Page(s).
David Anderson. Toxicology Branch.
Review Male Reproductive Effects of Metasystox-R (Oxydemeton
-methyl) After Short Term Exposure (Dominant Lethal Plus).
Pages 28-38 removed, registrant data.
Tox review 007494.
October 18, 1989. Memorandum. 3 Page(s).
Mary Waller. Registration Support Branch.
EPA Reg. No./File Symbol 3125-99, Metasystox-R.
Tox Review No. 009129.
September 29, 1992. Memorandum. 18 Page(s).
Gary Burin. Science Analysis & Coordination Branch.
Developmental and Reproductive Toxicity Peer Review of
Oxydemeton-methyl.
July 24, 1997. Memorandum. 18 Page(s).
George Ghali. Health Effects Division.
Oxydemeton-Methyl (Metasystox-R): Hazard Identification
Report (Revised).
September 11, 1997. Memorandum. 64 Page(s).
C. Renee Costello. Environmental Risk Characterization Br.
EFED's Reregistration Eligibility Decision Chapter
for Oxydemeton methyl.
September 29, 1997. Memorandum. 10 Page(s).
Jerome Blondell. Chemistry and Exposure Branch.
Review of Oxydemeton Methyl Incident Reports.
December 10, 1997. Memorandum. 62 Page(s).
Paula Deschamp. Health Effects Division.
Oxydemeton-methyl: Product and Residue Chemistry Chapters
for the Reregistration Eligibility Decision (RED) Document.
Tox review 012429.
May 7, 1998. Memorandum. 28 Page(s).
Robert Fricke. Health Effects Division.
OXYDEMETON-METHYL - REVISED Report of the Hazard
Identification Assessment Review Committee.
Tox review 012606.
May 26, 1998. Memorandum. 2 Page(s).
Richard Griffin. Health Effects Division.
Oxydemeton-methyl. Dietary Exposure and Risk Estimates
for Reregistration.
May 26, 1998. Letter. 2 Page(s).
Kathy Monk. SRRD.
To: Elizabeth Codrea [Gowan Company]
Re: Monte Carlo Style Dietary Exposure Assessment
for Oxydemeton-methyl.
August 3, 1998. Memorandum. 39 Page(s).
Kelly O'Rourke. Chemistry and Exposure Branch.
Occupational and Residential Exposure Assessment
and Recommendations for the Reregistration
Eligibility Decision Document for Oxydemeton-Methyl
Revised to Reflect New Toxicological Endpoints and Aggregate
Dermal and Inhalation Risk.
September 22, 1998. Memorandum. 36 Page(s).
Robert Fricke. Health Effects Division.
OXYDEMETON-METHYL: HED Toxicology Chapter for the
Reregistration Eligibility Decision (RED) Document.
Tox review 012877.
October 7, 1998. Memorandum. 24 Page(s).
Paula Deschamp. Health Effects Division.
OXYDEMETON- METHYL: HED Risk Assessment and Disciplinary
Chapters for the Reregistration Eligibility Decision (RED)
Document.
Tox review 012900.
November 19, 1998. Letter. 2 Page(s).
Kathleen Meier. SRRD.
To: Betsy Codrea, Gowan Company
'... to discuss issues pertaining to ODM, particularly
the Monte Carlo.'.
December 14, 1998. Memorandum. 2 Page(s).
Paula Deschamp. Health Effects Division.
OXYDEMETON-METHYL: HED Phase 2 Comments on the Gowan Company
30-day (error only) Response to HED RED Preliminary Risk
Assessment dated october 7, 1998.
December 14, 1998. Memorandum. 21 Page(s).
Paula Deschamp. Health Effects Division.
OXYDEMETON-METHYL:
HED Preliminary Risk Assessment for Public Comment Period
(60 days).
December 15, 1998. Letter. 2 Page(s).
Kathleen Meier. SRRD.
To: Betsy Codrea, Gowan Company
'This packet of information includes: 1) the EPA's review
of Gowan's Monte Carlo, dated June 10, 1998 (MRID#445944-01)
2) letter requesting Gowan's Monte Carlo data files... 3)
EPA's updated Quantitative Usage Analysis'.
