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Index of Cleared Science Reviews for Triclosan (Pc Code 054901)

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Undated. Review. 15 Page(s).
Dr. Dale. Toxicology Branch.
Bacteriostatic CH 3565 Acute Oral Toxicity (Rat) (subacute oral, inhalation, dermal, eye...)
Tox review 001955.
Document (PDF) (879 KB PDF).

January 03, 1969. Review. 10 Page(s).
Lamar Dale. Toxicology Branch.
The additional toxicological data on Bacteriostatic CH 3565... has been reviewed.
(subacute dermal tox, repeated insult patch, acute intravenous...) Tox review 001956.
Document (PDF) (489 KB PDF).

September 25, 1969. Review. 24 Page(s).
Robert Coberly. Toxicology Branch.
Reg. No 100-RT The toxicological data on 2,4,4'-Trichloro-2-hydroxydiphenyl ether has
been reviewed. (Guinea Pig Photosensitization, Phototoxicity, Photoallergy, 14 Day
Rat Dermal...) Tox review 001953.
Document (PDF) (1339 KB PDF).

September 30, 1970. Review. 12 Page(s).
David Greenman. Toxicology Branch.
Reg. Nos. 100-491, 100-502 The additional toxicological data on Irgasan DP 300 and
Bacteriostat CH 3565... have been reviewed. (Excretion, Percutaneous Absorption,
Use in Hospital...) Tox review 009162.
Document (PDF) (735 KB PDF).

February 11, 1977. Review. 41 Page(s).
C. Frick. Toxicology Branch.
Reg. No. 9687-RR Registration of product for use on diaper. (90 day subacute oral
toxicity... in Beagle Dogs) Tox review 001968.
Document (PDF) (1708 KB PDF).

July 16, 1979. Review. 3 Page(s).
Anna Skapars. Disinfectants Branch.
In foam latex - Deodorant.
Document (PDF) (61 KB PDF).

October 09, 1979. Review. 3 Page(s).
William Campbell. Disinfectants Branch.
Impregnated foam latex; new registration.
Document (PDF) (139 KB PDF).

June 25, 1980. Memorandum. 2 Page(s).
Gary Burin. Toxicology Branch.
Validation review of IBT Study P. 7113 Three Phase Reproduction Study in Albino
Rats of Irgasan. Tox review 001967.
Document (PDF) (111 KB PDF).

March 05, 1981. Memorandum. 18 Page(s).
William Dykstra. Toxicology Branch.
EPA Reg.# 100-502; Irgasan DP 300 (Triclosan); Request for Removal of Label
disclaimer "Do Not Use For Baby Diaper Laundry".
Document (PDF) (960 KB PDF).

June 04, 1982. Review. 1 Page(s).
Laurence Chitlik. Toxicology Branch.
IBT Validation Report (3) Citation: IBT No. J 4915. 18-Month Study of the
Carcinogenic Potential of Irgasan CF3 (in) Swiss White Mice Tox review 002980.
Document (PDF) (55 KB PDF).

September 03, 1982. Memorandum. 5 Page(s).
Arturo Castillo. Disinfectants Branch.
Irgasan (R) DP 300. (Triclosan) Request for Removal of Label Warning: DO NOT USE
FOR BABY DIAPER LAUNDRY. Manufacturing process information on page 4 not included.
Document (PDF) (224 KB PDF).

September 17, 1982. Review. 1 Page(s).
Laurence Chitlik. Toxicology Branch.
IBT Validation Report (3) Citation: IBT No. 622-05278. Eighteen-Month
Carcinogenicity Study with FAT 80'023/A in Albino Mice Tox review 002984.
Document (PDF) (72 KB PDF).

March 23, 1983. Review. 1 Page(s).
Laurence Chitlik. Toxicology Branch.
IBT Validation Report (3) Citation: IBT No. 622-06047. Two-Year Chronic Oral Tox
Study with FAT 80'023/A in Albino Rats. December 1, 1977. Tox review 002981.
Document (PDF) (63 KB PDF).

February 27, 1984. Memorandum. 24 Page(s).
Robert Zendzian. Toxicology Branch.
Irgasan Toxicology Data Requirements Tox review 003655.
Document (PDF) (1025 KB PDF).