December 15, 1998. Letter. 3 Page(s).
Jack Housenger. SRRD.
To: Betsy Codrea, Gowan Company
'Your company has submitted or has an intention to submit,
a probabilistic dietary (Monte Carlo) risk assessment
to EPA...'.
December 22, 1998. Memorandum. 5 Page(s).
David Farrar. Environmental Risk Branch.
Oxydemeton-methyl (30 day registrant response):
EFED RED chapter for the ODM docket;
Partial Response to the Gowan comments;
Terrestrial chronic risk.
April 26, 1999. Letter. 2 Page(s).
Kathy Monk. SRRD.
To: Betsy Codrea, Gowan Company
EPA's Response to Gowan's Comments on the FQPA Safety Factor
for ODM.
May 3, 1999. Letter. 2 Page(s).
Kathleen Meier. SRRD.
To: Betsy Codrea, Gowan Company
Acknowledgement of Gowan's letter of April 19th regarding
the chronic dietary endpoint for ODM.
May 10, 1999. Letter. 13 Page(s).
Kathleen Meier. SRRD.
To: Betsy Codrea, Gowan Company
Oxydemeton-methyl - Review of additional information
submitted in support of in vivo alkaline elution assay.
* attached: mutagenicity; MRID 43776102
Tox review 013345.
June 14, 1999. Memorandum. 4 Page(s).
James Breithaupt. Environmental Risk Branch.
Updated Surface Water EECs for ODM Use on all Modeled Crops
in the RED.
June 21, 1999. Memorandum. 11 Page(s).
Jess Rowland. Health Effects Division.
OXYDEMETON METHYL (ODM) - REPLACEMENT OF HUMAN STUDY
USED IN RISK ASSESSMENTS-Report of the Hazard Identification
Assessment Review Committee.
June 22, 1999. Memorandum. 14 Page(s).
Sheila Piper. Chemistry and Exposure Branch.
Oxydemeton-methyl (ODM) Anticipated Residues (ARs) for
Chronic Dietary Risk Assessment and Chronic Dietary Exposure
Analysis.
July 8, 1999. Memorandum. 42 Page(s).
Kelly O'Rourke. Health Effects Division.
Revised Occupational and Residential Exposure Assessment
and Recommendations for the Re-registration Eligibility
Decision Document for Oxydemeton-Methyl. Revision
Reflects Assessment Refinements Based on Information
Provided by the Registrant. (continued).
Attachment(s) following:
July 8, 1999. Memorandum. Page(s).
Kelly O'Rourke. Health Effects Division.
EPA MRID Nos: 00158006, 00158208, 00158209, 00158210,
412017-01, 438214-01.
July 20, 1999. Memorandum. 29 Page(s).
Carol Christensen. Health Effects Division.
Acute and Chronic Dietary Exposure Analysis for
Oxydemeton-Methyl (ODM).
July 21, 1999. Memorandum. 11 Page(s).
Robert Fricke. Health Effects Division.
OXYDEMETON METHYL (ODM) - REVISED HIARC REPORT - Report of
the Hazard Identification Assessment Review Committee.
Tox review 013579.
July 22, 1999. Memorandum. 6 Page(s).
Brenda Tarplee. Health Effects Division.
OXYDEMETON-METHYL (ODM) - Report of the FQPA Safety Factor
Committee.
August 24, 1999. Memorandum. 42 Page(s).
Robert Fricke. Health Effects Division.
OXYDEMETON-METHYL: Revised HED Toxicology Chapter for the
Reregistration Eligibility Decision (RED) Document.
September 13, 1999. Memorandum. 64 Page(s).
David Farrar. Environmental Risk Branch.
Current EFED RED chapter for Oxydemeton methyl.
December 3, 1999. Memorandum. 10 Page(s).
Kathleen Meier. SRRD.
Response to Public Comments on the Preliminary Risk
Assessment for the Organophosphate Oxydemeton-methyl.
December 8, 1999. Risk Assessment. 53 Page(s).
Paula Deschamp. Health Effects Division.
Human Health Risk Assessment, Oxydemeton-methyl.