February 29, 1984. Memorandum. 3 Pages.
Robert Zendzian. Toxicology Branch.
Irgasan; Toxicology Data Requirements. Registration # 100-502.
Accession #s 251771-74.
Document (PDF) (67 KB PDF).

May 06, 1986. Efficacy Review. 3 Pages.
Robert Zendzian. Toxicology Branch.
EPA Reg. No. or File Symbol: 42182-1. Product Name(s): Microban Plastaic Additive "B".
Protocol Review/Resubmission.
Document (PDF) (30 KB PDF).

July 20, 1988. Memorandum. 24 Page(s).
Linda Taylor. Toxicology Branch.
Irgasan - Two-Generation Reproduction Study in Rats. Review of Study.
Pages 13-24 removed, registrant data. MRID 40623701. Tox review 006842.
Document (PDF) (684 KB PDF).

March 23, 1989. Memorandum. 37 Page(s).
Whang Phang. Toxicology Branch.
Irgasan: Review of Chronic Feeding / Oncogenicity Study in Rats
Acc. No. 263791 - 263794 Tox review 007098.
Document (PDF) (2170 KB PDF).

July 23, 1990. Review. 17 Page(s).
James Akerman. Ecological Effects Branch.
EPA Reg. No. 875-RRN. Issue Plus II. Microbiocide. Alkyl (50% C14, 40% C12, 10% C16)
dimethylbenzyl ammonium chloride. Proposed registration of use in laundries.
MRIDs 41008910 thru 41008914.
Document (PDF) (769 KB PDF).

March 25, 1991. Memorandum. 17 Page(s).
Elizabeth Resek. Environmental Fate & Ground Water Branch.
Review of List B Phase IV Package for Irgasan.
Document (PDF) (853 KB PDF).

February 24, 1992. Memorandum. 7 Page(s).
Deborah McCall. Toxicology Branch.
Agency Responses to Irgasan Phase 4 Review Rebuttal Comments
Tox Review 009310.
Document (PDF) (409 KB PDF).

October 28, 1994. Memorandum. 48 Page(s).
Deborah McCall. Toxicology Branch.
Irgasan: review of 3 Toxicity Studies 90-day Study in Mice (82-1); MRID 430226-05
Developmental Toxicity in Rats (83-3a); MRID 430226-06 Developmental Toxicity in
Rabbits (83-3b); MRID 430226-07 Tox review 011304.
Document (PDF) (2405 KB PDF).

February 23, 1995. Memorandum. 37 Page(s).
Whang Phang. Toxicology Branch.
Irgasan: Review of a 14-day dermal dose rangefinding study and a 90-day dermal
toxicity study in rats MRID 432519-01 (rangefinding); 433280-01 (dermal tox).
Pages 12-37 removed, registrant data. Tox review 011417.
Document (PDF) (724 KB PDF).

June 17, 1996. Memorandum. 9 Pages.
Whang Phang. Toxicology Branch II.
Irgasan R Dp 300 (Triclosan): Review of a company response concerning a chronic
feeding/oncogenicity study in rats (Accession No. 263791). DP BARCODE: D209137.
MRID No.: 42027906. TOX. CHEM. No.: 168A.
Document (PDF) (429 KB PDF).
Attachment(s) Following:

February 24, 1992. Memorandum.
Deborah McCall. Toxicology Branch II.
Agency Responses to Irgasan Phase 4 Review Rebuttal Comments.

*End of Attachments*

April 06, 1998. DER. 20 Pages.
Timothy McMahon. Risk Assessment & Science Support Branch.
Liver Biochemical Induction -hamster- non-guideline. DP Barcode D240164.
MRID No. 44389706.
Document (PDF) (1729 KB PDF).

April 27, 1998. Memorandum. 11 Pages.
Timothy McMahon. Risk Assessment & Science Support Branch.
Triclosan: Review of Toxicology Data Submitted by the Registrant.
DP Barcode D240164. MRID Nos. 443897-01 thru -11.
Document (PDF) (7077 KB PDF).

October 15, 1998. Memorandum. 3 Page(s).
Timothy McMahon. Risk Assessment & Science Support Branch.
5-Chloro-2-(2,4-dichlorophenoxy)phenol (Triclosan): Review of data on the safety
of the active ingredient. (tox data, chemistry, impurities and exposure from toothbrush
handles and bristles.) MRID 44604003, 44604007.
Document (PDF) (126 KB PDF).

October 22, 1998. Memorandum. 12 Page(s).
Jess Rowland. Health Effects Division.
TRICLOSAN: Report of the Hazard Identification Assessment Review Committee.
Tox review 012919.
Document (PDF) (636 KB PDF).

October 28, 1998. Memorandum. 5 Page(s).
Timothy McMahon. Risk Assessment & Science Support Branch.
5-Chloro-2-(2,4-dichlorophenoxy)phenol (Triclosan): Review of data on the safety
of the active ingredient. MRID's: N/A (summary report on toxicology). Review of
"Implications for Human Health of the Triclosan Animal Safety Bioassy Data".
Document (PDF) (207 KB PDF).

February 11, 1999. Memorandum. 2 Page(s).
Srinivas Gowda. Efficacy & Science Support Branch.
Efficacy Review for 6459-G/Rentokill Calmic Type S Formulation - Cascade.
DP Barcode D249413. MRIDs 44632111, 44632112.
Document (PDF) (53 KB PDF).

March 12, 1999. Memorandum. 4 Page(s).
Srinivas Gowda. Efficacy & Science Support Branch.
Efficacy Review for 42182-1/Microban Additive "B" DP Barcode D251051.
MRID 44514501.
Document (PDF) (186 KB PDF).

March 30, 1999. Memorandum. 4 Pages.
Timothy McMahon. Risk Assessment & Science Support Branch.
5-Chloro-2-(2,4-dichlorophenoxy)phenol [Triclosan]: Review of preliminary results from
a hamster chronic bioassay submitted under FIFRA 6(a)(2). DP Barcode: D253398.
MRIDs: N/A. (MRID No. 44751101).
Document (PDF) (622 KB PDF).

December 13, 1999. Memorandum. 5 Page(s).
Timothy McMahon. Risk Assessment & Science Support Branch.
5-Chloro-2-(2,4-dichlorophenoxy)phenol (Triclosan): Request for dietary risk assessment.
MRID's: N/A.
Document (PDF) (230 KB PDF).

January 19, 2000. Memorandum. 4 Page(s).
Doreen Aviado. Risk Assessment & Science Support Branch.
Non-Dietary Exposure Considerations for MICROBAN ADDITIVE B
Bacteriostatic/Fungistatic Agent Containing the Active Ingredient
5-Chloro-2-(2,4-dichlorophenoxy)phenol. D256201 ice making equipment.
Product ingredient source info on page 2 deleted.
Document (PDF) (261 KB PDF).

August 04, 2000. Package. 235 Pages.
B. Sjoblad. Health Effects division.
HIARC Briefing Packages.
Document (PDF) (10278 KB PDF).

November 27, 2000. Letter. 73 Page(s).
Robert Brennis. Regulatory Management Branch AD.
Metabolism Toxicology Data. Irgasan EPA Registration 70404-2.
Document (PDF) (3418 KB PDF).
Attachment(s) Following:

November 02, 2000. Memorandum.
Timothy McMahon. Risk Assessment & Science Support Branch.
5-Chloro-2-(2,4-dichlorophenoxy)phenol (Triclosan): Review of Metabolism data.
MRID's: 149464, 79590, 68163, 68162, 68161.

*End of Attachments*

August 21, 2003. Memorandum. 12 Page(s).
Ian Blackwell. Product Science Branch.
Efficacy Review for EPA Reg. No. 10466-27 / Ultra Fresh NM.
DP Barcode: D289500. MRIDs 45897701 thru -04.
Document (PDF) (596 KB PDF).

January 04, 2008. Memorandum. 46 Pages.
Jessica Kidwell. Cancer Assessment Review Committee.
TRICLOSAN: Report of the Cancer Assessment Review Committee. Tox review No. 0054799.
MRID Nos. 44874001, 43533301, 437408-01, -02,472766-01 & -02.
Document (PDF) (1599 KB PDF).

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